Osteoarthritis and cartilage open最新文献

{"title":"Effect of biological sex and short-term high-fat diet on cellular proliferation, ribosomal biogenesis, and targeted protein abundance in murine articular cartilage","authors":"Kamil A. Kobak ,&nbsp;Albert Batushansky ,&nbsp;Anita Jopkiewicz ,&nbsp;Frederick F. Peelor III ,&nbsp;Michael T. Kinter ,&nbsp;Benjamin F. Miller ,&nbsp;Timothy M. Griffin","doi":"10.1016/j.ocarto.2024.100495","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100495","url":null,"abstract":"<div><h3>Objective</h3><p>To identify factors contributing to sex-differences in OA risk by evaluating the short-term effect of high-fat (HF) diet on sex-specific changes in cartilage cell proliferation, ribosomal biogenesis, and targeted extra-cellular and cellular protein abundance.</p></div><div><h3>Materials and methods</h3><p>Knee cartilage was harvested to the subchondral bone from 20-week-old female and male C57BL/6J mice fed a low-fat or HF diet for 4 weeks and labeled with deuterium oxide for 1, 3, 5, 7, 15, or 21 days. Deuterium enrichment was quantified in isolated DNA and RNA to measure cell proliferation and ribosomal biogenesis, respectively. Protein concentration was measured using targeted high resolution accurate mass spectrometry.</p></div><div><h3>Results</h3><p>HF diet increased the maximal deuterium incorporation into DNA from approximately 40 to 50%, albeit at a slower rate. These findings, which were magnified in female versus male mice, indicate a greater number of proliferating cells with longer half-lives under HF diet conditions. HF diet caused distinct sex-dependent effects on deuterium incorporation into RNA, increasing the fraction of ribosomes undergoing biogenesis in male mice and doubling the rate of ribosome biogenesis in female mice. HF diet altered cartilage protein abundance similarly in both sexes, except for matrilin-3, which was more abundant in HF versus LF conditions in female mice only. Overall, HF diet treatment had a stronger effect than sex on cartilage protein abundance, with most changes involving extracellular matrix and matrix-associated proteins.</p></div><div><h3>Conclusions</h3><p>Short-term HF diet broadly altered cartilage matrix protein abundance, while sex-dependent effects primarily involved differences in cell proliferation and ribosomal biogenesis.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100495"},"PeriodicalIF":0.0,"publicationDate":"2024-06-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000621/pdfft?md5=e56a53c9083da05acbe4a67cf35d3aca&pid=1-s2.0-S2665913124000621-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141486260","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association of peripheral inflammatory indicators with osteoarthritis risk","authors":"Shiyong Zhang ,&nbsp;Yanlin Zhong ,&nbsp;Xudong Wang ,&nbsp;Wei Jiang ,&nbsp;Xicong Chen ,&nbsp;Yunze Kang ,&nbsp;Zhiwen Li ,&nbsp;Weiming Liao ,&nbsp;Linli Zheng ,&nbsp;Puyi Sheng ,&nbsp;Ziji Zhang","doi":"10.1016/j.ocarto.2024.100496","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100496","url":null,"abstract":"<div><h3>Objectives</h3><p>Numerous studies have established the role of inflammation in osteoarthritis (OA) progression, yet limited research explores the association between systemic inflammatory indicators and pre-diagnosis OA risk. This study aimed to investigate the association between peripheral inflammatory indicators and the risk of OA using data from the UK Biobank.</p></div><div><h3>Methods</h3><p>The study analyzed data from 417,507 participants in the UK Biobank, including neutrophil count, lymphocyte count, monocyte count, platelet count, and C-reactive protein meter. Additionally, derived ratios such as NLR(neutrophils-lymphocytes ratio), PLR(Platelets-lymphocytes ratio), SII(systemic immune-inflammation index), and LMR (lymphocytes-monocytes ratio) were examined. Cox proportional hazards models and restricted cubic spline models were used to assess both linear and nonlinear associations.