Osteoarthritis and cartilage open最新文献

{"title":"Increased nerve growth factor expression and osteoclast density are associated with subchondral bone marrow lesions in osteoarthritic knees","authors":"Koji Aso,&nbsp;Natsuki Sugimura,&nbsp;Hiroyuki Wada,&nbsp;Syo Deguchi,&nbsp;Masahiko Ikeuchi","doi":"10.1016/j.ocarto.2024.100504","DOIUrl":"10.1016/j.ocarto.2024.100504","url":null,"abstract":"<div><h3>Objectives</h3><p>Subchondral bone marrow lesions (BMLs) detected on magnetic resonance imaging in knee osteoarthritis (OA) are associated with knee pain, though the mechanisms remain unknown. Increased nerve growth factor (NGF) expression and osteoclast density in subchondral bone appear to be the key features associated with bone pain in knee OA. Therefore, we aimed to identify associations among NGF, osteoclasts, and BMLs in knee OA.</p></div><div><h3>Methods</h3><p>Twenty tibial plateaus were obtained from patients undergoing total knee arthroplasty for medial knee OA with BMLs at the medial tibial plateau (MTP). Osteochondral tissue samples from the weight-bearing part of the MTP, with and without BML, and from the weight-bearing part of the lateral tibial plateau (LTP), without BML, were collected. NGF expression and density of osteoclasts were compared among the three osteochondral tissue types.</p></div><div><h3>Results</h3><p>MTP bone with BMLs exhibited significantly higher NGF expression in bone marrow space and osteochondral channel, and higher osteoclast density than MTP bone without BML and LTP bone. The mean differences in NGF-positive area in the bone marrow space and the percentage of NGF-positive channels between MTP bones with and without BML were 9.0% (95% confidence interval [CI]: 5.9–12.1%) and 23.1% (95% CI: 11.3–35.0%), respectively. The difference in osteoclast density between MTP bones with and without BML was 0.6 osteoclasts per mm (95% CI: 0.3–0.9 osteoclasts per mm).</p></div><div><h3>Conclusions</h3><p>Increased NGF expression and osteoclast density are associated with subchondral BMLs in knee OA, contribute to understanding the mechanisms underlying BML-related bone pain in knee OA.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100504"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000712/pdfft?md5=2e6c3a040f160d43e3794e939150efe6&pid=1-s2.0-S2665913124000712-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852764","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The design of a sample rapid magnetic resonance imaging (MRI) acquisition protocol supporting assessment of multiple articular tissues and pathologies in knee osteoarthritis","authors":"Felix Eckstein ,&nbsp;Thula Cannon Walter-Rittel ,&nbsp;Akshay S. Chaudhari ,&nbsp;Nicholas M. Brisson ,&nbsp;Tazio Maleitzke ,&nbsp;Georg N. Duda ,&nbsp;Anna Wisser ,&nbsp;Wolfgang Wirth ,&nbsp;Tobias Winkler","doi":"10.1016/j.ocarto.2024.100505","DOIUrl":"10.1016/j.ocarto.2024.100505","url":null,"abstract":"<div><h3>Objective</h3><p>This expert opinion paper proposes a design for a state-of-the-art magnetic resonance image (MRI) acquisition protocol for knee osteoarthritis clinical trials in early and advanced disease. Semi-quantitative and quantitative imaging endpoints are supported, partly amendable to automated analysis. Several (peri-) articular tissues and pathologies are covered, including synovitis.</p></div><div><h3>Method</h3><p>A PubMed literature search was conducted, with focus on the past 5 years. Further, osteoarthritis imaging experts provided input. Specific MRI sequences, orientations, spatial resolutions and parameter settings were identified to align with study goals. We strived for implementation on standard clinical scanner hardware, with a net acquisition time ≤30 ​min.</p></div><div><h3>Results</h3><p>Short- and long-term longitudinal MRIs should be obtained at ≥1.5T, if possible without hardware changes during the study. We suggest a series of gradient- and spin-echo-sequences, supporting MOAKS, quantitative analysis of cartilage morphology and T2, and non-contrast-enhanced depiction of synovitis. These sequences should be properly aligned and positioned using localizer images. One of the sequences may be repeated in each participant (re-test), optimally at baseline and follow-up, to estimate within-study precision. All images should be checked for quality and protocol-adherence as soon as possible after acquisition. Alternative approaches are suggested that expand on the structural endpoints presented.