Osteoarthritis and cartilage open最新文献

{"title":"High glucose upregulates BMAL1 in chondrocytes from macroscopically normal and osteoarthritic human cartilage but this only results in increased collagen synthesis in chondrocytes from macroscopically normal cartilage regions","authors":"Lekha Jain ,&nbsp;Jacob T. Munro ,&nbsp;Jade Tamatea ,&nbsp;Nicola Dalbeth ,&nbsp;Raewyn C. Poulsen","doi":"10.1016/j.ocarto.2026.100744","DOIUrl":"10.1016/j.ocarto.2026.100744","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritic (OA) chondrocytes exhibit limited capacity for new collagen synthesis. High glucose promotes collagen I and III production by fibroblasts. The purpose of this study was to determine if it also promotes collagen II (COL2) synthesis by chondrocytes.</div></div><div><h3>Design</h3><div>Chondrocytes isolated from osteoarthritic (OA) and macroscopically normal (MN) cartilage from patients with knee OA were maintained in 1 % oxygen in 4 mM or 10 mM glucose for up to 24 h.</div></div><div><h3>Results</h3><div>Secreted COL2 levels were higher in MN but not OA chondrocytes maintained in 10 mM versus 4 mM glucose with increased COL2 production specifically evident in the first 6 h of high glucose exposure. <em>COL2A1</em> and proly-4-hydroxylase α2 (P4HA2) RNA and protein were upregulated by high glucose in MN and OA chondrocytes at this timepoint. While P4HA2 levels were similar in MN and OA chondrocytes, <em>COL2A1</em> RNA and SOX9 protein levels were lower in OA chondrocytes. BMAL1 protein levels were elevated by high glucose in both MN and OA chondrocytes at 6 h and BMAL1 knockdown reduced <em>P4HA2</em> and <em>COL2A1</em> in both MN and OA chondrocytes at this timepoint.</div></div><div><h3>Conclusions</h3><div>These data demonstrate a novel mechanism by which high glucose-mediated upregulation of BMAL1 promotes collagen synthesis in chondrocytes. Although high glucose leads to similar upregulation of BMAL1 and P4HA2 in both MN and OA chondrocytes, overall lower <em>COL2A1</em> RNAin OA chondrocytes likely limits their ability to upregulate secreted procollagen II levels. Hence, MN but not OA chondrocytes show increased collagen II production in high glucose.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100744"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037301","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Investigating predictors of pain events during trials of knee osteoarthritis: A post-hoc analysis of two phase III trials","authors":"Andrea Bak Kaaber ,&nbsp;Jakob Mejdahl Bentin ,&nbsp;Ida Sofie Adrian ,&nbsp;Morten Asser Karsdal ,&nbsp;Asger Reinstrup Bihlet","doi":"10.1016/j.ocarto.2026.100746","DOIUrl":"10.1016/j.ocarto.2026.100746","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to explore the associations between clinical characteristics, including medical history, and the frequency, severity, and type of pain events (PEs) over a two-year period in patients with knee osteoarthritis (OA).</div></div><div><h3>Design</h3><div>A post-hoc analysis was conducted on data from two double-blinded, randomized, placebo-controlled, multicenter phase-III trials assessing the efficacy and safety of salmon calcitonin in patients with painful and radiographic knee OA. 2206 patients aged 51–80 years were included. Adverse events (AEs) were recorded and categorized into PEs and non-PEs. Logistic regression models were used to assess associations, adjusting for confounders such as age, sex, and body mass index (BMI).</div></div><div><h3>Results</h3><div>Of the 8183 AEs recorded, 27.6 % were classified as PEs. Higher BMI was associated with lower odds of reporting PEs (OR: 0.94, p = 0.02), while male patients reported fewer PEs than females (OR: 0.83, p = 0.04). Insomnia and depression were linked to increased odds of PEs. In the PE population, higher BMI was associated with increased odds of moderate and severe PEs. KL grade 3 was linked to lower odds of moderate and severe PEs.