Osteoarthritis and cartilage open最新文献

{"title":"Progression and influencing factors of knee osteoarthritis based on a multi-state Markov model: Data from OAI","authors":"Aerman Nuer ,&nbsp;Yasi Yang ,&nbsp;Boran Sun ,&nbsp;Yunhan Wang ,&nbsp;Wenbo Xiao ,&nbsp;Lei Wang ,&nbsp;Shu Wang ,&nbsp;Wenli Lu","doi":"10.1016/j.ocarto.2025.100703","DOIUrl":"10.1016/j.ocarto.2025.100703","url":null,"abstract":"<div><h3>Background</h3><div>Knee osteoarthritis (KOA) is a chronic disorder marked by progressive cartilage loss and functional decline. Current classifications miss bidirectional transitions, particularly in early and late stages, hindering early intervention.</div></div><div><h3>Methods</h3><div>Participants aged 45–79 years from the Osteoarthritis Initiative (OAI) were analyzed over eight years, classifying KOA states as normal, early-KOA, radiographic KOA (rKOA), and end-stage KOA (es-KOA) using Kellgren-Lawrence (K-L) grades, symptoms, and patient-reported outcomes. A Multi-state Markov (MSM) model evaluated state transitions and risk factors.</div></div><div><h3>Results</h3><div>The study comprised 2043 individuals (55.0 ​% female, 85.9 ​% White) with a total of 13,997 records of KOA state assessment. Of the individuals currently classified as early-KOA, 34.0 ​% returned to normal state, 60.9 ​% remained in early-KOA, and 5.1 ​% progressed to rKOA or es-KOA at next follow-up. The transition intensity from early-KOA to rKOA (0.05, 95 ​% CI: 0.04–0.06) was 2.6 times greater than that from normal to rKOA (0.02, 95 ​% CI: 0.01–0.02). The longest sojourn time was observed in rKOA, with a mean of 15.17 years. In covariate analysis, progression risk increased with obesity (HR: 2.57, Normal to rKOA), poor contralateral knee condition (HR: 3.68, Normal to rKOA), and depressive symptoms (HR: 2.16, rKOA to es-KOA). Better physical function reduced risk (HR: 0.65, Normal to early-KOA).</div></div><div><h3>Conclusion</h3><div>This study reveals dynamic KOA transitions, with early-KOA and es-KOA showing recovery potential. Identifying risk factors like obesity and contralateral knee condition offers opportunities for targeted interventions to slow progression and improve joint health, emphasizing early management's role in KOA care.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100703"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Sex-specific patterns and limited bilateral symmetry in coronal knee alignment: Insights from the modified coronal plane alignment of the knee classification","authors":"Kyota Ishibashi ,&nbsp;Ryoto Kura ,&nbsp;Eiji Sasaki ,&nbsp;Hikaru Kristi Ishibashi ,&nbsp;Yuka Kimura ,&nbsp;Yukiko Sakamoto ,&nbsp;Eiichi Tsuda ,&nbsp;Yasuyuki Ishibashi","doi":"10.1016/j.ocarto.2025.100721","DOIUrl":"10.1016/j.ocarto.2025.100721","url":null,"abstract":"<div><h3>Objective</h3><div>The modified Coronal Plane Alignment of the Knee (CPAK) classification broadens the neutral boundaries of arithmetic hip–knee–ankle angle (aHKA) and introduces the concept of arithmetic joint line obliquity (aJLO). This study aimed to compare the original and modified CPAK classifications and to evaluate their impact on sex-specific distribution and bilateral asymmetry.</div></div><div><h3>Design</h3><div>A total of 673 adults (400 women) from the Iwaki Health Promotion Project were analyzed. The aHKA was calculated as follows: aHKA = medial proximal tibial angle (MPTA) – lateral distal femoral angle (LDFA). The aJLO was calculated as follows: 90° – (LDFA + MPTA)/2. The original CPAK classification categorized knees into nine phenotypes using the aHKA and JLO, with neutral boundaries defined as 0° ± 2°. The modified CPAK classification adopted a wider neutral boundary of 0° ± 3° for the aHKA and aJLO. Sex-stratified analyses and bilateral comparisons were conducted.</div></div><div><h3>Results</h3><div>The modified CPAK classification redistributed the phenotypes more evenly and increased the proportion of neutral–neutral type V knees to 23.2% (vs. only 3.1% with the original CPAK classification). Men more frequently showed varus phenotypes, particularly type I (20.8%), whereas women had a higher prevalence of neutral (25.8%) and valgus phenotypes. Bilateral knee analysis revealed strong correlations with aHKA (<em>r</em> ​= ​0.71, <em>p</em> ​&lt; ​0.001) and aJLO (<em>r</em> ​= ​0.73, <em>p</em> ​&lt; ​0.001). However, only 58% of individuals showed identical CPAK types bilaterally.