Osteoarthritis and cartilage open最新文献

{"title":"Associations of clinical measures and structural knee magnetic resonance imaging findings with knee symptoms in a birth cohort of 33-year-old adults","authors":"Antti Kemppainen ,&nbsp;Joona Tapio ,&nbsp;Miika T. Nieminen ,&nbsp;Simo Saarakkala ,&nbsp;Mika T. Nevalainen","doi":"10.1016/j.ocarto.2025.100730","DOIUrl":"10.1016/j.ocarto.2025.100730","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the associations between knee magnetic resonance imaging (MRI) findings, knee joint symptoms and related health factors in a random subpopulation of 33-year-olds from the Northern Finland 1986 Birth Cohort.</div></div><div><h3>Method</h3><div>Subjects with questionnaire, knee MRI, and clinical symptom data, were included in this study (n = 284, 60.9 % females, age 33.7 years). Knee MRI data was graded using the MRI Osteoarthritis Knee Score (MOAKS) system. Symptoms were evaluated using the Visual Analogue Scale (VAS) version of the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC), and participants with VAS &gt;3 in any WOMAC sub-question were considered symptomatic.</div></div><div><h3>Results</h3><div>12.2 % (74.3 % females) of the study population were symptomatic, and were more likely to have a higher BMI, adverse lipid profile and a family history of knee OA. Advanced MRI findings were sparse. Most MRI findings, such as bone marrow lesions (BMLs) and osteophytes, were more prevalent and severe in symptomatic participants. In adjusted regression analyses, BMLs in the medial femoral compartment and osteophytes in the lateral tibial and medial femoral compartments, patellar tendon signal and joint effusion were associated with knee symptoms.</div></div><div><h3>Conclusion</h3><div>Several MRI findings, most notably medial femoral BMLs, osteophytes, patellar tendinopathy and joint effusion were associated with knee symptoms. Of other factors, sex, family history and clinical factors such as body composition are associated with knee joint symptomatology from early adulthood.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100730"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840137","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Lower limb malalignment on whole-leg radiography predicts medial or lateral talar osteochondral lesion location: Implications for osteoarthritis assessment","authors":"Ralf Henkelmann ,&nbsp;Raphael Greifeldt ,&nbsp;Pierre Hepp ,&nbsp;Robert Hennings ,&nbsp;Hans-Jonas Meyer ,&nbsp;Timm Denecke ,&nbsp;Jeanette Henkelmann","doi":"10.1016/j.ocarto.2025.100707","DOIUrl":"10.1016/j.ocarto.2025.100707","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the association between coronal plane malalignment of the lower extremity and talar osteochondritis dissecans (OCD) localization, and assess the influence of mechanical axis deviations and local joint morphology on lesion distribution.</div></div><div><h3>Design</h3><div>This retrospective monocentric study included 50 patients (mean age 31 ​± ​12 years) with 52 talar OCD lesions who underwent standing whole-leg radiography, which were analyzed digitally. The primary outcome was OCD lesion localization (medial vs. lateral) in relation to coronal plane lower limb alignment (varus, neutral, valgus). Secondary outcomes included angular parameters of the knee and ankle (mLDFA, mMPTA, mLDTA, JLCA, KAJA, talar inclination, talar tilt) and associations lower limb alignment patterns with lesion location. Associations were assessed via univariate testing and binary logistic regression.</div></div><div><h3>Results</h3><div>Talar OCDs occurred medially in 83 ​% and laterally in 17 ​%. Lower limb malalignment was significantly associated with lesion localization (p ​= ​0.024), with varus correlated with medial, while valgus predicted lateral OCD lesions (OR 2.63; 95 ​% CI 1.1–6.4; p ​= ​0.034). Talar tilt independently correlated with lesion site (p ​&lt; ​0.001); tibiotalar valgus tilt increased odds for lateral lesions (OR 0.084; 95 ​% CI 0.01–0.73; p ​= ​0.025). Combined knee and ankle alignment subtypes also influenced lesion laterality (p ​= ​0.017).