</p></div><div><h3>Results</h3><p>Over a mean follow-up period of 12.7 years, a total of 49,509 OA events were identified. The findings revealed that CRP (HR:1.06, 95%CI:1.05–1.07), NLR (HR:1.02, 95%CI:1.01–1.03), PLR (HR:1.02, 95%CI:1.01–1.03), and SII (HR:1.03, 95%CI:1.01–1.04) were associated with an increased risk of OA, while LMR (HR:0.97, 95%CI:0.96–0.99) showed a significant negative correlation with OA risk. Subgroup analyses further emphasized that these associations were significant across most of the population. Although neutrophils, lymphocytes, monocytes, and platelets showed a nominal association with the risk of OA, the results were unreliable, especially for specific joint OA.</p></div><div><h3>Conclusion</h3><p>The study provides evidence of a significant association between elevated peripheral inflammatory indicators and OA risk. These findings underscore the importance of low-grade chronic inflammation in OA development. The potential clinical utility of these indicators as early predictors of OA is suggested, warranting further exploration.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100496"},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000633/pdfft?md5=644473921c1c5bd19c1f697482d9a962&pid=1-s2.0-S2665913124000633-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444334","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Telehealth mindful exercise for people with knee osteoarthritis: A decentralized feasibility randomized controlled trial","authors":"Nirali Shah ,&nbsp;Natalia Morone ,&nbsp;Ehyun Kim ,&nbsp;Terry D. Ellis ,&nbsp;Ellen Cohn ,&nbsp;Michael P. LaValley ,&nbsp;Deepak Kumar","doi":"10.1016/j.ocarto.2024.100494","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100494","url":null,"abstract":"<div><h3>Objective</h3><p>Negative psychological beliefs like fear avoidance and catastrophizing can interfere with exercise engagement in people with knee osteoarthritis (OA). Mindfulness, when integrated with exercise, could potentially address both psychological and physical impairments. Our objectives were to optimize and assess the feasibility of a novel telehealth, group-based mindful exercise intervention for people with knee OA.</p></div><div><h3>Methods</h3><p>We conducted a decentralized randomized controlled trial where participants (n ​= ​40) with symptomatic knee OA were randomized into mindful exercise (n ​= ​21) or exercise-only (n ​= ​19) groups. Both groups received supervised group-based interventions weekly for 8-weeks via Zoom. Primary outcomes were safety, fidelity, and feasibility of the mindful exercise intervention. Participants completed patient-reported outcomes (PRO) for pain, function, and psychological measures at baseline, week-8, and week-14.</p></div><div><h3>Results</h3><p>Participants were from 21 US states; &gt;90% identified as having White race, 16% were from rural areas, and approximately 40% had an annual income &lt; $50,000. At 8-weeks, mindful exercise and exercise groups had retention rates of 86% (18/21) and 100% (19/19), and attendance was 54% (11.4/21) and 68% (13/19) respectively. There were no adverse events in the mindful exercise group and four in the exercise group related to exacerbation of knee pain. Preliminary findings showed numerically larger improvements in several PROs for the mindful exercise group.</p></div><div><h3>Conclusion</h3><p>An 8-week telehealth, group-based, mindful exercise intervention was safe for people with knee OA. Our decentralized approach was feasible in terms of recruitment and retention. Further refinement is needed to improve intervention attendance and participant diversity.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100494"},"PeriodicalIF":0.0,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266591312400061X/pdfft?md5=dfc7c37f319aba60bb09091b6557775c&pid=1-s2.0-S266591312400061X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141444333","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Planned or recent first consultation with the general practitioner for knee complaints: Is it indicative of early-stage knee osteoarthritis?","authors":"Nuria EJ. Jansen ,&nbsp;Dieuwke Schiphof ,&nbsp;Jos Runhaar ,&nbsp;Edwin HG. Oei ,&nbsp;Sita MA. Bierma-Zeinstra ,&nbsp;Marienke van Middelkoop","doi":"10.1016/j.ocarto.2024.100493","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100493","url":null,"abstract":"<div><h3>Objective</h3><p>No established definition for early-stage knee osteoarthritis (KOA) is available, nor classification criteria. Identifying the characteristics of individuals presenting with early-stage KOA symptoms can enhance diagnosis to prevent progression. This study aimed to describe clinical and structural features of individuals presenting with knee complaints within two years after their first consultation, while exploring differences in the duration of knee complaints.