</div></div><div><h3>Conclusions</h3><div>Compared with the original system, the modified CPAK classification offers a more balanced representation of coronal alignment in Asian knees.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100721"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The severity of fatigue and its interplay with biological and psychological factors in people with hand osteoarthritis – Results from the Nor-Hand study","authors":"Daniel H. Bordvik ,&nbsp;Marthe Gløersen ,&nbsp;Elisabeth Mulrooney ,&nbsp;Pernille Steen Pettersen ,&nbsp;Lene Maria Sundbakk ,&nbsp;Tuhina Neogi ,&nbsp;Ingvild Kjeken ,&nbsp;Ida K. Haugen","doi":"10.1016/j.ocarto.2026.100747","DOIUrl":"10.1016/j.ocarto.2026.100747","url":null,"abstract":"<div><h3>Background</h3><div>Fatigue represents a concurrent yet uncommonly addressed symptom among people with hand osteoarthritis (OA). We aimed to explore fatigue severity and its interplay with other variables among hand OA patients.</div></div><div><h3>Methods</h3><div>We used baseline data collected in the Nor-Hand study, a cohort comprising participants with hand OA recruited at Diakonhjemmet Hospital. We measured fatigue severity by using a numeric rating scale (NRS, range: 0–10). Drawing on correlations from our dataset, existing literature, and input from a patient research partner, we estimated regularized networks to explore the interplay of fatigue. Network nodes represented variables (i.e., measures of fatigue, all bodily pain, anxiety/depression, self-efficacy, age, comorbidities, body mass index and sleep), and edges represented weighted conditional non-directional relationships between nodes. In sensitivity models, radiographic OA severity, high-sensitivity C-reactive protein, grip strength and indices of central pain sensitization were added. Network accuracy and stability were tested by bootstrapping (n = 1000).</div></div><div><h3>Results</h3><div>Our sample included 300 participants (mean (standard deviation) age; 60.8 (6.2) years, 88 % women). The mean (SD) severity of fatigue was 4.1 (2.9) NRS points. Network analyses identified comorbidities, all bodily pain, symptoms of anxiety/depression, and sleep problems as central and strongly related to fatigue, independent of additional variables included in sensitivity analyses. Edge weights and node centrality estimates were considered accurate and stable based on bootstrapped confidence intervals.</div></div><div><h3>Conclusion</h3><div>Fatigue is likely significant and strongly related to comorbidities, pain, symptoms of anxiety/depression, and sleep problems among hand OA patients. Longitudinal studies using more diverse samples and comprehensive variable selections are warranted.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100747"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037402","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between knee osteoarthritis and volumetric bone mineral density","authors":"Duy K. Hoang ,&nbsp;An T. Truong ,&nbsp;Linh N. Luu ,&nbsp;Tan D. Nguyen ,&nbsp;Nhan M. Le ,&nbsp;Huy G. Nguyen ,&nbsp;Lan T. Ho-Pham ,&nbsp;David J. Hunter ,&nbsp;Tuan V. Nguyen","doi":"10.1016/j.ocarto.2025.100740","DOIUrl":"10.1016/j.ocarto.2025.100740","url":null,"abstract":"<div><h3>Objective</h3><div>Although patients with radiographic knee osteoarthritis (OA) have a higher areal bone mineral density (BMD) than non-OA individuals, their fracture risk was not significantly different. This study sought to define the association between radiographic knee OA and volumetric BMD.</div></div><div><h3>Methods</h3><div>We enrolled 944 men and 1506 women aged 40 years or older, selected randomly from Ho Chi Minh City, Vietnam. Knee radiographs were assessed using the Kellgren and Lawrence scale, with grades two or higher indicating knee osteoarthritis (OA). Areal bone mineral density (aBMD) at the femoral neck and lumbar spine was measured using DXA (Hologic Corp, USA). Trabecular and cortical volumetric bone density (vBMD) at the tibia bone were also measured using pQCT XCT2000 (Stratec, Germany). The difference in aBMD and vBMD between individuals with and without OA was quantified using effect size (ES) and 95 % confidence interval (CI).</div></div><div><h3>Results</h3><div>The prevalence of radiographic knee OA in this cohort was approximately 31 % (n = 755), which increased with age. Compared to non-OA individuals, those with knee OA had higher femoral neck aBMD (ES = 0.04, 95 % CI: 0.02–0.05; P = 0.0002). However, knee OA patients had lower vBMD at the cortical tibia bone (ES = − 8.15, 95 % CI: −14.52 to −1.8; P = 0.01).