Osteoarthritis and cartilage open最新文献

{"title":"Comorbid hypertension and osteoarthritis exacerbates joint remodeling and gait compensations in female rats with milder effects observed in males","authors":"Carlos J. Cruz ,&nbsp;Folly M. Patterson ,&nbsp;Janak Gaire ,&nbsp;Julianna Gonzalez ,&nbsp;Jacob L. Griffith ,&nbsp;Angela Philistin ,&nbsp;Kyle D. Allen","doi":"10.1016/j.ocarto.2025.100649","DOIUrl":"10.1016/j.ocarto.2025.100649","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) often presents with comorbidities such as hypertension, potentially accelerating OA pathogenesis. We hypothesized that hypertension would exacerbate joint-level pathogenesis and OA-related symptoms in a sex-dependent manner.</div></div><div><h3>Methods</h3><div>Male and female Spontaneously Hypertensive rats (hypertensive) and Sprague Dawley rats (normotensive) underwent either medial collateral ligament and medial meniscus transection (OA) or skin incision (sham) in the right knee (N ​= ​80; n ​= ​10/group/sex). Symptoms were measured monthly (gait) and bi-weekly (tactile sensitivity) for 8 weeks. Endpoint histology assessed joint-level damage, neurovascular changes, and cytokine levels in synovial fluid.</div></div><div><h3>Results</h3><div>At endpoint, hypertensive-OA rats had thinner cartilage across the medial tibial plateau than normotensive-OA rats (non-overlapping 95 ​% CI), regardless of sex. While not observed in males, hypertensive-OA females developed larger osteophytes (Q1–Q3 ​= ​0.049–0.124 ​mm²) than normotensive-OA females (Q1–Q3 ​= ​0.026–0.047 ​mm², p ​= ​0.02) and ranked higher for CD31⁺ vasculature in the subchondral bone plate (Q1–Q3 ​= ​18.2–21.5) than normotensive-OA females (Q1–Q3 ​= ​1; p ​= ​0.01). Hypertensive-OA females developed a limping gait, shifting stance times from their OA to non-OA limb (stance time imbalance ​= ​1.20 ​± ​1.15 ​%, p ​= ​0.04), offloaded their injured limb quicker (temporal symmetry ​= ​52.5 ​± ​1.4 ​%, p ​&lt; ​0.001), and reduced stride lengths (weeks 4 and 8; hypertensive-OA ​&lt; ​normotensive-OA, p ​&lt; ​0.001). These gait changes were not observed in normotensive-OA females or males, nor in hypertensive-OA males.</div></div><div><h3>Conclusions</h3><div>Hypertension worsened OA pathogenesis at the joint level, more substantially affecting joint remodeling and gait compensations in females. Our results encourage further investigation into the pathophysiologic drivers linking hypertension and OA, particularly vascular changes and sex differences.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100649"},"PeriodicalIF":0.0,"publicationDate":"2025-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144686459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Networking in the osteoarthritis research community in the digital era","authors":"Rachel K. Nelligan ,&nbsp;Anca Maglaviceanu ,&nbsp;Jocelyn Bowden ,&nbsp;Jackie L. Whittaker ,&nbsp;Tobias Winkler ,&nbsp;Jos Runnhar ,&nbsp;Mohit Kapoor ,&nbsp;Chunyi Wen","doi":"10.1016/j.ocarto.2025.100650","DOIUrl":"10.1016/j.ocarto.2025.100650","url":null,"abstract":"<div><div>Networking is a vital skill for osteoarthritis (OA) researchers, offering pathways to collaboration, visibility, and career development. Recognising the evolving nature of networking in the digital era, the OARSI Early Career Investigator (ECI) Committee hosted a workshop at the 2025 OARSI World Congress titled “Navigating Networking: Strategies for Connecting Across Cultures and Personalities.” This editorial summarises key insights from the session’s expert presentations and panel discussion. Dr Jocelyn Bowden highlighted the enduring value of face-to-face networking for rapport-building, encouraging ECIs to approach interactions with curiosity and preparation. Dr Jackie Whittaker explored virtual networking and personality-based strategies, noting that aligning communication methods with individual preferences can enhance engagement. She stressed that there is no one-size-fits-all approach. Professor Tobias Winkler provided guidance on industry networking, underscoring the importance of understanding corporate decision-making processes and collaboration dynamics. The session closed with reflections on cultural competence and the role of authenticity in communication. While digital tools may support networking, the speakers agreed that genuine, personalised interactions remain essential. Across all formats, researchers were encouraged to build inclusive, diverse networks grounded in sincerity and mutual respect. For those unable to attend, this summary offers practical strategies to support effective networking across platforms, cultures, and career stages.