</div></div><div><h3>Conclusions</h3><div>Lower limb malalignment and talar tilt are independent predictors of OCD localization. Coronal plane deviations and joint morphology alter load across the talar dome, contributing to medial or lateral predilection. Whole-leg alignment analysis should be considered in diagnostic and surgical planning, particularly in revision cases.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100707"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694226","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the bidirectional temporal association between daily knee pain and physical activity in people with knee osteoarthritis: An exploratory smartwatch study","authors":"Ayobami E. Olanrewaju ,&nbsp;Matthew J. Parkes ,&nbsp;Jamie C. Sergeant ,&nbsp;Emma Pritchard ,&nbsp;Shuai Shao ,&nbsp;Stephanie R. Filbay ,&nbsp;Sabine N. van der Veer ,&nbsp;David Wong ,&nbsp;William G. Dixon","doi":"10.1016/j.ocarto.2026.100753","DOIUrl":"10.1016/j.ocarto.2026.100753","url":null,"abstract":"<div><h3>Objective</h3><div>Effective physical activity interventions for knee osteoarthritis (OA) require an understanding of the relationship between physical activity and pain. Using daily concurrent activity and pain measurements, we explored day-to-day changes and the bidirectional temporal association at individual and population level.</div></div><div><h3>Design</h3><div>This is a secondary analysis of step count and pain collected for 90 days using smartwatches in 26 people with knee OA. People reported pain twice daily on a Numerical Rating Scale (NRS 0–10). We used regression (individual level) and generalized linear mixed models (population) to explore same-day associations, as well as whether step count on one day predicted pain the next day, and vice versa.</div></div><div><h3>Results</h3><div>We analysed 1473 daily pain and step count measurements, recorded over a median 58 days. There were considerable day-to-day changes in individuals’ median step count (range 423–7142) and pain (range 0–9). At individual level, associations varied in the strength and direction. At population level, a higher step count was associated with higher pain on the same day (0.04 NRS/1000 step increase, 95%CI 0.01–0.06) and following day (0.05/1000 step increase, 0.03–0.07).</div></div><div><h3>Conclusions</h3><div>There was a modest association at population level between step count assessed on one day and pain assessed on the same and following day. However, there was variation in the strength and direction of associations when examined at the individual level. This exploratory analysis shows how smartwatches allow daily data collection that enables detailed exploration of complex time-varying relationships in OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100753"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146215202","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Histological analysis of age-related degeneration in human female and male knee cartilage and meniscus","authors":"Amanda Sjögren ,&nbsp;Sara Bodahl ,&nbsp;Velocity Hughes ,&nbsp;Aleksandra Turkiewicz ,&nbsp;Anders Aspberg ,&nbsp;Iida Hellberg ,&nbsp;Ville-Pauli Karjalainen ,&nbsp;Neserin Ali ,&nbsp;Patrik Önnerfjord ,&nbsp;Martin Englund","doi":"10.1016/j.ocarto.2025.100734","DOIUrl":"10.1016/j.ocarto.2025.100734","url":null,"abstract":"<div><h3>Objectives</h3><div>To assess level of degeneration in human knee cartilage and meniscus in donors without clinically-evident knee arthritis, in relation to age and sex. Further, to investigate the association between cartilage and meniscus degeneration.</div></div><div><h3>Design</h3><div>Histological sections of knee cartilage and meniscus from 44 deceased donors (ages 18–85 years) without clinically-evident osteoarthritis or inflammatory arthritis were assessed for the level of degeneration using OARSI grades (cartilage) and modified Pauli scores (meniscus). We used Poisson regression models with robust standard errors to investigate the association of age and sex with grades/scores, and the association between cartilage and meniscus degeneration.