Osteoarthritis and cartilage open最新文献

{"title":"Defining and measuring varus thrust in knee osteoarthritis: A scoping review of current evidence and challenges","authors":"Vincenzo E. Di Bacco ,&nbsp;Zaryan Masood ,&nbsp;Joshua A.J. Keogh ,&nbsp;Matthew C. Ruder ,&nbsp;Fatima Gafoor ,&nbsp;Jenny Wu ,&nbsp;Yalda Azari ,&nbsp;Eseoghene Orogun ,&nbsp;Dylan Kobsar","doi":"10.1016/j.ocarto.2025.100683","DOIUrl":"10.1016/j.ocarto.2025.100683","url":null,"abstract":"<div><h3>Objective</h3><div>This scoping review investigated the definitions, assessment methods, and current applications of varus thrust (VT) in knee osteoarthritis (OA).</div></div><div><h3>Methods</h3><div>Five databases (MEDLINE, EMBASE, CINAHL, SPORTDiscus, and Web of Science Core Collection) were searched in this scoping review for studies assessing VT during walking in adults with knee OA using the terms “varus” and “lateral” in proximity to thrust. Data were extracted and categorized by study characteristics (OA sample, publication year, design, and aim) and VT assessment protocol (method and definition).</div></div><div><h3>Results</h3><div>A total of 63 studies were included, examining 12,569 individuals with knee OA using visual (<em>n</em> ​= ​24), optical motion capture (<em>n</em> ​= ​27), or inertial/wearable sensor (<em>n</em> ​= ​19) methods. Designs included prospective, experimental, cross-sectional, and case series. VT was most often assessed to examine disease severity, progression, surgical outcomes, and symptom associations. Visual VT was commonly defined as dynamic worsening or abrupt onset of varus alignment during weight acceptance. Optical motion capture commonly measured VT as frontal plane knee excursion from foot contact to mid-stance, while inertial methods typically used peak lateral tibial acceleration or angular velocity.</div></div><div><h3>Conclusion</h3><div>Despite growing research interest in VT, inconsistent definitions and measurement protocols limit comparability across studies and hinder broader adoption. Greater standardization and validation are needed to clarify its potential clinical utility in knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100683"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145105128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Peripheral blood DNA methylation changes are predictive of incident radiographic osteoarthritis development: Data and biospecimens from the osteoarthritis initiative","authors":"Cindy Miranda Brawner ,&nbsp;Gabriella Dyson ,&nbsp;Montana Barrett ,&nbsp;Nicholas Hanebutt ,&nbsp;Aleksander Szymczak ,&nbsp;Padmaja Mehta-D’souza ,&nbsp;Matlock A. Jeffries","doi":"10.1016/j.ocarto.2025.100692","DOIUrl":"10.1016/j.ocarto.2025.100692","url":null,"abstract":"<div><h3>Objective</h3><div>The lack of biomarkers to predict knee osteoarthritis (OA) progression is a key unmet need in the OA field. The objective of this study was to evaluate epigenetic changes in baseline peripheral blood cells of healthy individuals who subsequently developed radiographic knee OA (incident OA) as a preclinical biomarker.</div></div><div><h3>Methods</h3><div>Genome-wide DNA methylation data were generated using Illumina Methylation EPICv2 arrays on baseline blood samples from 234 incident OA patients and 234 controls matched by age±5y, sex, ethnicity, and BMI±5 units. Peripheral blood cellular composition was estimated. Lasso was used for CpG selection. Models were first trained using a 40-round Monte Carlo cross-validated generalized logistic modeling approach, then parsimonious models developed using CpG sites selected in ≥10 rounds.</div></div><div><h3>Results</h3><div>Future incident OA cases were estimated to have increased monocyte frequency (0.089 ​± ​0.0001 vs. 0.083 ​± ​0.0001 mean ​± ​SEM, <em>q</em> ​= ​0.01), although cell composition models were not predictive (AUC ​= ​0.56 ​± ​0.01) Full methylation models accurately differentiated future incident OA patients from controls but suffered from overfitting (development: AUC ​= ​0.91 ​± ​0.001, validation: AUC ​= ​0.64 ​± ​0.006). Parsimonious models developed using 21 top CpG sites performed similarly with less overfitting (development: AUC ​= ​0.91 ​± ​0.001, validation: AUC ​= ​0.87 ​± ​0.003, accuracy 0.79 ​± ​0.004, sensitivity 0.78 ​± ​0.004, specificity 0.80 ​± ​0.006). Previously developed OA progression models did not predict incident OA (AUC ​= ​0.48 ​± ​0.002). Five of 21 CpG sites were located proximate to known genes, including <em>RGS9BP, TOLLIP, UOX, L3MBTL1,</em> and <em>IFI27L1</em>.