Osteoarthritis and cartilage open最新文献

{"title":"Friction of osteoarthritic cartilage with patient-specific synovial fluid: Effect of different loading conditions","authors":"Luisa de Roy ,&nbsp;Jonas Walter Metzger ,&nbsp;Martin Faschingbauer ,&nbsp;Anita Ignatius ,&nbsp;Andreas Martin Seitz","doi":"10.1016/j.ocarto.2025.100568","DOIUrl":"10.1016/j.ocarto.2025.100568","url":null,"abstract":"<div><h3>Objective</h3><div>The objective of this study was to quantify the friction coefficients of degenerated human cartilage lubricated with patient-specific synovial fluid under four different loading regimes in order to identify those regimes that cause the highest friction.</div></div><div><h3>Method</h3><div>Lateral tibial plateaus and synovial fluid samples were obtained from six patients undergoing total knee replacement surgery. Friction tests were performed on cylindrical samples using an established cartilage against glass tribometer. Four different loading regimes were applied, representing physiologic loads and velocities observed during daily activities. To account for effects of osteoarthritis (OA)-related alterations in the synovial fluid (SF) on friction, patient-specific SF was used as lubricant. Friction coefficients were derived from the first (μ₀) and final 60 ​s (μ_end) of testing.</div></div><div><h3>Results</h3><div>Under stance phase conditions, friction was lowest at the beginning of testing (μ₀ ​= ​0.021), but increased the most (+276 %, μ_end ​= ​0.079) compared to low (+47 %) and moderate loading regimes (+31 %). Under swing phase conditions low friction was maintained over time (+0 %, μ₀ ​= ​0.041, μ_end ​= ​0.041).</div></div><div><h3>Conclusion</h3><div>The friction properties of degenerated cartilage samples indicated a strong dependency on the loading regime, whereby prolonged stance phase loading led to the highest time-dependent increase in friction. Moreover, our data suggested that osteoarthritic synovial fluid was sufficient to provide low cartilage friction.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100568"},"PeriodicalIF":0.0,"publicationDate":"2025-01-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168391","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Associations between work characteristics and osteoarthritis: A cross-sectional study of 285,947 UK Biobank participants","authors":"A. Hashmi ,&nbsp;S. Scott ,&nbsp;M. Jung ,&nbsp;Q.-J. Meng ,&nbsp;J.H. Tobias ,&nbsp;R.A. Beynon ,&nbsp;B.G. Faber","doi":"10.1016/j.ocarto.2025.100565","DOIUrl":"10.1016/j.ocarto.2025.100565","url":null,"abstract":"<div><h3>Objectives</h3><div>Shift work-induced circadian rhythm disruption has been identified as a risk factor for specific diseases. Additionally, physically demanding work has been linked to osteoarthritis. This study investigated the independent associations of shift work and physical work with risk of osteoarthritis.</div></div><div><h3>Design</h3><div>UK Biobank participants completed questionnaires detailing their employment status, including shift work, night shifts, heavy manual work and prolonged non-sedentary work. Responses were categorised into binary and categorical variables. Knee and hip osteoarthritis diagnoses were extracted from hospital records and osteoarthritis (any site) was self-reported. Logistic regression models, adjusted for age, sex, BMI, Townsend Deprivation Index and other work factors, were used to investigate the relationships between work characteristics and osteoarthritis outcomes.</div></div><div><h3>Results</h3><div>This study included 285,947 participants (mean age 52.7 years; males 48.0 ​%). Shift work and night shifts were associated with knee osteoarthritis (fully adjusted OR: 1.12 [95 ​% CI:1.07–1.17] and 1.12 [1.04–1.20], respectively), and self-reported osteoarthritis but there was little evidence of an association with hip osteoarthritis (1.01 [0.95–1.08] and 1.03 [0.93–1.14]). Heavy manual work and prolonged non-sedentary work were associated with increased risk of all osteoarthritis outcomes.</div></div><div><h3>Conclusions</h3><div>Shift work showed independent associations with knee osteoarthritis and self-reported osteoarthritis but not hip osteoarthritis, suggesting circadian rhythm dysfunction may play a role in knee osteoarthritis pathogenesis. Heavy manual work and prolonged non-sedentary work were associated with all outcomes, with stronger associations in knee osteoarthritis, possibly reflecting the knee’s higher susceptibility to biomechanical stress. Further research is needed to explore workplace interventions for reducing these risks.