</p></div><div><h3>Method</h3><p>Baseline data was used from the LITE randomized controlled trial, assessing the effectiveness of a lifestyle intervention for individuals with knee complaints and overweight in primary care. Baseline assessments included questionnaires, clinical assessment, and MRI of the most symptomatic knee. Differences between groups with varying durations of knee complaints (&lt;12, ≥12-&lt;24, ≥24 months) were evaluated.</p></div><div><h3>Results</h3><p>Participants (N ​= ​218, 65% female, mean age 59 ​± ​6 years, mean BMI 32 ​± ​5 ​kg/m²) had a median knee complaint duration of 14 months, with an average KOOS pain score of 60 ​± ​17.46% reported their symptoms as unacceptable. Structural MRI-defined KOA was observed in 71% of participants. There were no significant differences in clinical or structural MRI features between different durations of knee complaints.</p></div><div><h3>Conclusion</h3><p>Within 24 months of initial consultation, over two-thirds of participants displayed MRI-defined structural KOA, and nearly half reported unacceptable symptom states. This study found no association between the duration of knee complaints and symptoms severity or structural KOA presence, underscoring the complexity of identifying stages of KOA among individuals with overweight. Future studies should explore additional features beyond current considerations to facilitate early-stage KOA diagnosis, specifically for individuals with overweight.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100493"},"PeriodicalIF":0.0,"publicationDate":"2024-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000608/pdfft?md5=214ac545493efaec446310c1dba17e3a&pid=1-s2.0-S2665913124000608-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141307917","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dextran-tryamine hydrogel maintains position and integrity under simulated loading in a human cadaver knee model","authors":"G.S. van der Weiden ,&nbsp;S.C. Mastbergen ,&nbsp;S.K. Both ,&nbsp;M. Karperien ,&nbsp;F.P. Lafeber ,&nbsp;N. van Egmond ,&nbsp;R.J.H. Custers","doi":"10.1016/j.ocarto.2024.100492","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100492","url":null,"abstract":"<div><h3>Objective</h3><p>This dextran-tyramine hydrogel is a novel cartilage repair technique, filling focal cartilage defects to provide a cell-free scaffold for subsequent cartilage repair. We aim to asses this techniques’ operative feasibility in the knee joint and its ability to maintain position and integrity under expected loading conditions.</p></div><div><h3>Method</h3><p>Seven fresh-frozen human cadaver legs (age range 55–88) were used to create 30 cartilage defects on the medial and lateral femoral condyles dependent of cartilage quality, starting with 1.0 ​cm²; augmenting to 1.5 ​cm² and eventually 2.0 ​cm². The defects were operatively filled with the injectable hydrogel scaffold. The knees were subsequently placed on a continues passive motion machine for 30 ​min of non-load bearing movement, mimicking post-operative rehabilitation. High resolution digital photographs documented the hydrogel scaffold after placement and directly after movement. Three independent observers blinded for the moment compared the photographs on outline attachment, area coverage and hydrogel integrity.</p></div><div><h3>Results</h3><p>The operative procedure was uncomplicated in all defects, application of the hydrogel was straightforward and comparable to common cartilage repair techniques. No macroscopic iatrogenic damage was observed. The hydrogel scaffold remained predominately unchanged after non-load bearing movement. Outline attachment, area coverage and hydrogel integrity were unaffected in 87%, 93% and 83% of defects respectively. Larger defects appear to be more affected than smaller defects, although not statistically significant (p ​&gt; ​0.05).</p></div><div><h3>Conclusion</h3><p>The results of this study show operative feasibility of this cell-free hydrogel scaffold for chondral defects of the knee joint. Sustained outline attachment, area coverage and hydrogel integrity were observed after non-load bearing knee movement.