Osteoarthritis and cartilage open最新文献

{"title":"The potential of unstructured “physical activity” data for understanding relationships between movement-induced joint loading and osteoarthritis progression","authors":"Peter Schaefer,&nbsp;Zoe Struk,&nbsp;Kerry E. Costello","doi":"10.1016/j.ocarto.2025.100731","DOIUrl":"10.1016/j.ocarto.2025.100731","url":null,"abstract":"<div><div>Gait and exercise have been extensively studied in knee osteoarthritis (OA) as potential interventions to modify mechanical loading at the joint and, subsequently, influence biological processes and disease progression. However, this research has often failed to account for mechanical loading encountered in daily life outside structured activities. Wearable sensors help address this limitation by capturing movement as it occurs in daily life. Yet most analyses have relied on coarse summary measures (e.g., step count), overlooking biologically relevant variation in loading patterns across activities and time. Given that these sensors record millions of data points per day, there is an opportunity to move beyond summary measures and quantify within- and between-day variations in movement patterns. We propose that a deeper exploration of these rich datasets, guided by OA literature and related fields, may reveal how load-inducing human movement contributes to knee OA, informing the development of personalized, activity-based interventions.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100731"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Management of glenohumeral osteoarthritis in the younger patient: A population level analysis of usual care delivery in a large health system","authors":"Daniel I. Rhon ,&nbsp;Maggie E. Horn ,&nbsp;Rebecca Milan ,&nbsp;Steven Z. George","doi":"10.1016/j.ocarto.2025.100705","DOIUrl":"10.1016/j.ocarto.2025.100705","url":null,"abstract":"<div><h3>Objective</h3><div>To characterize healthcare utilization in a younger population with glenohumeral osteoarthritis.</div></div><div><h3>Methods</h3><div>Adults seeking care for glenohumeral osteoarthritis between July 2013 and March 2019 were analyzed. Ambulatory visits, pharmacological, and non-pharmacological treatment, and surgical and radiological procedures, were compared by active-duty status and sex. The association between exercise therapy receipt and subsequent surgery was modeled using an adjusted logistic regression, reporting adjusted odds ratios (OR).</div></div><div><h3>Results</h3><div>There were 21,369 individuals (29.4 ​% female; mean age 50.3 [standard deviation (SD) 9.9] years), with 24.1 ​% military patients. The mean number of ambulatory shoulder visits per patient was 9.4 (SD 12.5). For pharmacological care 26.2 ​% received an injection, 14.8 ​% received non-steroidal anti-inflammatory drugs, 13.4 ​% opioids, 11.8 ​% muscle relaxants, and 9.9 ​% other analgesics. Non-pharmacological care included 44.5 ​% receiving exercise therapy, 41.6 ​% physiotherapy, and 32.6 ​% manual therapy, while 54.0 ​% received none of these. Radiographs were obtained for 51.3 ​% and advanced imaging for 47.1 ​%. Arthroscopic surgery occurred in 18.9 ​% and arthroplasty in 0.2 ​%. Military patients received less pharmacological and more non-pharmacological treatment that non-military patients. Males had 1.5x the odds of surgery and higher pharmacological treatment use than females. Receipt of exercise therapy (adjusted OR ​= ​0.01; 95 ​% confidence interval 0.01, 0.02) significantly reduced the odds of arthroscopic surgery.</div></div><div><h3>Conclusion</h3><div>Many patients received no interventions. For those receiving care, &lt;50 ​% received guideline-recommended non-pharmacological care, including exercise therapy which significantly reduced the likelihood of surgery. Military patients had overall less pharmacological but more non-pharmacological treatment than non-military patients. A greater frequency of males had surgery. These findings indicate the need to further explore health care delivery for glenohumeral osteoarthritis in younger populations, highlighting potential guideline to practice gaps.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100705"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145555508","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The infrapatellar fat pad mediates environmental exposure for clinical outcomes in knee osteoarthritis","authors":"Anping Shen ,&nbsp;Ruoyu Zhuang ,&nbsp;Yan Xue ,&nbsp;Jin Wang ,&nbsp;Laijun Yan ,&nbsp;Muyun Yang ,&nbsp;Qinguang Xu ,&nbsp;Yuelong Cao","doi":"10.1016/j.ocarto.2026.100749","DOIUrl":"10.1016/j.ocarto.2026.100749","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study aimed to investigate whether the infrapatellar fat pad (IPFP) mediates the relationship between environmental exposures and clinical symptoms in patients with knee osteoarthritis (KOA).