</div></div><div><h3>Conclusions</h3><div>The study identifies female sex and certain medical histories as significant predictors of PEs in knee OA patients. A higher BMI was associated with lower odds of reporting PEs but for those who reported PEs, higher BMI was associated with more severe PEs. These results should be interpreted with caution due to methodological limitations, however the findings indicate risk factors for pain events and suggest further research into these associations.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100746"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical characteristics and physical activity levels of patients with knee osteoarthritis with and without a previous knee injury: A cross-sectional study","authors":"Richard E. Magony,&nbsp;Jeffrey S. Brooks,&nbsp;Jenna M. Schulz,&nbsp;Derek N. Pamukoff,&nbsp;Jane S. Thornton","doi":"10.1016/j.ocarto.2025.100741","DOIUrl":"10.1016/j.ocarto.2025.100741","url":null,"abstract":"<div><h3>Objective</h3><div>To compare clinical characteristics and physical activity levels of patients with mild-to-moderate knee osteoarthritis (OA).</div></div><div><h3>Methods</h3><div>A total of 262 individuals with mild-to-moderate knee OA recruited from the Technology, Exercise Programming, and Activity Prescription for Enhanced Mobility (TEAM) Study (NCT04544904) were categorized into two groups: 1) no previous knee injury (NTOA group), or 2) previous knee injury (PTOA group). We collected participants’ demographics, Knee Injury and Osteoarthritis Outcome Score (KOOS) subscales, Arthritis Self-Efficacy questionnaire, Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire, previous sport participation, radiographic OA features, and medical history. A smartphone application measured daily steps and self-reported physical activity levels were measured using the Global Physical Activity Questionnaire. A 30-s chair-stand and 40-m walk test assessed physical function.</div></div><div><h3>Results</h3><div>The NTOA group was older (62.3 ± 9.0 vs. 58.2 ± 7.4 years, <em>p</em> &lt; 0.05) and had lower daily steps (4372 ± 263 vs. 5776 ± 445 steps, <em>p</em>_<em>adj</em> &lt; 0.05) and previous sport participation (62.6 % vs. 81.7 %, <em>p</em> &lt; 0.05) than the PTOA group. Anthropometric measurements, sex, radiographic OA scores, comorbidities, smoking, and alcohol consumption were not different. The NTOA group had lower KOOS Pain (58.0 ± 1.2 vs. 64.3 ± 2.1, <em>p</em>_<em>adj</em> &lt; 0.05) and Activities of Daily Living (65.6 ± 1.3 vs. 73.9 ± 2.3, <em>p</em>_<em>adj</em> &lt; 0.05), higher ICOAP (44.2 ± 1.6 vs. 34.7 ± 2.8, <em>p</em>_<em>adj</em> &lt; 0.05), longer 40-m walk times (27.1 ± 0.4 vs. 24.1 ± 0.7 s, <em>p</em>_<em>adj</em> &lt; 0.05) and lower 30-s chair-stand repetitions (12.1 ± 0.4 vs. 14.3 ± 0.7, <em>p</em>_<em>adj</em> &lt; 0.05).</div></div><div><h3>Conclusion</h3><div>The PTOA group had higher daily steps and better physical and psychological health status than the NTOA group, independent of age and sex. Physical activity interventions may benefit those with NTOA more given their lower activity and greater symptomatology.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100741"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938466","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Magnetic resonance imaging-defined knee osteoarthritis rarely occurs without cartilage damage","authors":"Alison H. Chang ,&nbsp;Leena Sharma ,&nbsp;Frank W. Roemer ,&nbsp;Orit Almagor ,&nbsp;Jungwha Lee ,&nbsp;Ali Guermazi","doi":"10.1016/j.ocarto.2025.100733","DOIUrl":"10.1016/j.ocarto.2025.100733","url":null,"abstract":"<div><h3>Objective</h3><div>Magnetic resonance imaging (MRI) enables detection of early, multi-tissue changes in knee osteoarthritis (OA). A Delphi-derived MRI definition integrates findings across multiple joint tissues to classify tibiofemoral OA (TFOA), though it may identify OA in the absence of cartilage damage. We examined how often MRI-defined TFOA occurs without cartilage involvement in two large US cohorts.