Osteoarthritis and cartilage open最新文献

{"title":"White paper – A proposal towards objective biomechanical metrics as novel endpoints to document improvements in musculoskeletal function and mobility","authors":"Sónia A. Alves , Nicholas M. Brisson , Alison N. Agres , Mark Heyland , Ali Mobasheri , David J. Hunter , Tobias Winkler , Georg N. Duda","doi":"10.1016/j.ocarto.2025.100648","DOIUrl":"10.1016/j.ocarto.2025.100648","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100648"},"PeriodicalIF":0.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144662267","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A fully-automated technique for cartilage morphometry in knees with severe radiographic osteoarthritis – Method development and validation","authors":"Wolfgang Wirth ,&nbsp;Felix Eckstein","doi":"10.1016/j.ocarto.2025.100645","DOIUrl":"10.1016/j.ocarto.2025.100645","url":null,"abstract":"<div><h3>Objective</h3><div>Denuded areas of subchondral bone (dAB) pose a challenge for fully automated segmentation of articular cartilage and subchondral bone in knees with severe radiographic osteoarthritis using convolutional neural networks (CNNs). Here we propose an automated post-processing relying on a selection-based multi-atlas registration for reconstructing the total area of subchondral bone (tAB) to overcome this issue. We evaluate the agreement, accuracy and longitudinal sensitivity to cartilage change of this novel methodology.</div></div><div><h3>Design</h3><div>CNN-based models were trained using manual cartilage segmentations from sagittal DESS and coronal FLASH MRI of knees with radiographic (KLG2-4) or severe radiographic osteoarthritis (KLG4 only). These were then applied to KLG4 test knees with manual cartilage segmentations. Automated post-processing was applied to reconstruct missing parts of the tAB and to refine the segmentations, particularly for dABs. The agreement and accuracy of automated cartilage analysis were evaluated using Dice Similarity Coefficients (DSC) and Bland-Altman analyses; sensitivity to one-year change was assessed using the standardized response mean (SRM).</div></div><div><h3>Results</h3><div>Stronger agreement (DSC 0.80 ​± ​0.07 to 0.89 ​± ​0.05) and lower systematic offsets for cartilage thickness (1.2 ​%–8.4 ​%) and tAB area (−0.4 ​%–4.3 ​%) were observed for CNNs trained on KLG2-4 rather than KLG4 knees; overall, results were superior to those without registration-based post-processing. Sensitivity to change was greatest for manual segmentation of DESS (SRM ​≥ ​−0.69; automated: ≥−0.56) and for automated segmentation of FLASH (≥−0.74; manual ≥−0.44).</div></div><div><h3>Conclusion</h3><div>CNN-based segmentation combined with registration-based post-processing for accurate delineation of tABs/dABs substantially improves fully-automated (longitudinal) analysis of cartilage and subchondral bone morphology in knees with severe radiographic osteoarthritis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100645"},"PeriodicalIF":0.0,"publicationDate":"2025-07-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144631789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Good long-term functional outcomes after rotationplasty despite osteoarthritis in the (pseudo)knee","authors":"G.G.J. Krebbekx ,&nbsp;F.F. Smithuis ,&nbsp;M.J.C. Duivenvoorden ,&nbsp;R. Hemke ,&nbsp;I.N. Sierevelt ,&nbsp;G.R. Schaap ,&nbsp;J.A.M. Bramer ,&nbsp;G.M.M.J. Kerkhoffs ,&nbsp;F.G.M. Verspoor","doi":"10.1016/j.ocarto.2025.100644","DOIUrl":"10.1016/j.ocarto.2025.100644","url":null,"abstract":"<div><h3>Objective</h3><div>Rotationplasty is a surgical procedure primarily performed in patients with malignancies around the knee. Altered gait mechanics after surgery, such as reduced flexion of the (pseudo)knee and ipsilateral hip and changes in ground reaction forces, may predispose patients to osteoarthritis (OA) in the lower extremities. This study evaluated the long-term prevalence of OA and its association with pain and daily functioning.</div></div><div><h3>Method</h3><div>Rotationplasty survivors who underwent surgery between 1980 and 2002 in Amsterdam received radiographic assessment of the (pseudo)knee, contralateral ankle, and both hips (weight-bearing mortise, lateral and AP views). OA was graded using the Kellgren-Lawrence scale. Functional outcomes, pain, quality of life, and sports participation were evaluated with the FAOS, AOFAS, and Harris Hip Score questionnaires. Statistical analyses included t-tests, Mann-Whitney U, chi-square, and Fisher's exact tests.