Osteoarthritis and cartilage open最新文献

{"title":"Guideline-informed care for osteoarthritis: Support needs of community pharmacists and healthcare professionals in Nigeria, West-Africa","authors":"Oladapo Adetunji ,&nbsp;Ibidunni Alonge ,&nbsp;Ebunoluwa Ayinmode ,&nbsp;Tolulope Owoyemi ,&nbsp;Adebimpe Ogunbanjo ,&nbsp;Simon White ,&nbsp;Adewale Adebajo ,&nbsp;Christian Mallen ,&nbsp;Krysia Dziedzic ,&nbsp;Opeyemi O. Babatunde","doi":"10.1016/j.ocarto.2025.100678","DOIUrl":"10.1016/j.ocarto.2025.100678","url":null,"abstract":"<div><h3>Objective</h3><div>The study examined the context, training needs, and extent to which community pharmacists in Nigeria have the knowledge, resources, and capability to manage OA in line with evidence-based recommendations.</div></div><div><h3>Methods</h3><div>Focus group discussions (n ​= ​2) were conducted. Discussions explored current practice, the support needs, and perceptions of a new OA care model where pharmacists could be trained to screen, educate, and refer patients. Data was analyzed thematically, including stakeholder workshops to aid interpretation.</div></div><div><h3>Results</h3><div>Data from two focus groups with 22 healthcare professionals revealed five key themes. Community pharmacies were the first point of call for most patients. Care pathway and navigation onwards were influenced by patient affordability. Radiological examinations and blood tests underpinned diagnosis and care predominantly involved pharmacological approaches. There was no local care pathway agreed/established for health professionals, and multidisciplinary team collaboration/care for OA was limited. Participants expressed the need for professional education and the development of national guidelines to inform osteoarthritis management in primary care.</div></div><div><h3>Conclusions</h3><div>Nigeria's OA care pathway is fragmented, involves overuse of medication, and has limited access to non-pharmaceutical treatments. A unified, evidence-based approach with adequate training and multidisciplinary collaboration is essential for effective primary care and reducing health inequalities.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100678"},"PeriodicalIF":2.8,"publicationDate":"2025-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145049661","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence, incidence, and progression of hip osteoarthritis in a young military population: The ADVANCE cohort study","authors":"F.C.E. Watson ,&nbsp;O. O'Sullivan ,&nbsp;A. Bennett ,&nbsp;R. Agricola ,&nbsp;S. Schofield ,&nbsp;D. Hanff ,&nbsp;C. Boos ,&nbsp;P. Cullinan ,&nbsp;N. Fear ,&nbsp;H. Kemp ,&nbsp;A.M.J. Bull","doi":"10.1016/j.ocarto.2025.100675","DOIUrl":"10.1016/j.ocarto.2025.100675","url":null,"abstract":"<div><h3>Objective</h3><div>Prevalence of hip osteoarthritis (OA) is rarely reported in young populations (e.g., military). We will report the prevalence of hip OA in a young military cohort and investigate the relationship between injury and progression/incidence.</div></div><div><h3>Design</h3><div>ADVANCE is a prospective cohort study comparing physical and psychosocial outcomes in 1145 men who served in Afghanistan including 579 men with combat injury (Exposed) who were frequency-matched to 566 controls (Unexposed). The Exposed group was sub-divided into hip injured (Exp-H), lower limb amputation (Exp-A) and other (Exp-NA). Kellgren-Lawrence (KL) scores of pelvic radiographs and Non-Arthritic Hip Score (NAHS) questionnaires were collected across two waves (Baseline and Follow-up). Prevalence at Baseline (KL ​≥ ​2), progression (KL ​≥ ​1 ​at Baseline, KL ​≥ ​2 ​at Follow-up) and incidence (KL0 at Baseline, KL ​≥ ​2 ​at Follow-up) at Follow-up were reported and compared between groups for KL and NAHS.</div></div><div><h3>Results</h3><div>Baseline prevalence of radiographic hip OA was 8.5 ​% and 4.4 ​% in the Exposed and Unexposed groups, respectively. Exp-A and Exp-H groups had 3.88 (95%CI:2.27–6.63) and 7.18 (95%CI:3.44–14.98 times increased risk for radiographic hip OA than Unexposed. Exp-A and Exp-H had a 2.15 (95%CI:1.22–3.80) and 3.28 (95%CI:1.42–7.59) times increased radiographic progression risk, compared to Unexposed. Risk of NAHS Progression and Incidence were not significantly different between groups.