Osteoarthritis and cartilage open最新文献

{"title":"MonitOring the health trajectory of patients with kNee osteoarthritis referred for orthopaedic opinion: Protocol for the MOTION parallel cohort-implementation study","authors":"Christian J. Barton ,&nbsp;Michelle Dowsey ,&nbsp;Anne Smith ,&nbsp;Ilana N. Ackerman ,&nbsp;Zanfina Ademi ,&nbsp;Samantha Bunzli ,&nbsp;Peter Choong ,&nbsp;Kay M. Crossley ,&nbsp;Joanne Kemp ,&nbsp;Jason A. Wallis ,&nbsp;Alison Gibbs ,&nbsp;Vincent Lengkong ,&nbsp;Allison M. Ezzat ,&nbsp;Juanita Low ,&nbsp;Zhomart Orman ,&nbsp;Nicholas F. Taylor ,&nbsp;Anna Wong Shee ,&nbsp;Natasha A. Lannin ,&nbsp;Ewa M. Roos ,&nbsp;Raph Hau ,&nbsp;Danilo De Oliveira Silva","doi":"10.1016/j.ocarto.2025.100622","DOIUrl":"10.1016/j.ocarto.2025.100622","url":null,"abstract":"<div><h3>Objective</h3><div>This parallel cohort-implementation study, termed MonitOring the health Trajectory of patients with kNee osteoarthritis (MOTION), aims to understand treatment pathways and outcomes for people with knee osteoarthritis referred to Australian public hospitals for orthopaedic assessment (Part A cohort study), and how improving access to first-line care might improve outcomes (Part B implementation study).</div></div><div><h3>Methods and analysis</h3><div>We will recruit approximately 400 adults with knee osteoarthritis referred for orthopaedic opinion to one of four public hospitals in Victoria, Australia. A subgroup enrolled in the study (n ​= ​109) will receive improved access to community-based first-line care. Outcomes will be evaluated at baseline, 4-, 8-, 12- (primary end point), 24- and 60-months. The primary outcome will divide the cohort into 1's (willing to undergo, waitlisting for, or undergone, TKR surgery) or 0's (not willing to undergo, not undergone, and not waitlisted for, TKR surgery). Secondary outcomes include pain, knee- and health-related quality of life, physical activity participation and health care utilisation. Surgical and health trajectories will be reported descriptively, with factors associated with outcomes explored. The effectiveness of improving access to first-line care will be determined through propensity score methods. The cost-effectiveness of improving access to first-line care will be also be determined, and semi-structured interviews (1:1 and focus groups) involving participants, health professionals, administrators, and research team will inform a comprehensive process evaluation.</div></div><div><h3>Ethics and dissemination</h3><div>Approved by St Vincent's Hospital Melbourne Human Research Ethics Committee (HREC 251/21). Findings will be disseminated to stakeholders including via conferences, peer-reviewed journals, and social and mainstream media.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100622"},"PeriodicalIF":0.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144134898","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Molecular treatments to reduce catabolic effects in human meniscus explant models","authors":"Amanda Sjögren ,&nbsp;Karin Lindblom ,&nbsp;Aleksandra Turkiewicz ,&nbsp;Martin Englund ,&nbsp;Patrik Önnerfjord","doi":"10.1016/j.ocarto.2025.100618","DOIUrl":"10.1016/j.ocarto.2025.100618","url":null,"abstract":"<div><h3>Objectives</h3><div>1. To validate catabolic meniscus explant models induced by cytokines: interleukin-6 ​+ ​interleukin-6 receptor ​+ ​tumor necrosis factor alpha (IL6/TNF) and oncostatin M ​+ ​tumor necrosis factor alpha (OSM/TNF). 2. To evaluate three potential anti-catabolic treatments: i) dexamethasone (DEX), ii) a Link-N peptide (Link-N) and iii) a peptide from chondroadherin (CKF).</div></div><div><h3>Design</h3><div>Healthy lateral menisci from deceased donors (n ​= ​6; age ​= ​25–70 years, 4 males, 2 females), were sliced and randomized for experimental groups (combinations of the catabolic models and anti-catabolic treatments) and a control group. Culture media were analyzed, every third day until day 18, by mass spectrometry-based proteomics. Linear mixed effect models were used to estimate differences in protein abundances between groups.