</div></div><div><h3>Methods</h3><div>A total of 108 participants with KOA were included in this study, and environmental exposure data, including temperature, wind speed, and relative humidity, were obtained from local meteorological records. IPFP characteristics were quantitatively assessed using 3.0T magnetic resonance imaging (MRI), including morphometric and signal intensity (SI) parameters. Clinical symptoms were evaluated using the Western Ontario and McMaster Universities Osteoarthritis Index (WOMAC). Principal component analysis (PCA) was used to reduce dimensionality of IPFP MRI features. Mediation analysis was performed to examine whether IPFP parameters mediated the effect of environmental exposures on WOMAC scores.</div></div><div><h3>Results</h3><div>PCA revealed that SI parameters accounted for 56.87 % of the total variance in IPFP features, while morphometric parameters explained 16.65 %. Correlation analysis showed that most SI parameters (e.g., mean SI, SD SI) were significantly associated with WOMAC scores (ranging from r = 0.20 to 0.49, p &lt; 0.05), in contrast to morphometric measures. Environmental exposures, particularly lower temperatures, higher wind speed, and daily weather changes, were significantly correlated with increased SI. Mediation analysis demonstrated that IPFP MRI parameters, particularly SI parameters, significantly mediated the effects of environmental exposures on pain and total WOMAC scores.</div></div><div><h3>Conclusions</h3><div>The IPFP, particularly its SI characteristics, mediates the relationship between environmental exposures and clinical symptoms in KOA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100749"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146090291","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Baseline pain medication is associated with longer duration of high adherence in a three-month digital treatment program for hip and knee osteoarthritis","authors":"Leif E. Dahlberg ,&nbsp;Simon P. Rowland ,&nbsp;Jack T. Pearson ,&nbsp;L. Stefan Lohmander ,&nbsp;Ali Kiadaliri","doi":"10.1016/j.ocarto.2025.100727","DOIUrl":"10.1016/j.ocarto.2025.100727","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether baseline use of pain medication is associated with program adherence during a three-month digital treatment program for individuals with hip or knee osteoarthritis (OA).</div></div><div><h3>Design</h3><div>An observational cohort study using registry data on weekly participant adherence from 33078 participants enrolled in a digital education and exercise therapy program. Poor adherence was defined as completing less than 80 % of the approximately 20 prescribed weekly activities for two consecutive weeks during the 13-week treatment period. Baseline analgesic use was categorized into six groups: no medication, paracetamol (with/without dietary supplements), NSAIDs (with/without supplements), paracetamol combined with NSAIDs (with/without dietary supplements), dietary supplements only, and opioids (with/without other medications). Interval-censored parametric survival models adjusted for baseline characteristics were used for statistical analysis. In sensitivity analyses, alternative definitions of poor adherence were used. A complete case analysis was conducted as a subgroup analysis.</div></div><div><h3>Results</h3><div>Compared to the no-medication group, individuals taking paracetamol—either alone (hazard ratio 0.94, 95 % CI 0.91, 0.98) or in combination with NSAIDs (0.91, 0.87, 0.94) reached poor adherence later. In contrast, opioid users (hazard ratio 1.12, 95 % CI 1.06, 1.19) reached poor adherence earlier. Adjusted median days to reach poor adherence ranged from 39.2 (95 % CI 36.9, 41.4) for opioids to 49.2 (47.7, 50.7) for paracetamol + NSAIDs users. Alternative definitions of poor adherence and a complete-case analysis generally yielded similar findings.</div></div><div><h3>Conclusion</h3><div>Baseline use of paracetamol, alone or with NSAIDs, was associated with longer time to reach poor adherence, whereas opioid use predicted poor adherence earlier.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100727"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840187","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Two years efficacy and safety outcomes of using allogeneic, pooled mesenchymal stromal cells for osteoarthritis of knee in a double-blind randomized placebo-controlled phase 3 study","authors":"Pawan Kumar Gupta ,&nbsp;Sunil Maheshwari ,&nbsp;Joe Joseph Cherian ,&nbsp;Vijay Goni ,&nbsp;Arun Kumar Sharma ,&nbsp;Sujit Kumar Tripathy ,&nbsp;Keerthi Talari ,&nbsp;Vivek Pandey ,&nbsp;Parag Kantilal Sancheti ,&nbsp;Saurabh Singh ,&nbsp;Syamasis Bandyopadhyay ,&nbsp;Naresh Shetty ,&nbsp;Surendra Umesh Kamath ,&nbsp;Purohit Sharad Prahaldbhai ,&nbsp;Jijy Abraham ,&nbsp;Suresh Kannan ,&nbsp;Nikhil N. Verma ,&nbsp;Uday Kumar","doi":"10.1016/j.ocarto.2025.100723","DOIUrl":"10.1016/j.ocarto.2025.100723","url":null,"abstract":"<div><h3>Objective</h3><div>The aim of this study was to assess whether allogeneic cultured, pooled, bone marrow derived mesenchymal stromal cells (BMMSCs), has potential to impact progression of osteoarthritis (OA).