</div></div><div><h3>Conclusion</h3><div>Radiographic hip OA prevalence is higher in a young military population than in a similarly aged general population. Combat injury alone may not increase hip OA prevalence; but hip and lower limb loss injuries do. Progression risk is highest in those with hip or limb loss injuries.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100675"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145004507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations between bilateral versus unilateral knee osteoarthritis and physical performance measures","authors":"Jennifer S. Hanberg ,&nbsp;Faith Selzer ,&nbsp;Elena Losina ,&nbsp;Jeffrey N. Katz ,&nbsp;Jamie E. Collins","doi":"10.1016/j.ocarto.2025.100676","DOIUrl":"10.1016/j.ocarto.2025.100676","url":null,"abstract":"<div><h3>Background</h3><div>Bilateral knee osteoarthritis (KOA) is common, but evidence for the effect of bilateral versus unilateral KOA on functional outcomes is conflicting. We aimed to examine the association between bilateral versus unilateral KOA and physical performance measures over two years.</div></div><div><h3>Methods</h3><div>Our cohort included adults with symptomatic, radiographic KOA. Study assessments at baseline, 12 and 24 months included the 30-s chair sit-to-stand task (CST) and 40-m walk (40 ​MW). We defined bilateral KOA as Kellgren-Lawrence grade ≥2 and Knee Osteoarthritis Outcome Pain Scale ≥17/100 in both knees. We used linear mixed models to (1) assess the cross-sectional association between the presence of bilateral versus unilateral KOA at each timepoint and performance measures, and (2) assess the association between bilateral versus unilateral KOA at baseline and longitudinal changes in performance measures. Models were adjusted for clinical and demographic covariates.</div></div><div><h3>Results</h3><div>101 participants were included. At baseline, 43/101 (43 ​%) had bilateral KOA. In adjusted models, bilateral, versus unilateral, KOA was associated with 1.0 fewer stands on the CST (95 ​% CI: 2.2–0.1), and a 0.03 ​m/s slower 40 ​MW (95 ​% CI: 0.10–0.04). Average 2-year change in CST was −0.6 stands in those with baseline bilateral KOA and −0.7 in those with unilateral KOA (between-group difference, 0.1 stands (95 ​% CI: 1.7–1.8)). The baseline bilateral KOA group had greater worsening in 40 ​MW time (between-group difference −0.10 ​m/s (95 ​% CI: -0.20–0.00)).</div></div><div><h3>Conclusions</h3><div>We did not find clinically significant associations between bilateral vs unilateral KOA and performance on two physical performance tasks over two years of follow-up in this cohort study.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100676"},"PeriodicalIF":2.8,"publicationDate":"2025-09-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Preoperative neuropathic-like pain and central sensitisation are risk factors for chronic pain after total knee arthroplasty: A systematic review and meta-analysis","authors":"Felipe F. Gonzalez ,&nbsp;Alessandro Barone ,&nbsp;Rithik Palaniappan ,&nbsp;Raffaella Russo ,&nbsp;Giorgio Gasparini ,&nbsp;Leonardo Metsavaht ,&nbsp;Jorge Chahla ,&nbsp;Filippo Familiari","doi":"10.1016/j.ocarto.2025.100674","DOIUrl":"10.1016/j.ocarto.2025.100674","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the effects of preoperative neuropathic-like pain and central sensitisation on clinical outcomes after total knee arthroplasty (TKA).</div></div><div><h3>Design</h3><div>This systematic review and meta-analysis followed PRISMA guidelines and was prospectively registered. Studies were included if they assessed preoperative neuropathic-like pain or central sensitisation before TKA and clinical outcomes after surgery, such as pain, function, or psychological status. Cross-sectional studies and case reports were excluded. Two authors independently screened, extracted data and rated articles' quality using a quality assessment tool. A meta-analysis was performed for studies reporting comparable methods and outcomes.