</div></div><div><h3>Results</h3><div>Thirty patients (mean age 49.4 ​± ​9.2 years; mean follow-up 32.4 ​± ​4.6 years) participated. Moderate-to-severe OA was found in 43 ​% of ipsilateral (pseudo)knees, 10 ​% of contralateral ankles, 33 ​% of ipsilateral hips, and 11 ​% of contralateral hips. Osteophytes were most common in the anterior tibial and subtalar regions (20 ​%), and joint space narrowing was most frequent in the subtalar (20 ​%) and medial tibiotalar (13 ​%) regions. Functional scores were generally favorable. The presence of osteoarthritis in the pseudo-knee was significantly associated with longer follow-up time.</div></div><div><h3>Conclusion</h3><div>Functional outcomes after rotationplasty are well preserved over time, despite a higher prevalence of osteoarthritis in the (pseudo)knee compared to the contralateral ankle as a long-term consequence of the procedure.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100644"},"PeriodicalIF":0.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144523151","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"In knee osteoarthritis, the production of cytokines and metalloproteinases in presence of chondrocytes and CD4+ T cells depends on T cell subset: An in vitro analysis","authors":"H. Platzer ,&nbsp;M. Wellbrock ,&nbsp;G. Pourbozorg ,&nbsp;R. Mayakrishnan ,&nbsp;S. Gantz ,&nbsp;B. Khamees ,&nbsp;S. Maciej ,&nbsp;B. Moradi","doi":"10.1016/j.ocarto.2025.100642","DOIUrl":"10.1016/j.ocarto.2025.100642","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is driven by biomechanical and biochemical inflammatory processes, including CD4⁺ T cell infiltration and activation. However, the role of CD4⁺ T cell subsets interacting with neighboring cells shaping the local inflammatory milieu have remained largely unexplored. This study aimed to investigate in vitro whether interaction of chondrocyte and CD4⁺ T cells modulate cytokine and metalloproteinase production in OA, and to determine if this modulation differ depending on CD4⁺ T cell subsets.</div></div><div><h3>Method</h3><div>Nineteen patients with knee OA undergoing knee replacement were enrolled. From peripheral blood CD4⁺ T cells were isolated and differentiated into subsets (Th1, Th2, Th17, Treg) using a novel developed protocol. T cell differentiation was validated by flow cytometry. Chondrocytes were mono- and co-cultured with T cell subsets and in culture supernatant cytokine and metalloproteinase levels were quantified using ELISA and multiplex assays.</div></div><div><h3>Results</h3><div>Compared to monocultures levels MMP-1/3/9/13 and IL-6 were elevated in all co-cultures of chondrocytes and CD4⁺ T cell subsets, with the highest levels in Th17 co-cultures. GM-CSF, IL-9, IL-17 were specifically elevated in Th17 co-cultures and IFN-γ in Th1 co-cultures. TNF-α production was significantly reduced only in Treg co-culture compared to monoculture approach.</div></div><div><h3>Conclusion</h3><div>This study indicates that chondrocytes can interact with CD4⁺ T cell subsets in OA, modulating the production of metalloproteinases and cytokines to varying degrees, depending on the CD4⁺ T cell subset. Our findings can open new avenues in OA treatment using T cell-based or T cell subset-targeted therapies to modulate inflammatory patterns in affected OA joints.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100642"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144335752","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular injections for knee osteoarthritis management: Analysis of cost-effectiveness","authors":"Hanna Mass ,&nbsp;Jamie E. Collins ,&nbsp;Catherine Yang ,&nbsp;David J. Hunter ,&nbsp;Morgan H. Jones ,&nbsp;Love Tsai ,&nbsp;Stephen P. Messier ,&nbsp;Tuhina Neogi ,&nbsp;Jeffrey N. Katz ,&nbsp;Elena Losina","doi":"10.1016/j.ocarto.2025.100641","DOIUrl":"10.1016/j.ocarto.2025.100641","url":null,"abstract":"<div><h3>Objective</h3><div>Intra-articular injections (IAI) are commonly used to treat knee pain in persons with knee osteoarthritis (OA). We sought to determine the value of commonly used IAIs in knee OA management.</div></div><div><h3>Methods</h3><div>We used the validated Osteoarthritis Policy Model (OAPol) to assess the value of saline, corticosteroid (CS), hyaluronic acid (HA), and platelet-rich plasma (PRP) IAIs in knee OA management. We conducted a meta-analysis of high quality studies to estimate IAI-specific pain reduction. We assumed that repeat CS injections increase the risk of OA progression threefold in the base case. We determined the value of specific IAIs with incremental cost-effectiveness ratios (ICERs). We conducted sensitivity analyses to account for uncertainty in input parameters.