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100492"},"PeriodicalIF":0.0,"publicationDate":"2024-05-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000591/pdfft?md5=a87936afaaedb292a6bb58ed6bc8a0fe&pid=1-s2.0-S2665913124000591-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141328616","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cobalt ions induce a cellular senescence secretory phenotype in human synovial fibroblast-like cells that may be an early event in the development of adverse local tissue reactions to hip implants","authors":"Michael P. Grant ,&nbsp;Raheef Alatassi ,&nbsp;Mohamad Omar Diab ,&nbsp;Mohammed Abushal ,&nbsp;Laura M. Epure ,&nbsp;Olga L. Huk ,&nbsp;Stephane G. Bergeron ,&nbsp;Hee-Jeong Im Sampen ,&nbsp;John Antoniou ,&nbsp;Fackson Mwale","doi":"10.1016/j.ocarto.2024.100490","DOIUrl":"10.1016/j.ocarto.2024.100490","url":null,"abstract":"<div><h3>Objectives</h3><p>Total hip arthroplasty is a successful procedure for treating advanced osteoarthritis (OA). Metal bearing surfaces remain one of the most widely implanted prosthesis, however approximately 10% of patients develop adverse local tissue reactions (ALTRs), namely lymphocytic predominant soft tissue reaction with or without necrosis and osteolysis resulting in high revision rates. The mechanism(s) for these reactions remains unclear although T lymphocyte mediated type IV hypersensitivity to cobalt (Co) and chromium (Cr) ions have been described. The purpose of this study was to determine the prolonged effects of Co and Cr metal ions on synovial fibroblasts to better understand the impact of the synovial membrane in the development of ALTRs.</p></div><div><h3>Methods</h3><p>Human synovial fibroblast-like cells were isolated from donors undergoing arthroplasty. DNA content and Alamar blue assay were used to determine cellular viability against exposure to Co and Cr. A beta-galactosidase assay was used to determine the development of cellular senescence. Western blotting and RT-qPCR were employed to determine changes in senescent associated secretory factors, signaling and anti-oxidant enzyme expression. A fluorescent assay was used to measure accumulation of hydrogen peroxide.</p></div><div><h3>Results</h3><p>We demonstrate that prolonged cobalt exposure results in a downregulation of the enzyme catalase resulting in cytosolic accumulation of hydrogen peroxide, decreased Akt activity and cellular senescence. Senescent fibroblasts demonstrated upregulation of proinflammatory cytokines IL-1β and TNFα in addition to the neurotrophic factor NGF.</p></div><div><h3>Conclusion</h3><p>Our results provide evidence that metal ions induce a senescent associated secretory phenotype in synovial fibroblasts that could contribute to the development of adverse local tissue reactions.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100490"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000578/pdfft?md5=8f62bb51e4501c248e2701cc17d9ac29&pid=1-s2.0-S2665913124000578-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047569","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Expanding the ABCC-tool for osteoarthritis: Development and content validation","authors":"V.H.J. Debie ,&nbsp;T.A.E.J. Boymans ,&nbsp;R.P.G. Ottenheijm ,&nbsp;O.C.P. van Schayck ,&nbsp;A.H.M. Gidding-Slok","doi":"10.1016/j.ocarto.2024.100488","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100488","url":null,"abstract":"<div><h3>Objective</h3><p>Osteoarthritis (OA) care should be more person-centered based on physical, emotional and social aspects, instead of the current stepped-care approach solely based on physical symptoms, according to OA patients. By developing a novel module for OA in the Assessment of Burden of Chronic Condition (ABCC)-tool, a tool based on these three aspects, experienced quality of OA care and shared-decision making are expected to improve.</p></div><div><h3>Design</h3><p>The development of the novel OA module involved a triangular iterative process, interviewing OA patients and healthcare professionals in the field of OA, an expert panel and a literature search to identify the needs to improve OA care. Patients provided feedback on the first version of the OA module, leading to a second version. This second version was used to evaluate content validity. OA patients and healthcare professionals in the field of OA were asked to evaluate relevance, comprehensiveness and comprehensibility, based on the COSMIN methodology. For healthcare professionals, the item-content validity index (I-CVI) was calculated.