</div></div><div><h3>Conclusions</h3><div>Blood-based DNA methylation models may predict incident knee OA in healthy individuals using a small set of CpG sites. Further work should focus on evaluating the pathophysiological role of DNA methylation in incident OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100692"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265591","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Artificial intelligence in osteoarthritis research: summary of the 2025 OARSI pre-congress workshop","authors":"Matthew S. Harkey ,&nbsp;Kerry E. Costello ,&nbsp;Bella Mehta ,&nbsp;Chunyi Wen ,&nbsp;Anne-Marie Malfait ,&nbsp;Henning Madry ,&nbsp;Brooke Patterson","doi":"10.1016/j.ocarto.2025.100687","DOIUrl":"10.1016/j.ocarto.2025.100687","url":null,"abstract":"<div><h3>Objective</h3><div>Artificial intelligence (AI) is transforming musculoskeletal research, offering new approaches to diagnosis, prognosis, and patient management in osteoarthritis (OA). However, implementation and ethical challenges persist. This manuscript summarizes insights from the OARSI 2025 Pre-Congress Workshop on Artificial Intelligence in Osteoarthritis Research, highlighting opportunities and challenges in applying AI across biomechanics, imaging, and clinical research domains.</div></div><div><h3>Design</h3><div>The workshop, organized by the OARSI Early Career Investigator Committee and co-chaired by Drs. Matthew Harkey and Brooke Patterson, convened experts to discuss the use of AI in real-world biomechanics data collection, radiomics for imaging-based biomarkers, and large language models (LLMs) for clinical and research applications. Emphasis was placed on the need for interdisciplinary collaboration and ethical oversight.</div></div><div><h3>Results</h3><div>In biomechanics, AI-driven markerless motion capture and wearable sensors enable scalable, ecologically valid data collection, though issues such as class imbalance, data privacy, and model interpretability remain. In imaging, radiomics and deep learning models show promise for early OA detection and progression prediction but face challenges in domain adaptation and external validation. In clinical research, LLMs can streamline documentation and thematic analysis but must address concerns around bias, data security, and transparency. Across domains, transparency, reproducibility, and ethical use of AI were emphasized as critical for maintaining scientific rigor.</div></div><div><h3>Conclusions</h3><div>Cross-disciplinary collaboration and AI literacy are essential to responsibly advance AI integration in OA research. The workshop's collective insights call for ethical, patient-centered approaches that leverage AI's strengths while preserving research integrity and trust.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100687"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158066","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organ-on-chip technologies: Novel tools with the potential to revolutionize osteoarthritis research and clinical development","authors":"Carlo Alberto Paggi","doi":"10.1016/j.ocarto.2025.100686","DOIUrl":"10.1016/j.ocarto.2025.100686","url":null,"abstract":"<div><h3>Objective</h3><div>To critically evaluate the evolution of in vitro models for osteoarthritis (OA) research, with a specific focus on organ-on-chip (OOC) technologies, and to discuss their potential to overcome the limitations of traditional 2D, 3D, and explant models in disease modelling, drug discovery, and preclinical toxicology.</div></div><div><h3>Methods</h3><div>This review synthesizes findings from recent literature regarding historical and current in vitro platforms used in OA research. It categorizes models based on biological complexity and physiological relevance, with particular emphasis on biomechanical and biochemical stimulation in OOC systems. Key examples from the literature are discussed to illustrate the utility and scalability of emerging platforms.</div></div><div><h3>Results</h3><div>Traditional 2D cultures, while widely used, lack the spatial and environmental complexity necessary to replicate native joint physiology. 