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100565"},"PeriodicalIF":0.0,"publicationDate":"2025-01-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143168392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of radiographic structure deformity phenotypes of knee OA to clinical symptoms and risk for progression: Proposing a modification of Kellgren-Lawrence grade - Data from the Osteoarthritis Initiative and the MOST study","authors":"Sunho Ko ,&nbsp;Yunhee Choi ,&nbsp;Hyuk-Soo Han ,&nbsp;Seong Hwan Kim ,&nbsp;Du Hyun Ro","doi":"10.1016/j.ocarto.2025.100566","DOIUrl":"10.1016/j.ocarto.2025.100566","url":null,"abstract":"<div><h3>Objective</h3><div>This study aims to define Kellgren-Lawrence grade (KLG) using OARSI grade and stratify radiographic knee osteoarthritis (KOA) into distinct phenotypes based on radiographic structure changes and compare clinical symptoms and disease progression.</div></div><div><h3>Design</h3><div>We used radiographic grading data provided by the OAI and MOST study. Decision tree was used to (1) Find OARSI grade criteria for each KLG and (2) Phenotype early osteoarthritic knees (=KLG1, 2) by the radiographic structure changes. Pain, function, and progression to KLG ≥3 were compared between phenotypes.</div></div><div><h3>Results</h3><div>10,804 knees from 5802 patients were included. The mean follow-up duration was 55.6 ​± ​24.5 months. Criteria for KLG1 was: (1) Joint space narrowing (JSN) grade (more severe grade among medial and lateral compartments) ​= ​1 without osteophytes (i.e., KLG1Jt) (2) A single grade 1 osteophyte without JSN (i.e., KLG1Ost). Criteria for KLG2 was (1) JSN ​= ​1 with a sum of osteophyte grades ≥1 (i.e., KLG2Jt): (2) Sum of osteophyte grades ≥2 without JSN (i.e., KLG2Ost). In terms of pain and function, there was no difference between KLG1Ost and KLG1Jt or between KLG2Ost and KLG2Jt. For progression to KLG ≥3, the mean survival time of KLG1Ost was 1.87-fold (95 ​% CI: 1.31–2.67) longer than that of KLG1Jt, while KLG2Ost was 5.42-fold (95 ​% CI: 3.69–7.96) longer than KLG2Jt.</div></div><div><h3>Conclusions</h3><div>We proposed the criteria for each KLG using OARSI grade and phenotypes characterized by radiographic structure deformity in early KLG. Within the same KLG, the rate of disease progression was different depending on the structural deformity.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100566"},"PeriodicalIF":0.0,"publicationDate":"2025-01-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11787473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082447","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Effect of weight loss and liraglutide on neutrophil gelatinase-associated lipocalin levels among individuals with overweight and knee osteoarthritis: Exploratory analyses of a randomized controlled trial","authors":"Asbjørn Seenithamby Poulsen ,&nbsp;Zara Rebecca Stisen ,&nbsp;Marie Skougaard ,&nbsp;Robin Christensen ,&nbsp;Anders Overgaard ,&nbsp;Henrik Gudbergsen ,&nbsp;Stine Jacobsen ,&nbsp;Andreas Peter Balslev-Clausen ,&nbsp;Marius Henriksen ,&nbsp;Lars Erik Kristensen ,&nbsp;Henning Bliddal","doi":"10.1016/j.ocarto.2024.100562","DOIUrl":"10.1016/j.ocarto.2024.100562","url":null,"abstract":"<div><h3>Objective</h3><div>Obesity is a major risk factor for osteoarthritis (OA). Adipose tissues may be linked to OA development through secretion of potential proinflammatory cytokines including neutrophil gelatinase-associated lipocalin (NGAL). Our objective was to assess changes in serum NGAL after a low-calorie diet (LCD) and subsequent glucagon-like peptide 1 receptor agonist (GLP-1 RA) treatment.</div></div><div><h3>Design</h3><div>A secondary analysis of a randomized, double-blinded, placebo-controlled trial in adults with overweight (BMI≥27 ​kg/m²) and symptomatic, early-to-moderate radiographic knee OA. Prior to randomization, participants underwent an 8-week LCD (week −8 to 0). Participants who lost min. 5 ​% of initial bodyweight were randomized 1:1 to liraglutide 3 ​mg/d or placebo for 52 weeks. Main outcome was change in serum NGAL from enrollment (week −8) to randomization (week 0). Other outcome was change in serum NGAL from week 0 to week 52 comparing liraglutide and placebo.</div></div><div><h3>Results</h3><div>168 participants were enrolled to the initial intensive diet intervention; 127 participants, with NGAL samples, were randomized. Following the 8-week diet intervention, NGAL concentrations rose by 93.0 ​ng/mL (95 ​% CI: 18.9 to 167.1, <em>P</em> ​= ​0.015), with no correlation to weight loss magnitude. 