</div></div><div><h3>Results</h3><div>Mean [median] (standard deviation) OARSI grade and Pauli score were 2.2 [1.8] (1.2) and 8.2 [8] (2.5), respectively. The mean OARSI grade increased by a factor of 1.19 (95 % confidence interval 1.11 to 1.28) per 10 years of age, and the Pauli score by 1.10 (1.07–1.14). Males had on average 1.29 (0.99–1.69) higher OARSI grades than females, and 1.11 (0.96–1.28) higher Pauli scores. The crude association between Pauli score and OARSI grade was 1.12 (1.05–1.18), while the age and sex adjusted association was 1.06 (0.99–1.13).</div></div><div><h3>Conclusions</h3><div>Tissue degeneration assessed by OARSI grades and modified Pauli scores increase with age in persons without clinically-evident knee arthritis. However, about half of the elderly donors show only mild degeneration. There was a small association between degeneration and male sex, for both tissues. Cartilage and meniscus degeneration within knees without clinically-evident arthritis were weakly associated.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100734"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840139","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The stability of pain phenotypes in people with hand osteoarthritis – results from the NOR-HAND study","authors":"Daniel H. Bordvik ,&nbsp;Elisabeth Mulrooney ,&nbsp;Pernille Steen Pettersen ,&nbsp;Marthe Gløersen ,&nbsp;Lene Maria Sundbakk ,&nbsp;Tuhina Neogi ,&nbsp;Ingvild Kjeken ,&nbsp;Ida K. Haugen","doi":"10.1016/j.ocarto.2026.100745","DOIUrl":"10.1016/j.ocarto.2026.100745","url":null,"abstract":"<div><h3>Objective</h3><div>In a hand osteoarthritis (OA) cohort, we aimed to explore pain phenotypes and characterize their stabilities using the multidimensional framework developed by The Initiative on Methods, Measurement and Pain Assessment in Clinical Trials (IMMPACT).</div></div><div><h3>Methods</h3><div>We included participants attending the visits at baseline (2016–17) and follow-up (2019–21) in the Nor-Hand study. To identify pain phenotypes (i.e., classes), we conducted latent transition analyses modelling self-reported pain severity, neuropathic-like pain, fatigue, sleep, anxiodepressive symptoms, pain catastrophizing, and quantitative sensory testing (QST). We compared a model including QST with a model without. Longitudinal stability of classes was assessed. Changes in indicator variables across participants with vs. without between-class transitioning were compared.</div></div><div><h3>Results</h3><div>We analysed 213 participants (86.9 % women) with a baseline mean age (standard deviation) of 60.9 (6.0) years. Both models identified four classes exhibiting similar results on differences in pain severity and psychosocial burden (kappa 0.91). Although phenotype stability varied (probability range: 0.48–0.95), most participants (_∼80 %) remained in the same class at both visits. Most participants transitioning between classes shifted to a less severe pain class (32/44 (72.7 %) in the QST model; 36/45 (80.0 %) in the clinical model), showing larger improvements in pain and psychosocial burden than non-transitioners.</div></div><div><h3>Conclusion</h3><div>Four distinct pain phenotypes were identified among persons with hand OA. Excluding QST from our model did not influence phenotype composition or characteristics. Various longitudinal phenotype stability was observed. Between-class transitions were often characterized by less pain and psychosocial burden, potentially due to regression to the mean or improved disease coping.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100745"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037302","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Studying the formation of the zone of calcified cartilage in bovine cartilage explants ex vivo","authors":"Jietao Xu ,&nbsp;Andrea Schwab ,&nbsp;Elias Salzer ,&nbsp;Nicole Kops ,&nbsp;Pieter A.J. Brama ,&nbsp;Eric Farrell ,&nbsp;Gerjo J.V.M. van Osch","doi":"10.1016/j.ocarto.2026.100743","DOIUrl":"10.1016/j.ocarto.2026.100743","url":null,"abstract":"<div><h3>Objective</h3><div>The zone of calcified cartilage (ZCC) connects non-calcified articular cartilage to the subchondral bone, acting as transitional layer. Regeneration of this layer is key for cartilage repair but remains a challenge. Knowledge on the formation of this layer during development is limited. This study describes the use of an <em>ex vivo</em> explant culture model to investigate the formation of the ZCC.