Early age-related changes to articular cartilage T1ρ in hips with Legg–Calvé–Perthes disease deformity

Osteoarthritis and cartilage open Pub Date : 2025-02-27 DOI:10.1016/j.ocarto.2025.100589

Luke G. Johnson , Carly E. Jones , Daniel G. Rosenbaum , Benjamin Joseph , Emily K. Schaeffer , Kishore Mulpuri , David R. Wilson

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引用次数: 0

Abstract

Objective

To determine whether the relationship between cartilage T_1ρ relaxation time and age during adolescence and young adulthood is different in hips with Legg–Calvé–Perthes disease (LCPD) deformity compared to hips without LCPD deformity.

Design

We recruited 17 participants with LCPD deformity and 15 control participants aged 10–25 years in this frequency-matched cohort study. Quantitative magnetic resonance images were obtained for both hips in LCPD participants and one hip from each control using a T_1ρ MAPSS sequence. The average T_1ρ relaxation time in the weight-bearing articular cartilage was calculated, and we tested the interacting effects of age and participant group (LCPD vs non-LCPD) or subgroup (control, contralateral LCPD, spherical LCPD, and aspherical LCPD) on T_1ρ using mixed effects models.

Results

The main effect of age on T_1ρ relaxation time in hips without LCPD deformity was −0.63 ms/year (95 % confidence interval [−0.94, −0.32]). The age-adjusted main effect of LCPD deformity was +2.93 ms [0.65, 3.42] and the interaction effect of age and LCPD deformity was +0.46 ms/year [0.16, 0.76]. Moderate differences were observed between control and contralateral LCPD subgroups, and between spherical LCPD and aspherical LCPD subgroups.

Conclusions

Age-related changes in T_1ρ relaxation time differ between hips with and without LCPD deformity, suggesting that cartilage degradation in LCPD is progressive and begins early in the healed stage of LCPD. By young adulthood, the difference in T_1ρ between LCPD and non-LCPD hips is clinically important when considering osteoarthritis progression and outcomes.

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legg - calv - perthes病畸形髋关节软骨T1ρ的早期年龄相关变化

目的探讨legg - calv - perthes病（LCPD）畸形髋与非LCPD畸形髋在青春期和青年期软骨T1ρ松弛时间与年龄的关系。设计：在这项频率匹配的队列研究中，我们招募了17名LCPD畸形患者和15名10-25岁的对照组。使用T1ρ MAPSS序列获得LCPD参与者的双髋关节和每个对照组的一个髋关节的定量磁共振图像。计算负重关节软骨的平均T1ρ松弛时间，并使用混合效应模型测试年龄和参与者组（LCPD与非LCPD）或亚组（对照组，对侧LCPD，球形LCPD和非球形LCPD）对T1ρ的相互作用。结果年龄对无LCPD畸形髋部T1ρ松弛时间的主要影响为- 0.63 ms/年（95%可信区间[- 0.94,- 0.32]）。年龄调整后LCPD畸形的主效应为+2.93 ms[0.65, 3.42]，年龄与LCPD畸形的交互效应为+0.46 ms/年[0.16,0.76]。在对照组和对侧LCPD亚组之间，以及球形LCPD和非球形LCPD亚组之间，观察到中度差异。结论LCPD畸形患者与非LCPD畸形患者髋关节T1ρ松弛时间的年龄相关变化存在差异，提示LCPD的软骨退化是进行性的，早在LCPD愈合期就开始了。到成年早期，LCPD和非LCPD髋关节之间的T1ρ差异在考虑骨关节炎进展和结局时具有重要的临床意义。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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来源期刊

Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation

CiteScore

3.30

自引率

0.00%

发文量