Osteoarthritis and cartilage open最新文献

{"title":"Longitudinal changes in adiposity following anterior cruciate ligament reconstruction and associations with knee symptoms and function","authors":"Amélie Michaud ,&nbsp;Chris Koskoletos ,&nbsp;Brooke E. Patterson ,&nbsp;Kay M. Crossley ,&nbsp;Trevor B. Birmingham ,&nbsp;Adam G. Culvenor ,&nbsp;Harvi F. Hart","doi":"10.1016/j.ocarto.2024.100473","DOIUrl":"10.1016/j.ocarto.2024.100473","url":null,"abstract":"<div><h3>Objective</h3><p>To evaluate adiposity after anterior cruciate ligament reconstruction (ACLR): i) cross-sectionally (1-year post-ACLR) compared to uninjured controls; ii) longitudinally up to 5 years post-ACLR; and iii) associations with patient-reported symptoms and physical performance.</p></div><div><h3>Methods</h3><p>In 107 individuals post-ACLR and 19 controls, we assessed global (BMI), peripheral (subcutaneous adipose tissue thickness on the posteromedial side of knee MRI), and central (waist circumference in ACLR group) adiposity. Patient-reported symptoms (Knee injury and Osteoarthritis Outcome Score) and physical performance (hop for distance) were evaluated at 1 and 5 years post-ACLR. Linear regression models evaluated adiposity between groups. Paired t-tests evaluated changes in adiposity from 1- to 5 years post-ACLR. Linear regression models analyzed adiposity's associations with patient-reported symptoms and physical performance at 1-year post-ACLR, changes in symptoms and performance over 4 years post-ACLR, and longitudinal changes in adiposity and symptoms and performance, controlling for age, sex, and activity level.</p></div><div><h3>Results</h3><p>Individuals 1-year post-ACLR were associated with higher average global (3 ​kg/m²) and peripheral adiposity (2.3 ​mm). From 1- to 5 years post-ACLR, higher average global (0.58 ​kg/m²) and central (5 ​cm) adiposity, and lower average peripheral adiposity (1.3 ​mm) were observed. In general, adiposity at one-year post-ACLR was negatively associated with patient-reported symptoms and physical performance, and changes from 1 to 5 years post-ACLR. Increases in adiposity were negatively associated with changes in patient-reported symptoms and physical performance over four years post-ACLR.</p></div><div><h3>Conclusion</h3><p>Greater global and central adiposity is a feature of young adults following ACLR and influences current and future patient-reported symptoms and physical performance.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100473"},"PeriodicalIF":0.0,"publicationDate":"2024-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000402/pdfft?md5=c04776d90082c80bdde6a432ee7d82c0&pid=1-s2.0-S2665913124000402-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140764344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Visual narratives in medicine – Bridging the gap in graphic medicine with an illustrated narrative of osteoarthritis","authors":"Vicky Duong ,&nbsp;Samantha Bunzli ,&nbsp;Leigh F. Callahan ,&nbsp;Corné Baatenburg de Jong ,&nbsp;David J. Hunter ,&nbsp;Jason S. Kim ,&nbsp;Ali Mobasheri","doi":"10.1016/j.ocarto.2024.100471","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100471","url":null,"abstract":"<div><h3>Objective</h3><p>Visual narratives have been used in medicine to share information in the form of stories with the potential to improve understanding of conditions and change behaviours. One genre of visual narratives is “graphic medicine”, which integrates comics into medical education and the delivery of healthcare. Graphic medicine can maximise the impact of research findings by presenting them in a more accessible format, which may be particularly useful in certain populations, such as those with low levels of health literacy. Those with lower health literacy levels and osteoarthritis (OA) are less likely to manage their condition with guideline recommended management strategies, experience a higher burden of disease, and have lower access to care. Our objectives were to review the current visual narratives in the field of and create a graphic medicine visual narrative based on existing research.</p></div><div><h3>Design</h3><p>This paper summarises the current visual narratives in OA and presents a graphic medicine visual narrative to illustrate the experience of living with OA. Considerations for the dissemination of visual narratives to target audiences are also discussed.</p></div><div><h3>Results</h3><p>The most common visual narratives in are infographics, videos, and graphic medicine. A graphic medicine visual narrative, based on previous qualitative work and informed by a framework, was created to illustrate two distinct narratives – impairment and participatory.</p></div><div><h3>Conclusion</h3><p>Visual narratives remain an emerging field in OA but may serve as a useful resource for patients or clinicians to discuss various aspects of OA management. Future research should evaluate and validate the use of visual narratives in OA.