</div></div><div><h3>Method</h3><div>Randomized, double blind, multicentric, placebo-controlled trial to assess efficacy and safety of BMMSCs in Grade 2 and 3 OA of knee. 146 patients were randomized, 73 patients each received either BMMSCs (25 million cells) or placebo followed by 20 mg HA. The primary end point was evaluation of WOMAC Composite Index and secondary end points were WOMAC sub-scores, VAS, magnetic resonance (MR) assessment (T2 mapping and cartilage volume).</div></div><div><h3>Results</h3><div>58 patients from BMMSC arm and 60 patients from placebo arm completed 24 months follow-up. At 24 months follow up, WOMAC composite index and WOMAC sub scores showed significant improvements in cell arm as compared to placebo (p &lt; 0.0001); T2 mapping showed there is no worsening of the cartilage in the medial femoral tibial compartment in BMMSC arm whereas placebo arm shows gradual worsening (p &lt; 0.0001). Cartilage volume increased in BMMSC arm. At Day 90 &amp; 730, Urinary C – terminal cross linked telopeptide of type II collagen significantly decreased in the cell arm and increased in the placebo arm (p-value&lt;0.0001). 5 AEs were possibly related to the study drug and were local site administration effects. By 24 months follow-up, 4 patients in the placebo group underwent TKR versus 1 patient in the BMMSC arm.</div></div><div><h3>Conclusions</h3><div>This study demonstrates that BMMSC's is safe and effective for the treatment of grade 2 &amp; 3 OA of knee.</div></div><div><h3>Ctri registration</h3><div>CTRI/2018/09/015785 [Registered on: September 20, 2018]</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100723"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145840186","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PIEZO mechanosensitivity in chondrocytes is differentially modulated by L-type and T-type voltage-sensitive ion channels","authors":"Alireza Savadipour ,&nbsp;Gabrielle K. Marushack ,&nbsp;Robert J. Nims ,&nbsp;Jaquelin M. Garcia-Castorena ,&nbsp;Wolfgang Liedtke ,&nbsp;Farshid Guilak","doi":"10.1016/j.ocarto.2025.100710","DOIUrl":"10.1016/j.ocarto.2025.100710","url":null,"abstract":"<div><h3>Objective</h3><div>One of the primary factors contributing to OA development is altered or excessive mechanical stress on the joint, which chondrocytes sense in part through the PIEZO mechanosensitive ion channels. These channels activate signaling pathways that result in joint inflammation and cartilage degeneration. In addition to PIEZO channels, voltage-gated calcium (Ca²⁺) channels (VGCCs) have been shown to contribute to Ca²⁺ influx into chondrocytes in response to mechanical loads.</div></div><div><h3>Design</h3><div>To better understand the relationship between PIEZO1 and VGCCs, we quantified porcine chondrocytes' intracellular Ca²⁺ response to mechanical loading or Yoda1 (a PIEZO1 agonist) after various classes of VGCCs were chemically inhibited. We also studied the effects of VGCC blockers on chondrocyte viability in porcine cartilage explants subjected to mechanical compression.</div></div><div><h3>Results</h3><div>In primary chondrocytes, nifedipine, an L-type VGCC blocker, reduced PIEZO1 sensitivity to both mechanical compression and pharmacological agonism, while NNC-55, a T-type VGCC blocker, increased PIEZO1 activation in response to both stimuli. Similarly, treating cartilage explants exposed to injurious mechanical loads with nifedipine reduced mechanically induced cell death compared to the control, while treatment with NNC-55 increased cell death.</div></div><div><h3>Conclusions</h3><div>In addition to contributing to the current understanding of the mechanisms through which VGCCs modify chondrocyte mechanobiology, our findings suggest the potential of L-type VGCC inhibitors as therapeutic targets for decreasing PIEZO1 signaling and reducing chondrocyte death in response to supraphysiologic mechanical loads.