Osteoarthritis and cartilage open最新文献

{"title":"Corrigendum to ‘Networking in the osteoarthritis research community in the digital era’ [Osteoarthr Cartil Open 7 (2025) 100650]","authors":"Rachel K. Nelligan , Anca Maglaviceanu , Jocelyn Bowden , Jackie L. Whittaker , Tobias Winkler , Jos Runhaar , Mohit Kapoor , Chunyi Wen","doi":"10.1016/j.ocarto.2025.100659","DOIUrl":"10.1016/j.ocarto.2025.100659","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100659"},"PeriodicalIF":2.8,"publicationDate":"2025-08-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144826417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without","authors":"Felix Eckstein ,&nbsp;Wolfgang Wirth ,&nbsp;Ali Guermazi ,&nbsp;Frank Roemer ,&nbsp;Michael Nevitt ,&nbsp;Christoph Ladel ,&nbsp;Leena Sharma ,&nbsp;David J. Hunter ,&nbsp;C. Kent Kwoh","doi":"10.1016/j.ocarto.2025.100658","DOIUrl":"10.1016/j.ocarto.2025.100658","url":null,"abstract":"<div><h3>Objective</h3><div>We examined whether the trajectory of femorotibial cartilage loss differs between knees meeting a clinically defined virtual knee replacement (vKR) status based on patient-reported outcomes vs. those with low probability.</div></div><div><h3>Design</h3><div>vKR cases (highest 10 ​% of probabilities for having surgical KR) were selected using knee pain and quality of life criteria, developed from knees with actual KR. Knees reaching such symptom state at 48 months (M) follow-up (vKR case 60 ​M) were matched 1:1 with vKR controls (lowest 20 ​% probability) by sex, age, and baseline radiographic status. Of 65 knees displaying vKR case status at 60 ​M; 33 maintained or increased pain and QOL levels at 72 ​M (vKR+/+); 32 did not (vKR+/−). The thickness of medial and lateral tibial and femoral cartilages was determined from MRI, at up to five annual visits prior to 60 ​M.</div></div><div><h3>Results</h3><div>vKR case knees displayed substantially greater central medial femorotibial compartment cartilage thickness loss 2 years prior to reaching case status (−151 ​± ​337 [mean ​± ​SD] vs. −38 ​± ​249 ​μm; odds ratio [OR] 1.95 (95 ​% confidence interval: 1.23–3.08). Cartilage loss did not apparently differ between vKR+/+ and vKR +/− knees (p ​= ​0.73).</div></div><div><h3>Conclusions</h3><div>Substantially greater cartilage thickness loss was detected in knees reaching vKR case status defined by patient-reported clinical criteria vs. vKR controls. This was found independently of whether this status was maintained at a later annual visit. The observed association suggests greater knee cartilage loss to be prospectively related to worse clinical outcome. It indicates further that the vKR criterion used here may be useful to explore relationships with other structural (imaging) assessments.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100658"},"PeriodicalIF":2.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Comparison between coronal FLASH and sagittal double echo steady state MRI in detecting longitudinal cartilage thickness change by fully automated segmentation - Data from the FNIH biomarker cohort.","authors":"Felix Eckstein, Akshay S Chaudhari, David J Hunter, Wolfgang Wirth","doi":"10.1016/j.ocarto.2025.100657","DOIUrl":"10.1016/j.ocarto.2025.100657","url":null,"abstract":"<p><strong>Objective: </strong>Artificial intelligence (AI-) based automated cartilage analysis demonstrated similar sensitivity to change and only slighty inferior differentiation between radiographic progressors and non-progressors compared with manual segmentation. However, this finding was based on DESS MRI from the Osteoarthritis Initiative (OAI), whereas the vast majority of multicenter clinical trials rely on T1-weighted gradient echo (e.g. FLASH). Here we directly compare fully automated analysis of coronal FLASH vs. sagittal DESS, and vs. manually segmented DESS, in a sample with both FLASH and DESS MRI acquisitions.</p><p><strong>Design: </strong>Convolutional neural network (CNN) algorithms were trained on 86 radiographically osteoarthritic knees with manual expert segmentation of the medial and lateral femorotibial cartilages (coronal FLASH and sagittal DESS). Post-processing involved automated registration of CNN-based subchondral bone segmentation to reference areas. The models were applied to baseline and two-year follow-up MRIs of radiographic progressor and non-progressor knees in the Foundation of the NIH Biomarker sample of the OAI.