</div></div><div><h3>Methods</h3><div>We analyzed baseline data from participants without definite radiographic TFOA [Kellgren–Lawrence (KL) grade &lt;2 in both knees] in the Osteoarthritis Initiative (OAI) and Multicenter Osteoarthritis Study (MOST) cohorts. OAI knees were scored using the MRI Osteoarthritis Knee Score (MOAKS) and MOST knees using the Whole-Organ MRI Score (WORMS). MRI-defined TFOA was determined per Delphi criteria, and these knees were assessed for absence of cartilage lesions, with a secondary analysis for osteophyte absence.</div></div><div><h3>Results</h3><div>Among participants with KL &lt;2 in both knees, MRI-defined TFOA was observed in 283 of 1621 (17.5 %) in OAI and 206 of 641 (32.1 %) in MOST. Nearly all cases showed partial- or full-thickness cartilage lesions. Knees without cartilage involvement were rare: 1/283 (0.4 %) in OAI and 3/206 (1.5 %) in MOST. By contrast, knees without osteophytes were more common (13.4 % OAI, 5.8 % MOST).</div></div><div><h3>Conclusions</h3><div>In two large cohorts at elevated risk for knee OA, MRI-detected cartilage damage was almost always present when knees met multi-tissue MRI-based TFOA criteria, suggesting cartilage involvement may be a consistent feature of disease characterization. These findings indicate that the Delphi definition rarely identifies OA in the absence of cartilage involvement.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100733"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840138","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"How are patient-reported pain outcomes associated with biomarker and structural pathology subtypes in knee osteoarthritis? An explorative evaluation in the IMI-APPROACH cohort","authors":"M.P. Jansen ,&nbsp;S.C. Mastbergen ,&nbsp;W. Wirth ,&nbsp;F.W. Roemer ,&nbsp;J. Bacardit ,&nbsp;A.C. Bay-Jensen ,&nbsp;M. Kloppenburg ,&nbsp;F.J. Blanco ,&nbsp;I.K. Haugen ,&nbsp;F. Berenbaum ,&nbsp;N. Eijkelkamp ,&nbsp;M. Jarraya","doi":"10.1016/j.ocarto.2025.100726","DOIUrl":"10.1016/j.ocarto.2025.100726","url":null,"abstract":"<div><h3>Objective</h3><div>To explore associations between patient-reported pain outcomes and knee osteoarthritis (OA) subtypes based on systemic biochemical markers and joint structural pathology as defined by MRI.</div></div><div><h3>Methods</h3><div>Data were obtained from 297 knee OA patients from the IMI-APPROACH study. Pain outcomes were assessed using the KOOS, WOMAC, ICOAP, NRS, PainDETECT, and a pain diary. Biochemical markers in serum and urine were used to classify patients into systemic biomarker subtypes (low tissue turnover, structural damage, and systemic inflammation) via k-means clustering. Structural pathology subtypes were determined using MRI into an inflammatory, meniscus/cartilage damage, and subchondral bone pathology subtype. Associations between pain measures and subtypes were analyzed using multivariable regression models adjusted for age, sex, and BMI.</div></div><div><h3>Results</h3><div>The systemic inflammation biomarker subtype was significantly associated with higher KOOS pain, WOMAC weight-bearing pain, NRS knee pain, and PainDETECT scores (all p ​≤ ​0.042 and β ​≥ ​0.12). The low tissue turnover subtype negatively associated with lower KOOS, WOMAC, and ICOAP constant pain (all p ​≤ ​0.22 and β ​≤ ​−0.13), and the structural damage subtype with lower PainDETECT scores (more nociceptive-like pain; p ​= ​0.046 and β ​= ​−0.12). Among MRI subtypes, meniscus/cartilage damage was significantly associated with lower PainDETECT scores (p ​= ​0.005 and β ​= ​−0.16). No significant associations were found for the subchondral bone subtype or pain diary outcomes.