</div></div><div><h3>Design</h3><div>Explants were harvested from immature bovine metacarpophalangeal joints and cultured in the presence of β-glycerophosphate for 3 weeks as osteochondral explants, full-thickness cartilage or divided in top and bottom cartilage layers. To investigate cell-driven vs matrix-dependent calcification, explants were devitalized. Calcification was analysed using calcium uptake, micro-computed tomography, gene expression analysis, and histological stainings.</div></div><div><h3>Results</h3><div>A distinct area of calcified cartilage formed in the explants <em>ex vivo</em><em>.</em> This layer showed similar characteristics to the ZCC in mature bovine tissue. Viable chondrocytes in bottom layers actively contributed to cartilage calcification, while calcification in top layers was only present in devitalized top layer explants. Top layers inhibited cartilage calcification in bottom layers and expressed higher levels of <em>FGF18</em>, <em>PTHLH</em> and <em>MGP</em>, while the bottom layers expressed more <em>ALPL</em>, <em>COL10A1</em> and <em>IHH</em>.</div></div><div><h3>Conclusion</h3><div>We present the first <em>ex vivo</em> model allowing to study and modulate cartilage calcification and the formation of the ZCC. We demonstrated an inherent zone-specific calcification pattern within the cartilage explants. This model allows future studies investigating mechanisms of ZCC formation in cartilage repair procedures, and the role of the top layer in pathological cartilage calcifications and potential interventions.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100743"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037401","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Feasibility of a randomized trial comparing exercise-based rehabilitation to no exercise-based rehabilitation after total knee arthroplasty: DRAW-TKA hybrid 1 RCT","authors":"Birk M. Grønfeldt ,&nbsp;Søren T. Skou ,&nbsp;Jeanette W. Kirk ,&nbsp;Anders Troelsen ,&nbsp;Thomas Bandholm","doi":"10.1016/j.ocarto.2025.100708","DOIUrl":"10.1016/j.ocarto.2025.100708","url":null,"abstract":"<div><h3>Objective</h3><div>Trials comparing the effectiveness of exercise-based rehabilitation against no exercise-based rehabilitation are needed, but their feasibility is unclear. The DRAW-TKA feasibility trial aimed to assess recruitment-, retention-, harms-, and procedural feasibility to inform a full-scale effectiveness trial.</div></div><div><h3>Design</h3><div>This pragmatic, multicentre, parallel, two-arm feasibility trial included participants scheduled for total knee arthroplasty due to osteoarthritis, aged ≥18, who could read and write Danish. Participants were recruited pre-operatively from two hospitals. At discharge, participants were encouraged to be physically active and randomised (one-to-one) to “Referral to exercise” (usual care) or “No exercise”. Recruiters, outcome assessors, and intervention-deliverers were masked to allocation. The primary feasibility criteria were based on recruitment rate, retention, participation barriers, and data completeness. Secondary criteria on harms, procedural feasibility, and intervention acceptance.</div></div><div><h3>Results</h3><div>Between Aug 22nd^, 2023, and Feb 29th^, 2024, all 445 patients planned for TKA were screened, of whom 338 (76 ​%) were ineligible, 49 of 107 eligible (45·8 ​%) declined participation (wanted exercise), and 25 of 107 (23·4 ​%) were randomly assigned exercise (n ​= ​12) or no exercise (n ​= ​13). Because of intervention-specific withdrawals (n ​= ​3) and attrition, 18 of 25 completed all three-month assessments. Three of four predefined, primary feasibility criteria were met. Clinicians and participants found the trial procedurally feasible and acceptable. No interventional harms occurred.