</div></div><div><h3>Results</h3><div>In the base case, ICERs were $8300/QALY for saline compared to no injection, $54,500/QALY for HA compared to saline, and $112,100/QALY for PRP compared to HA. CS was dominated (more costly, less effective) by saline. <strong>If saline was not included, ICER for HA was reduced to $22,400/QALY.</strong> In sensitivity analyses that assumed CS does not increase OA progression, ICERs were $6000/QALY for CS compared to no injection, HA dominated compared to CS. ICER for PRP was estimated at $151,300/QALY. ICERs for PRP were higher than currently accepted willingness to pay thresholds. PRP ICER ranges were most sensitive to discontinuation probability and cost.</div></div><div><h3>Conclusions</h3><div>CS could offer good value for knee OA management if the impact on OA progression is small. <strong>Value of PRP depends greatly on its price, with current prices leading to value exceeding well</strong><strong>-</strong><strong>accepted cost-effectiveness thresholds</strong>. Better data on the impact of CS on OA progression and pain efficacy related to PRP would offer critical insights for policymakers into the value of specific IAIs in the management of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100641"},"PeriodicalIF":0.0,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144654817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The frequency and severity of ultrasound-detected osteoarthritis features in the knees and their associations with pain: Cross-sectional analyses of the Nor-Hand study","authors":"Caroline H. Dekkerhus ,&nbsp;Alexander Mathiessen ,&nbsp;Caroline M. Fjellstad ,&nbsp;Barbara Slatwkosky-Christensen ,&nbsp;Hilde Berner Hammer ,&nbsp;Ida K. Haugen","doi":"10.1016/j.ocarto.2025.100640","DOIUrl":"10.1016/j.ocarto.2025.100640","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate the frequency and severity of ultrasound-detected osteophytes and synovitis in people with and without knee osteoarthritis (OA), and to explore the association between these ultrasound features and pain.</div></div><div><h3>Design</h3><div>In the Nor-Hand study, both knees were assessed for osteophytes (0–3 scale, four locations per knee) and grey-scale synovitis (0–3 scale). The frequency and severity of the ultrasound-detected features were compared in individuals with and without knee OA defined by the American College of Rheumatology criteria. Pain was self-reported in each knee (yes/no) and by the Western/Ontario McMaster University index (WOMAC). The associations between ultrasound-detected features and pain were examined by regression analyses adjusted for age, sex, and body mass index.</div></div><div><h3>Results</h3><div>We analyzed 286 participants. Osteophytes of all sizes were more common in participants with knee OA compared to those without (65.9 ​% vs. 40.8 ​%, p ​&lt; ​0.001). No between-group difference was found for the frequency of any grey-scale synovitis (45.5 ​% vs. 44.7 ​%, p ​= ​0.67), while severe synovitis was more common in those with knee OA. Ultrasound-detected osteophyte sum score, but not synovitis, was associated with WOMAC pain (B ​= ​0.18, 95 ​% CI 0.03–0.32). Osteophytes of all sizes were associated with pain in the same knee with odds ratio (OR, 95 ​% CI) ranging from 1.85 (1.20–2.84) to 9.02 (4.04–20.10). Statistically significant association was found for severe synovitis only (OR ​= ​6.63, 95 ​% CI 2.26–19.43).</div></div><div><h3>Conclusions</h3><div>Ultrasound-detected osteophytes were prevalent in people with knee OA and were associated with pain. OA pathology in individuals without fulfilling the knee OA criteria may reflect early or subclinical OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100640"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262530","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between weather features and symptoms in hand osteoarthritis: Results from the DIGICOD cohort","authors":"Mathilde Pezot ,&nbsp;Romane Lacoste-Badie ,&nbsp;Sophie Tuffet ,&nbsp;Alexandra Rousseau ,&nbsp;Pascal Richette ,&nbsp;Bruno Fautrel ,&nbsp;Francis Berenbaum ,&nbsp;Alice Courties ,&nbsp;Jérémie Sellam","doi":"10.1016/j.ocarto.2025.100639","DOIUrl":"10.1016/j.ocarto.2025.100639","url":null,"abstract":"<div><h3>Objective</h3><div>This cross-sectional study aimed to investigate the association between weather and joint symptoms in patients with hand osteoarthritis (HOA).