</div></div><div><h3>Conclusion</h3><div>For commonly used pain questionnaires, pain severity seems linked with inflammatory activity more than structural damage. Structural damage is primarily associated with nociceptive-like pain according to PainDETECT, which might be valuable for patient selection to clinical trials and observational studies.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100726"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145796683","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prevalence and impact of sleep disorders in osteoarthritis: A systematic review and meta-analysis","authors":"Sylvain Mathieu ,&nbsp;Anne-Christine Rat ,&nbsp;Jérémie Sellam","doi":"10.1016/j.ocarto.2025.100738","DOIUrl":"10.1016/j.ocarto.2025.100738","url":null,"abstract":"<div><h3>Objective</h3><div>Sleep disorders (SD) are increasingly recognized as a major contributor to the symptom burden of osteoarthritis (OA), yet their epidemiology and clinical impact remain insufficiently characterized. This systematic literature review with meta-analysis aims to quantify the prevalence of SD in OA patients and to assess their influence on patient-reported outcomes.</div></div><div><h3>Method</h3><div>We searched the PubMed, Embase, Web of Science and Cochrane Library databases up to 22 July 2025 (PROSPERO CRD120251067310). The Pittsburgh Sleep Quality Index (PSQI), sleep efficiency, and the number of patients with SD, including insomnia, sleep apnea and restless legs syndrome (RLS) were collected. The prevalence of SD was calculated using metaproportion. Differences were measured using the inverse variance method or the Mantel–Haenszel method.</div></div><div><h3>Results</h3><div>We selected 81 articles representing 289,914 patients, including 75,129 knee, 708 hand and 236 hip OA. For the remaining patients, OA location was not noticed or multiple. The prevalence of SD was 68.9 % (63 studies, 276,092 patients), 32.0 % for sleep apnea, 34.0 % for insomnia and 51.6 % for RLS. Compared to healthy controls, the prevalence of SD was higher in OA patients which had poorer sleep quality with a higher PSQI score (7.9 ± 3.4 vs. 6.5 ± 2.7; p = 0.002) and lower sleep efficiency (82.1 ± 12.5 vs. 89.8 ± 6.0 %; p = 0.02). OA patients with SD were younger, had a higher BMI, a greater pain intensity and a higher frequency of depression and catastrophizing.</div></div><div><h3>Conclusion</h3><div>Sleep disorders are common in OA patients and should be investigated and managed since they have a negative impact on pain, fatigue and disability.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100738"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883765","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Clinical validation of fully automated (peri-)articular tissue analysis for assessing osteoarthritis progression: A narrative review","authors":"Wolfgang Wirth ,&nbsp;Jana Eder","doi":"10.1016/j.ocarto.2025.100719","DOIUrl":"10.1016/j.ocarto.2025.100719","url":null,"abstract":"<div><div>Numerous studies have presented fully automated techniques for assessing structural osteoarthritis (OA) progression, with recent work increasingly relying on deep learning (DL)-based methods. The objective of this narrative review was to summarize findings from studies comparing the validity of fully automated methods for assessing progression in (peri-) articular joint tissues with reference measures (e.g., manual segmentation) in clinical OA models. A literature search in PubMed and arXiv.org identified 873 studies. Of these, nine evaluated the clinical validity of fully automated longitudinal measures for assessing progression. Five met the inclusion criteria by comparing sensitivity to differences in change in clinically defined cohorts between fully automated vs. reference assessments, and four reported at least the sensitivity to change for both methods. One of the studies evaluated longitudinal change in radiographic joint space width, five