3D cultures and explant models provide improved architecture and cellular context, but face challenges related to standardization, longevity, and reproducibility. OOC systems offer a dynamic and tunable microenvironment that supports real-time monitoring and integration of mechanical cues such as shear stress and compression. These platforms have been successfully employed to investigate immune cell migration, drug permeability across barriers, and cytokine-induced matrix degradation. Furthermore, their application in preclinical modelling for efficacy and safety studies highlights the potential for more predictive, human-relevant data compared to conventional methods.</div></div><div><h3>Conclusion</h3><div>OOCs technology represents a transformative advance in OA modelling, offering increased physiological relevance and experimental precision. With continued refinement and validation, OOC platforms could significantly improve the translational success of disease-modifying OA therapies.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100686"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158709","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"M2a macrophages identified as a potential therapeutic candidate for intervertebral disc herniation regression","authors":"Zorica Buser ,&nbsp;Catarina Correia ,&nbsp;Melissa Baker ,&nbsp;Catarina Meireles ,&nbsp;Tiago Castanheira ,&nbsp;Pedro Santos Silva ,&nbsp;Paulo Pereira ,&nbsp;Michael Gerling ,&nbsp;Gabriel Courties ,&nbsp;Mário A. Barbosa ,&nbsp;Hans-Joerg Meisel ,&nbsp;Carla Cunha","doi":"10.1016/j.ocarto.2025.100701","DOIUrl":"10.1016/j.ocarto.2025.100701","url":null,"abstract":"<div><h3>Objective</h3><div>Lumbar disc herniation (LDH) is one of the most common spine pathologies and its spontaneous regression has been attributed to the activation of immune cells by inflammatory processes and extracellular matrix remodelling. This study aims to identify a macrophage candidate with potential for physiological treatment of LDH.</div></div><div><h3>Study design</h3><div><em>In vitro</em> co-culture model of phagocytosis using human surgical hernia explants and monocyte-derived macrophages. Lumbar disc hernia tissues were collected from patients who underwent discectomy for LDH and co-cultured in transwell assays with M0, M1, M2a and M2d macrophages derived from blood monocytes. The macrophage phenotypes and phagocytic activity were analyzed by flow cytometry using pHrodo™ BioParticles™ conjugates and immunostaining for classical M1 and M2 markers. Explants were analyzed histologically with Alcian blue/Sirius red.</div></div><div><h3>Results</h3><div>A total of 21 samples were included, patient's average age was 48.8 ​± ​12.9 years and the most common levels were L4-5 (42.9 ​%) and L5-S1 (33.3 ​%). After three days co-culture with monocyte-derived macrophages, explants maintained the structure and high proteoglycans/collagen ratio. Flow cytometry analysis revealed that the explants modified the immune profile of macrophages, increasing the proportion of pro-inflammatory CD86⁺ cells, while reducing the percentage of anti-inflammatory CD163⁺ cells. Additionally, the M2a phenotype presented larger cells and had the highest phagocytic profile towards the explants.</div></div><div><h3>Conclusions</h3><div>M2a macrophages showed the highest potential towards the design of a macrophage-based therapy for LDH. This study holds great promise for translational medicine aimed at accelerating spontaneous LDH using a physiological treatment that could prevent need for surgical intervention.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100701"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145578650","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study","authors":"Caroline H. Dekkerhus ,&nbsp;Alexander Mathiessen ,&nbsp;Caroline M. Fjellstad ,&nbsp;Barbara Slatwkosky-Christensen ,&nbsp;Hilde Berner Hammer ,&nbsp;Ida K. Haugen","doi":"10.1016/j.ocarto.2025.100640","DOIUrl":"10.1016/j.ocarto.2025.100640","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the frequency and severity of ultrasound-detected osteophytes and synovitis in people with and without knee osteoarthritis (OA), and to explore the association between these ultrasound features and pain.</div></div><div><h3>Design</h3><div>In the Nor-Hand study, both knees were assessed for osteophytes (0–3 scale, four locations per knee) and grey-scale synovitis (0–3 scale). The frequency and severity of the ultrasound-detected features were compared in individuals with and without knee OA defined by the American College of Rheumatology criteria. Pain was self-reported in each knee (yes/no) and by the Western/Ontario McMaster University index (WOMAC). The associations between ultrasound-detected features and pain were examined by regression analyses adjusted for age, sex, and body mass index.