</div></div><div><h3>Design</h3><div>We used baseline data from the DIGICOD cohort, a monocentric cohort of patients with HOA, and meteorological measurements (temperature, humidity, barometric pressure) in the Paris region during the 72 ​h before inclusion in the cohort. Clinical outcomes were AUSCAN subscores (pain, stiffness, function), spontaneous and pressure tender joint count (TJC), visual analog scale (VAS) score for hand pain during activity and at rest, and the Functional Index for Hand Osteoarthritis score. We used logistic regression models to search for associations between meteorological measurements and clinical outcomes, adjusting for sex, age, Kellgren-Lawrence score and Hospital Anxiety and Depression Scale score.</div></div><div><h3>Results</h3><div>We analyzed data for 377 patients (mean age 66.5 ​± ​7.4 years, 85 ​% female). The AUSCAN-pain subscale score was not significantly associated with temperature, humidity or barometric pressure. Only spontaneous TJC was associated with relative humidity, and TJC at pressure was negatively associated with barometric pressure, both without dose-effect. Pain scores were not associated with temperature, and function and stiffness scores were not associated with any meteorological variable.</div></div><div><h3>Conclusions</h3><div>This is the first study to investigate in a large cohort the association between meteorological factors and HOA symptoms. Despite a few isolated associations, our results do not clearly support the worsening of hand joint symptom during humid or rainy weather.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100639"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144470098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Analysis of multiple MRI-based quantitative structural measurements of knee osteoarthritis in a case control study – association with pain and structural progression and comparison to semi-quantitative scoring","authors":"Stacy E. Smith ,&nbsp;Lawrence Lo ,&nbsp;Meera Sury ,&nbsp;Sara M. Bahouth ,&nbsp;Ming Yin ,&nbsp;Lena F. Schaefer ,&nbsp;Jamie E. Collins ,&nbsp;Jeffrey Duryea","doi":"10.1016/j.ocarto.2025.100638","DOIUrl":"10.1016/j.ocarto.2025.100638","url":null,"abstract":"<div><h3>Objective</h3><div>To use software-based magnetic resonance imaging (MRI) measures of multiple features of knee osteoarthritis (KOA) to predict radiographic and pain progression in persons with KOA, and compare to a study that used primarily semi-quantitative (SQ) scoring.</div></div><div><h3>Design</h3><div>Data from the Foundation for the National Institutes of Health Osteoarthritis Biomarkers Consortium (FNIH) nested case-control study (600 subjects divided into case and control groups based on knee pain and/or radiographic progression) were used. The MRI Osteoarthritis Software Scoring (MOSS) was used to quantitatively assess medial femoral cartilage, bone marrow lesions, osteophyte volume, effusion-synovitis volume, and a measure of Hoffa's synovitis at baseline and 24-months using readers with diverse levels of expertise. Association between baseline and baseline to 24-month change with progressor status was examined and discriminative ability assessed using the c-statistic (AUC) computed under 10-fold cross validation.</div></div><div><h3>Results</h3><div>AUC values ranged from 0.690 to 0.726 to predict combined pain/radiographic progression and from 0.709 to 0.804 to predict radiographic progression alone. Bone marrow lesions and osteophyte volume played a role in all analyses. Medial femoral cartilage was significant for all but the cross-sectional analysis involving pain progression. Comparison to results from a separate publication showed that MOSS offered similar discrimination to a published model that primarily used SQ scoring.</div></div><div><h3>Conclusions</h3><div>We found a high level of discrimination particularly for radiographic progression analysis. Use of fast automated software and readers with varied prior experience make MOSS a useful tool for enriching future clinical trials and for other large studies of KOA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100638"},"PeriodicalIF":0.0,"publicationDate":"2025-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144262531","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Familial risks of five types of osteoarthritis in first-, second- and third-degree relatives - A nationwide Swedish family study","authors":"Christian Anker-Hansen,&nbsp;MirNabi Pirouzifard,&nbsp;Jan Sundquist,&nbsp;Kristina Sundquist,&nbsp;Bengt Zöller","doi":"10.1016/j.ocarto.2025.100637","DOIUrl":"10.1016/j.ocarto.2025.100637","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a common degenerative disease with a genetic contribution. However, no large nationwide family study concerning the heredity of OA has been published. This first nationwide study aimed to determine the familial risks of the main types of OA in twins, full-siblings, half-siblings, and cousins in Sweden.