</p></div><div><h3>Conclusions</h3><p>We aim to bridge the gap between technical MRI acquisition guides and the wealth of imaging literature, proposing a balance between image acquisition efficiency (time), safety, and technical/methodological diversity. This approach may entertain scientific innovation on tissue structure and composition assessment in clinical trials on disease modification of knee osteoarthritis.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100505"},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000724/pdfft?md5=96e0dd47c01c18757ea8fcdf812e70cb&pid=1-s2.0-S2665913124000724-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141844671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diagnostic models to predict structural spinal osteoarthritis on lumbar radiographs in older adults with back pain: Development and internal validation","authors":"Mirna Chamoro ,&nbsp;Martijn W. Heymans ,&nbsp;Edwin H.G. Oei ,&nbsp;Sita M.A. Bierma-Zeinstra ,&nbsp;Bart W. Koes ,&nbsp;Alessandro Chiarotto","doi":"10.1016/j.ocarto.2024.100506","DOIUrl":"10.1016/j.ocarto.2024.100506","url":null,"abstract":"<div><h3>Objective</h3><p>It is difficult for health care providers to diagnose structural spinal osteoarthritis (OA), because current guidelines recommend against imaging in patients with back pain. Therefore, the aim of this study was to develop and internally validate multivariable diagnostic prediction models based on a set of clinical and demographic features to be used for the diagnosis of structural spinal OA on lumbar radiographs in older patients with back pain.</p></div><div><h3>Design</h3><p>Three diagnostic prediction models, for structural spinal OA on lumbar radiographs (i.e. multilevel osteophytes, multilevel disc space narrowing (DSN), and both combined), were developed and internally validated in the ‘Back Complaints in Older Adults’ (BACE) cohort (N ​= ​669). Model performance (i.e. overall performance, discrimination and calibration) and clinical utility (i.e. decision curve analysis) were assessed. Internal validation was performed by bootstrapping.</p></div><div><h3>Results</h3><p>Mean age of the cohort was 66.9 years (±7.6 years) and 59% were female. All three models included age, gender, back pain duration and duration of spinal morning stiffness as predictors. The combined model additionally included restricted lateral flexion and spinal morning stiffness severity, and exhibited the best model performance (optimism adjusted c-statistic 0.661; good calibration with intercept −0.030 and slope of 0.886) and acceptable clinical utility. The other models showed suboptimal discrimination, good calibration and acceptable decision curves.</p></div><div><h3>Conclusion</h3><p>All three models for structural spinal OA displayed lesuboptimal discrimination and need improvement. However, these internally validated models have potential to inform primary care clinicians about a patient with risk of having structural spinal OA on lumbar radiographs. External validation before implementation in clinical care is recommended.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100506"},"PeriodicalIF":0.0,"publicationDate":"2024-07-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000736/pdfft?md5=3a73cba299343e579f07295b2868c5d2&pid=1-s2.0-S2665913124000736-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141852722","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A significant difference of synovial mast cells in synovium from rotator cuff arthropathy compared to rotator cuff tears: A histological pilot study","authors":"Luca Farinelli ,&nbsp;Francesco D'Angelo ,&nbsp;Carlo Ciccullo ,&nbsp;Sandra Manzotti ,&nbsp;Antonio Gigante","doi":"10.1016/j.ocarto.2024.100503","DOIUrl":"10.1016/j.ocarto.2024.100503","url":null,"abstract":"<div><h3>Objective</h3><p>Aim of the present study was to compare the presence of Mast Cells (MCs) in synovial samples from gleno-humeral osteoarthritis (OA) and from control group.</p></div><div><h3>Methods</h3><p>Synovial tissue samples were obtained during arthroplasty from 23 patients with gleno-humeral OA due to rotator cuff arthropathy (RCA) and from 20 patients without OA, constituting OA group and control group respectively. Before surgery self-reported pain was assessed using VAS score and OSS was used to value functional ability. Shoulder radiograph (Antero-posterior, Y-view and Grashey views) was evaluated by musculoskeletal radiologist and graded according to modified Samilson-Prieto classification.