</div></div><div><h3>Conclusion</h3><div>The trial's scientific rationale – allocation to exercise, or no exercise – introduced significant risk of selection and attrition bias in this clinical context, severely limiting the generalisability. Although recruitment was predominantly feasible, further adaptations are required to warrant full-scale initiation.</div><div>NCT05935020.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100708"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694223","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Reducing the burden of osteoarthritis in Australia: A 2024–2025 research priority-setting study","authors":"Kim L. Bennell ,&nbsp;Jesse J. Pardo ,&nbsp;Rana S. Hinman ,&nbsp;Christopher B. Little ,&nbsp;Carina L. Blaker ,&nbsp;Jocelyn L. Bowden ,&nbsp;Belinda J. Lawford ,&nbsp;Ben Metcalf ,&nbsp;Neil Bidgood ,&nbsp;Carolyn Yii ,&nbsp;Sarah Stratulate ,&nbsp;David J. Hunter","doi":"10.1016/j.ocarto.2025.100706","DOIUrl":"10.1016/j.ocarto.2025.100706","url":null,"abstract":"<div><h3>Objective</h3><div>To identify research priorities for osteoarthritis (OA) in Australia to reduce the individual and societal burden of OA.</div></div><div><h3>Design</h3><div>We used accepted priority setting methodology involving multiple stages: 1) gathering unanswered research priorities from selected literature; 2) assembling an expert panel and using an online survey to obtain additional priorities from panelists; 3) consolidating research priorities (eg. removing duplicates); 4) panel rating of priorities for importance on an 11-point numeric rating scale (0 ​= ​‘not at all important; 10 ​= ​‘extremely important’) via another online survey; 5) analyzing and compiling the final list of priorities; and 6) addressing implementation via a one-day National Summit.</div></div><div><h3>Results</h3><div>38 research priorities were identified from the literature. 288 nation-wide panel experts (204 consumers/carers/consumer organisations; 47 clinicians from 9 disciplines; 32 researchers; and 5 industry/research funders) provided an additional 99 priorities. Following consolidation, 90 priorities remained and were organised under 8 themes. 204 of the original panelists (71 ​%) rated the priorities. All priorities scored a mean importance rating ≥6 and so were retained, giving a final list of 90. Mean (SD) importance scores for the top 20 priorities ranged from 8.2 (1.9) to 8.9 (1.9). Overall, the top 3 priorities related to developing drugs/strategies to prevent disease progression and regeneration of damaged cartilage. There was variation across consumers, clinicians and researchers, with only 2 of the same priorities ranked in each of their top 20.</div></div><div><h3>Conclusions</h3><div>We determined key research priorities for OA. These can help guide research directions and funding to enhance outcomes for people with OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100706"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624880","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Osteoarthritis physical activity care pathway: Results of an exploratory trial","authors":"Kelli D. Allen ,&nbsp;Katie F. Huffman ,&nbsp;Leigh F. Callahan ,&nbsp;Natalie Fullenkamp ,&nbsp;Yvonne M. Golightly ,&nbsp;Derek P. Hales ,&nbsp;Amanda E. Nelson ,&nbsp;Stephanie Ntim ,&nbsp;Ami Pathak ,&nbsp;Jennifer Rees ,&nbsp;Riya Vasa ,&nbsp;Maihan B. Vu ,&nbsp;Rebecca J. Cleveland","doi":"10.1016/j.ocarto.2025.100724","DOIUrl":"10.1016/j.ocarto.2025.100724","url":null,"abstract":"<div><h3>Objective</h3><div>To conduct an exploratory randomized controlled trial of a physical activity intervention for individuals with osteoarthritis (OA) involving telephone-delivered coaching, activity self-monitoring, and connection with resources to support activity (Osteoarthritis Physical Activity Care Pathway; OA-PCP).