52 weeks of treatment with either liraglutide or placebo, liraglutide did not cause a greater decrease in serum NGAL (14.9 ​ng/ml, 95%CI: −92.1 to 121.7 ​ng/mL, <em>P</em> ​= ​0.78).</div></div><div><h3>Conclusion</h3><div>An intensive 8-week calorie restriction was associated with a rise in serum NGAL. Compared to placebo, 52 weeks of liraglutide did not cause additional changes in NGAL. This indicates a complex pattern of proinflammatory cytokine-release during hypocaloric diet interventions.</div></div><div><h3>Trial registration</h3><div>Clinicaltrials.gov: <span><span>NCT02905864</span><svg><path></path></svg></span>.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100562"},"PeriodicalIF":0.0,"publicationDate":"2025-01-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11773487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061719","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"CT scan-based morphometric comparison of human and canine lumbar spine generates instrumental data for intervertebral disc percutaneous surgery","authors":"N. Gavira ,&nbsp;C. Decante ,&nbsp;N. Bouhsina ,&nbsp;D. Rouleau ,&nbsp;B. Miannay ,&nbsp;N. Bronsard ,&nbsp;A. David ,&nbsp;R. Jossier ,&nbsp;O. Gauthier ,&nbsp;A. Hamel ,&nbsp;J. Guicheux ,&nbsp;J. Clouet ,&nbsp;M. Fusellier","doi":"10.1016/j.ocarto.2024.100557","DOIUrl":"10.1016/j.ocarto.2024.100557","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to describe the anatomical landmarks for intervertebral disc (IVD) percutaneous approaches (transpedicular TPA and transannular TAA) using CT scans in humans and dogs for regenerative medicine research.</div></div><div><h3>Method</h3><div>CT scans of 57 human (30 supine, 27 prone) and 49 canine (29 chondrodystrophic, 20 non-chondrodystrophic) lumbar spines were analyzed. Morphometric data, cutaneous landmarks, and approach angles were measured, with additional sections assessing nerve root distances from TPA routes.</div></div><div><h3>Results</h3><div>Over 15,000 measurements were taken, creating a comprehensive anatomical database. Significant differences in TPA and TAA angles were noted between humans and dogs (p ​&lt; ​0.0001).</div></div><div><h3>Conclusion</h3><div>This study provides detailed anatomical landmarks for safe and effective IVD approaches, offering valuable guidance for translational research and surgical interventions.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100557"},"PeriodicalIF":0.0,"publicationDate":"2024-12-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11754510/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells","authors":"Yoshiyuki Mizushina ,&nbsp;Liping Sun ,&nbsp;Megumi Nishio ,&nbsp;Sanae Nagata ,&nbsp;Takeshi Kamakura ,&nbsp;Masayuki Fukuda ,&nbsp;Kousuke Tanaka ,&nbsp;Junya Toguchida ,&nbsp;Yonghui Jin","doi":"10.1016/j.ocarto.2024.100564","DOIUrl":"10.1016/j.ocarto.2024.100564","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis, a degenerative joint disease, requires innovative therapies due to the limited ability of cartilage to regenerate. Since mesenchymal stem cells (MSCs) provide a cell source for chondrogenic cells, we hypothesize that chemicals capable of enhancing the chondrogenic potential of MSCs with transforming growth factor-beta (TGFβ) in vitro may similarly promote chondrogenesis in articular cartilage in vivo.</div></div><div><h3>Design</h3><div>Chemical compounds that enhance the TGFβ signaling for chondrogenesis were investigated utilizing mesenchymal stem cells derived from human induced pluripotent stem cells. The mechanisms of action underlying the identified compound were explored in vitro, and its therapeutic effects were validated in vivo using a mouse model of exercise-induced osteoarthritis.</div></div><div><h3>Results</h3><div>Hydroxycitric acid (HCA) emerged as the lead compound. In vitro, HCA effectively enhanced chondrogenesis by inhibiting ATP citrate lyase, inducing citrate and alpha-ketoglutarate (α-KG), while reducing cytosolic acetyl coenzyme A (Ac-CoA). This induction of α-KG promoted collagen prolyl-4-hydroxylase activity, boosting hydroxyproline production and matrix formation. The reduction of Ac-CoA attenuated the inhibitory effect of β-catenin on mitochondrial activity by diminishing its acetylation. In vivo, orally administered HCA accumulated in joint tissues of mice and histological examination demonstrated newly synthesized cartilage tissues in damaged area. Analysis of joint tissue extracts revealed a downregulation of Ac-CoA and an upregulation of citrate and α-KG, accompanied by a systemic increase in an anabolic biomarker.