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100650"},"PeriodicalIF":0.0,"publicationDate":"2025-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654818","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain informed movement compared to neuromuscular exercise and standard education in people with knee osteoarthritis: A pilot and feasibility randomized controlled trial","authors":"Lisa C. Carlesso ,&nbsp;Shirin Modarresi ,&nbsp;Neil Pearson ,&nbsp;Kim Madden ,&nbsp;Margaret Fahnestock ,&nbsp;Kim L. Bennell ,&nbsp;Tuhina Neogi ,&nbsp;Erfan Shafiee","doi":"10.1016/j.ocarto.2025.100646","DOIUrl":"10.1016/j.ocarto.2025.100646","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the feasibility of conducting a full-scale randomized controlled trial to test the effectiveness of pain informed movement (PIM) (includes mind-body techniques, neuromuscular strengthening exercises (NEMEX) and pain neuroscience education), compared to NEMEX and standard education in people with knee osteoarthritis (KOA).</div></div><div><h3>Methods</h3><div>Adults ≥40 years with KOA were randomized to a twice weekly in-person group program for 8 weeks. Education was delivered through weekly videos. Recruitment, follow-up, adherence (attendance), compliance to home exercises, burden of procedures as well as patient-reported clinical outcomes, quantitative sensory tests, the sit to stand test, and serum levels of brain derived neurotrophic factor and nerve growth factor were assessed before and immediately after treatment. Focus groups were conducted post intervention.</div></div><div><h3>Results</h3><div>210 people were screened for eligibility. 69 (33 ​%) were randomized and 59 (28 PIM, 31 NEMEX; 86 ​%) completed the trial. The primary outcome of follow up rate was met along with all other a priori criteria. There was high acceptability of both interventions (≥86 ​%), and perceived low burden of procedures (≥80 ​%). Only minor adverse events were reported. Secondary outcomes improved across most clinical measures in both groups with the PIM group showing clinically important improvement in pain. Focus group feedback suggests the need to consider an alternative format to video delivery of the education content.</div></div><div><h3>Conclusion</h3><div>This pilot RCT indicates that a full trial is feasible and warranted to test the effectiveness of PIM versus NEMEX and standard education with the potential to provide mechanistic insights based on nervous system modulation.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100646"},"PeriodicalIF":0.0,"publicationDate":"2025-07-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the comparison of remote versus face-to-face osteoarthritis management programs (COASTAL): A randomized implementation trial","authors":"Shiwen Yuan ,&nbsp;Jocelyn L. Bowden ,&nbsp;Jillian P. Eyles ,&nbsp;Vicky Duong ,&nbsp;Stephen Messier ,&nbsp;Elena Losina ,&nbsp;Jean Frederic Levesque ,&nbsp;Andrew M. Briggs ,&nbsp;Michelle M. Dowsey ,&nbsp;Leticia Alle Deveza ,&nbsp;Nicole M. Rankin ,&nbsp;Christian J. Barton ,&nbsp;Blake F. Dear ,&nbsp;Carin Pratt ,&nbsp;Jonathan Smithers ,&nbsp;Louise Hardy ,&nbsp;Caroline Bills ,&nbsp;Julia Thompson ,&nbsp;Tom Buttel ,&nbsp;Daniel Ewald ,&nbsp;David J. Hunter","doi":"10.1016/j.ocarto.2025.100647","DOIUrl":"10.1016/j.ocarto.2025.100647","url":null,"abstract":"<div><h3>Objective</h3><div>To determine the comparative effectiveness of three evidence-informed approaches to delivering osteoarthritis (OA) care in real-world settings: face-to-face services, telehealth services or a mobile application (app).