</div></div><div><h3>Conclusion</h3><div>These data suggest that approximately a third of Vietnamese people aged 40 and over might have radiographic knee OA. The tibial cortical vBMD was significantly lower in persons with knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100740"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145938467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A consumer co-designed community physical activity program for Australians living with osteoarthritis (CASCADE-OA): A randomised controlled trial protocol","authors":"Sarah Kobayashi ,&nbsp;David J. Hunter ,&nbsp;Leigh F. Callahan ,&nbsp;Dawn Aitken ,&nbsp;Christian J. Barton ,&nbsp;Kim L. Bennell ,&nbsp;Frances Daley ,&nbsp;Jillian P. Eyles ,&nbsp;Rana S. Hinman ,&nbsp;Elena Losina ,&nbsp;Nicole M. Rankin ,&nbsp;Emily Si ,&nbsp;Emmanuel Stamatakis ,&nbsp;Venkatesha Venkatesha ,&nbsp;Bill Vicenzino ,&nbsp;Daniel K. White ,&nbsp;Shirley P. Yu ,&nbsp;Vicky Duong","doi":"10.1016/j.ocarto.2026.100751","DOIUrl":"10.1016/j.ocarto.2026.100751","url":null,"abstract":"<div><h3>Objective</h3><div>This protocol will detail the methodology of the CASCADE-OA trial that will determine the effectiveness of an evidence-based and co-designed walking program, Walk with Ease Australia in increasing physical activity levels in people with osteoarthritis (OA).</div></div><div><h3>Design</h3><div>We will undertake a two-arm parallel assessor blinded RCT in a hybrid type 1 effectiveness-implementation design. 414 participants with a clinical diagnosis of knee or hip OA will be recruited across Australia through state and territory arthritis consumer advocacy groups, an OA management program in a public hospital setting, and social media. Participants with co-existing inflammatory arthritis or those already meeting physical activity guidelines will be excluded. Participants will be randomised 1:1 into either the Walk with Ease Australia + Fitbit™ group (intervention) or the Fitbit™ only group (comparator). The intervention period will be 12 weeks and participants will be followed for 12 months from randomisation. The primary outcome is average daily step count at 12 weeks as assessed by Fitbit™. Secondary outcomes include pain, disability, quality of life, self-efficacy, work absenteeism and healthcare utilisation. Implementation outcomes will be collected based on the RE-AIM framework domains and process evaluation framework for complex interventions.</div></div><div><h3>Results</h3><div>The trial was registered on the Australia and New Zealand Clinical Trials Registry (ACTRN12625000185460) on February 17th, 2025 and received ethics approval from the Northern Sydney Local Health District Human Research Ethics Committee (2024/ETH01898).</div></div><div><h3>Conclusion</h3><div>CASCADE-OA will determine whether Walk with Ease Australia will support people in the community with OA in increasing physical activity and improving symptoms.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100751"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215150","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hispanic American osteoarthritis patients' and partners' perspectives regarding exercise: A qualitative study","authors":"E.R. Vina ,&nbsp;L. Stauber ,&nbsp;C. Villamil Grest ,&nbsp;R.A. Gomez ,&nbsp;F. Razzaq ,&nbsp;J. Dagnino ,&nbsp;K.L. Bennell ,&nbsp;C.K. Kwoh","doi":"10.1016/j.ocarto.2025.100704","DOIUrl":"10.1016/j.ocarto.2025.100704","url":null,"abstract":"<div><h3>Objective</h3><div>Identify facilitators and barriers to engaging in exercise or other physical activity (PA) programs among Hispanics with knee OA (osteoarthritis) and to inform the development of a dyadic telehealth-delivered program.</div></div><div><h3>Design</h3><div>Hispanics with symptomatic knee OA were recruited. Participants were asked to invite a family member/friend to join them in a semi-structured Zoom interview. Interviews, guided by the Theoretical Domains Framework of behavior change, explored participants' beliefs about exercise and identified barriers and facilitators to engaging in exercise or other PA programs. Transcripts were analyzed primarily using deductive content analysis in MAXQDA 2024.