</div></div><div><h3>Conclusions</h3><div>HCA demonstrates promise as an osteoarthritis therapy by enhancing chondrogenic differentiation. Its ability to modulate crucial metabolic pathways and facilitate cartilage repair suggests potential for clinical translation, addressing a critical need in the treatment of osteoarthritis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100564"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial","authors":"Cale A. Jacobs ,&nbsp;Morgan H. Jones ,&nbsp;Jamie E. Collins ,&nbsp;Lily M. Waddell ,&nbsp;Xiaojuan Li ,&nbsp;Carl S. Winalski ,&nbsp;Brian Pietrosimone ,&nbsp;Virginia Byers Kraus ,&nbsp;Miguel Otero ,&nbsp;Elizabeth Wellsandt ,&nbsp;Laura C. Schmitt ,&nbsp;Kurt P. Spindler ,&nbsp;Donald D. Anderson ,&nbsp;Scott A. Rodeo ,&nbsp;Robert A. Magnussen ,&nbsp;Brian R. Wolf ,&nbsp;Joe M. Hart ,&nbsp;Austin V. Stone ,&nbsp;Caitlin E. Conley ,&nbsp;Yvonne M. Golightly ,&nbsp;Elena Losina","doi":"10.1016/j.ocarto.2024.100563","DOIUrl":"10.1016/j.ocarto.2024.100563","url":null,"abstract":"<div><h3>Objective</h3><div>Given the high burden and increasing prevalence of post-traumatic osteoarthritis (PTOA), identifying clinically beneficial strategies to prevent or delay its onset could improve the quality of life of those at high risk of developing the disease.</div></div><div><h3>Methods</h3><div>Preventing Injured Knees from OsteoArthritis: Severity Outcomes (PIKASO) is a multicenter blinded, parallel, two-arm randomized controlled trial of 512 individuals aged 18–45 years undergoing anterior cruciate ligament reconstruction (ACLR). This study is designed to evaluate the efficacy of a 12-month intervention of oral metformin vs. placebo in decreasing the rate of structural knee changes and pain. Participants will be asked to take up to 1500 ​mg/day of either metformin or placebo as tolerated. The primary outcomes are Knee injury and Osteoarthritis Outcome Score (KOOS) Pain subscale scores averaged between 12 and 24 months after randomization, and MRI derived cartilage structural change at 24 months. The trial will be deemed successful if at least one of the two primary outcomes reaches the preplanned effect size with sufficient statistical certainty. In this paper, we describe PIKASO elements according to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines.</div></div><div><h3>Results</h3><div>Our multidisciplinary team developed the methods and statistical analysis plan for a placebo controlled, randomized clinical trial to determine whether metformin alters pain and early osteoarthritic changes after ACLR.</div></div><div><h3>Discussion</h3><div>This manuscript outlines the rationale, study design, and implementation of the PIKASO trial aiming to prevent the onset of PTOA after ACLR.</div></div><div><h3>Trial registration</h3><div>clinicaltrials.gov NCT06096259.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100563"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-assay variability in the measurement of urinary C-terminal cross-linked telopeptide of type II collagen following anterior cruciate ligament reconstruction","authors":"Lachlan M. Batty ,&nbsp;Kate E. Webster ,&nbsp;Natasha Vassileff ,&nbsp;Jereme G. Spiers ,&nbsp;Haydn J. Klemm ,&nbsp;Brian Devitt ,&nbsp;Timothy S. Whitehead ,&nbsp;Andrew F. Hill ,&nbsp;Julian A. Feller","doi":"10.1016/j.ocarto.2024.100561","DOIUrl":"10.1016/j.ocarto.2024.100561","url":null,"abstract":"<div><h3>Objective</h3><div>To compare urinary C-terminal cross-linked telopeptide of type II collagen (u-CTX-II) concentrations and trends as measured by two different commercially available enzyme-linked immunosorbent assays (ELISA) in a cohort of patients in the first year following anterior cruciate ligament (ACL) reconstruction.</div></div><div><h3>Design</h3><div>22 ACL-injured patients undergoing reconstructive surgery (mean age 25.2 (SD 8.0) years; 12 (54.5 ​%) male) had urine samples taken on the day of surgery (baseline) and at 6 and 12 months post-operatively. Concentrations of u-CTX-II were measured using the CloudClone® and the CartiLaps® ELISA. u-CTX-II concentrations were normalized to urinary creatinine (Cr).</div></div><div><h3>Results</h3><div>The u-CTX-II concentrations were significantly different between the 2 assays at each timepoint (p ​≤ ​0.01). When measured using the CloudClone® Assay, mean (standard error) u-CTX-II concentrations were 26.5 (2.5) ng/mmol Cr, 29.4 (3.8) ng/mmol Cr and 40.6 (6.9) ng/mmol Cr at the baseline, 6-month and 12-month timepoints respectively. When measured using the CartiLaps® Assay, at the same respective timepoints, u-CTX-II concentrations were 981.2 (256.5) ng/mmol Cr, 867.0 (234.3) ng/mmol Cr and 764.3 (220.3) ng/mmol Cr. Concentrations of u-CTX-II using the CloudClone® Assay increased with time (p ​= ​0.04). Concentrations of u-CTX-II using the CartiLaps® Assay decreased over time (p ​= ​0.2).