</div></div><div><h3>Results</h3><div>A total of 662 proteins were identified in all menisci. Cytokine-treated meniscus explant models showed increased release of osteoarthritis-related proteins such as matrix metalloproteinases (MMPs). For example, MMP1: IL6/TNF vs. ctrl; log2 fold-change 2.2 95 ​% confidence interval [1.8, 2.5] and OSM/TNF vs. ctrl; log2 fold-change 2.8 [2.4, 3.1]. There was no treatment effect in explant meniscus with the addition of either Link-N or CKF. Treatment effects were, however, evident with the addition of DEX. For example, MMP1: IL6/TNF ​+ ​DEX vs. ctrl; log2 fold-change −1.8 [-2.2, −1.4] and OSM/TNF ​+ ​DEX vs. ctrl; log2 fold-change −0.3 [-0.7, 0.04].</div></div><div><h3>Conclusion</h3><div>We confirmed that both catabolic models induce changes in osteoarthritis-related proteins. DEX treatment is effective in mitigating the catabolic response in meniscus explant models and may be further explored for its effects in the treatment of meniscus degeneration.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100618"},"PeriodicalIF":0.0,"publicationDate":"2025-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143911787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"From mechanism to medicine: The progress and potential of epigenetics in osteoarthritis","authors":"Jack B. Roberts ,&nbsp;Jason S. Rockel ,&nbsp;Rick Mulders ,&nbsp;Terence D. Capellini ,&nbsp;C. Thomas Appleton ,&nbsp;Douglas H. Phanstiel ,&nbsp;Rik Lories ,&nbsp;Jeroen Geurts ,&nbsp;Shabana Amanda Ali ,&nbsp;Nidhi Bhutani ,&nbsp;Laura Stone ,&nbsp;Yenisel Cruz-Almeida ,&nbsp;Igor Jurisica ,&nbsp;Cindy G. Boer ,&nbsp;Yolande F.M. Ramos ,&nbsp;Sarah J. Rice ,&nbsp;Mohit Kapoor","doi":"10.1016/j.ocarto.2025.100621","DOIUrl":"10.1016/j.ocarto.2025.100621","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a chronic, degenerative disease of the articular joints. The disease presents an enormous clinical and economic burden globally, due in part to the lack of disease modifying therapies. For over a decade, OA researchers have been working to determine epigenetic mechanisms underlying the disease to better understand pathology, identify biomarkers of progression, and pinpoint novel targets for therapeutic intervention.</div></div><div><h3>Design</h3><div>This article presents a summary of the 3rd International Workshop on the Epigenetics of Osteoarthritis held in Toronto, Ontario, Canada, in September 2024. The purpose of this meeting was to gather the international community to discuss the status of OA epigenetic research and share expertise on innovative techniques for future.</div></div><div><h3>Results</h3><div>Since the two previous meetings, there has been increasing adoption of advanced single-cell and spatial sequencing technologies and bioinfomatic analyses. Furthermore, investigations of multiple joint tissues has highlighted the shifting paradigm from OA as a cartilage centric disease to the consideration of all joint tissues.</div></div><div><h3>Conclusions</h3><div>The workshop provided a unique opportunity for early-career researchers to expand their network, and for all participants to discuss new or improved approaches to advance the field, including international consortia and data sharing. The highlights and outcomes from this OA epigenetics workshop are described in this report.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100621"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942263","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Fibrocartilage repair involves chronic cellular senescence in a rat model of bone marrow stimulation","authors":"Luke Childress ,&nbsp;Landon B. Gatrell ,&nbsp;Hong Wu ,&nbsp;Elisabeth Ferreira ,&nbsp;Intawat Nookaew ,&nbsp;Ryan M. Porter","doi":"10.1016/j.ocarto.2025.100620","DOIUrl":"10.1016/j.ocarto.2025.100620","url":null,"abstract":"<div><h3>Objective</h3><div>Cellular senescence has been implicated in the progression of post-traumatic osteoarthritis, but any role in pre-osteoarthritic cartilage repair is unknown. Our objective was to determine whether senescent cells contribute to fibrocartilage repair using a rodent model of marrow stimulation.</div></div><div><h3>Design</h3><div>A 1 ​mm osteochondral defect was generated in the trochlear groove of young adult and middle-aged Lewis rats, modeling the age range when humans receive marrow stimulation. Some rats were treated by intra-articular (IA) injection of senolytic drugs navitoclax or dasatinib plus quercetin. Repair tissue was characterized during the first months after marrow stimulation by histology as well as bulk and single cell transcriptomic analysis.