代谢综合征与手骨关节炎疼痛相关：来自DIGICOD队列的结果

Osteoarthritis and cartilage open Pub Date : 2025-02-05 DOI:10.1016/j.ocarto.2025.100573

Alix Charton , Romane Lacoste-Badie , Sophie Tuffet , Alexandra Rousseau , Emmanuel Maheu , Bruno Fautrel , Maxime Dougados , Francis Berenbaum , Alice Courties , Jérémie Sellam

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引用次数: 0

摘要

代谢综合征（MetS）在骨关节炎（OA）疼痛中的作用，特别是在手（HOA）等非负重关节（HOA）中，仍然存在争议。本研究评估了MetS是否与HOA患者手部疼痛增加有关。方法采用DIGICOD队列分析352例HOA患者（85%为女性，平均年龄66.4±7.4岁）。通过视觉模拟量表（VAS）、AUSCAN疼痛评分和AIMS2疼痛评分评估疼痛水平。MetS（成人治疗组III标准）的存在及其组成与人口统计学和临床特征一起评估，包括BMI和放射学严重程度（KL总评分）。根据混杂因素（年龄、性别、KL评分和HAD量表）调整相关性。结果被分为高/低疼痛水平，结果以比值比（OR）和95%置信区间（CI）表示。结果36%的患者存在met，并与活动期间较高的疼痛水平（VAS OR = 1.61, 95% CI 1.02-2.57）和整体OA疼痛（AIMS2 OR = 1.85, 95% CI 1.14-2.99）相关。调整后的AUSCAN疼痛评分也与MetS相关（OR = 1.66, 95% CI 1.05-2.62），但当调整HAD时，显著性降低（OR = 1.56, 95% CI 0.98-2.48）。甘油三酯（MetS成分）升高与较高的AIMS2疼痛评分显著相关（OR = 2.58, 95% CI 1.09-6.07）。没有发现BMI与疼痛独立相关。结论mets与HOA患者疼痛增加相关，独立于结构损伤和焦虑/抑郁，强调其对oa相关疼痛的全身性影响。

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Metabolic syndrome is associated with more pain in hand osteoarthritis: Results from the DIGICOD cohort

Background

The role of metabolic syndrome (MetS) in osteoarthritis (OA) pain, particularly in non-weight-bearing joints like the hand (HOA), remains debated. This study assessed whether MetS is linked to increased hand pain in patients with HOA.

Methods

Using the DIGICOD cohort, 352 HOA patients (85 % women, mean age 66.4 ± 7.4 years) were analyzed. Pain levels were evaluated via visual analog scale (VAS), AUSCAN pain subscore, and AIMS2 pain subscore. The presence of MetS (Adult Treatment Panel III criteria) and its components were assessed alongside demographic and clinical characteristics, including BMI and radiological severity (KL sum score). Associations were adjusted for confounders (age, sex, KL score, and HAD scale). Outcomes were dichotomized into high/low pain levels, with results expressed as odds ratios (OR) and 95 % confidence intervals (CI).

Results

MetS was present in 36 % of patients and associated with higher pain levels during activity (VAS OR = 1.61, 95 % CI 1.02–2.57) and overall OA pain (AIMS2 OR = 1.85, 95 % CI 1.14–2.99). Adjusted AUSCAN pain subscore also correlated with MetS (OR = 1.66, 95 % CI 1.05–2.62), but significance was reduced when adjusting for HAD (OR = 1.56, 95 % CI 0.98–2.48). Elevated triglycerides, a MetS component, were significantly linked to higher AIMS2 pain scores (OR = 2.58, 95 % CI 1.09–6.07). BMI was not found to be independently associated with pain.

Conclusion

MetS correlates with increased pain in HOA, independent of structural damage and anxiety/depression, underscoring its systemic impact on OA-related pain.

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来源期刊

Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation

CiteScore

3.30

自引率

0.00%

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