Osteoarthritis and cartilage open最新文献

{"title":"The relationship between circulating and tissue biomarkers and OA-related pain: A systematic literature review","authors":"Sylvain Mathieu ,&nbsp;Liisa Kuhi ,&nbsp;Marie Binvignat ,&nbsp;Philip G. Conaghan ,&nbsp;Niels Eijkelkamp ,&nbsp;Yves Henrotin ,&nbsp;Eva Kosek ,&nbsp;Ali Mobasheri ,&nbsp;Hans-George Schaible ,&nbsp;Kalle Kisand ,&nbsp;Jérémie Sellam","doi":"10.1016/j.ocarto.2025.100684","DOIUrl":"10.1016/j.ocarto.2025.100684","url":null,"abstract":"<div><h3>Objective</h3><div>This study aimed to provide an overview of the relationship between osteoarthritis (OA) pain and various fluid biomarkers by conducting a systematic literature review (SLR), to help the development of OA-related pain endotyping.</div></div><div><h3>Method</h3><div>An SLR was conducted, using the PubMed, Embase, Scopus, Web of Science and the Cochrane Library databases, up to December 2024. Pain measures (VAS, WOMAC, HOOS/KOOS, AUSCAN, PainDETECT and Pain Pressure Threshold) were analysed for their association with circulating biomarkers in blood, urine, synovial and cerebrospinal fluids or tissue and genetic biomarkers. Biomarkers were categorised as “associated” depending on statistical significance and further subcategorised as “consistently associated”, “uncertainly associated” or “not associated” based on the quality of evidence determined by the number of studies, sample size and the strength of correlation.</div></div><div><h3>Results</h3><div>The five databases yielded 30,088 citations, of which 263 relevant papers were selected. Total cholesterol in the blood was the only biomarker consistently associated with pain. Among blood biomarkers, CRP, hsCRP and IL-17 showed suggestive but inconsistent associations with OA-related pain. In synovial fluid, IL-17, C2C and VEGF were consistently associated with increasing pain intensity, based on multiple concordant studies. In cerebrospinal fluid, CX3CL1 and Flt-1 were consistently associated with pain, displaying a negative correlation.</div></div><div><h3>Conclusion</h3><div>This SLR identified no relevant biomarkers in different body fluids that were associated with OA-related pain. Further investigation of CRP and IL-17 is required to achieve greater consistency across studies.</div></div><div><h3>PROSPERO</h3><div>CRD42024550244.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100684"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145109130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Willingness to participate in a randomized trial of surgical vs. nonoperative care among patients with meniscal tear and knee pain after a course physical therapy","authors":"Katharine B. Fox ,&nbsp;Kyna Long ,&nbsp;Jon Dhani ,&nbsp;Faith Selzer ,&nbsp;Andrea L. Carland ,&nbsp;Paul M. Oh ,&nbsp;Nomi S. Weiss-Laxer ,&nbsp;Jeffrey N. Katz","doi":"10.1016/j.ocarto.2025.100698","DOIUrl":"10.1016/j.ocarto.2025.100698","url":null,"abstract":"<div><h3>Objective</h3><div>Randomized controlled trials (RCTs) frequently fail to meet sample size requirements within their proposed timeline. Prospective preference assessments (PPAs) estimate the number of eligible individuals likely to enroll. The COSMIC Trial (Conservative care or Surgery for Meniscal tear after IneffeCtive physical therapy), currently in planning stages, will compare arthroscopic partial meniscectomy (APM) to non-operative treatment among those with meniscal tear who experience knee pain following a course of physical therapy (PT). We conducted a PPA to estimate willingness to enroll in the hypothetical trial and identify factors associated with willingness.</div></div><div><h3>Method</h3><div>We invited eligible patients 45–85 years old with meniscal tear who were prescribed PT to participate in the PPA. Participants completed up to two questionnaires: one prior to a course of PT (Baseline questionnaire), and another following 10 weeks of PT (End of PT questionnaire). Both questionnaires assessed willingness to enroll in the COSMIC trial and knee treatment preferences.</div></div><div><h3>Results</h3><div>In total, 94 participants completed both questionnaires, and 50 completed the End of PT questionnaire only. For those who completed both questionnaires, willingness to enroll in the hypothetical COSMIC RCT fell from 62 ​% at Baseline to 46 ​% in the End of PT questionnaires. Respondents’ strongest preference was to avoid APM (47 ​%). Preference for APM at baseline was associated with willingness to enroll.