</p></div><div><h3>Results</h3><p>The module includes questions about pain, kinesiophobia and joint stiffness. For all three questions, 94% of the patients found these questions important for patients with OA. The I-CVI scores of the healthcare professionals ranged from 1.0 (pain, kinesiophobia) to 0.75 (joint stiffness).</p></div><div><h3>Conclusion</h3><p>A novel, condition-specific OA module is developed for the ABCC-tool, as a supplement to the generic questions. The module includes three questions, to measure OA specific complaints. This novel module is intended to make the ABCC-tool more elaborate and useable for a larger population.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100488"},"PeriodicalIF":0.0,"publicationDate":"2024-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000554/pdfft?md5=e3a8dfb7fd3d09d9acc80eede7d9aae9&pid=1-s2.0-S2665913124000554-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141067789","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Association between sarcopenic obesity and knee osteoarthritis: A narrative review","authors":"Saliu Balogun ,&nbsp;David Scott ,&nbsp;Dawn Aitken","doi":"10.1016/j.ocarto.2024.100489","DOIUrl":"10.1016/j.ocarto.2024.100489","url":null,"abstract":"<div><p>Sarcopenia and obesity have been studied independently as risk factors for knee osteoarthritis. However, there is now research interest in investigating whether the co-existence of sarcopenia and obesity (sarcopenic obesity) within the same individual significantly increases the risk of knee osteoarthritis, compared to sarcopenia or obesity alone. This review synthesises current literature to explore the association between sarcopenic obesity and knee osteoarthritis, emphasising both the clinical evidence and existing gaps. We highlight the challenges and progress in defining sarcopenic obesity and discuss the impact that the lack of a consensus definition of sarcopenic obesity has on comparing outcomes of studies investigating the relationship between sarcopenic obesity and knee OA. We offer methodological insights to guide future studies investigating whether sarcopenic obesity increases the risk of knee osteoarthritis above and beyond the risk associated with each condition on its own. The implications for clinical practice are discussed, including the need to incorporate effective resistance exercise into weight loss programs for individuals with sarcopenic obesity. This is critical as a general weight loss program alone among individuals with sarcopenic obesity can include substantial loss of muscle mass, potentially predisposing patients to further functional decline.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100489"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000566/pdfft?md5=7bfef1cf88e660e3c1870978a0734603&pid=1-s2.0-S2665913124000566-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141047853","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pre-exercise and acute movement-evoked pain trajectories during a 24-week outdoor walking program for knee osteoarthritis (WALK)","authors":"S.J.J. Drummen ,&nbsp;D. Aitken ,&nbsp;S. Balogun ,&nbsp;K.L. Bennell ,&nbsp;R.S. Hinman ,&nbsp;M.L. Callisaya ,&nbsp;P. Otahal ,&nbsp;L. Blizzard ,&nbsp;B. Antony ,&nbsp;I.P. Munugoda ,&nbsp;T. Winzenberg ,&nbsp;G. Jones ,&nbsp;L.E.J.M. Scheepers","doi":"10.1016/j.ocarto.2024.100481","DOIUrl":"10.1016/j.ocarto.2024.100481","url":null,"abstract":"<div><h3>Objectives</h3><p>Exploring (1) pre-exercise and acute movement-evoked pain (AMEP) during an outdoor walking program in individuals with knee osteoarthritis (OA); and (2) comparing baseline physical performance and AMEP flares initiated by walking between participants with either a higher or lower attendance rate.