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100471"},"PeriodicalIF":0.0,"publicationDate":"2024-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000384/pdfft?md5=a73d0cead32b4f065af645fd625d392c&pid=1-s2.0-S2665913124000384-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140646251","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"PLOD2 gene expression in infrapatellar fat pad is correlated with fat mass in obese patients with end-stage knee osteoarthritis","authors":"J. Van den Langenbergh ,&nbsp;Y.M. Bastiaansen-Jenniskens ,&nbsp;G.J.V.M. van Osch ,&nbsp;J. Runhaar ,&nbsp;S.M.A. Bierma-Zeinstra ,&nbsp;K. Soballe ,&nbsp;J. Laursen ,&nbsp;A. Liljensoe ,&nbsp;N. Kops ,&nbsp;I. Mechlenburg ,&nbsp;S. Clockaerts","doi":"10.1016/j.ocarto.2024.100469","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100469","url":null,"abstract":"<div><h3>Objective</h3><p>To investigate associations between obesity-linked systemic factors and gene expression indicative for the inflammatory and fibrotic processes in the infrapatellar fat pad (IFP), in a population of obese patients with end-stage knee osteoarthritis (KOA).</p></div><div><h3>Methods</h3><p>We collected human IFPs from 48 patients with a mean body mass index (BMI) of 35.44 ​kg/m² during total knee replacement procedures. These patients were part of a randomized controlled trial and met the criteria of having OA and a BMI of ≥30 ​kg/m². Blood samples were collected to assess serum levels of glucose, total cholesterol, HDL cholesterol, LDL cholesterol, triglycerides, and leptin. Total body composition was measured using dual-energy X-ray absorptiometry. Gene expressions of <em>IL6, TNFA, COL1A1, IL1B, ASMA, PLOD2</em> in the IFP were analyzed.</p></div><div><h3>Results</h3><p>Univariate analysis resulted in a positive correlation between BMI and procollagen-lysine,2-oxoglutarate 5-dioxygenase 2 (<em>PLOD2</em>) expression (<em>r</em>² ​= ​0.13). In univariate analyses of obesity-linked systemic factors and <em>PLOD2</em>, significant correlations were found for lean mass (<em>r</em>² ​= ​0.20), fat mass (<em>r</em>² ​= ​0.20), serum cholesterol (<em>r</em>² ​= ​0.17), serum triglycerides (<em>r</em>² ​= ​0.19) and serum leptin (<em>r</em>² ​= ​0.10). A multiple linear regression model indicated fat mass to be a strong predictor of PLOD2 production in the IFP (<em>r</em>² ​= ​0.22, <em>P</em> ​= ​0.003).</p></div><div><h3>Conclusion</h3><p>Our study demonstrates the positive association between fat mass and <em>PLOD2</em> expression in the IFP of obese end-stage knee OA patients. This may indicate that within this patient population the fibrotic process in the IFP is influenced by systemic adipose tissue, next to local inflammatory processes.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100469"},"PeriodicalIF":0.0,"publicationDate":"2024-04-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000360/pdfft?md5=029957e552c0c1922cc034b405684d7a&pid=1-s2.0-S2665913124000360-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140632538","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Changes in educational inequalities in knee and hip osteoarthritis surgery and non-surgery specialist care visits over time in Sweden","authors":"Maria Lindéus ,&nbsp;George Peat ,&nbsp;Martin Englund ,&nbsp;Ali Kiadaliri","doi":"10.1016/j.ocarto.2024.100470","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100470","url":null,"abstract":"<div><h3>Objective</h3><p>To examine changes in prevalence and socioeconomic inequalities in knee and hip OA outcomes, in more specific surgery and non-surgery specialist care visits, from 2001 to 2011 in Sweden and to what extent sociodemographic factors can explain the changes.</p></div><div><h3>Design</h3><p>We included all individuals aged ≥35 years resident in Sweden from 2001 to 2011. Individual-level data was retrieved from the Swedish Interdisciplinary Panel. Highest educational attainment was used as socioeconomic measure and the concentration index was used to assess relative and absolute educational inequalities. We used decomposition method to examine changes in prevalence and relative educational inequalities.</p></div><div><h3>Results</h3><p>A total of 4,794,693 and 5,359,186 people were included for the years 2001 and 2011, respectively. The crude prevalence of surgery and specialist visits for knee and hip OA was 36–83% higher in 2011 than in 2001. The increase in hip OA outcomes was largely explained by changes in the sociodemographic composition of the population, whereas for knee OA outcomes, changes in the strength of the associations with sociodemographic factors appeared more important. All outcomes were concentrated among people with lower education in all study years. The relative inequalities declined over the study period, while the absolute inequalities increased for knee OA outcomes and remained stable for hip OA.