</div></div><div><h3>Conclusions</h3><div>Our findings suggest that about half of eligible patients would be willing to participate in the COSMIC RCT and that, except for APM, participants’ preference for treatments was not strongly related to willingness to participate.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100698"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465393","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A proteomics investigation of primary human articular chondrocyte isolation","authors":"Abby Brumwell ,&nbsp;Simran Raheja ,&nbsp;William Cawley ,&nbsp;Emily Birkett-Jones ,&nbsp;Sarah E. Orr ,&nbsp;Caitlin Todd ,&nbsp;David J. Deehan ,&nbsp;Nichola J. Conlon ,&nbsp;Matthias Trost ,&nbsp;Sarah J. Rice","doi":"10.1016/j.ocarto.2025.100664","DOIUrl":"10.1016/j.ocarto.2025.100664","url":null,"abstract":"<div><h3>Objective</h3><div>Human primary articular chondrocytes (hPACs) are routinely isolated from articular cartilage for pre-clinical OA research. Collagenase digest of tissue is an essential step, yet the impact of lengthy enzymatic incubation on the hPAC phenotype is unclear. We aimed to delineate this through proteomic analysis.</div></div><div><h3>Design</h3><div>hPACs were isolated from human knee cartilage (n ​= ​4) from patients undergoing total knee replacement. Collagenase treatment was performed with or without prior fixation of the tissue. Proteomes were quantified using LC-MS/MS. The Proteomic Ruler was employed to estimate protein copy numbers and cell protein masses. Significant differences in protein intensities were determined using paired t-testing and Benjamini-Hochberg correction. Proteomic data were integrated with existing transcriptomes (GSE217871) of hPACs and ground cartilage (<em>ex vivo</em>) RNA.</div></div><div><h3>Results</h3><div>Following collagenase treatment, we identified 498 differentially expressed proteins (DEP) in the unfixed cells. We observed depletion of FOXO signaling and enrichment of ribosomal RNA processing, indicative of increased cell cycle progression. This was supported by depletion of cell cycle inhibitors including CDKN1C. Transcriptomic analysis identified 3937 differentially expressed genes (DEG), and a 53 ​% overlap in DEP and DEG. Propidium iodide staining did not identify significant differences in cell cycle between fixed and unfixed hPACs.</div></div><div><h3>Conclusions</h3><div>We identified shifts in the proteome and transcriptome of hPACs following collagenase digest, supporting the use of tissue fixation before extracting nucleic acids for analysis where possible. Despite widespread expression changes, hPACs largely retain their chondrocyte phenotype. These datasets and analyses will serve as a valuable resource for the OA and cartilage research community.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100664"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145158068","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Methodology and predictive accuracy of the prospective preference assessment for randomized trial enrollment: A literature review","authors":"Jon S. Dhani ,&nbsp;Faith Selzer ,&nbsp;Jamie E. Collins ,&nbsp;Katharine B. Fox ,&nbsp;Paul Oh ,&nbsp;Elena Losina ,&nbsp;Jeffrey N. Katz","doi":"10.1016/j.ocarto.2025.100696","DOIUrl":"10.1016/j.ocarto.2025.100696","url":null,"abstract":"<div><h3>Objective</h3><div>The success of a randomized controlled trial (RCT) depends, in part, on the willingness to participate (WTP) of eligible subjects. Prospective preference assessments (PPA) offer insights into future RCT enrollment by evaluating eligible individuals’ WTP in the RCT. We sought to summarize the methods and findings of published PPAs and to compare the WTP estimates of published PPAs to the actual enrollment rates from these trials.</div></div><div><h3>Design</h3><div>We performed a systematic literature search using PubMed for studies that assessed eligible participants’ WTP in a hypothetical trial. We abstracted sample size, proposed interventions, WTP response options, WTP percentage, presence of qualitative analyses, and assessment of trial feasibility from each publication. We defined WTP as a response of “probably” or “definitely” willing in the PPA; in sensitivity analyses, we included only “definitely” willing responses. We searched for registered and published RCTs connected to each PPA and extracted enrollment data from the corresponding trial publications where available.