</p><p><strong>Results: </strong>Of the 322 FNIH knees with both FLASH and DESS; 157 were radiographic progressors. Sensitivity to medial femorotibial cartilage thickness change (standardized response mean) in the progressor subcohort was -0.81 for FLASH (automated analysis), -0.74 for automatically, and -0.72 for manually segmented DESS. Differentiation from non-progressors (Cohen's D) was -0.82. -0.70, and -0.87, respectively.</p><p><strong>Conclusions: </strong>Fully automated, AI-based cartilage segmentation with advanced post-processing reveals that coronal FLASH is at least as discriminative between radiographic progressor vs. non-progressor knees as sagittal DESS MRI. Yet, performance of fully automated segmentation is slightly inferior to manual analysis with expert quality control.</p><p><strong>Trial id: </strong>Clinicaltrials.gov identification: NCT00080171.</p>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"100657"},"PeriodicalIF":2.8,"publicationDate":"2025-08-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12356010/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144877178","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Ultrasound findings in patients with knee osteoarthritis: Relationships with clinical characteristics, radiographic findings and generalized osteoarthritis","authors":"Ahmet Sumen ,&nbsp;Kubra Neslihan Kurt Oktay","doi":"10.1016/j.ocarto.2025.100656","DOIUrl":"10.1016/j.ocarto.2025.100656","url":null,"abstract":"<div><h3>Objective</h3><div>To evaluate the relationship between ultrasound (US) findings and radiographic Kellgren–Lawrence (K/L) grades, symptom severity, and the presence of generalized osteoarthritis (GOA) in patients with knee osteoarthritis (OA), and to identify key US parameters associated with OA severity.</div></div><div><h3>Methods</h3><div>This cross-sectional study included 166 patients (332 knees) with radiographically confirmed knee OA. US assessments included medial and lateral meniscus extrusion (MME, LME), suprapatellar effusion, synovitis, femoral cartilage thickness (FCT), femoral cartilage lesions, Baker's cyst, pes anserine bursitis, patellar tendinopathy, and Hoffa's fat pad pathology. K/L grades were determined by radiography. Pain and function were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). GOA was defined as OA in five or more joints or the presence of Heberden's nodes with additional joint involvement.</div></div><div><h3>Results</h3><div>MME showed a strong correlation with K/L grade (r ​= ​0.954, p ​&lt; ​0.001), with 91.57 ​% exact agreement. LME showed a moderate correlation (r ​= ​0.693, p ​&lt; ​0.001). GOA was identified in 12.65 ​% of patients and was independently associated with lower BMI, reduced FCT (&lt;2 ​mm), and the presence of femoral cartilage lesions. Moderate correlations were observed between K/L grade and pain, WOMAC scores, and symptom duration<strong>.</strong></div></div><div><h3>Conclusion</h3><div>MME and FCT measured by US are strong indicators of OA severity and may help identify patients at risk for GOA. US appears to be a practical, radiation-free tool for assessing and monitoring OA progression. Further validation in larger cohorts is recommended.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100656"},"PeriodicalIF":2.8,"publicationDate":"2025-07-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767038","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Therapeutic effects of teriparatide on subchondral bone lesions and pain in mono-iodoacetate-induced osteoarthritis rat model","authors":"Koji Aso,&nbsp;Natsuki Sugimura,&nbsp;Masashi Izumi,&nbsp;Ikeuchi Masahiko","doi":"10.1016/j.ocarto.2025.100655","DOIUrl":"10.1016/j.ocarto.2025.100655","url":null,"abstract":"<div><h3>Objectives</h3><div>Knee osteoarthritis (OA) represents a leading cause of chronic pain, with subchondral bone marrow lesions recognized as a critical contributor. Teriparatide (TPTD), a treatment for osteoporosis, promotes subchondral bone remodeling. However, its effects on subchondral bone lesions and associated pain in OA remain unclear. Thus, we aimed to evaluate the therapeutic effects of TPTD in a rat model of monoiodoacetate-induced (MIA)-induced OA.</div></div><div><h3>Methods</h3><div>Male Sprague-Dawley rats were divided into TPTD ​+ ​MIA, saline ​+ ​MIA, and control groups. OA was induced through intra-articular injection of MIA (1 ​mg). TPTD (30 ​μg/kg) or saline was administered subcutaneously three times per week for 12 weeks. Subchondral bone integrity was assessed by micro-computed tomography imaging. Histological scoring of the cartilage, subchondral bone, and synovium was performed after 12 weeks of treatment. Pain-related behavior was assessed based on hind paw weight distribution and mechanical sensitivity of the hind paw and knee joint.