</div></div><div><h3>Results</h3><div>Multiple senescence markers were measured within repair tissue during the first months of repair, in contrast to adjacent, intact articular cartilage. The IA delivery of senolytic drugs reduced p16^Ink4a-immunopositive cell numbers but did not promote chondrogenesis. The numbers of p16-positive cells were similar between young adult and middle-aged rats, despite proteoglycan deposition decreasing markedly with age. Bulk RNA sequencing of repair tissue demonstrated sustained upregulation of factors linked to established forms of the senescence-associated secretory phenotype. Single cell RNA sequencing revealed heterogeneity in mesenchymal cells within the early repair tissue, confirmed differences in senescence marker expression between newly-formed chondrocytes and those within adjacent intact cartilage, and established differences in oxidative stress response between these two populations during the chondrogenic phase of repair.</div></div><div><h3>Conclusions</h3><div>Senescent cells, including neochondrocytes, are abundant within inferior repair tissue following marrow stimulation. While their fibrogenic SASP is associated with poor healing, their removal after senescence induction does not improve repair tissue quality, possibly due to the lack of a replacement chondrogenic population.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100620"},"PeriodicalIF":0.0,"publicationDate":"2025-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143948478","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inflammatory mechanisms underlying metabolic syndrome-associated and potential treatments","authors":"Shiqian Huang ,&nbsp;Jiawei Chen ,&nbsp;Hao Zhang ,&nbsp;Wenjing Wu ,&nbsp;Song Xue ,&nbsp;Zhaohua Zhu ,&nbsp;Changhai Ding","doi":"10.1016/j.ocarto.2025.100614","DOIUrl":"10.1016/j.ocarto.2025.100614","url":null,"abstract":"<div><h3>Objectives</h3><div>Osteoarthritis (OA), a debilitating disease, has been recognized as a heterogenous disease, with metabolic syndrome-associated osteoarthritis (MetS-OA) emerging as a significant area of interest. Currently, the understanding of MOA remains limited, with a prevailing consensus attributing its etiology to the core components of metabolic syndrome: obesity, hyperglycemia, dyslipidemia, and hypertension. The aim of this review is to summarize the current understanding of the complex relationship between metabolic syndrome and OA from the perspectives of epidemiology and molecular biology, and to explore potential targeting strategies for metabolic syndrome in MetS-OA management.</div></div><div><h3>Methods</h3><div>This narrative review evaluated literature (2010–2024) from PubMed, examining clinical and mechanistic evidence linking metabolic syndrome to OA, including therapeutic studies targeting MetS-OA.</div></div><div><h3>Results</h3><div>Metabolic syndrome aggravate the cartilage injury in MetS-OA through metabolic biomarkers (adipokines, advanced glycation end-products and oxidized LDL), metabolic responses (oxidative stress, insulin resistance and ischemic hypoxic injuries), and abnormally activated cells (adipocytes and macrophages). It ultimately lead to the aggravation of synovitis in MetS-OA through inflammatory mediators.</div></div><div><h3>Conclusions</h3><div>The exploration of the relationship between metabolic syndrome and OA could benefit the development of targeting strategies for MetS-OA, including currently FDA-approved drugs for the treatment of metabolic syndrome and potential drugs targeting metabolic factors, which might provide a novel avenue for the future management of MetS-OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100614"},"PeriodicalIF":0.0,"publicationDate":"2025-04-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143898641","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Measurement of expectations regarding exercise therapy of patients with hip and knee osteoarthritis: A scoping review","authors":"A.P.M. Konings-Pijnappels ,&nbsp;M.C. van der Steen ,&nbsp;H. Seetsen-van Schelven ,&nbsp;I. Hoogendoorn ,&nbsp;T.P.M. Vliet Vlieland ,&nbsp;R.P.A. Janssen","doi":"10.1016/j.ocarto.2025.100617","DOIUrl":"10.1016/j.ocarto.2025.100617","url":null,"abstract":"<div><h3>Objective</h3><div>While exercise therapy generally yields positive outcomes in patients with hip or knee osteoarthritis (HOA or KOA), individual results vary. Expectations may influence treatment results, but research on this topic is scarce. Therefore, this study aimed to describe methods to assess pre-treatment expectations of patients with HOA or KOA with respect to exercise therapy.