</p><p>Synovial tissue, obtained during arthroplasty and arthroscopic procedure, was prepared to immunohistochemical analysis with anti-CD31 and anti-CD117 antibodies, to detect respectively endothelial cells and MCs at 40x magnification. Synovitis scores have been assessed. Under the control of the image processing system the distribution and the total number of vessels and MCs were determined.</p></div><div><h3>Results</h3><p>The numbers of MCs and the area fraction (20x magnification) occupied by them were significantly higher in OA samples than in control tissue. The synovitis score was higher in OA patients with a positive correlation. Vessels number and area fraction were higher in OA patients than in controls. Analysis of MC number in relation to clinical data indicated positive correlation with the VAS score.</p></div><div><h3>Conclusions</h3><p>The distribution of MCs on synovium significantly differ between OA and control groups. Despite the design of the study could not conclude the cause-effect relationship, the presence of MCs might have role in OA pathogenesis.</p></div><div><h3>Level of evidence</h3><p>Histological study.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100503"},"PeriodicalIF":0.0,"publicationDate":"2024-07-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000700/pdfft?md5=e91f4330c9681838f4ec018ee8366ddf&pid=1-s2.0-S2665913124000700-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141851197","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Morphological and histological features of thicker cartilage at the posterior medial femoral condyle in advanced knee osteoarthritis","authors":"Jeroen Geurts ,&nbsp;François Andrey ,&nbsp;Julien Favre ,&nbsp;Thomas Hügle ,&nbsp;Patrick Omoumi","doi":"10.1016/j.ocarto.2024.100502","DOIUrl":"10.1016/j.ocarto.2024.100502","url":null,"abstract":"<div><h3>Objective</h3><p>To assess morphological and histological features of cartilage at the posterior medial condyle in advanced pre-prosthetic osteoarthritis (OA), which is notably thicker compared to non-OA knees.</p></div><div><h3>Design</h3><p>Cartilage thickness was measured pre-operatively using MRI in 10 subjects with medial femorotibial OA (mean age: 70.2 years). Posterior condyles were obtained during arthroplasty and cartilage thickness, relative collagen content and subchondral bone volume fraction (BV/TV) were determined using phosphotungstic acid (PTA)-enhanced micro-CT. Regions of interest (ROI) around the maximum cartilage thickness were further analyzed through histomorphometry (Mankin score) and immunohistochemistry (cell density and apoptosis rates).</p></div><div><h3>Results</h3><p>Maximum cartilage thickness was 2.63 ​± ​0.51 ​mm <em>in vivo</em> and 3.04 ​± ​0.55 ​mm <em>ex vivo</em> and both measurements were strongly correlated (<em>r</em> ​= ​0.84, <em>p</em> ​= ​0.003). Cartilaginous collagen content measured by PTA-enhanced micro-CT was negatively correlated with maximum cartilage thickness (<em>r</em> ​= ​–0.70, <em>p</em> ​= ​0.02). Average subchondral BV/TV was 31.6 ​± ​3.4% and did not correlate with cartilage thickness. Extensive loss of proteoglycan staining and tidemark multiplication were common histomorphological features around the maximum cartilage thickness. Chondrocyte densities were 315 ​± ​67 and 194 ​± ​36 ​cells/mm² at the superficial and transitional cartilage zones, respectively. Chondrocyte apoptosis rates were approximately 70% in both zones. Maximum cartilage thickness correlated with superficial chondrocyte densities (<em>r</em> ​= ​0.79, <em>p</em> ​= ​0.01).</p></div><div><h3>Conclusions</h3><p>Thicker cartilage at the posterior medial condyle in OA knees displayed degenerative changes both in cartilage tissue and at the osteochondral junction. Cartilage thickening may be influenced by alterations in the superficial zone, necessitating further investigation through molecular studies.