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100710"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145624881","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tolerability of high intensity interval training (HIIT) in individuals living with knee OA and at risk for cardiovascular disease: A prospective cohort study (THIPO)","authors":"Mathilde Espe Pedersen ,&nbsp;Thomas Bandholm ,&nbsp;Mathias Ried-larsen ,&nbsp;Cecilie Bartholdy ,&nbsp;Tanja Schjødt Jørgensen ,&nbsp;Asbjørn Seenithamby Poulsen ,&nbsp;Kasper Stagberg Madsen ,&nbsp;Marius Henriksen","doi":"10.1016/j.ocarto.2025.100712","DOIUrl":"10.1016/j.ocarto.2025.100712","url":null,"abstract":"<div><h3>Objective</h3><div>To explore the tolerability of a 12-week High Intensity Interval Training (HIIT) program in individuals with knee osteoarthritis (OA) at elevated risk for cardiovascular disease (CVD).</div></div><div><h3>Methods</h3><div>Forty-one individuals with knee OA and elevated CVD risk participated in a 12-week HIIT program with three weekly supervised sessions (36 in total) on treadmills, cross-trainers, row- and cycle ergometers. The program comprised a 10-min warm-up, followed by eight 2-min intervals of high intensity (&gt;80 % of HRmax) followed by 2 min of moderate training intensity (60 % of HRmax), and 5 min of cool down. Tolerability was assessed by investigator consensus using a decision guiding framework based on attendance, incidence of knee pain flares resulting in non-compliance with the HIIT program during the 12-week period and change in knee pain (0–10 scale) at session start from the first to the last week of the program.</div></div><div><h3>Results</h3><div>The average Borg Rating of Perceived Exertion (RPE) score during intervals was 16.2 (SD 1.2) over the 12 weeks. Average attendance to sessions was 88 %. The prevalence of knee flares increased from 3 to 5 from the first to the last 6 weeks, and the number of participants with ≥1 point knee pain reduction from week 1 to week 12 was 19 (46 %). According to KOOS thresholds, participants had mild difficulty in Pain, ADL, and Symptoms; moderate difficulty in Knee-related Quality of Life; and moderate-to-severe difficulty in Function in Sports and Recreation.</div></div><div><h3>Conclusion</h3><div>In conclusion, the HIIT program appeared tolerable for most individuals with knee OA and elevated CVD risk including those with mild-to-moderate difficulties in pain, function, and quality of life, supporting its potential feasibility in this clinical population.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100712"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037305","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The role of metabolic syndrome in osteoarthritis development: Is obesity the key driver?","authors":"Dell’Isola Andrea ,&nbsp;Magnusson Karin ,&nbsp;Vinblad Johanna ,&nbsp;Lohmander L. Stefan ,&nbsp;Englund Martin ,&nbsp;Kiadaliri Ali","doi":"10.1016/j.ocarto.2025.100739","DOIUrl":"10.1016/j.ocarto.2025.100739","url":null,"abstract":"<div><h3>Objective</h3><div>Investigate the role of metabolic syndrome and obesity in incident osteoarthritis (OA).</div></div><div><h3>Methods</h3><div>Prospective cohort study with up to 11 years follow-up. From a general population cohort of 28,786 individuals from Sweden aged 45 to 75, we selected individuals without OA diagnosis and without joint pain during the year prior to the baseline. Metabolic syndrome was defined at baseline by the presence of at least three out of five components: elevated waist circumference (WC), elevated plasma triglycerides, reduced HDL-cholesterol, elevated blood pressure, and hyperglycaemia. Individuals were followed from baseline until incident OA diagnosis in any joint (outcome), death, relocation outside Region Skåne/Region Uppsala, or December 31, 2022. Associations between metabolic syndrome and OA incidence were estimated using parametric survival models with restricted cubic splines and adjusted for sex, age, education, immigration status, marital status, physical activity, and diet score.</div></div><div><h3>Results</h3><div>Among the 10,633 individuals, 1167 (11 %) received an OA diagnosis (median follow-up 8.6 years). Metabolic syndrome was associated with an increased risk of OA (hazard ratio [HR] 1.17, confidence intervals [1.04, 1.33]). Elevated WC alone was associated with a similar risk of OA (HR 1.42 [1.06, 1.90]), while metabolic syndrome without elevated WC did not show a conclusive association (HR 1.02 [0.73, 1.43]). Substituting WC with BMI led to similar results.</div></div><div><h3>Conclusions</h3><div>Metabolic syndrome leads to an increased risk of developing OA even in individuals free of joint pain at baseline. The association is largely driven by obesity, which underscores the importance of weight management to mitigate OA development.