The relationship between circulating and tissue biomarkers and OA-related pain: A systematic literature review

IF 2.8

Osteoarthritis and cartilage open Pub Date : 2025-09-17 DOI:10.1016/j.ocarto.2025.100684

Sylvain Mathieu , Liisa Kuhi , Marie Binvignat , Philip G. Conaghan , Niels Eijkelkamp , Yves Henrotin , Eva Kosek , Ali Mobasheri , Hans-George Schaible , Kalle Kisand , Jérémie Sellam

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引用次数: 0

Abstract

Objective

This study aimed to provide an overview of the relationship between osteoarthritis (OA) pain and various fluid biomarkers by conducting a systematic literature review (SLR), to help the development of OA-related pain endotyping.

Method

An SLR was conducted, using the PubMed, Embase, Scopus, Web of Science and the Cochrane Library databases, up to December 2024. Pain measures (VAS, WOMAC, HOOS/KOOS, AUSCAN, PainDETECT and Pain Pressure Threshold) were analysed for their association with circulating biomarkers in blood, urine, synovial and cerebrospinal fluids or tissue and genetic biomarkers. Biomarkers were categorised as “associated” depending on statistical significance and further subcategorised as “consistently associated”, “uncertainly associated” or “not associated” based on the quality of evidence determined by the number of studies, sample size and the strength of correlation.

Results

The five databases yielded 30,088 citations, of which 263 relevant papers were selected. Total cholesterol in the blood was the only biomarker consistently associated with pain. Among blood biomarkers, CRP, hsCRP and IL-17 showed suggestive but inconsistent associations with OA-related pain. In synovial fluid, IL-17, C2C and VEGF were consistently associated with increasing pain intensity, based on multiple concordant studies. In cerebrospinal fluid, CX3CL1 and Flt-1 were consistently associated with pain, displaying a negative correlation.

Conclusion

This SLR identified no relevant biomarkers in different body fluids that were associated with OA-related pain. Further investigation of CRP and IL-17 is required to achieve greater consistency across studies.

PROSPERO

CRD42024550244.

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循环和组织生物标志物与oa相关疼痛的关系：系统的文献综述

目的本研究旨在通过系统的文献综述（SLR），概述骨关节炎（OA）疼痛与各种液体生物标志物之间的关系，以帮助OA相关疼痛内分型的发展。方法使用PubMed， Embase, Scopus， Web of Science和Cochrane Library数据库进行SLR，截止到2024年12月。分析疼痛测量（VAS、WOMAC、HOOS/ oos、AUSCAN、PainDETECT和痛压阈值）与血液、尿液、滑膜和脑脊液或组织中的循环生物标志物和遗传生物标志物的相关性。根据统计显著性将生物标志物分类为“相关”，并根据研究数量、样本量和相关性强度确定的证据质量进一步分类为“一致相关”、“不确定相关”或“不相关”。结果5个数据库共收录引文30,088篇，共收录相关论文263篇。血液中的总胆固醇是唯一与疼痛一致的生物标志物。在血液生物标志物中，CRP、hsCRP和IL-17与oa相关性疼痛有提示但不一致的关联。在滑液中，基于多项一致性研究，IL-17、C2C和VEGF与疼痛强度增加一致相关。在脑脊液中，CX3CL1和Flt-1与疼痛一致，呈负相关。结论：该SLR在不同体液中未发现与oa相关疼痛相关的相关生物标志物。需要进一步研究CRP和IL-17，以在研究中实现更大的一致性。

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来源期刊

Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation

CiteScore

3.30

自引率

0.00%

发文量