</div></div><div><h3>Results</h3><div>From 6061 identified records, 15 studies met the inclusion criteria (total sample: 2385 individuals; follow-up periods: less than 1 year to 5 years). Most studies exhibited low/moderate risk of bias, primarily due to small sample sizes. The risk ratio of chronic pain (VAS ≥3 after at least 3 months) was 2.75 (CI: 1.78; 4.26) for patients with neuropathic-like pain (PainDETECT score ≥13). Seven out of eleven studies identified neuropathic-like pain and central sensitisation as risk factors for clinical outcomes such as decreased self-reported function, satisfaction, and anxiety (p ​&lt; ​0.05). Studies that adjusted for covariates showed mixed results, with some losing statistical significance.</div></div><div><h3>Conclusion</h3><div>The presence of neuropathic-like pain and central sensitisation in candidates for TKA is a risk factor for postoperative chronic pain. Evidence for decreased function, satisfaction, and psychological conditions is inconsistent. Screening and managing neuropathic-like pain and central sensitisation preoperatively could possibly improve clinical outcomes. Further research with standardized methods is needed.</div></div><div><h3>Prospero id</h3><div>CRD42024622693.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100674"},"PeriodicalIF":2.8,"publicationDate":"2025-08-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145019372","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Corrigendum to “The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial” [Osteoarthr Cartil Open 7 (2025) 100563]","authors":"Cale A. Jacobs ,&nbsp;Morgan H. Jones ,&nbsp;Jamie E. Collins ,&nbsp;Lily M. Waddell ,&nbsp;Xiaojuan Li ,&nbsp;Carl S. Winalski ,&nbsp;Brian Pietrosimone ,&nbsp;Virginia Byers Kraus ,&nbsp;Miguel Otero ,&nbsp;Elizabeth Wellsandt ,&nbsp;Laura C. Schmitt ,&nbsp;Kurt P. Spindler ,&nbsp;Donald D. Anderson ,&nbsp;Scott A. Rodeo ,&nbsp;Robert A. Magnussen ,&nbsp;Brian R. Wolf ,&nbsp;Joe M. Hart ,&nbsp;Austin V. Stone ,&nbsp;Caitlin E. Conley ,&nbsp;Yvonne M. Golightly ,&nbsp;Elena Losina","doi":"10.1016/j.ocarto.2025.100665","DOIUrl":"10.1016/j.ocarto.2025.100665","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100665"},"PeriodicalIF":2.8,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144892330","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proteomics investigation of primary human articular chondrocyte isolation","authors":"Abby Brumwell ,&nbsp;Simran Raheja ,&nbsp;William Cawley ,&nbsp;Emily Birkett-Jones ,&nbsp;Sarah E. Orr ,&nbsp;Caitlin Todd ,&nbsp;David J. Deehan ,&nbsp;Nichola J. Conlon ,&nbsp;Matthias Trost ,&nbsp;Sarah J. Rice","doi":"10.1016/j.ocarto.2025.100664","DOIUrl":"10.1016/j.ocarto.2025.100664","url":null,"abstract":"<div><h3>Objective</h3><div>Human primary articular chondrocytes (hPACs) are routinely isolated from articular cartilage for pre-clinical OA research. Collagenase digest of tissue is an essential step, yet the impact of lengthy enzymatic incubation on the hPAC phenotype is unclear. We aimed to delineate this through proteomic analysis.</div></div><div><h3>Design</h3><div>hPACs were isolated from human knee cartilage (n ​= ​4) from patients undergoing total knee replacement. Collagenase treatment was performed with or without prior fixation of the tissue. Proteomes were quantified using LC-MS/MS. The Proteomic Ruler was employed to estimate protein copy numbers and cell protein masses. Significant differences in protein intensities were determined using paired t-testing and Benjamini-Hochberg correction. Proteomic data were integrated with existing transcriptomes (GSE217871) of hPACs and ground cartilage (<em>ex vivo</em>) RNA.</div></div><div><h3>Results</h3><div>Following collagenase treatment, we identified 498 differentially expressed proteins (DEP) in the unfixed cells. We observed depletion of FOXO signaling and enrichment of ribosomal RNA processing, indicative of increased cell cycle progression. This was supported by depletion of cell cycle inhibitors including CDKN1C. Transcriptomic analysis identified 3937 differentially expressed genes (DEG), and a 53 ​% overlap in DEP and DEG. Propidium iodide staining did not identify significant differences in cell cycle between fixed and unfixed hPACs.</div></div><div><h3>Conclusions</h3><div>We identified shifts in the proteome and transcriptome of hPACs following collagenase digest, supporting the use of tissue fixation before extracting nucleic acids for analysis where possible. Despite widespread expression changes, hPACs largely retain their chondrocyte phenotype. These datasets and analyses will serve as a valuable resource for the OA and cartilage research community.