</div></div><div><h3>Design</h3><div>Scoping review, with the Pubmed, Embase, CINAHL and Cochrane databases searched for original clinical studies of any design reporting a method or instrument to assess expectations of exercise therapy in patients with HOA or KOA. Data extraction from selected studies concerned study characteristics and the method or instrument used, as well as their content, categorized into expectations of structure, process or outcomes of exercise therapy treatment.</div></div><div><h3>Results</h3><div>Twenty-nine studies met the inclusion criteria. Twenty-three different methods used to address expectations were identified, 3 of which had a qualitative nature (interviews) and 20 concerned questionnaires. There was a large variation in number of items and measurement scales in the identified methods. Nine methods addressed expectations of outcomes of treatment, 7 addressed both outcomes and the process/structure of treatment. One instrument was found to measure willingness to receive exercise rather than expectations. For the remaining 6 instruments no content nor aspects measured were reported.</div></div><div><h3>Conclusion</h3><div>In the literature, apart from interviews, mainly quantitative methods have been used to measure expectations with regard to exercise therapy in patients with HOA or KOA. Most of their content concerned the outcomes of care, rather than its structure and/or process.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100617"},"PeriodicalIF":0.0,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143942264","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Prefrontal cortex activation during daily movements and its association with clinical symptoms in knee osteoarthritis","authors":"Soyoung Lee ,&nbsp;Ehyun Kim ,&nbsp;Baekdong Cha ,&nbsp;Claudio L. Ferre ,&nbsp;Meryem Yücel ,&nbsp;Deepak Kumar","doi":"10.1016/j.ocarto.2025.100615","DOIUrl":"10.1016/j.ocarto.2025.100615","url":null,"abstract":"<div><h3>Objective</h3><div>For people with knee osteoarthritis (OA), step-up is one of the most physically demanding and pain-evoking daily movements. Given the significant role of the prefrontal cortex (PFC) in executive function and pain modulation, our objectives were (1) to assess PFC activation during walking and step-up in people with knee OA and (2) to examine the association of pain and psychological outcomes with changes in PFC activation from walking to step-up.</div></div><div><h3>Design</h3><div>This cross-sectional study included 44 individuals with symptomatic knee OA. Participants completed Knee Injury and Osteoarthritis Outcome Score (KOOS), Pain, Enjoyment of Life, and General Activity (PEG) scale, Patient Health Questionnaire (PHQ-8) for mood, 3-item Pain Catastrophizing Scale (PCS), and Fear-Avoidance Beliefs Questionnaire (FABQ). Oxygenated hemoglobin concentration changes (HbO₂) in the bilateral PFC were assessed using functional Near-Infrared Spectroscopy. HbO₂ were compared between tasks using repeated measures ANCOVA. Multiple linear regression models tested the association between clinical outcomes and changes in HbO₂ from walking to step-up while adjusting for confounders.</div></div><div><h3>Results</h3><div>HbO₂ during step-up was higher compared to walking, with moderate effect size (<em>d</em> ​= ​0.3–0.5). Greater pain catastrophizing (R² ​= ​0.10) was correlated with smaller changes in HbO₂ from walking to step-up.</div></div><div><h3>Conclusion</h3><div>People with knee OA utilized greater executive control during step-up compared to walking. Similar to stair climbing, step-up is more physically demanding and more frequently impaired than walking. Greater pain catastrophizing was related to smaller increases in PFC activation from walking to step-up, reflecting the availability of fewer executive resources to maintain task performance.