</div></div><div><h3>Methods</h3><div>Older adults (age ≥65 years) with symptomatic hip or knee OA and comorbid health conditions (N ​= ​240) were randomized to OA-PCP or an attention control (AC) condition. OA-PCP included coaching calls at baseline and at 3-month intervals through 12 months, as well as email-delivered content. The ACgroup received calls and emails focused on OA education. The primary outcome was minutes of moderate to vigorous physical activity (MVPA) per week, measured at baseline, 6-months and 12-months via accelerometer. Secondary outcomes included other physical activity metrics and the Western Ontario and McMaster Universities Osteoarthritis Index pain and function subscales. Linear mixed regression was used to estimate between-group differences from baseline to follow-up time points.</div></div><div><h3>Results</h3><div>At 6-month and 12-month follow-up, the changes in weekly MVPA favored the OA-PCP by 9.5 ​min (95 ​% Confidence Interval −6.7, 25.8; p ​= ​0.252) and 12.3 ​min (95 ​% Confidence Interval −3.8, 28.4; p ​= ​0.136), respectively, but differences were not statistically or clinically significant. There were no significant between-group differences in secondary outcomes other than steps per day at 12-months</div></div><div><h3>Conclusions</h3><div>A more intensive intervention approach may be needed to enhance physical activity among older adults with OA and comorbid health conditions.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100724"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145747788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frequency and mutual associations of knee osteoarthritis features on ultrasound imaging in recent-onset symptomatic knee osteoarthritis patients: A cross-sectional analysis in a convenience sample of Dutch patients","authors":"Lianne Straetemans ,&nbsp;Joost Verbruggen ,&nbsp;Luc J.M. Heijnens ,&nbsp;Jochen W.L. Cals ,&nbsp;Chris L. de Korte ,&nbsp;Thomas L.A. van den Heuvel ,&nbsp;Ramon P.G. Ottenheijm","doi":"10.1016/j.ocarto.2025.100736","DOIUrl":"10.1016/j.ocarto.2025.100736","url":null,"abstract":"<div><h3>Objectives</h3><div>To understand the diagnostic utility of ultrasound (US) for early diagnosis of knee osteoarthritis (KOA), this study aims to assess the frequency of KOA-associated US-detectable synovitis, osteophytes, and meniscal extrusion and their mutual association in patients diagnosed with recent-onset symptomatic KOA.</div></div><div><h3>Methods</h3><div>The study included 476 patients (median age: 61) diagnosed with unilateral KOA in a recent-onset symptomatic (&lt;2 years of pain) stage. All patients underwent an US exam assessing the presence of synovitis, osteophytes (lateral, medial, trochlear) and meniscus extrusion (medial, lateral), dichotomized as present or absent. A multivariate logistic regression analysis was performed to assess their mutual association.</div></div><div><h3>Results</h3><div>The frequency of synovitis, osteophytes, and meniscal extrusion on US was 82.8 %, 87.0 %, and 44.7 %, respectively. At least one feature was detected in 97.7 % of the knees. All three features together were found in 32.6 % of the knees. In 73.1 % of the knees both synovitis and osteophytes were observed (odds ratio [OR] = 1.81, 95 % CI 0.95–3.45) and 37.8 % of the knees displayed meniscal extrusion along with synovitis (OR = 1.19, 95 % CI 0.73–1.94). Medial osteophytes alongside medial meniscal extrusion was identified in 30.5 % of the knees (OR = 1.26, 95 % CI 0.76–2.08), while lateral osteophytes alongside lateral extrusion was observed in 8.4 % of the knees (OR = 6.50, 95 % CI 3.31–12.77).</div></div><div><h3>Conclusions</h3><div>Nearly all recent-onset symptomatic osteoarthritic knees exhibit at least one US-detectable KOA-associated feature. This underlines that even in KOA patients with short duration of pain, significant changes are already evident on US, offering potential support for earlier intervention and more targeted management strategies.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100736"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145883726","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}