</p></div><div><h3>Conclusion</h3><p>Our findings show an increasing burden of all studied OA outcomes. Moreover, our findings suggest persistent educational inequalities with more surgeries and specialist visits among lower-educated individuals. Future research should incorporate additional variables to better understand and address these inequalities.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100470"},"PeriodicalIF":0.0,"publicationDate":"2024-04-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000372/pdfft?md5=6f10dc5d32bd4847bb65a0c36d957006&pid=1-s2.0-S2665913124000372-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140618728","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Dual-energy X-ray absorptiometry derived knee shape may provide a useful imaging biomarker for predicting total knee replacement: Findings from a study of 37,843 people in UK Biobank","authors":"Rhona A. Beynon ,&nbsp;Fiona R. Saunders ,&nbsp;Raja Ebsim ,&nbsp;Monika Frysz ,&nbsp;Benjamin G. Faber ,&nbsp;Jennifer S. Gregory ,&nbsp;Claudia Lindner ,&nbsp;Aliya Sarmanova ,&nbsp;Richard M. Aspden ,&nbsp;Nicholas C. Harvey ,&nbsp;Timothy Cootes ,&nbsp;Jonathan H. Tobias","doi":"10.1016/j.ocarto.2024.100468","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100468","url":null,"abstract":"<div><h3>Objective</h3><p>We aimed to create an imaging biomarker for knee shape using knee dual-energy x-ray absorptiometry (DXA) scans and investigate its potential association with subsequent total knee replacement (TKR), independently of radiographic features of knee osteoarthritis and established risk factors.</p></div><div><h3>Methods</h3><p>Using a 129-point statistical shape model, knee shape (expressed as a B-score) and minimum joint space width (mJSW) of the medial joint compartment (binarized as above or below the first quartile) were derived. Osteophytes were manually graded in a subset of images and an overall score was assigned. Cox proportional hazards models were used to examine the associations of B-score, mJSW and osteophyte score with TKR risk, adjusting for age, sex, height and weight.</p></div><div><h3>Results</h3><p>The analysis included 37,843 individuals (mean age 63.7 years). In adjusted models, B-score was associated with TKR: each unit increase in B-score, reflecting one standard deviation from the mean healthy shape, corresponded to a hazard ratio (HR) of 2.25 (2.08, 2.43), while a lower mJSW had a HR of 2.28 (1.88, 2.77). Among the 6719 images scored for osteophytes, mJSW was replaced by osteophyte score in the most strongly predictive model for TKR. In ROC analyses, a model combining B-score, osteophyte score, and demographics outperformed a model including demographics alone (AUC ​= ​0.87 vs 0.73).</p></div><div><h3>Conclusions</h3><p>Using statistical shape modelling, we derived a DXA-based imaging biomarker for knee shape that was associated with kOA progression. When combined with osteophytes and demographic data, this biomarker may help identify individuals at high risk of TKR, facilitating targeted interventions.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100468"},"PeriodicalIF":0.0,"publicationDate":"2024-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000359/pdfft?md5=579f1241bd8b6c6e7f10dba8cf4cf3d4&pid=1-s2.0-S2665913124000359-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555692","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Vagotomy accelerates the onset of symptoms during early disease progression and worsens joint-level pathogenesis in a male rat model of chronic knee osteoarthritis","authors":"Carlos J. Cruz ,&nbsp;Taylor D. Yeater ,&nbsp;Jacob L. Griffith ,&nbsp;Kyle D. Allen","doi":"10.1016/j.ocarto.2024.100467","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100467","url":null,"abstract":"<div><h3>Objective</h3><p>Low vagal tone is common in osteoarthritis (OA) comorbidities and results in greater peripheral inflammation. Characterizing vagal tone's role in OA pathogenesis may offer insights into OA's influences beyond the articular joint. We hypothesized that low vagal tone would accelerate onset of OA-related gait changes and worsen joint damage in a rat knee OA model.</p></div><div><h3>Methods</h3><p>Knee OA was induced in male Sprague Dawley rats by transecting the medial collateral ligament and medial meniscus. Then, left cervical vagus nerve transection (VGX, n ​= ​9) or sham VGX (non-VGX, n ​= ​6) was performed. Gait and tactile sensitivity were assessed at baseline and across 12 weeks, with histology and systemic inflammation evaluated at endpoint.