</div></div><div><h3>Results</h3><div>Interviews were conducted with 8 female and 7 male patients (mean age: 67.7 years) and their chosen partners (10 spouses, 3 friends, 2 relatives). The most frequently mentioned facilitator of PA program uptake was participants' expectation that exercise would lead to positive outcomes, including improvement of OA-related symptoms. Another key facilitator to engaging in a PA intervention was access to professional guidance—both for initiating and implementing the program. Participants highlighted the importance of receiving prescriptions from providers and expert guidance (e.g., physical therapists). Barriers to participation were not prominent. There were limited concerns about telehealth navigation for most. However, some expressed lack of concordance with partner schedule and incompatible exercise pace/style as potential barriers.</div></div><div><h3>Conclusions</h3><div>A telehealth PA intervention for knee OA would be well-received by Hispanics in the US southwest, particularly when prescribed and overseen by healthcare providers. Barriers to intervention participation were limited but included discordance with partner schedule and exercise pace.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100704"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145579929","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Emerging concepts in osteoarthritis and musculoskeletal diseases: Insights from the University of Debrecen Musculoskeletal Symposium 2025","authors":"Patrik Kovács ,&nbsp;Judit Vágó ,&nbsp;Ali Mobasheri ,&nbsp;Zsuzsa Jenei-Lanzl ,&nbsp;Frank Zaucke ,&nbsp;Henning Madry ,&nbsp;László Csernoch ,&nbsp;Zoltán Szekanecz ,&nbsp;Zsuzsa Szondy ,&nbsp;Árpád Szöőr ,&nbsp;Istvan Szatmari ,&nbsp;Tamás Oláh ,&nbsp;Csaba Matta","doi":"10.1016/j.ocarto.2025.100728","DOIUrl":"10.1016/j.ocarto.2025.100728","url":null,"abstract":"<div><h3>Objective</h3><div>To highlight the key translational advances and interdisciplinary discussions from the 2025 University of Debrecen Musculoskeletal Symposium (UD-MUSK), focusing on osteoarthritis (OA) and related musculoskeletal (MSK) diseases.</div></div><div><h3>Method</h3><div>The UD-MUSK Symposium convened international and local experts for keynote presentations and scientific dialogue spanning OA and MSK disease mechanisms, translational therapies, and tissue regeneration. Core topics included extracellular matrix (ECM) remodelling, cell/gene therapies, animal disease models, chronic stress, autoimmunity, immunotherapies, and muscle and stem cell biology, reflecting the Symposium's broad interdisciplinary spectrum.</div></div><div><h3>Results</h3><div>ECM proteomics revealed degradation fragments that act as drivers and potential modulators of OA, offering new biomarkers and therapeutic targets. Advances in cell- and gene-based therapies were presented, including the use of growth differentiation factor 6 (GDF6) and CRISPR approaches for cartilage and intervertebral disc repair. Large animal models simulating spatio-temporal changes in human OA, and studies demonstrating chronic stress-accelerated OA via neuroendocrine mechanisms, were highlighted. Novel strategies in immune modulation, such as chimeric antigen receptor (CAR) T cell therapy for autoimmune myopathies, alongside research on muscle regeneration and circadian regulation by mechanical loading, further exemplified the translational breadth of the meeting.</div></div><div><h3>Conclusion</h3><div>The symposium underscored the value and need of integrating molecular research and disease modeling. Interdisciplinary collaboration continues to enhance understanding of MSK disease mechanisms and supports development of targeted, regenerative therapies with translational potential for OA and related disorders.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100728"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A randomized, double-blind, placebo-controlled and dose-ranging study to evaluate the safety and efficacy of XG005 in subjects with painful osteoarthritis of the knee","authors":"Limin Ren ,&nbsp;Wenjie Zheng ,&nbsp;Zhenpeng Guan ,&nbsp;Yang Zhang ,&nbsp;Zeyu Huang ,&nbsp;Tong Li ,&nbsp;Yuwei Peng ,&nbsp;Qiuli Wu ,&nbsp;Wei Gou ,&nbsp;Wei Zhao ,&nbsp;Pengyan Qiao ,&nbsp;Xiaoli Pan ,&nbsp;Guang-Liang Jiang","doi":"10.1016/j.ocarto.2025.100737","DOIUrl":"10.1016/j.ocarto.2025.100737","url":null,"abstract":"<div><h3>Objective</h3><div>Symptomatic treatment for osteoarthritis (OA) remains a major unmet need. This trial evaluated XG005, a novel, non-opioid, dual-mechanism agent targeting both inflammatory and neuropathic pathways in patients with knee OA.