</div></div><div><h3>Design</h3><div>The Swedish Multigeneration register was linked to the National Patient Register (NPR) to investigate the heredity of OA (poly-, hip-, knee-, first carpometacarpal joint-, and other-OA) between 1997 and 2018. Offspring born by Swedish parents were included. The adjusted familial hazard ratios (HRs) with 95 ​% confidence interval (CI) were determined for OA among twins, full-siblings, half-siblings, and cousins. Adjustments were made for birth year, sex, educational level, and comorbidities (chronic obstructive pulmonary disease, alcoholism, and obesity).</div></div><div><h3>Results</h3><div>A total of 6 547 966 individuals (48.77 ​% women) were included with mean age 41.44 years (range 0–86.96 years) at end of follow-up. Familial HRs were increased for all five types of OA (even in cousins) and correlated to degree of genetic resemblance between relatives. For instance, adjusted HRs among full-siblings were for poly-OA 2.29 (95 ​% CI 2.09–2.51), hip-OA 2.04 (95 ​% CI 1.98–2.07), knee-OA 1.75 (95 ​% CI 1.73–1.77), thumb-OA 2.60 (95 ​% CI 2.45–2.76), and other-OA 1.52 (95 ​% CI 1.48–1.56).</div></div><div><h3>Conclusions</h3><div>Heredity is an important predictor of future risk of OA for all five types of OA in the Swedish population. Strongest heredity was observed for first carpometacarpal joint -OA followed by poly-OA and hip-OA. Weakest heredity was observed for knee-OA and other-OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100637"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144212740","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bidirectional causal relationship between obesity and osteoarthritis: Insights from a two-sample Mendelian randomization study","authors":"Anne Kamps ,&nbsp;Jos Runhaar ,&nbsp;Katerina Trajanoska ,&nbsp;William D. Thompson ,&nbsp;Weiya Zhang ,&nbsp;Bahar Sedaghati-khayat ,&nbsp;Joyce B.J. van Meurs ,&nbsp;Sita M.A. Bierma-Zeinstra","doi":"10.1016/j.ocarto.2025.100636","DOIUrl":"10.1016/j.ocarto.2025.100636","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is a prevalent chronic disease associated with disability worldwide, and obesity is a key modifiable risk factor for OA. The study's aim was to investigate the causal relationship between obesity and OA.</div></div><div><h3>Method</h3><div>This study employed a two-sample Mendelian randomization (MR) approach to investigate the bidirectional causal relationship between obesity, using body mass index (BMI) as its proxy, and OA of the knee, hip, and hand. Genetic instruments were derived from large-scale GWAS meta-analyses, including ∼681,000 individuals for BMI and ∼827,000 individuals (177,000 OA cases) for OA. Inverse variance weighted with multiplicative random effects analysis was performed as primary analysis, and in addition sensitivity analyses relying on different assumptions were performed.</div></div><div><h3>Results</h3><div>The MR analysis revealed that genetically predicted BMI had a causal effect on increased risk of knee (OR 1.91, 95 ​% CI 1.80–2.03), hip (OR 1.52, 95 ​% CI 1.41–1.64) and hand OA (OR 1.21, 95 ​% CI 1.04–1.23). Sensitivity analyses confirmed the robustness of these associations. However, there was no evidence for a causal effect from knee, hip or hand OA on BMI.</div></div><div><h3>Conclusion</h3><div>This study provides strong evidence supporting a causal effect of obesity (measured by BMI) on OA, with a more pronounced effect in weight-bearing knee &amp; hip joints compared to non-weight-bearing hand joint. There was no causal evidence for the reverse direction. Future research could look more in depth into differences in the genetic variants that may represent different biological underlying mechanisms.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 3","pages":"Article 100636"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144330154","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}