Osteoarthritis and cartilage open最新文献

{"title":"Hydroxycitric acid reconstructs damaged articular cartilages by modifying the metabolic cascade in chondrogenic cells","authors":"Yoshiyuki Mizushina ,&nbsp;Liping Sun ,&nbsp;Megumi Nishio ,&nbsp;Sanae Nagata ,&nbsp;Takeshi Kamakura ,&nbsp;Masayuki Fukuda ,&nbsp;Kousuke Tanaka ,&nbsp;Junya Toguchida ,&nbsp;Yonghui Jin","doi":"10.1016/j.ocarto.2024.100564","DOIUrl":"10.1016/j.ocarto.2024.100564","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis, a degenerative joint disease, requires innovative therapies due to the limited ability of cartilage to regenerate. Since mesenchymal stem cells (MSCs) provide a cell source for chondrogenic cells, we hypothesize that chemicals capable of enhancing the chondrogenic potential of MSCs with transforming growth factor-beta (TGFβ) in vitro may similarly promote chondrogenesis in articular cartilage in vivo.</div></div><div><h3>Design</h3><div>Chemical compounds that enhance the TGFβ signaling for chondrogenesis were investigated utilizing mesenchymal stem cells derived from human induced pluripotent stem cells. The mechanisms of action underlying the identified compound were explored in vitro, and its therapeutic effects were validated in vivo using a mouse model of exercise-induced osteoarthritis.</div></div><div><h3>Results</h3><div>Hydroxycitric acid (HCA) emerged as the lead compound. In vitro, HCA effectively enhanced chondrogenesis by inhibiting ATP citrate lyase, inducing citrate and alpha-ketoglutarate (α-KG), while reducing cytosolic acetyl coenzyme A (Ac-CoA). This induction of α-KG promoted collagen prolyl-4-hydroxylase activity, boosting hydroxyproline production and matrix formation. The reduction of Ac-CoA attenuated the inhibitory effect of β-catenin on mitochondrial activity by diminishing its acetylation. In vivo, orally administered HCA accumulated in joint tissues of mice and histological examination demonstrated newly synthesized cartilage tissues in damaged area. Analysis of joint tissue extracts revealed a downregulation of Ac-CoA and an upregulation of citrate and α-KG, accompanied by a systemic increase in an anabolic biomarker.</div></div><div><h3>Conclusions</h3><div>HCA demonstrates promise as an osteoarthritis therapy by enhancing chondrogenic differentiation. Its ability to modulate crucial metabolic pathways and facilitate cartilage repair suggests potential for clinical translation, addressing a critical need in the treatment of osteoarthritis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100564"},"PeriodicalIF":0.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11743121/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017939","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The PIKASO trial (Preventing Injured Knees from Osteoarthritis: Severity Outcomes): Rationale and design features for a randomized controlled trial","authors":"Cale A. Jacobs ,&nbsp;Morgan H. Jones ,&nbsp;Jamie E. Collins ,&nbsp;Lily M. Waddell ,&nbsp;Xiaojuan Li ,&nbsp;Carl S. Winalski ,&nbsp;Brian Pietrosimone ,&nbsp;Virginia Byers Kraus ,&nbsp;Miguel Otero ,&nbsp;Elizabeth Wellsandt ,&nbsp;Laura C. Schmitt ,&nbsp;Kurt P. Spindler ,&nbsp;Donald D. Anderson ,&nbsp;Scott A. Rodeo ,&nbsp;Robert A. Magnussen ,&nbsp;Brian R. Wolf ,&nbsp;Joe M. Hart ,&nbsp;Austin V. Stone ,&nbsp;Caitlin E. Conley ,&nbsp;Yvonne M. Golightly ,&nbsp;Elena Losina","doi":"10.1016/j.ocarto.2024.100563","DOIUrl":"10.1016/j.ocarto.2024.100563","url":null,"abstract":"<div><h3>Objective</h3><div>Given the high burden and increasing prevalence of post-traumatic osteoarthritis (PTOA), identifying clinically beneficial strategies to prevent or delay its onset could improve the quality of life of those at high risk of developing the disease.