代谢综合征相关的炎症机制和潜在的治疗方法

Shiqian Huang , Jiawei Chen , Hao Zhang , Wenjing Wu , Song Xue , Zhaohua Zhu , Changhai Ding
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引用次数: 0

摘要

骨关节炎(OA)是一种使人衰弱的疾病,已被认为是一种异质性疾病,代谢综合征相关性骨关节炎(MetS-OA)成为一个重要的研究领域。目前,对MOA的了解仍然有限,普遍的共识将其病因归因于代谢综合征的核心组成部分:肥胖、高血糖、血脂异常和高血压。本文旨在从流行病学和分子生物学的角度对代谢综合征与骨性关节炎之间的复杂关系进行综述,并探讨代谢综合征在骨性关节炎治疗中的潜在靶向策略。方法:本叙述性综述评估了PubMed(2010-2024)的文献,研究了代谢综合征与OA相关的临床和机制证据,包括针对MetS-OA的治疗研究。结果代谢综合征通过代谢生物标志物(脂肪因子、晚期糖基化终产物和氧化LDL)、代谢反应(氧化应激、胰岛素抵抗和缺血性缺氧损伤)和异常活化细胞(脂肪细胞和巨噬细胞)加重MetS-OA软骨损伤。它最终通过炎症介质导致MetS-OA滑膜炎的加重。结论探索代谢综合征与OA之间的关系有助于制定代谢综合征的靶向治疗策略,包括目前fda批准的治疗代谢综合征的药物和潜在的靶向代谢因子的药物,这可能为未来代谢综合征的治疗提供新的途径。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
Inflammatory mechanisms underlying metabolic syndrome-associated and potential treatments

Objectives

Osteoarthritis (OA), a debilitating disease, has been recognized as a heterogenous disease, with metabolic syndrome-associated osteoarthritis (MetS-OA) emerging as a significant area of interest. Currently, the understanding of MOA remains limited, with a prevailing consensus attributing its etiology to the core components of metabolic syndrome: obesity, hyperglycemia, dyslipidemia, and hypertension. The aim of this review is to summarize the current understanding of the complex relationship between metabolic syndrome and OA from the perspectives of epidemiology and molecular biology, and to explore potential targeting strategies for metabolic syndrome in MetS-OA management.

Methods

This narrative review evaluated literature (2010–2024) from PubMed, examining clinical and mechanistic evidence linking metabolic syndrome to OA, including therapeutic studies targeting MetS-OA.

Results

Metabolic syndrome aggravate the cartilage injury in MetS-OA through metabolic biomarkers (adipokines, advanced glycation end-products and oxidized LDL), metabolic responses (oxidative stress, insulin resistance and ischemic hypoxic injuries), and abnormally activated cells (adipocytes and macrophages). It ultimately lead to the aggravation of synovitis in MetS-OA through inflammatory mediators.

Conclusions

The exploration of the relationship between metabolic syndrome and OA could benefit the development of targeting strategies for MetS-OA, including currently FDA-approved drugs for the treatment of metabolic syndrome and potential drugs targeting metabolic factors, which might provide a novel avenue for the future management of MetS-OA.
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来源期刊
Osteoarthritis and cartilage open
Osteoarthritis and cartilage open Orthopedics, Sports Medicine and Rehabilitation
CiteScore
3.30
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