</div></div><div><h3>Results</h3><div>TPTD preserved subchondral bone integrity, significantly improving bone volume fraction and mineral density. Histological scores for calcified cartilage and subchondral bone damage, and osteoarthritis bone score were reduced; however, no significant differences were observed in cartilage degeneration or synovial inflammation. TPTD administration improved asymmetric weight distribution in advanced OA, although mechanical hyperalgesia in the knee and hind paws remained unchanged. Subchondral bone pathology scores were significantly correlated with asymmetric weight distribution.</div></div><div><h3>Conclusion</h3><div>TPTD attenuated subchondral bone lesions and improved weight-bearing function in MIA-induced OA, highlighting its therapeutic potential in OA-related pain.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100655"},"PeriodicalIF":2.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144772987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Machine learning models for clinical and structural knee osteoarthritis prediction: Recent advancements and future directions","authors":"Gabby B. Joseph ,&nbsp;Charles E. McCulloch ,&nbsp;Michael C. Nevitt ,&nbsp;Nancy E. Lane ,&nbsp;Sharmila Majumdar ,&nbsp;Thomas M. Link","doi":"10.1016/j.ocarto.2025.100654","DOIUrl":"10.1016/j.ocarto.2025.100654","url":null,"abstract":"<div><div>Machine learning (ML), increasingly used for predictive modeling, has seen rapid growth in osteoarthritis (OA) research over the past decade. This review highlights recent advances in ML model development across four OA outcome domains: clinical, structural (radiographic and MRI-based), and surgical endpoints, each addressing different but interrelated aspects of the disease.</div><div>For clinical outcomes, ML studies have focused on predicting changes in patient-reported clinical measures (e.g., pain and function). Radiographic OA has been characterized using deep learning (DL) models, and ML approaches have also been used to predict progression of Kellgren Lawrence grades and joint space narrowing. For MRI-based features, DL-based tools have been developed for automatic quantification of cartilage, bone marrow lesions, and subcutaneous fat; they have improved scalability and supported development of ML prediction models with cartilage loss outcomes. For total knee replacement outcomes, ML models have demonstrated strong performance, offering the potential for both early intervention and surgical planning.</div><div>This review also discusses emerging directions for ML in OA research, including the integration of multimodal data sources, the development of interpretable and explainable ML models, and the use of automated ML to streamline model development. Future approaches may include OA subtype-specific prediction models, alignment of ML approaches with clinical workflows, and enhanced external validation to ensure generalizability. These evolving strategies underscore the growing potential of ML to improve the detection of early OA, individualized risk stratification, and personalized interventions in OA clinical care.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100654"},"PeriodicalIF":2.8,"publicationDate":"2025-07-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144767085","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Increased synovitis and pro-inflammatory macrophage abundance are observed in the synovia of patients at risk of developing post-traumatic OA compared to those with established OA","authors":"Timothy Hopkins ,&nbsp;John Garcia ,&nbsp;Charlotte H. Hulme ,&nbsp;Bernhard Tins ,&nbsp;Jade Perry ,&nbsp;Paul Jermin ,&nbsp;Pete Gallacher ,&nbsp;Andrew Barnett ,&nbsp;Sally Roberts ,&nbsp;Karina T. Wright","doi":"10.1016/j.ocarto.2025.100643","DOIUrl":"10.1016/j.ocarto.2025.100643","url":null,"abstract":"<div><h3>Objective</h3><div>Inflammation of the synovium (synovitis) is implicated in the onset, progression and clinical manifestation of osteoarthritis (OA), although its prevalence at different stages of the disease has yet to be definitively established. Synovial macrophages play a central role in synovitis and can demonstrate pro- and anti-inflammatory phenotypes. The pervasiveness and variation in phenotypic identity of macrophages in early- and late-OA synovia is unclear. In the present study we investigated the frequency and severity of synovitis and assessed macrophage phenotypes in synovia from patients with high risk of developing PTOA (deemed early-OA) or late-OA.