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100502"},"PeriodicalIF":0.0,"publicationDate":"2024-07-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000694/pdfft?md5=f58c089cfcbb3f5e63fbcb88926b76f9&pid=1-s2.0-S2665913124000694-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141638262","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Mitochondria-DNA copy-number in osteoporosis and osteoarthritis among middle-aged women - A population-based cohort study","authors":"Christian Anker-Hansen,&nbsp;MirNabi Pirouzifard,&nbsp;Ashfaque Memon,&nbsp;Jan Sundquist,&nbsp;Kristina Sundquist,&nbsp;Bengt Zöller","doi":"10.1016/j.ocarto.2024.100501","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100501","url":null,"abstract":"<div><h3>Background</h3><p>Mitochondrial DNA copy number (mtDNA-CN) is associated with aging. A relationship between mtDNA-CN and degenerative disorders, e.g. osteoarthritis (OA) and osteoporosis (OP), has been suggested. We aimed to investigate the relationship of mtDNA-CN and incident OA and OP.</p></div><div><h3>Materials and methods</h3><p>MtDNA-CN was studied in relationship to incident OA and OP in a population-based cohort study of 6916 middle-aged women (52–63 years). Totally 2521 women with sufficient quality of mtDNA were analyzed. After exclusions, 1978 women remained in the study population. Four different endpoints obtained from the National Patient register were studied: 1) OA, 2) OP 3) OA surgery, and 4) OP fracture. In the multivariate model adjustments were made for potential OA and OP risk factors.</p></div><div><h3>Results</h3><p>Women with low mtDNA-CN were older and had more activity at work. 125 women (6.32%) were affected by incident OP and 254 women (12.84%) had an OP fracture. Incident OA affected 451 women (22.80%) and 175 women (8.85%) had OA surgery. There were no associations between mtDNA-CN and incident risk of OA (Hazard ratio ​= ​1.00, 95% confidence interval 0.83–1.20), OA surgery (0.79, 0.58–1.07), OP (0.89, 0.62–1.27), or OP fracture (1.00, 0.78–1.29). However, incident OP was significantly associated with T-score (bone density), smoking, diabetes mellitus, and chronic obstructive bronchitis (COPD). OA was associated with body mass index and COPD.</p></div><div><h3>Conclusions</h3><p>The present study suggests that mtDNA-CN, reflecting mitochondrial dysfunction, is not a major predictor for incident OA or OP. However, due to the limited study size minor associations cannot be excluded.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100501"},"PeriodicalIF":0.0,"publicationDate":"2024-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000682/pdfft?md5=f794415499d3041cd5dec4edac47310e&pid=1-s2.0-S2665913124000682-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596338","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation in the treatment of knee osteoarthritis: A Phase I/IIa randomised controlled trial","authors":"Julien Freitag ,&nbsp;Matthew Chamberlain ,&nbsp;James Wickham ,&nbsp;Kiran Shah ,&nbsp;Flavia Cicuttini ,&nbsp;Yuanyuan Wang ,&nbsp;Ann Solterbeck","doi":"10.1016/j.ocarto.2024.100500","DOIUrl":"10.1016/j.ocarto.2024.100500","url":null,"abstract":"<div><h3>Objectives</h3><p>To assess the safety and efficacy of an allogeneic adipose-derived mesenchymal stem cell preparation (MAG200) in the treatment of knee osteoarthritis over 12 months.</p></div><div><h3>Design</h3><p>A single-centre, double-blind, ascending dose, randomised controlled trial. 40 participants with moderate knee osteoarthritis were randomised to receive a single intra-articular injection of MAG200 (dose cohorts:10, 20, 50, 100 ​× ​10⁶ ​cells) or placebo. Primary objectives were safety and efficacy according to a compound responder analysis of minimal clinically important difference in pain (numerical pain rating scale [NPRS]) and function (Knee Injury and Osteoarthritis Outcome Score - Function in Daily Living subscale [KOOS_ADL]) at month 12. Secondary efficacy outcomes included changes from baseline in patient reported outcome measures and evaluation of disease-modification using quantitative MRI.</p></div><div><h3>Results</h3><p>Treatment was well tolerated with no treatment-related serious adverse events. MAG200 cohorts reported a greater proportion of responders than placebo and demonstrated clinical and statistically significant improvement in pain and clinically relevant improvement in all KOOS subscales. MAG200 demonstrated a reproducible treatment effect over placebo, which was clinically relevant for pain in the 10 ​× ​10⁶ dose cohort (mean difference NPRS:-2.25[95%CI:-4.47,-0.03, p ​= ​0.0468]) and for function in the 20 ​× ​10⁶ and 100 ​× ​10⁶ dose cohorts (mean difference KOOS_ADL:10.12[95%CI:-1.51,21.76, p ​= ​0.0863] and 10.81[95%CI:-1.42,23.04, p ​= ​0.0810] respectively). A trend in disease-modification was observed with improvement in total knee cartilage volume in MAG200 10, 20, and 100 ​× ​10⁶ dose cohorts, with progression of osteoarthritis in placebo, though this was not statistically significant. No clear dose response was observed.