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100739"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"146037303","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Patient-reported outcomes of a comprehensive management program for osteoarthritis of the hip and knee","authors":"Trevor A. Lentz ,&nbsp;Preston Roundy ,&nbsp;Emily Poehlein ,&nbsp;Cynthia L. Green ,&nbsp;Richard C. Mather III ,&nbsp;William Jiranek","doi":"10.1016/j.ocarto.2025.100711","DOIUrl":"10.1016/j.ocarto.2025.100711","url":null,"abstract":"<div><h3>Objective</h3><div>This study describes the 2-year self-reported joint function outcomes of patients enrolled in a US-based comprehensive hip and knee osteoarthritis management program (OAMP), and demographic characteristics associated with change in function.</div></div><div><h3>Design</h3><div>This is a retrospective analysis of 598 patients with hip OA and 1533 patients with knee OA enrolled in the program between October 2017 and October 2024. Outcome measures for joint function (HOOS JR and KOOS JR) were collected via questionnaire at baseline, 6 weeks, 3 months, 6 months, 12 months, and 2 years after program enrollment. Generalized estimating equations (GEE) were used to describe trends in outcomes over time, and Kaplan Meier curves were constructed to assess time to meet minimal clinically important difference (MCID) thresholds. We conducted sensitivity analyses including several imputation strategies to address follow-up non-response. Interaction terms between timepoint and age, sex, race, and employment status were included in the covariate adjusted model.</div></div><div><h3>Results</h3><div>We observed statistically significant improvements in joint function over time for both hip and knee patients, and these significant improvements persisted in each sensitivity analysis. By 2 years, 61 ​% of knee patients and 60 ​% of hip patients met established MCIDs. Employment status, sex, and baseline function were associated with the trajectory of HOOS JR score.</div></div><div><h3>Conclusions</h3><div>Patients enrolled in this US-based OAMP experienced improvements, on average, for hip and knee symptoms, with most patients meeting clinically meaningful improvement thresholds by 2 years. These findings suggest that comprehensive OAMPs may offer an effective alternative to surgery.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"8 1","pages":"Article 100711"},"PeriodicalIF":2.8,"publicationDate":"2026-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145694224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Training load and pain response during progressive resistance training in patients with hip osteoarthritis in the PROHIP trial","authors":"Emma Smed Bryld ,&nbsp;Laura Christiansen ,&nbsp;Kim Gordon Ingwersen ,&nbsp;Søren Overgaard ,&nbsp;Lone Ramer Mikkelsen ,&nbsp;Inger Mechlenburg ,&nbsp;Thomas Frydendal","doi":"10.1016/j.ocarto.2025.100690","DOIUrl":"10.1016/j.ocarto.2025.100690","url":null,"abstract":"<div><h3>Objective</h3><div>To describe training load and repetitions, illustrate the pre- and post-exercise hip pain intensity trajectories throughout a 12-week progressive resistance training (PRT) program, and evaluate the difference in change in pre-exercise hip pain intensity between high and moderate-to-low adherence to PRT among individuals with severe hip osteoarthritis and indication for surgery.</div></div><div><h3>Design</h3><div>Secondary analysis of a randomized controlled trial reporting data only from participants who were enrolled from September 2019 through June 2021 from four orthopedic departments in Denmark and assigned to PRT. Patient-reported hip pain intensity at rest was measured before and after each session using a Numerical Rating Scale (NRS) ranging from 0 (no pain) to 10 (worst pain imaginable). High adherence was defined as attending at least 18 of 24 scheduled sessions.</div></div><div><h3>Results</h3><div>A total of 55 participants (mean age 67.7 years and 51 ​% females) received PRT. Training load increased while repetitions decreased from week 1 to week 12. The mean pre-exercise NRS decreased from 3.18 points at baseline to 2.13 points at 12-weeks (difference, 1.05 points [95%CI 0.46, 1.65]). The mean post-exercise NRS decreased from 2.87 points at baseline to 2.04 points at 12-weeks, (difference, 0.83 points [95%CI 0.30, 1.37]). There was no significant difference in mean change in pre-exercise NRS scores between high and moderate-to-low adherence (group difference, 1.08 points [95%CI -0.85, 3.02]).</div></div><div><h3>Conclusions</h3><div>Individuals with severe hip osteoarthritis and indication for surgery can exercise at progressively higher intensity while maintaining low hip pain intensity. High adherence did not result in greater pain relief.</div></div><div><h3>Clinical trial registration number</h3><div>NCT04070027.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100690"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265595","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}