</div></div><div><h3>Methods</h3><div>Preventing Injured Knees from OsteoArthritis: Severity Outcomes (PIKASO) is a multicenter blinded, parallel, two-arm randomized controlled trial of 512 individuals aged 18–45 years undergoing anterior cruciate ligament reconstruction (ACLR). This study is designed to evaluate the efficacy of a 12-month intervention of oral metformin vs. placebo in decreasing the rate of structural knee changes and pain. Participants will be asked to take up to 1500 ​mg/day of either metformin or placebo as tolerated. The primary outcomes are Knee injury and Osteoarthritis Outcome Score (KOOS) Pain subscale scores averaged between 12 and 24 months after randomization, and MRI derived cartilage structural change at 24 months. The trial will be deemed successful if at least one of the two primary outcomes reaches the preplanned effect size with sufficient statistical certainty. In this paper, we describe PIKASO elements according to the Standard Protocol Items: Recommendations for Interventional Trials (SPIRIT) guidelines.</div></div><div><h3>Results</h3><div>Our multidisciplinary team developed the methods and statistical analysis plan for a placebo controlled, randomized clinical trial to determine whether metformin alters pain and early osteoarthritic changes after ACLR.</div></div><div><h3>Discussion</h3><div>This manuscript outlines the rationale, study design, and implementation of the PIKASO trial aiming to prevent the onset of PTOA after ACLR.</div></div><div><h3>Trial registration</h3><div>clinicaltrials.gov NCT06096259.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100563"},"PeriodicalIF":0.0,"publicationDate":"2024-12-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11758201/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143048745","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Inter-assay variability in the measurement of urinary C-terminal cross-linked telopeptide of type II collagen following anterior cruciate ligament reconstruction","authors":"Lachlan M. Batty ,&nbsp;Kate E. Webster ,&nbsp;Natasha Vassileff ,&nbsp;Jereme G. Spiers ,&nbsp;Haydn J. Klemm ,&nbsp;Brian Devitt ,&nbsp;Timothy S. Whitehead ,&nbsp;Andrew F. Hill ,&nbsp;Julian A. Feller","doi":"10.1016/j.ocarto.2024.100561","DOIUrl":"10.1016/j.ocarto.2024.100561","url":null,"abstract":"<div><h3>Objective</h3><div>To compare urinary C-terminal cross-linked telopeptide of type II collagen (u-CTX-II) concentrations and trends as measured by two different commercially available enzyme-linked immunosorbent assays (ELISA) in a cohort of patients in the first year following anterior cruciate ligament (ACL) reconstruction.</div></div><div><h3>Design</h3><div>22 ACL-injured patients undergoing reconstructive surgery (mean age 25.2 (SD 8.0) years; 12 (54.5 ​%) male) had urine samples taken on the day of surgery (baseline) and at 6 and 12 months post-operatively. Concentrations of u-CTX-II were measured using the CloudClone® and the CartiLaps® ELISA. u-CTX-II concentrations were normalized to urinary creatinine (Cr).</div></div><div><h3>Results</h3><div>The u-CTX-II concentrations were significantly different between the 2 assays at each timepoint (p ​≤ ​0.01). When measured using the CloudClone® Assay, mean (standard error) u-CTX-II concentrations were 26.5 (2.5) ng/mmol Cr, 29.4 (3.8) ng/mmol Cr and 40.6 (6.9) ng/mmol Cr at the baseline, 6-month and 12-month timepoints respectively. When measured using the CartiLaps® Assay, at the same respective timepoints, u-CTX-II concentrations were 981.2 (256.5) ng/mmol Cr, 867.0 (234.3) ng/mmol Cr and 764.3 (220.3) ng/mmol Cr. Concentrations of u-CTX-II using the CloudClone® Assay increased with time (p ​= ​0.04). Concentrations of u-CTX-II using the CartiLaps® Assay decreased over time (p ​= ​0.2).</div></div><div><h3>Conclusion</h3><div>Using two commercially available assays, u-CTX-II differed significantly in terms of both concentration and trends in the first year following ACL reconstruction. The specific assay used is critical to consider when interpreting results and has implications for pooling data and meta-analysis.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100561"},"PeriodicalIF":0.