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100664"},"PeriodicalIF":2.8,"publicationDate":"2025-08-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The evolution of the meniscus: Where surgical advancements meet translational research","authors":"Darya I. Lee ,&nbsp;Rachel J. Lovejoy ,&nbsp;Morgan H. Jones ,&nbsp;Elizabeth G. Matzkin ,&nbsp;Jeffrey N. Katz","doi":"10.1016/j.ocarto.2025.100666","DOIUrl":"10.1016/j.ocarto.2025.100666","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate key historical developments in meniscal pathobiology research and surgical advancements to capture pivotal moments in the evolution towards contemporary meniscus treatment.</div></div><div><h3>Design</h3><div>We conducted a literature search in PubMed and Hollis, Harvard's online library database, to identify influential primary and secondary literature on meniscus form, function, and surgical techniques. Primary sources generally consisted of case reports or research investigations, while secondary sources included literature reviews. We used these sources to create a chronology of research findings, highlighting periods of controversy, shifts in opinion, and technological innovation.</div></div><div><h3>Results</h3><div>The meniscus was considered a functionless, vestigial structure for most of modern history until research in the mid-1940s identified significant degenerative changes among patients following total meniscectomy. Interest in the meniscus surged following this discovery, spurring investigations that broadened scientific understanding of the vasculature, neuroanatomy, and biochemical composition of the meniscus. In turn, these findings altered treatment practices in favor of meniscal preservation and stimulated research into the implications of altered hoop tension and meniscus vascularity.</div></div><div><h3>Conclusions</h3><div>The history and advancement of meniscal surgery has and continues to be shaped by translational research that has broadened scientific understanding of the form and function of the meniscus. We demonstrate that advancements in surgical techniques addressing meniscal tears were preceded by translational research that broadened understanding of the form and function of the meniscus. Future meniscal research should continue to utilize both translational and clinical findings to optimize meniscal tear treatment methodologies, while also minimizing risk of osteoarthritis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100666"},"PeriodicalIF":2.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144916807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Use of dual-energy X-ray absorptiometry to evaluate variation in bone shape and alignment associated with radiographic knee osteoarthritis: Findings from a study of 19,053 individuals in UK Biobank","authors":"Rhona A. Beynon ,&nbsp;Faten Alomar ,&nbsp;Fiona R. Saunders ,&nbsp;Raja Ebsim ,&nbsp;Benjamin G. Faber ,&nbsp;Mijin Jung ,&nbsp;Jennifer S. Gregory ,&nbsp;Claudia Lindner ,&nbsp;Simon G.F. Abram ,&nbsp;Richard M. Aspden ,&nbsp;Nicholas C. Harvey ,&nbsp;Timothy Cootes ,&nbsp;Jonathan H. Tobias","doi":"10.1016/j.ocarto.2025.100667","DOIUrl":"10.1016/j.ocarto.2025.100667","url":null,"abstract":"<div><h3>Objective</h3><div>Lower limb alignment may predispose to, or exacerbate, symptoms of knee osteoarthritis. To examine the role of this and other joint shape variation, we conducted a cross-sectional study investigating relationships between radiographic knee osteoarthritis (rKOA) and knee shape in dual-energy X-ray absorptiometry (DXA) images from UK Biobank (UKB).</div></div><div><h3>Methods</h3><div>Associations between the first ten knee shape modes (KSMs), derived from statistical shape modelling, and rKOA grade were analysed using logistic regression, adjusting for age, sex, height, weight, and ethnicity. An additional model included adjustment for hip-knee-ankle (HKA) angle, derived from total body DXA scans, to reflect knee alignment. Composite figures illustrate knee shape characteristics associated with each rKOA grade.