</div></div><div><h3>Design</h3><div>Synovial samples were collected from patients undergoing cell therapy treatment for early-OA or arthroplasty for late-OA. Synovitis was assessed using a semi-quantitative, histological scoring system. Macrophage abundance and phenotypic characteristics were assessed by immunohistochemistry and image analysis. Study parameters were compared between the early- and late-OA groups and correlated with demographic and clinical information.</div></div><div><h3>Results</h3><div>Synovitis was more prevalent and generally more severe in early-OA synovia compared to late-OA synovia (effect size; d ​= ​0.76). There were more macrophages overall (d ​= ​1.04), with more demonstrating markers characteristic of a pro-inflammatory (M1) phenotype (d ​= ​0.86), in the early-OA cohort. Synovitis severity was significantly correlated with the total number of macrophages (ρ ​= ​0.47), and with the presence of both M1 (ρ ​= ​0.65) and M2 (ρ ​= ​0.49) macrophage markers (M2 typically considered to indicate an anti-inflammatory or wound-healing phenotype).</div></div><div><h3>Conclusions</h3><div>Our data suggest that synovial inflammation may play a greater role in the early stages of OA than in end-stage disease, and is at least partly mediated by synovial macrophages.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100643"},"PeriodicalIF":0.0,"publicationDate":"2025-07-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144694871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bone shape changes over two years following acute anterior cruciate ligament injury: Reconstructed vs non-reconstructed knees","authors":"L. Hassanlou ,&nbsp;M.A. Bowes ,&nbsp;A. Turkiewicz ,&nbsp;J. Kvist ,&nbsp;H. Gauffin ,&nbsp;R. Frobell ,&nbsp;S. Saarakkala ,&nbsp;M. Englund","doi":"10.1016/j.ocarto.2025.100652","DOIUrl":"10.1016/j.ocarto.2025.100652","url":null,"abstract":"<div><h3>Objective</h3><div>To determine bone shape changes over two years after acute anterior cruciate ligament (ACL) injury and to compare knees treated with ACL reconstruction (ACLR) vs no ACLR.</div></div><div><h3>Design</h3><div>We used prospective data involving 129 young adults (46 ​% female, mean age 25 years) with recent ACL injury from a subcohort within the prospective multicenter NACOX study. Patients were treated according to Swedish guidelines with supervised rehabilitation before considering ACLR. 3D MR images obtained at baseline, 3-, 6-, 12, and 24-months post-injury were assessed for changes in the femur and tibia bone surface area using active appearance models. We used a linear mixed-effects model adjusted for age, sex, body mass index, and pre-injury Tegner physical activity level.</div></div><div><h3>Results</h3><div>We observed growth in bone areas over the first two years, particularly in the medial femur and medial tibia, with an average relative increase of 1.28 ​% (95 ​% CI 0.67 ​%, 1.88 ​%) and 1.04 ​% (0.44 ​%, 1.65 ​%), respectively. The lateral femur also showed growth, with an increase of 1.15 ​% (0.55 ​%, 1.75 ​%). We found little differences comparing ACLR patients to non-ACLR patients, adjusted relative percentage differences: medial femur, 0.01 ​% (95 ​% CI: 0.9 ​%, 1.1 ​%); medial tibia, −0.03 ​% (−1.2 ​%, 0.7 ​%); lateral femur, 0.04 ​% (−0.6 ​%, 1.4 ​%); and lateral tibia, −0.11 ​% (−2.1 ​%, −0.1 ​%).</div></div><div><h3>Conclusion</h3><div>After acute ACL injury, there is a growth primarily in the medial femoral and tibial condyles. The bone shape changes could hypothetically be a response to altered biomechanical conditions and may precede the development of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100652"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680424","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Synovitis mediates cartilage outcomes during weight-loss in knee osteoarthritis – 4-year follow-up data from the Osteoarthritis Initiative","authors":"Virginie Kreutzinger ,&nbsp;Katharina Ziegeler ,&nbsp;Gabby B. Joseph ,&nbsp;John A. Lynch ,&nbsp;Zehra Akkaya ,&nbsp;Nancy E. Lane ,&nbsp;Charles E. McCulloch ,&nbsp;Michael Nevitt ,&nbsp;Thomas M. Link","doi":"10.1016/j.ocarto.2025.100653","DOIUrl":"10.1016/j.ocarto.2025.100653","url":null,"abstract":"<div><h3>Objective</h3><div>Weight loss can modify the progression of osteoarthritis (OA), and this may, in part, be achieved by decreased synovitis, a known accelerator of cartilage degeneration. The purpose of this study was to investigate whether change in synovitis mediates the beneficial effect of weight loss on longitudinal cartilage outcomes.