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100615"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144231960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Potential sources of pain in symptomatic degenerative meniscal tear: A narrative review","authors":"Love Tsai ,&nbsp;Elizabeth Matzkin ,&nbsp;Morgan H. Jones ,&nbsp;Rachel E. Miller ,&nbsp;Jeffrey N. Katz","doi":"10.1016/j.ocarto.2025.100616","DOIUrl":"10.1016/j.ocarto.2025.100616","url":null,"abstract":"<div><h3>Importance</h3><div>Although degenerative meniscal tear is relatively prevalent in older persons, the sources of the accompanying pain and mechanical symptoms—such as knee clicking, locking, and popping—are unclear, making targeted treatment difficult. We conducted a narrative literature review to synthesize research surrounding sources of symptomatic degenerative meniscal tear.</div></div><div><h3>Observations</h3><div>We identified five mechanisms of symptom generation in patients with degenerative meniscal tear: obstruction, abnormal load bearing, inflammation, neoinnervation, and central sensitization. We confirmed clinical observations that degenerative meniscal tear often occurs concomitantly with knee osteoarthritis, which adds complexity to symptom attribution.</div></div><div><h3>Conclusions and relevance</h3><div>Degenerative meniscal tear may lead to pain or mechanical symptoms through a variety of pathways. In identifying the diversity in pathways and corresponding physiological changes leading to symptomatic degenerative meniscal tear, this review may help clinicians contextualize the condition and target therapies for their patients.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100616"},"PeriodicalIF":0.0,"publicationDate":"2025-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144072150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The current and changing role of glucagon-like peptide-1 receptor agonists in knee osteoarthritis","authors":"Anne D. Holleman,&nbsp;Jeffrey N. Katz","doi":"10.1016/j.ocarto.2025.100611","DOIUrl":"10.1016/j.ocarto.2025.100611","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100611"},"PeriodicalIF":0.0,"publicationDate":"2025-04-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143928336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effects of high impact exercise on systemic cytokines in women with mild knee osteoarthritis: A 12-month RCT","authors":"Ville-Markus Konola ,&nbsp;Juhani Multanen ,&nbsp;Johanna K. Ihalainen ,&nbsp;Jukka E. Hintikka ,&nbsp;Timo Jämsä ,&nbsp;Hannu Kautiainen ,&nbsp;Miika T. Nieminen ,&nbsp;Satu Pekkala ,&nbsp;Maarit Valtonen ,&nbsp;Ari Heinonen","doi":"10.1016/j.ocarto.2025.100609","DOIUrl":"10.1016/j.ocarto.2025.100609","url":null,"abstract":"<div><h3>Objective</h3><div>This study investigated the effects of a high-impact exercise regimen compared with a reference group on systemic cytokine levels in patients with mild knee osteoarthritis (OA). Furthermore, associations between cytokines and magnetic resonance imaging (MRI) transverse relaxation time (T2) mapping and metabolic equivalent task hours (MET-hours) during leisure-time physical activity (LTPA) were assessed.</div></div><div><h3>Method</h3><div>In this secondary analysis, 73 postmenopausal women aged 50–65 years with mild knee OA were randomized to a 12-month high-impact aerobic/step aerobics training group (n ​= ​35) or a non-training reference group (n ​= ​38). The serum cytokine levels, including interleukin-1 alpha (IL-1α), IL-2, IL-4, IL-5, IL-6, IL-10, IL-13, IL-17, interferon-gamma (IFN-γ), and tumor necrosis factor alpha (TNF-α), were determined via multiplex cytokine assays. The cartilage structure of the medial tibial condyle was assessed by MRI T2 mapping. The primary outcome was between-group differences in cytokine level changes.</div></div><div><h3>Results</h3><div>After a 12-month follow-up, no significant differences in cytokine level changes were found between the groups. In the intervention group, 12-month changes in TNF-α levels were associated with changes in medial tibial condyle T2. In the reference group, 12-month changes in IL-10 levels were associated with changes in medial tibial condyle T2 and the number of weekly LTPA MET-hours.</div></div><div><h3>Conclusion</h3><div>A progressive high-impact exercise regimen did not affect systemic cytokine levels compared to the reference group and could therefore offer a possible mode of exercise for postmenopausal women with mild knee OA.</div></div><div><h3>Trial registration number</h3><div>ISRCTN58314639.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 2","pages":"Article 100609"},"PeriodicalIF":0.0,"publicationDate":"2025-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143843899","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}