</div></div><div><h3>Results</h3><div>We identified 40 PPAs. The median WTP across all PPAs was 54.9 ​% (range: 13 ​%–92.4 ​%), and 42.1 ​% (range: 7 ​%–90.2 ​%) when including only “definitely willing” responses. We found ten registered RCTs; five are completed and one is ongoing. Four PPAs with a RCT provided both “definitely willing” and “total willing” estimates. In three of these four RCTs, the actual enrollment fell between the “definitely willing” and “total willing” PPA estimates.</div></div><div><h3>Conclusion</h3><div>“Definitely willing” and “total willing” findings in a PPA may provide useful upper and lower boundaries on participation for future trial planning.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100696"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145465343","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Exploring the relationship between allostatic load and osteoarthritis: A cross-sectional analysis from the North West Adelaide Health Study","authors":"Sarah N. Schwetlik ,&nbsp;Katherine L. Baldock ,&nbsp;Catherine L. Hill ,&nbsp;Tiffany K. Gill ,&nbsp;Katia Ferrar","doi":"10.1016/j.ocarto.2025.100689","DOIUrl":"10.1016/j.ocarto.2025.100689","url":null,"abstract":"<div><h3>Objective</h3><div>Cumulative stress-response system dysregulation, known as allostatic load (AL), is suggested as a possible mechanism that may connect upstream health determinants with OA. Our objective was to evaluate the cross-sectional association between AL and the presence of OA.</div></div><div><h3>Design</h3><div>This cross-sectional study used Stage Two (2004–2006) data from the North West Adelaide Health Study (NWAHS), a population-based cohort study. Osteoarthritis and joint pain were defined using self-report and medication data. Allostatic load was a composite index of nine equally-weighted biomarkers; systolic and diastolic blood pressures, waist-hip ratio, body mass index, total cholesterol, high-density lipoprotein, glycated haemoglobin, interleukin 6 and tumour necrosis factor alpha. Binary logistic regression models estimated the association between AL and OA, with adjustment for demographic, health behaviour and comorbidity covariates.</div></div><div><h3>Results</h3><div>Overall, 1600 participants were eligible for inclusion in the analysis. The OA group (<em>n</em> ​= ​459) and the group without arthritis (<em>n</em> ​= ​1151) had mean AL scores of 3.96 (SD 2.3) and 2.68 (SD 2.0), respectively. In adjusted analyses, each one-unit increase in AL was associated with a 12 ​% increased odds of OA presence (OR ​= ​1.12, 95 ​% CI 1.04, 1.19, <em>P</em> ​= ​0.002). There was a similar 11 ​% increase in odds of the presence of self-reported joint pain for every one-unit increase in AL score (OR ​= ​1.11, 95 ​% CI 1.04, 1.18, <em>P</em> ​= ​0.001).</div></div><div><h3>Conclusions</h3><div>There is a cross-sectional association between AL and the presence of OA and self-reported joint pain. Further investigations are warranted using longitudinal data.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100689"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265593","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The construct validity and responsiveness of measures of the predictability of intermittent knee pain in knee osteoarthritis","authors":"Gillian A. Hawker ,&nbsp;Hayton Chui ,&nbsp;Ian Stanaitis ,&nbsp;Lauren K. King ,&nbsp;Aileen M. Davis","doi":"10.1016/j.ocarto.2025.100693","DOIUrl":"10.1016/j.ocarto.2025.100693","url":null,"abstract":"<div><h3>Objective</h3><div>The Intermittent and Constant Osteoarthritis Pain (ICOAP) questionnaire was developed to assess the osteoarthritis (OA) pain experience, but does not currently incorporate pain predictability, which people with OA considered important. We assessed the construct validity and responsiveness of two supplemental questions assessing the frequency of predictable and unpredictable intermittent knee pain.</div></div><div><h3>Design</h3><div>This was a secondary analysis of a prospective cohort of individuals aged 30 years or older undergoing total knee arthroplasty, TKA, for knee OA. Standardized questionnaires assessed socio-demographics, health status, ICOAP intermittent and constant pain subscales, the frequency of predictable and unpredictable intermittent knee pain (5-point Likert scale from never to very often), KOOS-QOL, and two ICOAP comparator measures (Pain Catastrophizing, and Perceived Arthritis Coping Efficacy), pre- and 12-months post-TKA. Construct validity was assessed by examining the Spearman correlations between pre-TKA predictability scores, ICOAP, KOOS QOL and comparator measures. Responsiveness was assessed with standardized response means (SRMs) for pre-post TKA change in predictability scores.