</p></div><div><h3>Results</h3><p>At week 4, VGX animals showed limping gait characteristics through shifted stance times from their OA to non-OA limb (p ​= ​0.055; stance time imbalance ​= ​1.6 ​± ​1.6%) and shifted foot strike locations (p ​&lt; ​0.001; spatial symmetry ​= ​48.4 ​± ​0.835%), while non-VGX animals walked with a balanced and symmetric gait. Also at week 4, while VGX animals had a mechanical sensitivity (50% withdrawal threshold) of 13.97 ​± ​7.70 compared to the non-VGX animal sensitivity of 29.74 ​± ​9.43, this difference was not statistically significant. Histologically, VGX animals showed thinner tibial cartilage and greater subchondral bone area than non-VGX animals (p ​= ​0.076; VGX: 0.80 ​± ​0.036 ​mm²; non-VGX: 0.736 ​± ​0.066 ​mm²). No group differences in systemic inflammation were observed at endpoint.</p></div><div><h3>Conclusions</h3><p>VGX resulted in quicker onset of OA-related symptoms but remained unchanged at later timepoints. VGX also had thinner cartilage and abnormal bone remodeling than non-VGX. Overall, low vagal tone had mild effects on OA symptoms and joint remodeling, and not at the level seen in common OA comorbidities.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100467"},"PeriodicalIF":0.0,"publicationDate":"2024-04-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000347/pdfft?md5=804999bc0e3e96679ea9ece73fb6fb3c&pid=1-s2.0-S2665913124000347-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140555796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Laser-irradiating infrared attenuated total reflection spectroscopy of articular cartilage: Potential and challenges for diagnosing osteoarthritis","authors":"P. Krebs ,&nbsp;M. Nägele ,&nbsp;P. Fomina ,&nbsp;V. Virtanen ,&nbsp;E. Nippolainen ,&nbsp;R. Shaikh ,&nbsp;I.O. Afara ,&nbsp;J. Töyräs ,&nbsp;I. Usenov ,&nbsp;T. Sakharova ,&nbsp;V. Artyushenko ,&nbsp;V. Tafintseva ,&nbsp;J.H. Solheim ,&nbsp;B. Zimmermann ,&nbsp;A. Kohler ,&nbsp;O. König ,&nbsp;S. Saarakkala ,&nbsp;B. Mizaikoff","doi":"10.1016/j.ocarto.2024.100466","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100466","url":null,"abstract":"<div><h3>Objective</h3><p>A prototype infrared attenuated total reflection (IR-ATR) laser spectroscopic system designed for <em>in vivo</em> classification of human cartilage tissue according to its histological health status during arthroscopic surgery is presented. Prior to real-world <em>in vivo</em> applications, this so-called osteoarthritis (OA) scanner has been tested at <em>in vitro</em> conditions revealing the challenges associated with complex sample matrices and the accordingly obtained sparse spectral datasets.</p></div><div><h3>Methods</h3><p><em>In vitro</em> studies on human knee cartilage samples at different contact pressures (i.e., 0.2–0.5 ​MPa) allowed recording cartilage degeneration characteristic IR signatures comparable to <em>in vivo</em> conditions with high temporal resolution. Afterwards, the cartilage samples were assessed based on the clinically acknowledged osteoarthritis cartilage histopathology assessment (OARSI) system and correlated with the obtained sparse IR data.</p></div><div><h3>Results</h3><p>Amide and carbohydrate signal behavior was observed to be almost identical between the obtained sparse IR data and previously measured FTIR data used for sparse partial least squares discriminant analysis (SPLSDA) to identify the spectral regions relevant to cartilage condition. Contact pressures between 0.3 and 0.4 ​MPa seem to provide the best sparse IR spectra for cylindrical (d ​= ​3 ​mm) probe tips.</p></div><div><h3>Conclusion</h3><p>Laser-irradiating IR-ATR spectroscopy is a promising analytical technique for future arthroscopic applications to differentiate healthy and osteoarthritic cartilage tissue. However, this study also revealed that the flexible connection between the laser-based analyzer and the arthroscopic ATR-probe via IR-transparent fiberoptic cables may affect the robustness of the obtained IR data and requires further improvements.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100466"},"PeriodicalIF":0.0,"publicationDate":"2024-04-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000335/pdfft?md5=4ad1573ced78aac68fb5e0311ce92abc&pid=1-s2.0-S2665913124000335-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140543463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Acknowledgement to Reviewers 2023","authors":"Henning Madry (Editor in Chief)","doi":"10.1016/j.ocarto.2024.100460","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100460","url":null,"abstract":"","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100460"},"PeriodicalIF":0.0,"publicationDate":"2024-03-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S266591312400027X/pdfft?md5=5b042182e84e2b4af64c25bb4efb29c5&pid=1-s2.0-S266591312400027X-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140320586","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Approaches to optimize analyses of multidimensional ordinal MRI data in osteoarthritis research: A perspective","authors":"Jamie E. Collins ,&nbsp;Frank W. Roemer ,&nbsp;Ali Guermazi","doi":"10.1016/j.ocarto.2024.100465","DOIUrl":"10.1016/j.ocarto.2024.100465","url":null,"abstract":"<div><h3>Objective</h3><p>Knee osteoarthritis (OA) is a disease of the whole joint involving multiple tissue types. MRI-based semi-quantitative (SQ) scoring of knee OA is a method to perform multi-tissue joint assessment and has been shown to be a valid and reliable way to measure structural multi-tissue involvement and progression of the disease. While recent work has described how SQ scoring may be used for clinical trial enrichment and disease phenotyping in OA, less guidance is available for how these parameters may be used to assess study outcomes.