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733031/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017962","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Protocol for the MERINO study: A randomized placebo-controlled trial assessing the efficacy, safety, and cost-effectiveness of methotrexate in people with erosive hand osteoarthritis","authors":"Alexander Mathiessen ,&nbsp;Line Gaundal ,&nbsp;Joseph Sexton ,&nbsp;Dag Sjølie ,&nbsp;Pernille Steen Pettersen ,&nbsp;Barbara Slatkowsky-Christensen ,&nbsp;Ida Kristin Haugen","doi":"10.1016/j.ocarto.2024.100558","DOIUrl":"10.1016/j.ocarto.2024.100558","url":null,"abstract":"<div><h3>Objective</h3><div>Previous studies on the efficacy of methotrexate in people with hand osteoarthritis (OA) have shown conflicting results. The MERINO trial aims to investigate the efficacy and safety of methotrexate in people with painful inflammatory erosive hand OA.</div></div><div><h3>Design</h3><div>In total 163 participants with erosive hand OA, synovitis by ultrasound, and finger joint pain of 40–80 ​mm on a visual analogue scale (VAS) will be recruited from a rheumatology outpatient clinic. Participants are randomized 1:1 to receive either encapsulated oral methotrexate 20 ​mg/week or placebo for 12 months in a double-blind manner. The primary endpoint is VAS finger joint pain at 6 months. Key secondary outcomes are hand function by the Australian/Canadian hand index (AUSCAN) at 6 months and radiographic progression by the Verbruggen-Veys anatomical phase scoring system at 12 months. Other secondary endpoints include hand stiffness, disease activity, health-related quality of life, grip strength, clinical joint counts, synovitis by ultrasound and MRI, bone marrow lesions by MRI, cost-effectiveness, and symptoms in knees and hips. Adverse events will be recorded. The primary analysis will be performed on full analysis set.</div></div><div><h3>Conclusions</h3><div>The findings of this trial will be clinically relevant for patients with erosive hand OA and may influence future treatment recommendations.</div></div><div><h3>Clinical trial registration</h3><div>EU CT number: 2023-510523-30-00, NCT04579848.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100558"},"PeriodicalIF":0.0,"publicationDate":"2024-12-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Intra-articular injection of inorganic pyrophosphate improves IL-1β-induced cartilage damage in rat model of knee osteoarthritis in vivo","authors":"Émilie Velot,&nbsp;Mathilde Guibert,&nbsp;Meriem Koufany,&nbsp;Arnaud Bianchi","doi":"10.1016/j.ocarto.2024.100560","DOIUrl":"10.1016/j.ocarto.2024.100560","url":null,"abstract":"<div><h3>Objective</h3><div>Osteoarthritis (OA) is the most common form of chronic joint disease, affecting mainly the elderly population. This disorder is caused by cartilage degeneration with complex changes in the chondrocyte phenotype. Inorganic pyrophosphate (PPi) was shown to counteract the detrimental effect of interleukin (IL)-1β challenging in an in vitro OA model based on rat articular chondrocytes. It also maintained the differentiated articular phenotype, mostly by down regulating wingless-related integration site (Wnt)-5a secretion. These observations suggest a PPi protective role for chondrocyte in vitro.</div></div><div><h3>Methods</h3><div>To address this hypothesis in vivo, we investigated the impact on knee joint of three intra-articular injection (IAI) of PPi in a rat model of cartilage damage induced by IAI of IL-1β, where cartilage degradation and synovial inflammation are similar to that observed in OA. Cartilage and synovial membrane were collected after 7 days of challenge by IL-1β.</div></div><div><h3>Results</h3><div>PPi was able to reduce the deleterious effect of IL-1β. This effect was observable on the expression of cartilage extracellular matrix metabolism markers and confirmed by histology with safranin O and hematoxylin-eosin-saffron (HES) staining. Inorganic pyrophosphate also repressed the Wnt5a expression induced by IL-1β. No effect was observed on the inflammatory response of the synovial membrane.</div></div><div><h3>Conclusion</h3><div>These results demonstrate that PPi improves IL-1β-induced cartilage damage in rat but not the associated inflammation of synovial membrane. Thus, PPi could become a molecule of interest to restrict the progression of this disorder.