</div></div><div><h3>Conclusion</h3><div>Using two commercially available assays, u-CTX-II differed significantly in terms of both concentration and trends in the first year following ACL reconstruction. The specific assay used is critical to consider when interpreting results and has implications for pooling data and meta-analysis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100561"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis","authors":"Alexander Mathiessen ,&nbsp;Line Gaundal ,&nbsp;Joseph Sexton ,&nbsp;Dag Sjølie ,&nbsp;Pernille Steen Pettersen ,&nbsp;Barbara Slatkowsky-Christensen ,&nbsp;Ida Kristin Haugen","doi":"10.1016/j.ocarto.2024.100558","DOIUrl":"10.1016/j.ocarto.2024.100558","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive hand OA.</div></div><div><h3>Design</h3><div>In total 163 participants with erosive hand OA, synovitis by ultrasound, and finger joint pain of 40–80 ​mm on a visual analogue scale (VAS) will be recruited from a rheumatology outpatient clinic. Participants are randomized 1:1 to receive either encapsulated oral methotrexate 20 ​mg/week or placebo for 12 months in a double-blind manner. The primary endpoint is VAS finger joint pain at 6 months. Key secondary outcomes are hand function by the Australian/Canadian hand index (AUSCAN) at 6 months and radiographic progression by the Verbruggen-Veys anatomical phase scoring system at 12 months. Other secondary endpoints include hand stiffness, disease activity, health-related quality of life, grip strength, clinical joint counts, synovitis by ultrasound and MRI, bone marrow lesions by MRI, cost-effectiveness, and symptoms in knees and hips. Adverse events will be recorded. The primary analysis will be performed on full analysis set.</div></div><div><h3>Conclusions</h3><div>The findings of this trial will be clinically relevant for patients with erosive hand OA and may influence future treatment recommendations.</div></div><div><h3>Clinical trial registration</h3><div>EU CT number: 2023-510523-30-00, NCT04579848.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100558"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular injection of inorganic pyrophosphate improves IL-1β-induced cartilage damage in rat model of knee osteoarthritis in vivo","authors":"Émilie Velot,&nbsp;Mathilde Guibert,&nbsp;Meriem Koufany,&nbsp;Arnaud Bianchi","doi":"10.1016/j.ocarto.2024.100560","DOIUrl":"10.1016/j.ocarto.2024.100560","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is the most common form of chronic joint disease, affecting mainly the elderly population. This disorder is caused by cartilage degeneration with complex changes in the chondrocyte phenotype. Inorganic pyrophosphate (PPi) was shown to counteract the detrimental effect of interleukin (IL)-1β challenging in an in vitro OA model based on rat articular chondrocytes. It also maintained the differentiated articular phenotype, mostly by down regulating wingless-related integration site (Wnt)-5a secretion. These observations suggest a PPi protective role for chondrocyte in vitro.</div></div><div><h3>Methods</h3><div>To address this hypothesis in vivo, we investigated the impact on knee joint of three intra-articular injection (IAI) of PPi in a rat model of cartilage damage induced by IAI of IL-1β, where cartilage degradation and synovial inflammation are similar to that observed in OA. Cartilage and synovial membrane were collected after 7 days of challenge by IL-1β.</div></div><div><h3>Results</h3><div>PPi was able to reduce the deleterious effect of IL-1β. This effect was observable on the expression of cartilage extracellular matrix metabolism markers and confirmed by histology with safranin O and hematoxylin-eosin-saffron (HES) staining. Inorganic pyrophosphate also repressed the Wnt5a expression induced by IL-1β. No effect was observed on the inflammatory response of the synovial membrane.</div></div><div><h3>Conclusion</h3><div>These results demonstrate that PPi improves IL-1β-induced cartilage damage in rat but not the associated inflammation of synovial membrane. Thus, PPi could become a molecule of interest to restrict the progression of this disorder.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100560"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}