</p></div><div><h3>Conclusion</h3><p>This early-phase study provides supportive safety and efficacy evidence to progress MAG200 to later-stage trial development.</p></div><div><h3>Trial registration</h3><p>ACTRN12617001095358/ACTRN12621000622808.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100500"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000670/pdfft?md5=1c90eff7a605bb0d4e7ab9178e7671fa&pid=1-s2.0-S2665913124000670-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141694874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Chondroprotection of articular cartilage integrity: Utilizing ultrasonic scalpel and hyperosmolar irrigation solution during cutting","authors":"Nisreen Mohammed Al-Namnam ,&nbsp;Aneta T. Luczak ,&nbsp;Irene Yang ,&nbsp;Xuan Li ,&nbsp;Margaret Lucas ,&nbsp;Andrew C. Hall ,&nbsp;A. Hamish R.W. Simpson","doi":"10.1016/j.ocarto.2024.100499","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100499","url":null,"abstract":"<div><h3>Objectives</h3><p>Ultrasonic (US) cutting of cartilage in orthopaedic surgery has received little attention despite its potential to reduce chondrocyte death which could enhance cartilage repair. We aimed to investigate whether an ultrasonically-vibrating scalpel to cut human articular cartilage could reduce chondrocyte death, and to determine if hyper-osmolarity could provide chondroprotection during the procedure.</p></div><div><h3>Methods</h3><p>A scalpel (no. 15) was mounted on an ultrasonic transducer to resonate at 35 ​kHz with 30 ​μm vibrational displacement. Thirty-six fresh human femoral cartilage samples were divided into four groups based on ultrasonic activation (US or non-US) and saline osmolarity (300 or 600 mOsm/L). Cell viability was assessed using a live/dead cell assay and analysed quantitatively by confocal microscopy. Histology illustrated tissue surface changes at the cut site.</p></div><div><h3>Results</h3><p>The overall chondrocyte death percentage at both the US and non-US cut sites showed comparable results (p ​&gt; ​0.05) in both osmolarities. However, the zone of chondrocyte death was reduced by 31 ​± ​5% and 36 ​± ​6%, respectively, when comparing US cutting at 300 mOsm/L and 600 mOsm/L to the control group (non-US cutting; 300 mOsm/L) (p ​&lt; ​0.05). The width of the cut was consistent at both sites, regardless of the method of cutting.</p></div><div><h3>Conclusion</h3><p>Cutting human cartilage with US in the presence of 300 or 600 mOsm/L media was chondroprotective compared to normal (non-US) scalpel cutting in 300 mOsm/L medium. These results suggest chondroprotection can be achieved while cutting using a US scalpel and raised osmolarity, potentially improving cartilage regeneration and repair following injury.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100499"},"PeriodicalIF":0.0,"publicationDate":"2024-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000669/pdfft?md5=0947d8db129706496de7e10dd742b32a&pid=1-s2.0-S2665913124000669-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141596336","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Understanding the impact of physical activity level and sports participation on implant integrity and failure in patients following unicompartmental and total knee arthroplasty: A scoping review","authors":"Anthony Teoli ,&nbsp;Patrick Ippersiel ,&nbsp;André Bussières ,&nbsp;John Antoniou ,&nbsp;Shawn M. Robbins","doi":"10.1016/j.ocarto.2024.100498","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100498","url":null,"abstract":"<div><h3>Objective</h3><p>Recommendations discouraging high levels of physical activity and sports following unicompartmental (UKA) and total knee arthroplasty (TKA) have been questioned in recent years. This scoping review aimed to summarize the literature examining the impact of physical activity level and sports participation on implant integrity and failure in patients following UKA and TKA.