</div></div><div><h3>Results</h3><div>We analyzed 286 participants. Osteophytes of all sizes were more common in participants with knee OA compared to those without (65.9 ​% vs. 40.8 ​%, p ​&lt; ​0.001). No between-group difference was found for the frequency of any grey-scale synovitis (45.5 ​% vs. 44.7 ​%, p ​= ​0.67), while severe synovitis was more common in those with knee OA. Ultrasound-detected osteophyte sum score, but not synovitis, was associated with WOMAC pain (B ​= ​0.18, 95 ​% CI 0.03–0.32). Osteophytes of all sizes were associated with pain in the same knee with odds ratio (OR, 95 ​% CI) ranging from 1.85 (1.20–2.84) to 9.02 (4.04–20.10). Statistically significant association was found for severe synovitis only (OR ​= ​6.63, 95 ​% CI 2.26–19.43).</div></div><div><h3>Conclusions</h3><div>Ultrasound-detected osteophytes were prevalent in people with knee OA and were associated with pain. OA pathology in individuals without fulfilling the knee OA criteria may reflect early or subclinical OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100640"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mature and inactive microvessels are prominent in areolar synovium of femoroacetabular impingement and hip osteoarthritis patients","authors":"Ronan J. Anderson ,&nbsp;Brent A. Lanting ,&nbsp;C. Thomas Appleton ,&nbsp;Ryan M. Degen","doi":"10.1016/j.ocarto.2025.100625","DOIUrl":"10.1016/j.ocarto.2025.100625","url":null,"abstract":"<div><h3>Objective</h3><div>To provide insight into the earliest changes in hip osteoarthritis (OA) pathogenesis. Histopathology of synovium was investigated in patients with femoroacetabular impingement (FAI), FAI with early hip osteoarthritis, and advanced hip osteoarthritis.</div></div><div><h3>Methods</h3><div>Synovium biopsies were collected from ten FAI, fourteen FAI with early osteoarthritis, and twelve advanced osteoarthritis patients. Histopathological grading allowed assessment of osteoarthritis-associated features. Microvessel density and maturity were determined through immunofluorescent labelling of CD31 and α-smooth muscle actin. Immunohistochemical staining was applied to calculate CD105⁺ microvessel density, providing insight into microvessel activity.</div></div><div><h3>Results</h3><div>In all groups, vascularization was prominent, with a mean [95 ​% confidence interval] of 1.64 [1.40, 1.89]. In all three groups, mature microvessel density was greater than immature microvessel density (82.32 [62.92, 101.71] versus 14.84 [9.86, 19.83] microvessels/mm²). Low CD105⁺ microvessel density across all groups (3.14 [0.92, 5.37] microvessels/mm²) suggests microvessel inactivity. Inflammatory composite scores were significantly greater in the advanced OA (1.08 [0.84, 1.32]) versus the FAI group (0.47 [0.26, 0.68]), and in the advanced OA versus the FAI with early OA group (0.69 [0.49, 0.89]) (p ​&lt; ​0.017).</div></div><div><h3>Conclusion</h3><div>Synovium from patients with FAI (with and without hip osteoarthritis) demonstrated synovitis and other OA-associated changes. Mature, inactive microvasculature was prominent in all three groups investigated. Histopathological similarities between FAI and hip OA synovium indicate that disordered synovium appears in FAI patients. These findings highlight a potential role of synovial changes in the progression from FAI to hip OA, underscoring the need for early intervention and further investigation into early disease mechanisms.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100625"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144084025","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A novel mechanosensitive stress test in individuals following anterior cruciate ligament reconstruction: A pilot study","authors":"Prakash Jayabalan ,&nbsp;Rose Darcy ,&nbsp;Vikram Darbhe ,&nbsp;Zander Neuville ,&nbsp;Vehniah Tjong ,&nbsp;Levi Hargrove ,&nbsp;Leah Welty ,&nbsp;Thomas Schnitzer","doi":"10.1016/j.ocarto.2025.100619","DOIUrl":"10.1016/j.ocarto.2025.100619","url":null,"abstract":"<div><h3>Objectives</h3><div>1. Assess serum biomarker responses of the anterior cruciate ligament reconstructed (ACLR) knee compared to the non-injured contralateral knee in a lateral tilt paradigm. 