</div></div><div><h3>Design</h3><div>This randomized, double-blind, placebo-controlled study enrolled 318 patients with moderate-to-severe knee OA pain to receive XG005 750 mg, 500 mg, or placebo twice daily for 4 weeks. Efficacy measures included weekly average of daily walking pain (WADWP), Western Ontario and McMasters Universities Osteoarthritis Index (WOMAC), Knee Injury and Osteoarthritis Outcome Score (KOOS), Patient Global Impression of Change (PGIC), Sleep Interference Score (SIS), and Short-Form-12 Health Survey (SF-12).</div></div><div><h3>Results</h3><div>The primary efficacy endpoint of improvement from baseline in WADWP at week 4 was statistically greater for the 750 mg group than placebo with least squares mean difference (LSMD) (95 % CI) of −0.55 (−0.94, −0.16). Key secondary endpoints were significantly improved for high- and low-dose XG005 compared to placebo at week 4, with LSMD (95 % CI) of −0.43 (−0.74, −0.13) and −0.4 (−0.78, −0.02) in WOMAC pain, and 5.56 (2.69, 8.42) and 3.74 (0.17, 7.31) in KOOS pain. WOMAC and KOOS stiffness and function, PGIC, SIS and SF-12 mental and general health showed statistically significant improvements over placebo. Patients with neuropathic pain had approximately 2-3-fold greater symptom improvements than patients with nociceptive pain. Mild dizziness and somnolence were most seen in XG005 groups.</div></div><div><h3>Conclusion</h3><div>XG005 demonstrated consistent efficacy in improving OA symptoms with acceptable tolerability. Additional studies in OA patients with neuropathic pain are needed to confirm its dual mechanism advantages.</div></div><div><h3>Clinical trial registration</h3><div>CTR20222406.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100737"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883724","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Letter to the Editor regarding “Minimal important change of the knee injury and osteoarthritis outcome score in patients with mild to moderate knee osteoarthritis – Using three different anchor-based methods”","authors":"Daniel L. Riddle,&nbsp;Levent Dumenci","doi":"10.1016/j.ocarto.2026.100748","DOIUrl":"10.1016/j.ocarto.2026.100748","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100748"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Physical activity and diurnal variation have no impact on plasma microRNA-140 expression levels in patients with knee osteoarthritis and healthy controls","authors":"Tommy Frøseth Aae ,&nbsp;Rune Bruhn Jakobsen ,&nbsp;Mai Britt Dahl ,&nbsp;Asbjørn Årøen ,&nbsp;Per-Henrik Randsborg ,&nbsp;Myrthle Slettvåg Hoel ,&nbsp;Øystein Bjerkestrand Lian","doi":"10.1016/j.ocarto.2025.100720","DOIUrl":"10.1016/j.ocarto.2025.100720","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to determine whether physical activity or diurnal variation influence circulating microRNA-140-3p (miR-140-3p) and miR-140-5p expression levels in patients with knee osteoarthritis (OA) compared to healthy controls.</div></div><div><h3>Method</h3><div>Twenty-one patients with knee OA and ten healthy controls ran on a treadmill for 20 ​min and blood samples were taken prior to and after running. To assess diurnal variation, blood samples were drawn at six different times during a 24-h period. RNA was extracted from plasma and used for cDNA synthesis. Expression levels were assessed with real-time quantitative polymerase chain reaction and compared between patients and controls.</div></div><div><h3>Results</h3><div>All participants had detectable expression levels of miR-140-3p and miR-140-5p. A paired analysis could not demonstrate statistically significant differences between the groups.</div></div><div><h3>Conclusions</h3><div>Plasma miR-140-3p and miR-140-5p expression levels were found in all samples; however, the expression levels were not affected by physical activity and did not show diurnal variation. The observation of stable miR-140 expression supports its potential as a reliable biomarker for OA, providing a methodological foundation for future diagnostic and translational studies.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100720"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145693587","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}