</div></div><div><h3>Results</h3><div>Of 1366 participants (mean age 67.2 years; 60.8 ​% female), 1302 had intermittent knee pain. Predictable and unpredictable pain were reported ‘very often’ by 35.3 ​% and 18.1 ​%, respectively. Spearman correlations for frequency of predictable intermittent knee pain with KOOS QOL, PCS and Coping Efficacy were 0.39, 0.32 and −0.15, respectively; for unpredictable pain, correlations were 0.46, 0.46 and −0.27, respectively (p ​&lt; ​0.0001 for all). SRMs were 1.23 for predictable and 1.31 for unpredictable pain.</div></div><div><h3>Conclusion</h3><div>Our findings support the construct validity and responsiveness of the two predictability items.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100693"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145265594","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Diffusion model-empowered patella shape analysis predicts knee osteoarthritis outcomes","authors":"Sing-Hin Lau ,&nbsp;Lok-Chun Chan ,&nbsp;Tianshu Jiang ,&nbsp;Jiang Zhang ,&nbsp;Xiangqiao Meng ,&nbsp;Wei Wang ,&nbsp;Ping-Keung Chan ,&nbsp;Jing Cai ,&nbsp;Ping Li ,&nbsp;Chunyi Wen","doi":"10.1016/j.ocarto.2025.100663","DOIUrl":"10.1016/j.ocarto.2025.100663","url":null,"abstract":"<div><h3>Objective</h3><div>We developed and validated an artificial intelligence pipeline that leverages diffusion models to enhance prognostic assessment of knee osteoarthritis (OA) by analyzing longitudinal changes in patella shape on lateral knee radiographs.</div></div><div><h3>Method</h3><div>In this retrospective study of 2,913 participants from the Multicenter Osteoarthritis Study, left-knee weight-bearing lateral radiographs obtained at baseline and 60 months were analyzed. Our pipeline commences with an automatic segmentation for patella shapes, followed by a diffusion model to predict patella shape trajectories over 60 months. We developed the Synthetic Patella Shape Incorporated Convolutional Neural Network (SynPatNet), a specialized 2-channel 1-dimensional convolutional neural network (CNN), to incorporate both baseline and synthetic follow-up patella shapes for predicting key outcomes of disease onset and end-stage.</div></div><div><h3>Results</h3><div>The diffusion model generates plausible synthetic patella shapes that predict deformations and osteophyte developments at the 60-month follow-up. Incorporating synthetic follow-up shapes with baseline patella shapes significantly improved OA outcome prediction: for patellofemoral OA onset, SynPatNet achieved an area under receiver operating characteristic curve (AUC) of 0.909 (vs. 0.830 for baseline model); for knee replacement, an AUC of 0.823 (vs. 0.773 for baseline). Augmenting Kellgren-Lawrence (KL) grade with SynPatNet further improved knee replacement prediction (AUC 0.838) over KL grade alone (AUC 0.785). Noteworthily, our knee replacement risk prediction score showed significant correlations with MRI-based (osteophytes/cartilage morphology/bone attrition) gradings, with Spearman's rho up to (0.51/0.33/0.31, p ​&lt; ​0.001).</div></div><div><h3>Conclusion</h3><div>Generative diffusion modelling of patellar morphology on lateral knee radiographs provides complementary information to conventional radiographic and clinical metrics that substantially improves prognostication of knee OA.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100663"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144903947","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Longitudinal associations between bilateral versus unilateral knee osteoarthritis and physical performance measures","authors":"Jennifer S. Hanberg ,&nbsp;Faith Selzer ,&nbsp;Elena Losina ,&nbsp;Jeffrey N. Katz ,&nbsp;Jamie E. Collins","doi":"10.1016/j.ocarto.2025.100676","DOIUrl":"10.1016/j.ocarto.2025.100676","url":null,"abstract":"<div><h3>Background</h3><div>Bilateral knee osteoarthritis (KOA) is common, but evidence for the effect of bilateral versus unilateral KOA on functional outcomes is conflicting. We aimed to examine the association between bilateral versus unilateral KOA and physical performance measures over two years.