</p></div><div><h3>Methods</h3><p>Five databases (Medline, Embase, SCOPUS, CINAHL, ProQuest) were searched up to April 17, 2024. Retrospective, prospective and cross-sectional studies were included if they assessed the impact of physical activity level and/or sports participation (exposure variables) on implant integrity and/or failure (outcome variables) at ≥1 year following UKA or TKA. Two authors independently conducted abstract/full text reviews and data charting. Extracted data were summarized using descriptive analysis.</p></div><div><h3>Results</h3><p>Of 2014 potential records, 20 studies (UKA: n ​= ​6 studies, 2387 patients/TKA: n ​= ​14 studies, 7114 patients) met inclusion criteria. Following both UKA &amp; TKA, most patients regularly participated in light to moderate physical activities and lower impact sports (e.g. walking, cycling, golf). No studies reported a deleterious effect of physical activity level or sports participation on implant integrity or failure post UKA (mean follow-up: 3.3–10.3 years). Three studies reported an association between greater levels of physical activity with increased risk of implant failure post TKA (mean follow-up: 1–11.4 years).</p></div><div><h3>Conclusions</h3><p>No studies demonstrated an association between greater levels of physical activity and sports participation with increased implant wear or failure post UKA, whereas results were mixed following TKA. There is a need for large, prospective cohort studies with long-term follow-up.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100498"},"PeriodicalIF":0.0,"publicationDate":"2024-06-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000657/pdfft?md5=990f8fffbcc6668a60db764c2fd737bc&pid=1-s2.0-S2665913124000657-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141540997","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Non-pharmacological and non-surgical interventions to manage patients with knee osteoarthritis: An umbrella review 5-year update","authors":"Ricardo Maia Ferreira ,&nbsp;Pedro Nunes Martins ,&nbsp;Rui Soles Gonçalves","doi":"10.1016/j.ocarto.2024.100497","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100497","url":null,"abstract":"<div><h3>Objective</h3><p>This umbrella review aimed to summarize (and update) the effectiveness of non-pharmacological and non-surgical interventions for patients with knee osteoarthritis.</p></div><div><h3>Methods</h3><p>The study followed the PRISMA guidelines. Manual and electronic databases were searched, to identify systematic reviews, following the P (knee osteoarthritis) I (non-pharmacological and non-surgical treatments) C (pharmacological, surgical, placebo, no intervention, or other non-pharmacological/non-surgical conservative treatments) O (pain, function, quality of life, and other knee-specific measures) model. The quality of evidence was assessed using the R-AMSTAR checklist and GRADE principles.</p></div><div><h3>Results</h3><p>The search yielded 4086 records, of which 61 met the eligibility criteria. After evaluation with R-AMSTAR, four systematic reviews were excluded, resulting in 57 included systematic reviews, with an overall score of 29.6. The systematic reviews were published between 2018 and 2022 (29.8% in 2022), conducted in 19 countries (52.6% in China), and explored 24 distinct interventions. The systematic reviews encompassed 714 trials (mean of 13 ​± ​7.7 studies per systematic review), and 59,343 participants (mean 1041 ​± ​1002 per systematic review, and 82 ​± ​59.2 per study). The majority of participants were older obese women (61.6 ​± ​4.2 years, 30.2 ​± ​3.6 ​kg/m², 70%, respectively).</p></div><div><h3>Conclusions</h3><p>Based on the systematic reviews findings, Diet Therapy, Patient Education, and Resistance Training are strongly supported as core interventions for managing patients with knee osteoarthritis. Aquatic Therapy, Balance Training, Balneology, Dietary Supplements, Extracorporeal Shockwave Therapy, and Tai Ji show moderate support. For other interventions, the evidence quality was low, results were mixed or inconclusive, or there was not sufficient efficacy to support their use.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100497"},"PeriodicalIF":0.0,"publicationDate":"2024-06-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000645/pdfft?md5=58955d3f554e15d9b565dd844021a133&pid=1-s2.0-S2665913124000645-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486259","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}