</p></div><div><h3>Design</h3><p>Here we present recommendations for summarizing disease progression within specific tissue types. We illustrate how various methods may be used to quantify longitudinal change using SQ scoring and review examples from the literature.</p></div><div><h3>Results</h3><p>Approaches to quantify longitudinal change across subregions include the count of number of subregions, delta-subregion, delta-sum, and maximum grade changes. Careful attention should be paid to features that may fluctuate, such as bone marrow lesions, or with certain interventions, for example pharmacologic interventions with anticipated cartilage anabolic effects. The statistical approach must align with the nature of the outcome.</p></div><div><h3>Conclusions</h3><p>SQ scoring presents a way to understand disease progression across the whole joint. As OA is increasingly recognized as a heterogeneous disease with different phenotypes a better understanding of longitudinal progression across tissue types may present an opportunity to match study outcome to patient phenotype or to treatment mechanism of action.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100465"},"PeriodicalIF":0.0,"publicationDate":"2024-03-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000323/pdfft?md5=d48f2f35d43a8d2429f6118623bd755d&pid=1-s2.0-S2665913124000323-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140398998","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Factors associated with empowerment after participating in a supported osteoarthritis self-management program: An explorative study","authors":"Karin Sturesdotter Åkesson ,&nbsp;Eva Ekvall Hansson ,&nbsp;Teresa Pawlikowska ,&nbsp;Anne Sundén ,&nbsp;Kjerstin Stigmar ,&nbsp;Eva Ageberg","doi":"10.1016/j.ocarto.2024.100464","DOIUrl":"https://doi.org/10.1016/j.ocarto.2024.100464","url":null,"abstract":"<div><h3>Objective</h3><p>To explore factors associated with change in empowerment in patients that have participated in a 3-month Supported Osteoarthritis Self-Management Program (SOASP). Further, to evaluate empowerment in the longer term.</p></div><div><h3>Design</h3><p>An explorative analysis including patients from a cohort study conducted in primary healthcare in Sweden was performed. Univariable linear regression models were performed to assess associations between demographics and patient-reported outcome measures (explanatory factors), respectively, and change in empowerment from baseline to 3-month follow-up (outcome variable). Long-term follow-up of empowerment was at 9 months.</p></div><div><h3>Results</h3><p>Self-reported increase in enablement at the 3-month follow-up was associated with a greater improvement in empowerment (B ​= ​0.041, 95% CI (0.011, 0.07), p ​= ​0.008). Living alone was associated with less improvement in empowerment (B ​= ​−0.278, 95% CI (−0.469, −0.086), p ​= ​0.005) compared to living together. Physical exercise &gt;120 ​min per week at baseline was associated with less improvement in empowerment (B ​= ​−0.293, 95% CI (−0.583, −0.004), p ​= ​0.047) compared to reporting no exercise at baseline. No other associations were observed (p ​&gt; ​0.05). Empowerment improved from baseline to the 3-month follow-up (mean 0.20 (SD 0.5), p ​&lt; ​0.001) but there was no change from baseline to the 9-month follow-up (mean 0.02 (SD 0.6), p ​= ​0.641).</p></div><div><h3>Conclusions</h3><p>Self-reported increased enablement may lead to greater improvement in empowerment after SOASP. Greater efforts may be needed to support those that live alone, are physically active, and to sustain empowerment in the longer term after SOASP. More research is needed on empowerment to provide personalized support for patients with OA after SOASP.</p></div>","PeriodicalId":74377,"journal":{"name":"Osteoarthritis and cartilage open","volume":"6 2","pages":"Article 100464"},"PeriodicalIF":0.0,"publicationDate":"2024-03-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.sciencedirect.com/science/article/pii/S2665913124000311/pdfft?md5=132d4a9d6377fe95197280d079ade36b&pid=1-s2.0-S2665913124000311-main.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140328255","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}