</div></div><div><h3>Method</h3><div>We analyzed right knees with baseline Kellgren &amp; Lawrence grades 1–3 of 1153 obese and overweight participants of the Osteoarthritis Initiative (OAI) cohort with Whole Organ MRI Scores (WORMS) and semi-quantitative assessment of effusion synovitis and synovial proliferation scores form 3T MRIs at baseline and 48 months. There were 295 participants with weight-loss &gt;5 ​% and 858 stable weight controls. Ordered logistic regression was used to assess the association of weight-loss status with concurrent changes in synovitis as well as cartilage WORMS scores; models were adjusted for age, gender, race, presence of radiographic OA, and abdominal circumference at baseline. A mediation analysis was used to determine whether change in overall cartilage degeneration was mediated by change in synovitis scores.</div></div><div><h3>Results</h3><div>Individuals who lost weight had significantly lower odds for a higher grade on the scale assessing change in overall synovitis (OR 0.72; 95%CI 0.54, 0.95; p ​= ​0.018). Mediation analysis showed that slowing synovitis during weight loss had a small mediating effect on longitudinal cartilage outcomes.</div></div><div><h3>Conclusion</h3><div>Decreased cartilage degeneration during weight loss was partially mediated by concurrent deceleration in synovitis, showing that decreasing systemic inflammation during weight-loss may not be mirrored in imaging markers of joint inflammation.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100653"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686439","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluation of neuropathic-like symptoms and objective signs of neuropathy post-knee replacement in patients with knee osteoarthritis","authors":"Devin Driscoll ,&nbsp;Priyanka Ballal ,&nbsp;Na Wang ,&nbsp;Laura Frey-Law ,&nbsp;Cora E. Lewis ,&nbsp;Michael Nevitt ,&nbsp;Tuhina Neogi","doi":"10.1016/j.ocarto.2025.100651","DOIUrl":"10.1016/j.ocarto.2025.100651","url":null,"abstract":"<div><h3>Objective</h3><div>Why persistent pain post-knee replacement occurs is not understood. We examined the association of clinical measures of neuropathy and presence of ‘neuropathic-like pain’ with pain post-knee replacement.</div></div><div><h3>Design</h3><div>Participants with a knee replacement from the NIH-funded longitudinal cohort Multicenter Osteoarthritis (MOST) Study were examined ∼12-months post-surgery using clinical assessments of neuropathy (von Frey 2 ​g and 26 ​g monofilaments and pin prick) and the painDETECT questionnaire (PDQ; score ≥13 was considered neuropathic-like pain). We evaluated the relation of the clinical neuropathy assessments and the PDQ to achievement of the patient acceptable symptom state (PASS) post-knee replacement using WOMAC, and of the objective clinical neuropathy assessments to neuropathic-like pain on the PDQ using logistic regression.</div></div><div><h3>Results</h3><div>This cohort study evaluated 171 participants post-knee replacement (mean age 69, 62 ​% female, mean BMI 32.6). Overall, 57 ​% had any abnormality on ≥1 clinical neuropathy assessment (51 ​% hypoesthesia, 10 ​% allodynia/hyperalgesia), and 7 ​% had neuropathic-like pain. There was no association between presence of any abnormality on clinical assessment and not achieving the PASS (OR 1.4, 95 ​% CI 0.5–4.12). In contrast, higher PDQ scores were significantly associated with not achieving the PASS. There was no association between any abnormality on the clinical assessments of neuropathy with PDQ score ≥13 (OR 0.65 (95 ​% CI 0.14–3.02).</div></div><div><h3>Conclusions</h3><div>Objective clinical assessments of neuropathy were not associated with worse pain status post-knee replacement, while PDQ scores were. PDQ was not associated with clinical assessments of neuropathy. PDQ may be reflective of pain severity in general, and potentially nociplastic, rather than neuropathic, pain.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100651"},"PeriodicalIF":0.0,"publicationDate":"2025-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144680423","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}