</p></div><div><h3>Methods</h3><p>Individuals with knee OA were prescribed a 24-week walking program, including one unsupervised walk and two supervised walk classes per week. Participants self-reported knee pain on a numerical rating scale (NRS; 0–10) before and after each supervised class. Mixed-effects models were used to investigate trajectories over time for pre-exercise pain and AMEP change (post-minus pre-exercise pain; positive value indicates flare-up). Baseline physical performance (6 tests) and AMEP flares were compared between participants with higher (attending ≥70% of supervised classes) and lower attendance rates.</p></div><div><h3>Results</h3><p>Of 24 participants commencing the program, 7 (29%) withdrew. Over 24 weeks, pre-exercise pain improved by 1.20 NRS (95% CI -1.41 to −0.99), with estimated largest per class improvements during the first 8 weeks (−0.05 (−0.06 to −0.03) and plateauing around 20-weeks. The AMEP was estimated to improve by 0.19 NRS (95% CI -0.38 to −0.004) over 24-weeks, with improvements plateauing around 12-weeks. Participants with lower attendance (n ​= ​11) scored poorer on all physical performance tests and experienced a slight increase in AMEP during the first two weeks of the program.</p></div><div><h3>Conclusions</h3><p>Participants improved in pre-exercise pain and AMEP in the first 20 and 12 weeks, respectively. Despite supervision, physical performance and AMEP flares may have contributed to lower attendance.</p></div><div><h3>Trial registration number</h3><p>12618001097235.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100481"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000487/pdfft?md5=c5abc8c1fa2b6782274c6897cfb259cc&pid=1-s2.0-S2665913124000487-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141042087","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Severity and progression of structural hand OA is not associated with progression of structural knee OA: The IMI-APPROACH cohort","authors":"Sietse E.S. Terpstra ,&nbsp;Lotte A. van de Stadt ,&nbsp;Francis Berenbaum ,&nbsp;Francisco J. Blanco ,&nbsp;Ida K. Haugen ,&nbsp;Simon C. Mastbergen ,&nbsp;Harrie Weinans ,&nbsp;Mylène P. Jansen ,&nbsp;Frits R. Rosendaal ,&nbsp;Margreet Kloppenburg","doi":"10.1016/j.ocarto.2024.100487","DOIUrl":"10.1016/j.ocarto.2024.100487","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate whether structural hand OA or its progression is associated with structural knee OA progression after two years in a population with symptomatic knee OA.</p></div><div><h3>Methods</h3><p>We used baseline and two-year follow-up data from the IMI-APPROACH cohort. Symptomatic hand and knee OA were defined using ACR criteria. Radiographs of hands and knees were scored semi-quantitatively for osteophytes and joint space narrowing (JSN) following the OARSI atlas, and Kellgren-Lawrence (KL) scale. Knee images were also scored quantitatively with the Knee Image Digital Analysis (KIDA). Progression was defined as change above the minimal detectable change on patient level, except for KIDA (most affected knee compartment level). With logistic regression analyses the severity or progression of hand OA was associated with knee OA progression.</p></div><div><h3>Results</h3><p>In 221 participants (mean age 66, 77% women, mean BMI 27.7, 19% hand OA), OA progression occurred in 18%–28%, and 9%–38% in hands and knees respectively, depending on features. Baseline structural hand OA features were not significantly associated with knee OA progression, except for hand osteophytes with KIDA osteophytes progression (odds ratio (OR) 1.03, 95% confidence interval (CI) 1.01–1.06). Progression of structural hand OA features was not significantly associated with knee OA progression, except for hand osteophyte or JSN progression, which was significantly associated with knee osteophyte progression (OR 0.44, 95%CI 0.22–0.84 and OR 0.43, 95%CI 0.18–0.94, respectively), and hand osteophyte progression for knee JSN (OR 2.51, 95%CI 1.15–5.48).</p></div><div><h3>Conclusions</h3><p>In patients with symptomatic knee OA, no consistent associations between baseline structural hand OA or hand OA progression and knee OA progression were shown.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 3","pages":"Article 100487"},"PeriodicalIF":0.0,"publicationDate":"2024-05-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000542/pdfft?md5=13616b1ba4b062e8778ac5fe168de546&pid=1-s2.0-S2665913124000542-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141052300","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}