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100560"},"PeriodicalIF":0.0,"publicationDate":"2024-12-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11733043/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Knee joint extension limitation in female patients with knee osteoarthritis affects the infrapatellar fat pad hardness and hemoglobin concentration by isometric quadriceps exercise","authors":"Syoya Nakanishi ,&nbsp;Masahiro Tsutsumi ,&nbsp;Takashi Kitagawa ,&nbsp;Toshinori Miyashita ,&nbsp;Makoto Wada ,&nbsp;Shintarou Kudo","doi":"10.1016/j.ocarto.2024.100559","DOIUrl":"10.1016/j.ocarto.2024.100559","url":null,"abstract":"<div><h3>Objective</h3><div>To investigate whether there is a difference in hardness and hemoglobin concentration changes in the infrapatellar fat pad (IFP) during isometric quadriceps exercise (IQE) in patients with knee osteoarthritis (KOA) between those with and without knee extension limitation.</div></div><div><h3>Design</h3><div>In this cross-sectional study, data were collected at an orthopedic clinic from March 2022 to April 2023. Among patients diagnosed with KOA, those with knee joint extension range of motion &lt;0° and &gt;0° were defined as the limited group (n ​= ​16) and non-limited group (n ​= ​13), respectively. Ultrasonography was performed at rest and during IQE to measure IFP hardness based on shear wave velocity. Near-infrared spectroscopy was performed to measure oxygenated hemoglobin (O2Hb), deoxygenated hemoglobin (HHb), and total hemoglobin (cHb) in the IFP before (baseline), during (IQE task), and post IQE. IFP hardness and O2Hb, HHb, and cHb concentration were analyzed using a linear mixed model for the groups and measurement points.</div></div><div><h3>Results</h3><div>IFP hardness changes during IQE were significantly less in the limited group than in the non-limited group (limited: mean difference [MD] ​= ​−0.136, 95 ​% confidence interval [CI] [−0.475, 0.203]; non-limited: MD ​= ​−1.154, 95 ​% CI [−1.530, −0.778]). O2Hb concentration did not significantly change at post compared with baseline in the limited group but did in the non-limited group (limited: MD ​= ​−0.024, 95 ​% CI [−0.961, 0.913]; non-limited: MD ​= ​−4.118, 95 ​% CI [−5.156, −3.079]).</div></div><div><h3>Conclusions</h3><div>The limited group revealed no IFP hardness and hemoglobin concentration change following IQE, whereas the opposite was observed for the non-limited group, indicating oxygenation.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100559"},"PeriodicalIF":0.0,"publicationDate":"2024-12-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11728890/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142980839","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Tibiofemoral cartilage strain and recovery following a 3-mile run measured using deep learning segmentation of bone and cartilage","authors":"Patrick X. Bradley ,&nbsp;Sophia Y. Kim-Wang ,&nbsp;Brooke S. Blaisdell ,&nbsp;Alexie D. Riofrio ,&nbsp;Amber T. Collins ,&nbsp;Lauren N. Heckelman ,&nbsp;Eziamaka C. Obunadike ,&nbsp;Margaret R. Widmyer ,&nbsp;Chinmay S. Paranjape ,&nbsp;Bryan S. Crook ,&nbsp;Nimit K. Lad ,&nbsp;Edward G. Sutter ,&nbsp;Brian P. Mann ,&nbsp;Charles E. Spritzer ,&nbsp;Louis E. DeFrate","doi":"10.1016/j.ocarto.2024.100556","DOIUrl":"10.1016/j.ocarto.2024.100556","url":null,"abstract":"<div><h3>Objective</h3><div>We sought to measure the deformation of tibiofemoral cartilage immediately following a 3-mile treadmill run, as well as the recovery of cartilage thickness the following day. To enable these measurements, we developed and validated deep learning models to automate tibiofemoral cartilage and bone segmentation from double-echo steady-state magnetic resonance imaging (MRI) scans.</div></div><div><h3>Design</h3><div>Eight asymptomatic male participants arrived at 7 a.m., rested supine for 45 ​min, underwent pre-exercise MRI, ran 3 miles on a treadmill, and finally underwent post-exercise MRI. To assess whether cartilage recovered to its baseline thickness, participants returned the following morning at 7 a.m., rested supine for 45 ​min, and underwent a final MRI session. These images were used to generate 3D models of the tibia, femur, and cartilage surfaces at each time point. Site-specific tibial and femoral cartilage thicknesses were measured from each 3D model. To aid in these measurements, deep learning segmentation models were developed.