</div></div><div><h3>Design</h3><div>COASTAL (ACTRN12624000996561) comprises two aims: the primary aim is a three-arm, non-inferiority, comparative-effectiveness, type I hybrid implementation RCT; and the secondary aim is a superiority trial to compare the three interventions separately to an untreated, non-randomized control group. We will recruit 1348 participants (primary aim:1011 interventions; secondary aim:1011 interventions, 337 controls) with knee OA referred to a NSW public Osteoarthritis Chronic Care Program (OACCP). Eligible participants who consent to OACCP participation will be randomized 1:1:1 to receive care through the face-to-face OACCP, a telehealth service, or the “OA Coach” app, over 6-months. All participants will receive a standardized needs assessment; OA education; collaboratively developed, personalized management plan with a focus on therapeutic exercise, physical activity, pain management, and weight-management, according to each arm's mode of delivery. People who have declined OACCP participation will be eligible for the control group. The primary outcome is change in average knee pain during walking at 6-months (11-point NRS). Secondary, implementation, and economic evaluation outcomes will be collected at 6 and 12-months.</div><div>The protocol was co-developed with people with knee OA, clinicians delivering the services, and other stakeholders. Ethical approval granted by the Northern Sydney Local Health District (2024/ETH01461).</div></div><div><h3>Conclusion</h3><div>The results of this trial will provide critical evidence to help people with OA, clinicians, service planners and policymakers choose between different modes of delivering care for knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100647"},"PeriodicalIF":0.0,"publicationDate":"2025-07-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631775","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility","authors":"Sónia A. Alves ,&nbsp;Nicholas M. Brisson ,&nbsp;Alison N. Agres ,&nbsp;Mark Heyland ,&nbsp;Ali Mobasheri ,&nbsp;David J. Hunter ,&nbsp;Tobias Winkler ,&nbsp;Georg N. Duda","doi":"10.1016/j.ocarto.2025.100648","DOIUrl":"10.1016/j.ocarto.2025.100648","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100648"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fully-automated technique for cartilage morphometry in knees with severe radiographic osteoarthritis – Method development and validation","authors":"Wolfgang Wirth ,&nbsp;Felix Eckstein","doi":"10.1016/j.ocarto.2025.100645","DOIUrl":"10.1016/j.ocarto.2025.100645","url":null,"abstract":"<div><h3>Objective</h3><div>Denuded areas of subchondral bone (dAB) pose a challenge for fully automated segmentation of articular cartilage and subchondral bone in knees with severe radiographic osteoarthritis using convolutional neural networks (CNNs). Here we propose an automated post-processing relying on a selection-based multi-atlas registration for reconstructing the total area of subchondral bone (tAB) to overcome this issue. We evaluate the agreement, accuracy and longitudinal sensitivity to cartilage change of this novel methodology.</div></div><div><h3>Design</h3><div>CNN-based models were trained using manual cartilage segmentations from sagittal DESS and coronal FLASH MRI of knees with radiographic (KLG2-4) or severe radiographic osteoarthritis (KLG4 only). These were then applied to KLG4 test knees with manual cartilage segmentations. Automated post-processing was applied to reconstruct missing parts of the tAB and to refine the segmentations, particularly for dABs. The agreement and accuracy of automated cartilage analysis were evaluated using Dice Similarity Coefficients (DSC) and Bland-Altman analyses; sensitivity to one-year change was assessed using the standardized response mean (SRM).</div></div><div><h3>Results</h3><div>Stronger agreement (DSC 0.80 ​± ​0.07 to 0.89 ​± ​0.05) and lower systematic offsets for cartilage thickness (1.2 ​%–8.4 ​%) and tAB area (−0.4 ​%–4.3 ​%) were observed for CNNs trained on KLG2-4 rather than KLG4 knees; overall, results were superior to those without registration-based post-processing. Sensitivity to change was greatest for manual segmentation of DESS (SRM ​≥ ​−0.69; automated: ≥−0.56) and for automated segmentation of FLASH (≥−0.74; manual ≥−0.44).