2. Determine the relationship between kinematics at the ACLR knee and serum biomarker responses.</div></div><div><h3>Method</h3><div>Cross-sequential study. 16 participants 2–7 years post-ACLR, undertook two 30 ​min walking sessions on a 10° angular tilted treadmill towards the ACLR knee and/or contralateral non-injured knee. Serum collected at baseline and after 30 ​min of walking was tested for biomarkers associated with osteoarthritis (Cartilage oligomeric matrix protein [COMP]), C-terminal cross-linked telopeptides of type II collagen, matrix metalloproteinase-3,-13, ADAM a disintegrin and metalloproteinase with thrombospondin motifs 4-,-5 (ADAMTS-4,-5), interleukin-1β,-6,-8 and RANTES (regulated on activation, normal T-cell expressed and secreted). Kinematic measurements were also taken.</div></div><div><h3>Results</h3><div>When tilted towards the ACLR knee, there was a significant increase in COMP compared to baseline (mean 41.1 ​ng/mL (95%CI:13.8,68.4), not observed when tilted towards the contralateral knee. There was a significant correlation between change in COMP concentration and change in knee adduction/abduction angle (r ​= ​−0.58,p ​= ​0.02). There were no relationships to kinematics and the other biomarkers.</div></div><div><h3>Conclusions</h3><div>The tilt paradigm identified a differential response of a serum mechanosensitive marker (COMP) when testing an ACLR and contralateral knee. There was also a significant relationship between COMP response to tilt walking and the change in knee adduction angle of the ACLR knee. This paradigm could be an aid to provide individual knee biomarker response to a mechanical stress in asymptomatic individuals at risk of developing post-traumatic osteoarthritis at least 2 years post-ACLR.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100619"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144168300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Networking in the osteoarthritis research community in the digital era","authors":"Rachel K. Nelligan ,&nbsp;Anca Maglaviceanu ,&nbsp;Jocelyn Bowden ,&nbsp;Jackie L. Whittaker ,&nbsp;Tobias Winkler ,&nbsp;Jos Runnhar ,&nbsp;Mohit Kapoor ,&nbsp;Chunyi Wen","doi":"10.1016/j.ocarto.2025.100650","DOIUrl":"10.1016/j.ocarto.2025.100650","url":null,"abstract":"<div><div>Networking is a vital skill for osteoarthritis (OA) researchers, offering pathways to collaboration, visibility, and career development. Recognising the evolving nature of networking in the digital era, the OARSI Early Career Investigator (ECI) Committee hosted a workshop at the 2025 OARSI World Congress titled “Navigating Networking: Strategies for Connecting Across Cultures and Personalities.” This editorial summarises key insights from the session’s expert presentations and panel discussion. Dr Jocelyn Bowden highlighted the enduring value of face-to-face networking for rapport-building, encouraging ECIs to approach interactions with curiosity and preparation. Dr Jackie Whittaker explored virtual networking and personality-based strategies, noting that aligning communication methods with individual preferences can enhance engagement. She stressed that there is no one-size-fits-all approach. Professor Tobias Winkler provided guidance on industry networking, underscoring the importance of understanding corporate decision-making processes and collaboration dynamics. The session closed with reflections on cultural competence and the role of authenticity in communication. While digital tools may support networking, the speakers agreed that genuine, personalised interactions remain essential. Across all formats, researchers were encouraged to build inclusive, diverse networks grounded in sincerity and mutual respect. For those unable to attend, this summary offers practical strategies to support effective networking across platforms, cultures, and career stages.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100650"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current and changing role of glucagon-like peptide-1 receptor agonists in knee osteoarthritis","authors":"Anne D. Holleman,&nbsp;Jeffrey N. Katz","doi":"10.1016/j.ocarto.2025.100611","DOIUrl":"10.1016/j.ocarto.2025.100611","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100611"},"PeriodicalIF":0.0,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}