</div></div><div><h3>Results</h3><div>All trained deep learning models demonstrated repeatability within 0.03 ​mm or approximately 1 ​% of cartilage thickness. The 3-mile run induced mean compressive strains of 5.4 ​% (95 ​% CI ​= ​4.1 to 6.7) and 2.3 ​% (95 ​% CI ​= ​0.6 to 4.0) for the tibial and femoral cartilage, respectively. Furthermore, both tibial and femoral cartilage thicknesses returned to within 1 ​% of baseline thickness the following day.</div></div><div><h3>Conclusions</h3><div>The 3-mile treadmill run induced a significant decrease in both tibial and femoral cartilage thickness; however, this was largely ameliorated the following morning.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100556"},"PeriodicalIF":0.0,"publicationDate":"2024-12-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11720442/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142973580","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Frontal plane mechanical leg alignment estimation from knee x-rays using deep learning","authors":"Kenneth Chen ,&nbsp;Christoph Stotter ,&nbsp;Christopher Lepenik ,&nbsp;Thomas Klestil ,&nbsp;Christoph Salzlechner ,&nbsp;Stefan Nehrer","doi":"10.1016/j.ocarto.2024.100551","DOIUrl":"10.1016/j.ocarto.2024.100551","url":null,"abstract":"<div><h3>Objective</h3><div>Lower limb malalignment can complicate symptoms and accelerate knee osteoarthritis (OA), necessitating consideration in study population selection. In this study, we develop and validate a deep learning model that classifies leg alignment as “normal” or “malaligned” from knee antero-posterior (AP)/postero-anterior (PA) radiographs alone, using an adjustable hip-knee-ankle (HKA) angle threshold.</div></div><div><h3>Material and methods</h3><div>We utilized 8878 digital radiographs, including 6181 AP/PA full-leg x-rays (LLRs) and 2697 AP/PA knee x-rays (2292 with positioning frame, 405 without). The model's evaluation involved two steps: In step 1, the model's predictions on knee images cropped from LLRs were compared against the ground truth from the original LLRs. In step 2, the model was tested on knee AP radiographs, using corresponding same-day LLRs as a proxy for ground truth.</div></div><div><h3>Results</h3><div>The model effectively classified alignment, with step one achieving sensitivity and specificity of 0.92 for a threshold of 7.5°, and 0.90 and 0.85 for 5°. For positioning frame images, step two showed a sensitivity of 0.85 and specificity of 0.81 for 7.5°, and 0.79 and 0.74 for 5°. For non-positioning frame images, sensitivity and specificity were 0.91 and 0.83 for 7.5°, and 0.9 and 0.86 for 5°.</div></div><div><h3>Conclusion</h3><div>The model developed in this study accurately classifies lower limb malalignment from AP/PA knee radiographs using adjustable thresholds, offering a practical alternative to LLRs. This can enhance the precision of study population selection and patient management.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100551"},"PeriodicalIF":0.0,"publicationDate":"2024-11-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11729668/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985730","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Everyday living with osteoarthritis in the global South: A qualitative focus group inquiry in Nigeria","authors":"Tolulope Owoyemi ,&nbsp;Ibidunni Alonge ,&nbsp;Oladapo Adetunji ,&nbsp;Emmanuel Ogbu ,&nbsp;Adebimpe Ogunbanjo ,&nbsp;Simon White ,&nbsp;Adewale Adebajo ,&nbsp;Christian Mallen ,&nbsp;Opeyemi O. Babatunde ,&nbsp;Krysia Dziedzic","doi":"10.1016/j.ocarto.2024.100555","DOIUrl":"10.1016/j.ocarto.2024.100555","url":null,"abstract":"<div><h3>Objective</h3><div>Africa contributes significantly to the increasing global prevalence (&gt;37 ​%), unmet need and treatment burden for people with osteoarthritis. Despite this, little research has examined the expressed needs of patients with osteoarthritis (OA) and joint pain in West-Africa. This study aimed to explore lived experiences, expressed needs and current care gaps for people living with osteoarthritis in low-health resource contexts using Nigeria as a case study.