</div></div><div><h3>Methods</h3><div>Our cohort included adults with symptomatic, radiographic KOA. Study assessments at baseline, 12 and 24 months included the 30-s chair sit-to-stand task (CST) and 40-m walk (40 ​MW). We defined bilateral KOA as Kellgren-Lawrence grade ≥2 and Knee Osteoarthritis Outcome Pain Scale ≥17/100 in both knees. We used linear mixed models to (1) assess the cross-sectional association between the presence of bilateral versus unilateral KOA at each timepoint and performance measures, and (2) assess the association between bilateral versus unilateral KOA at baseline and longitudinal changes in performance measures. Models were adjusted for clinical and demographic covariates.</div></div><div><h3>Results</h3><div>101 participants were included. At baseline, 43/101 (43 ​%) had bilateral KOA. In adjusted models, bilateral, versus unilateral, KOA was associated with 1.0 fewer stands on the CST (95 ​% CI: 2.2–0.1), and a 0.03 ​m/s slower 40 ​MW (95 ​% CI: 0.10–0.04). Average 2-year change in CST was −0.6 stands in those with baseline bilateral KOA and −0.7 in those with unilateral KOA (between-group difference, 0.1 stands (95 ​% CI: 1.7–1.8)). The baseline bilateral KOA group had greater worsening in 40 ​MW time (between-group difference −0.10 ​m/s (95 ​% CI: -0.20–0.00)).</div></div><div><h3>Conclusions</h3><div>We did not find clinically significant associations between bilateral vs unilateral KOA and performance on two physical performance tasks over two years of follow-up in this cohort study.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100676"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145018376","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Erratum to ‘Causal association between subtypes of osteoarthritis and common comorbidities: A Mendelian randomisation study’ [Osteoarthritis and Cartilage Open 5 (2023) 100414]","authors":"Will Thompson ,&nbsp;Subhashisa Swain ,&nbsp;Sizheng Steven Zhao ,&nbsp;Anne Kamps ,&nbsp;Carol Coupland ,&nbsp;Changfu Kuo ,&nbsp;Sita Bierma-Zeinstra ,&nbsp;Jos Runhaar ,&nbsp;Michael Doherty ,&nbsp;Weiya Zhang","doi":"10.1016/j.ocarto.2025.100660","DOIUrl":"10.1016/j.ocarto.2025.100660","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100660"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145415570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Cartilage loss is greater in knees with virtual joint replacement status than in matched controls without","authors":"Felix Eckstein ,&nbsp;Wolfgang Wirth ,&nbsp;Ali Guermazi ,&nbsp;Frank Roemer ,&nbsp;Michael Nevitt ,&nbsp;Christoph Ladel ,&nbsp;Leena Sharma ,&nbsp;David J. Hunter ,&nbsp;C. Kent Kwoh","doi":"10.1016/j.ocarto.2025.100658","DOIUrl":"10.1016/j.ocarto.2025.100658","url":null,"abstract":"<div><h3>Objective</h3><div>We examined whether the trajectory of femorotibial cartilage loss differs between knees meeting a clinically defined virtual knee replacement (vKR) status based on patient-reported outcomes vs. those with low probability.</div></div><div><h3>Design</h3><div>vKR cases (highest 10 ​% of probabilities for having surgical KR) were selected using knee pain and quality of life criteria, developed from knees with actual KR. Knees reaching such symptom state at 48 months (M) follow-up (vKR case 60 ​M) were matched 1:1 with vKR controls (lowest 20 ​% probability) by sex, age, and baseline radiographic status. Of 65 knees displaying vKR case status at 60 ​M; 33 maintained or increased pain and QOL levels at 72 ​M (vKR+/+); 32 did not (vKR+/−). The thickness of medial and lateral tibial and femoral cartilages was determined from MRI, at up to five annual visits prior to 60 ​M.</div></div><div><h3>Results</h3><div>vKR case knees displayed substantially greater central medial femorotibial compartment cartilage thickness loss 2 years prior to reaching case status (−151 ​± ​337 [mean ​± ​SD] vs. −38 ​± ​249 ​μm; odds ratio [OR] 1.95 (95 ​% confidence interval: 1.23–3.08). Cartilage loss did not apparently differ between vKR+/+ and vKR +/− knees (p ​= ​0.73).</div></div><div><h3>Conclusions</h3><div>Substantially greater cartilage thickness loss was detected in knees reaching vKR case status defined by patient-reported clinical criteria vs. vKR controls. This was found independently of whether this status was maintained at a later annual visit. The observed association suggests greater knee cartilage loss to be prospectively related to worse clinical outcome. It indicates further that the vKR criterion used here may be useful to explore relationships with other structural (imaging) assessments.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 4","pages":"Article 100658"},"PeriodicalIF":2.8,"publicationDate":"2025-12-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144864812","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}