</div></div><div><h3>Conclusion</h3><div>CNN-based segmentation combined with registration-based post-processing for accurate delineation of tABs/dABs substantially improves fully-automated (longitudinal) analysis of cartilage and subchondral bone morphology in knees with severe radiographic osteoarthritis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100645"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good long-term functional outcomes after rotationplasty despite osteoarthritis in the (pseudo)knee","authors":"G.G.J. Krebbekx ,&nbsp;F.F. Smithuis ,&nbsp;M.J.C. Duivenvoorden ,&nbsp;R. Hemke ,&nbsp;I.N. Sierevelt ,&nbsp;G.R. Schaap ,&nbsp;J.A.M. Bramer ,&nbsp;G.M.M.J. Kerkhoffs ,&nbsp;F.G.M. Verspoor","doi":"10.1016/j.ocarto.2025.100644","DOIUrl":"10.1016/j.ocarto.2025.100644","url":null,"abstract":"<div><h3>Objective</h3><div>Rotationplasty is a surgical procedure primarily performed in patients with malignancies around the knee. Altered gait mechanics after surgery, such as reduced flexion of the (pseudo)knee and ipsilateral hip and changes in ground reaction forces, may predispose patients to osteoarthritis (OA) in the lower extremities. This study evaluated the long-term prevalence of OA and its association with pain and daily functioning.</div></div><div><h3>Method</h3><div>Rotationplasty survivors who underwent surgery between 1980 and 2002 in Amsterdam received radiographic assessment of the (pseudo)knee, contralateral ankle, and both hips (weight-bearing mortise, lateral and AP views). OA was graded using the Kellgren-Lawrence scale. Functional outcomes, pain, quality of life, and sports participation were evaluated with the FAOS, AOFAS, and Harris Hip Score questionnaires. Statistical analyses included t-tests, Mann-Whitney U, chi-square, and Fisher's exact tests.</div></div><div><h3>Results</h3><div>Thirty patients (mean age 49.4 ​± ​9.2 years; mean follow-up 32.4 ​± ​4.6 years) participated. Moderate-to-severe OA was found in 43 ​% of ipsilateral (pseudo)knees, 10 ​% of contralateral ankles, 33 ​% of ipsilateral hips, and 11 ​% of contralateral hips. Osteophytes were most common in the anterior tibial and subtalar regions (20 ​%), and joint space narrowing was most frequent in the subtalar (20 ​%) and medial tibiotalar (13 ​%) regions. Functional scores were generally favorable. The presence of osteoarthritis in the pseudo-knee was significantly associated with longer follow-up time.</div></div><div><h3>Conclusion</h3><div>Functional outcomes after rotationplasty are well preserved over time, despite a higher prevalence of osteoarthritis in the (pseudo)knee compared to the contralateral ankle as a long-term consequence of the procedure.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100644"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis","authors":"H. Platzer ,&nbsp;M. Wellbrock ,&nbsp;G. Pourbozorg ,&nbsp;R. Mayakrishnan ,&nbsp;S. Gantz ,&nbsp;B. Khamees ,&nbsp;S. Maciej ,&nbsp;B. Moradi","doi":"10.1016/j.ocarto.2025.100642","DOIUrl":"10.1016/j.ocarto.2025.100642","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is driven by biomechanical and biochemical inflammatory processes, including CD4⁺ T cell infiltration and activation. However, the role of CD4⁺ T cell subsets interacting with neighboring cells shaping the local inflammatory milieu have remained largely unexplored. This study aimed to investigate in vitro whether interaction of chondrocyte and CD4⁺ T cells modulate cytokine and metalloproteinase production in OA, and to determine if this modulation differ depending on CD4⁺ T cell subsets.</div></div><div><h3>Method</h3><div>Nineteen patients with knee OA undergoing knee replacement were enrolled. From peripheral blood CD4⁺ T cells were isolated and differentiated into subsets (Th1, Th2, Th17, Treg) using a novel developed protocol. T cell differentiation was validated by flow cytometry. Chondrocytes were mono- and co-cultured with T cell subsets and in culture supernatant cytokine and metalloproteinase levels were quantified using ELISA and multiplex assays.</div></div><div><h3>Results</h3><div>Compared to monocultures levels MMP-1/3/9/13 and IL-6 were elevated in all co-cultures of chondrocytes and CD4⁺ T cell subsets, with the highest levels in Th17 co-cultures. GM-CSF, IL-9, IL-17 were specifically elevated in Th17 co-cultures and IFN-γ in Th1 co-cultures. TNF-α production was significantly reduced only in Treg co-culture compared to monoculture approach.</div></div><div><h3>Conclusion</h3><div>This study indicates that chondrocytes can interact with CD4⁺ T cell subsets in OA, modulating the production of metalloproteinases and cytokines to varying degrees, depending on the CD4⁺ T cell subset. Our findings can open new avenues in OA treatment using T cell-based or T cell subset-targeted therapies to modulate inflammatory patterns in affected OA joints.