change in MRI-based cartilage thickness, two change in cartilage composition, and one change in thigh muscle and adipose tissue cross-sectional areas. Most of the studies were based on DL methods and relied on data from the Osteoarthritis Initiative (OAI). The included studies reported similar or greater sensitivity to change and similar discriminative power for detecting differences in change between clinically defined groups compared with reference measurements. Therefore, the techniques validated in these studies appear suitable for assessing structural progression provided that key requirements are met, including consistent imaging protocols, scanner settings, and data quality.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100719"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883763","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between symptomatic knee osteoarthritis and health-related quality of life in individuals with type 2 diabetes: A cross-sectional study","authors":"Abdalmohsen Almodahka ,&nbsp;Alanna Weisman ,&nbsp;Baiju R. Shah ,&nbsp;Tristan Watson ,&nbsp;Ian Stanaitis ,&nbsp;Amish Parikh ,&nbsp;Robert Goldberg ,&nbsp;Lorraine Lipscombe ,&nbsp;Gillian A. Hawker ,&nbsp;Lauren K. King","doi":"10.1016/j.ocarto.2025.100742","DOIUrl":"10.1016/j.ocarto.2025.100742","url":null,"abstract":"<div><h3>Objective</h3><div>Knee osteoarthritis (OA) and type 2 diabetes (T2D) commonly coexist, but their combined impact on health-related quality of life (HRQoL) remains understudied. We assessed the association between symptomatic knee OA and HRQoL in individuals with T2D and explored potential explanations.</div></div><div><h3>Design</h3><div>We conducted a secondary analysis of a cross-sectional study of individuals with T2D. Symptomatic knee OA was defined using NICE criteria (age ≥45 years, activity-related knee pain, morning stiffness ≤30 min; no inflammatory arthritis). HRQoL (EQ-VAS, 0–100), sleep disturbance (PROMIS Sleep Disturbance 4a), depressed symptoms (PROMIS Depression 8b), fatigue (PROMIS Fatigue 4a), and walking limitation (Health Assessment Questionnaire) were assessed via questionnaire. Linear regression modeled associations between knee OA and HRQoL, adjusting for age, gender, BMI, education, and comorbidities. The explanatory effects of sleep, mood, and mobility were assessed via further sequential adjustment.</div></div><div><h3>Results</h3><div>We included 341 participants: mean age 66.4 years, 51.9 % female, 29.0 % had knee OA. Participants with T2D and knee OA reported lower HRQoL, greater sleep disturbance, fatigue, depressive symptoms, and walking limitations than those without knee OA. Knee OA was associated with lower HRQoL (β = −11.96; 95 % CI: −16.59 to −7.32) in the unadjusted analysis. Adjustment for confounders partially attenuated this effect (β = −8.33; 95 % CI: −12.72 to −3.94). Further adjustment for sleep, mood, and walking limitations fully attenuated the association.</div></div><div><h3>Conclusion</h3><div>Symptomatic knee OA is strongly associated with impaired HRQoL in T2D, explained by sleep disturbance, low mood, and mobility limitation. Integrated care addressing OA may improve quality of life in this population.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100742"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Metabolic syndrome, accumulation of its components and risk of knee and hip replacement for osteoarthritis in community-dwelling older adults","authors":"Mengjie Zeng,&nbsp;Flavia M. Cicuttini,&nbsp;Angus Franks,&nbsp;John J. McNeil,&nbsp;Yuanyuan Wang","doi":"10.1016/j.ocarto.2025.100709","DOIUrl":"10.1016/j.ocarto.2025.100709","url":null,"abstract":"<div><h3>Objective</h3><div>To examined whether metabolic syndrome (MetS) and accumulation of its components were associated with incidence of knee and hip replacement for osteoarthritis in community-dwelling older individuals.