</div></div><div><h3>Results</h3><div>19,053 individuals were included (mean 63.7 years, 48 ​% males), of whom 80.7 ​%, 14.6 ​%, 3.6 ​% and 1.2 ​% had rKOA grades 0, 1, 2 and 3–4, respectively. Several KSMs were associated with rKOA in confounder-adjusted analyses, with higher grades showing stronger relationships. These associations were attenuated by adjustment for HKA. As expected, composite shape models revealed that higher rKOA grades were associated with greater varus malalignment. After HKA adjustment, composite shape models showed less varus alignment, with other shape differences, such as altered proximal tibial metaphysis and lateral patella displacement, emerging in higher-grade rKOA.</div></div><div><h3>Conclusions</h3><div>Our cross-sectional analyses between joint shape and DXA-derived rKOA grade showed expected relationships with varus malalignment, which were attenuated after adjusting for HKA. Other shape differences, particularly in higher-grade rKOA, emerged independently of alignment, warranting further investigation.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100667"},"PeriodicalIF":2.8,"publicationDate":"2025-08-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144988876","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes","authors":"Sing-Hin Lau ,&nbsp;Lok-Chun Chan ,&nbsp;Tianshu Jiang ,&nbsp;Jiang Zhang ,&nbsp;Xiangqiao Meng ,&nbsp;Wei Wang ,&nbsp;Ping-Keung Chan ,&nbsp;Jing Cai ,&nbsp;Ping Li ,&nbsp;Chunyi Wen","doi":"10.1016/j.ocarto.2025.100663","DOIUrl":"10.1016/j.ocarto.2025.100663","url":null,"abstract":"<div><h3>Objective</h3><div>We developed and validated an artificial intelligence pipeline that leverages diffusion models to enhance prognostic assessment of knee osteoarthritis (OA) by analyzing longitudinal changes in patella shape on lateral knee radiographs.</div></div><div><h3>Method</h3><div>In this retrospective study of 2,913 participants from the Multicenter Osteoarthritis Study, left-knee weight-bearing lateral radiographs obtained at baseline and 60 months were analyzed. Our pipeline commences with an automatic segmentation for patella shapes, followed by a diffusion model to predict patella shape trajectories over 60 months. We developed the Synthetic Patella Shape Incorporated Convolutional Neural Network (SynPatNet), a specialized 2-channel 1-dimensional convolutional neural network (CNN), to incorporate both baseline and synthetic follow-up patella shapes for predicting key outcomes of disease onset and end-stage.</div></div><div><h3>Results</h3><div>The diffusion model generates plausible synthetic patella shapes that predict deformations and osteophyte developments at the 60-month follow-up. Incorporating synthetic follow-up shapes with baseline patella shapes significantly improved OA outcome prediction: for patellofemoral OA onset, SynPatNet achieved an area under receiver operating characteristic curve (AUC) of 0.909 (vs. 0.830 for baseline model); for knee replacement, an AUC of 0.823 (vs. 0.773 for baseline). Augmenting Kellgren-Lawrence (KL) grade with SynPatNet further improved knee replacement prediction (AUC 0.838) over KL grade alone (AUC 0.785). Noteworthily, our knee replacement risk prediction score showed significant correlations with MRI-based (osteophytes/cartilage morphology/bone attrition) gradings, with Spearman's rho up to (0.51/0.33/0.31, p ​&lt; ​0.001).</div></div><div><h3>Conclusion</h3><div>Generative diffusion modelling of patellar morphology on lateral knee radiographs provides complementary information to conventional radiographic and clinical metrics that substantially improves prognostication of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100663"},"PeriodicalIF":2.8,"publicationDate":"2025-08-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the editor regarding “Symptoms indicative of early knee osteoarthritis after ACL reconstruction: Descriptive analysis of the SHIELD cohort”","authors":"Matthew S. Harkey ,&nbsp;Christopher Kuenze ,&nbsp;Grace H. Lo ,&nbsp;Jeffrey B. Driban","doi":"10.1016/j.ocarto.2025.100662","DOIUrl":"10.1016/j.ocarto.2025.100662","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100662"},"PeriodicalIF":2.8,"publicationDate":"2025-08-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864813","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}