</div></div><div><h3>Design</h3><div>Qualitative study using Focus Groups. People aged 45 years and over living with osteoarthritis and joint pain were recruited at local health services or via wide advertisements in the community. Discussions were recorded and transcribed verbatim. Data were analyzed using thematic analysis (inductive approach).</div></div><div><h3>Results</h3><div>Three focus groups were conducted with people living with osteoarthritis (n ​= ​30, age range 45–90 years) across socio-demographic strata. Participants described their experiences of living with osteoarthritis as emotionally, physically, and socio-economically challenging. Four main themes (and 14 sub-themes) were identified. Participants expressed the need for an information and health education campaign and access to appropriate health professionals (especially physiotherapists) for providing support, guidance, and assistance with self-management.</div></div><div><h3>Conclusions</h3><div>The provision of an accessible, and contextually appropriate patient education package, in line with evidence-based recommendations is a critical need for people living with osteoarthritis in Nigeria. This will promote evidence-based care for OA in low-resource settings, empowering patients to self-manage and reducing confusion related to inconsistent advice and mixed messages about cause, healthcare access and OA care.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100555"},"PeriodicalIF":0.0,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11665529/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142883890","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Brain functional imaging contributions in osteoarthritis-related pain: A viewpoint","authors":"Camille Fauchon ,&nbsp;Marie Binvignat ,&nbsp;Francis Berenbaum ,&nbsp;Philip G. Conaghan ,&nbsp;Roland Peyron ,&nbsp;Jérémie Sellam","doi":"10.1016/j.ocarto.2024.100554","DOIUrl":"10.1016/j.ocarto.2024.100554","url":null,"abstract":"<div><h3>Objective</h3><div>Neuroimaging investigations are critical to provide a more direct assessment of brain disturbances associated with osteoarthritis (OA)-related pain, and to better understand its pathophysiology to develop new treatment strategies. This viewpoint aims to summarize the importance of the brain in OA pain.</div></div><div><h3>Method</h3><div>A European working group on pain in osteoarthritis GO-PAIN (Going Inside Osteoarthritis-related Pain Phenotyping) has been created to work on a global assessment of the OA-related pain. Relevant scientific literature was evaluated, summarized and discussed to expose advances in functional brain alterations related-to OA pain.</div></div><div><h3>Results</h3><div>Findings of neuroimaging studies are highly heterogenous and based on small sample size, but some key brain alterations associated with OA pain can be identified across experiments. A systematic literature review conducted by Hall and colleagues (2023) found lower activity, connectivity, and grey matter volume in the right anterior insula in patients with OA than in healthy controls. Other works also pointed out that activity of specific brain regions could serve as a potential surrogate biomarker, but several limitations and confounding factors needs to be addressed.</div></div><div><h3>Conclusions</h3><div>Brain functional imaging provides opportunities to accurately address an OA-related pain endophenotype. To encompass limitations and fill the gaps from the previous studies, we propose a blueprint for the next 5 years and stimulate ideas for others working in the field.</div></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"7 1","pages":"Article 100554"},"PeriodicalIF":0.0,"publicationDate":"2024-11-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11667684/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142886446","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}