</div></div><div><h3>Design</h3><div>This study examined 9179 women and 7524 men from the ASPREE trial. MetS was defined if at least three of the five criteria were present: central obesity, elevated triglyceride, reduced high-density lipoprotein cholesterol, hypertension, and dysglycemia. Knee and hip replacement for osteoarthritis were defined by hospitalisations during the ASPREE trial for knee and hip surgical procedures with the indication recorded as osteoarthritis.</div></div><div><h3>Results</h3><div>Over a mean follow-up of 4.0 (standard deviation 1.4) years, 547 women and 346 men had knee replacements and 404 women and 290 men had hip replacements. Central obesity was associated with an increased risk of knee replacement in women [hazard ratio (HR) 1.62, 95 ​% confidence interval (CI) 1.26–2.10] but not men (HR 0.93, 95 ​% CI 0.70–1.23), independent of confounders including body mass index. MetS was independently associated with a decreased risk of hip replacement in men (HR 0.73, 95 ​% CI 0.57–0.95) but not women (HR 0.90, 95 ​% CI 0.73–1.12). Accumulation of MetS components was also associated with a decreased risk of hip replacement in men (p for trend 0.005) which was not seen in women (p for trend 0.94).</div></div><div><h3>Conclusion</h3><div>These findings suggest that targeting central obesity may reduce the risk of knee replacement in older women. The mechanism for the reduced risk of hip replacement in men associated with MetS and accumulation of MetS components is unclear and warrants further investigations.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100709"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555506","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI","authors":"Aerman Nuer ,&nbsp;Yasi Yang ,&nbsp;Boran Sun ,&nbsp;Yunhan Wang ,&nbsp;Wenbo Xiao ,&nbsp;Lei Wang ,&nbsp;Shu Wang ,&nbsp;Wenli Lu","doi":"10.1016/j.ocarto.2025.100703","DOIUrl":"10.1016/j.ocarto.2025.100703","url":null,"abstract":"<div><h3>Background</h3><div>Knee osteoarthritis (KOA) is a chronic disorder marked by progressive cartilage loss and functional decline. Current classifications miss bidirectional transitions, particularly in early and late stages, hindering early intervention.</div></div><div><h3>Methods</h3><div>Participants aged 45–79 years from the Osteoarthritis Initiative (OAI) were analyzed over eight years, classifying KOA states as normal, early-KOA, radiographic KOA (rKOA), and end-stage KOA (es-KOA) using Kellgren-Lawrence (K-L) grades, symptoms, and patient-reported outcomes. A Multi-state Markov (MSM) model evaluated state transitions and risk factors.</div></div><div><h3>Results</h3><div>The study comprised 2043 individuals (55.0 ​% female, 85.9 ​% White) with a total of 13,997 records of KOA state assessment. Of the individuals currently classified as early-KOA, 34.0 ​% returned to normal state, 60.9 ​% remained in early-KOA, and 5.1 ​% progressed to rKOA or es-KOA at next follow-up. The transition intensity from early-KOA to rKOA (0.05, 95 ​% CI: 0.04–0.06) was 2.6 times greater than that from normal to rKOA (0.02, 95 ​% CI: 0.01–0.02). The longest sojourn time was observed in rKOA, with a mean of 15.17 years. In covariate analysis, progression risk increased with obesity (HR: 2.57, Normal to rKOA), poor contralateral knee condition (HR: 3.68, Normal to rKOA), and depressive symptoms (HR: 2.16, rKOA to es-KOA). Better physical function reduced risk (HR: 0.65, Normal to early-KOA).</div></div><div><h3>Conclusion</h3><div>This study reveals dynamic KOA transitions, with early-KOA and es-KOA showing recovery potential. Identifying risk factors like obesity and contralateral knee condition offers opportunities for targeted interventions to slow progression and improve joint health, emphasizing early management's role in KOA care.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100703"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}