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100642"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness","authors":"Hanna Mass ,&nbsp;Jamie E. Collins ,&nbsp;Catherine Yang ,&nbsp;David J. Hunter ,&nbsp;Morgan H. Jones ,&nbsp;Love Tsai ,&nbsp;Stephen P. Messier ,&nbsp;Tuhina Neogi ,&nbsp;Jeffrey N. Katz ,&nbsp;Elena Losina","doi":"10.1016/j.ocarto.2025.100641","DOIUrl":"10.1016/j.ocarto.2025.100641","url":null,"abstract":"<div><h3>Objective</h3><div>Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.</div></div><div><h3>Methods</h3><div>We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.</div></div><div><h3>Results</h3><div>In the base case, ICERs were $8300/QALY for saline compared to no injection, $54,500/QALY for HA compared to saline, and $112,100/QALY for PRP compared to HA. CS was dominated (more costly, less effective) by saline. <strong>If saline was not included, ICER for HA was reduced to $22,400/QALY.</strong> In sensitivity analyses that assumed CS does not increase OA progression, ICERs were $6000/QALY for CS compared to no injection, HA dominated compared to CS. ICER for PRP was estimated at $151,300/QALY. ICERs for PRP were higher than currently accepted willingness to pay thresholds. PRP ICER ranges were most sensitive to discontinuation probability and cost.</div></div><div><h3>Conclusions</h3><div>CS could offer good value for knee OA management if the impact on OA progression is small. <strong>Value of PRP depends greatly on its price, with current prices leading to value exceeding well</strong><strong>-</strong><strong>accepted cost-effectiveness thresholds</strong>. Better data on the impact of CS on OA progression and pain efficacy related to PRP would offer critical insights for policymakers into the value of specific IAIs in the management of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100641"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study","authors":"Caroline H. Dekkerhus ,&nbsp;Alexander Mathiessen ,&nbsp;Caroline M. Fjellstad ,&nbsp;Barbara Slatwkosky-Christensen ,&nbsp;Hilde Berner Hammer ,&nbsp;Ida K. Haugen","doi":"10.1016/j.ocarto.2025.100640","DOIUrl":"10.1016/j.ocarto.2025.100640","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the frequency and severity of ultrasound-detected osteophytes and synovitis in people with and without knee osteoarthritis (OA), and to explore the association between these ultrasound features and pain.</div></div><div><h3>Design</h3><div>In the Nor-Hand study, both knees were assessed for osteophytes (0–3 scale, four locations per knee) and grey-scale synovitis (0–3 scale). The frequency and severity of the ultrasound-detected features were compared in individuals with and without knee OA defined by the American College of Rheumatology criteria. Pain was self-reported in each knee (yes/no) and by the Western/Ontario McMaster University index (WOMAC). The associations between ultrasound-detected features and pain were examined by regression analyses adjusted for age, sex, and body mass index.</div></div><div><h3>Results</h3><div>We analyzed 286 participants. Osteophytes of all sizes were more common in participants with knee OA compared to those without (65.9 ​% vs. 40.8 ​%, p ​&lt; ​0.001). No between-group difference was found for the frequency of any grey-scale synovitis (45.5 ​% vs. 44.7 ​%, p ​= ​0.67), while severe synovitis was more common in those with knee OA. Ultrasound-detected osteophyte sum score, but not synovitis, was associated with WOMAC pain (B ​= ​0.18, 95 ​% CI 0.03–0.32). Osteophytes of all sizes were associated with pain in the same knee with odds ratio (OR, 95 ​% CI) ranging from 1.85 (1.20–2.84) to 9.02 (4.04–20.10). Statistically significant association was found for severe synovitis only (OR ​= ​6.63, 95 ​% CI 2.26–19.43).</div></div><div><h3>Conclusions</h3><div>Ultrasound-detected osteophytes were prevalent in people with knee OA and were associated with pain. OA pathology in individuals without fulfilling the knee OA criteria may reflect early or subclinical OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100640"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}