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A literature review of "lawful" text and data mining. 合法 "文本和数据挖掘文献综述。
Open research Europe Pub Date : 2024-10-30 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.18013.2
Giorgos Vrakas
{"title":"A literature review of \"lawful\" text and data mining.","authors":"Giorgos Vrakas","doi":"10.12688/openreseurope.18013.2","DOIUrl":"https://doi.org/10.12688/openreseurope.18013.2","url":null,"abstract":"<p><p>Text and data mining (TDM) is a process, typically automated, that looks for patterns in data that may otherwise remain unnoticed. In a world where data driven solutions play a progressively more important role, TDM has become a vital tool in sectors ranging from medicine, to commerce, gaining widespread attraction. Nevertheless, a variety of regulatory frameworks not always specifically attuned towards regulating TDM continue to apply concurrently. The literature within the context of regulatory frameworks governing TDM is a fragmented piecemeal of valuable insights into what \"lawful\" TDM resembles. This literature review adopts a grounded theory approach analysing 88 pieces of literature, collating views regarding \"lawful\" TDM, ultimately providing a holistic assessment of academics' and practitioners' views and opinions regarding the regulatory framework which governs TDM. A total of 7 categories were identified and each of these are analysed. Tables are provided in the Appendix (accessible here: https://doi.org/10.5281/zenodo.12654691)highlighting which scholarly works were used for each section of the literature review, but also how those works were used. It is ultimately concluded that the regulatory frameworks that apply to users conducting TDM are multifaceted, and ever-changing on a case-by-case basis. There is an ever-growing need for a holistic interpretation of the regulatory frameworks which apply, creating a map which would allow for users conducting TDM to navigate this complex web of legal rules.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"153"},"PeriodicalIF":0.0,"publicationDate":"2024-10-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535487/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583570","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Investigating immersion and migration decisions for agent-based modelling: A cautionary tale. 调查基于代理建模的沉浸和迁移决策:一个警世故事。
Open research Europe Pub Date : 2024-10-29 eCollection Date: 2023-01-01 DOI: 10.12688/openreseurope.15581.3
Jakub Bijak, Ariana Modirrousta-Galian, Philip A Higham, Toby Prike, Martin Hinsch, Sarah Nurse
{"title":"Investigating immersion and migration decisions for agent-based modelling: A cautionary tale.","authors":"Jakub Bijak, Ariana Modirrousta-Galian, Philip A Higham, Toby Prike, Martin Hinsch, Sarah Nurse","doi":"10.12688/openreseurope.15581.3","DOIUrl":"10.12688/openreseurope.15581.3","url":null,"abstract":"<p><strong>Background: </strong>Agent-based modelling provides an appealing methodological choice for simulating human behaviour and decisions. The currently dominant approaches based on static transition rates or unverified assumptions are restrictive, and could be enhanced with insights from cognitive experiments on actual decision making. Here, one common concern is that standard surveys or experiments may lack ecological validity, limiting the extent to which research findings can be generalised to real-life settings. For complex, highly emotive decision-making scenarios, such as those related to irregular migration, the typically used short, methodical survey questions may not appropriately map onto complex real-world decisions of interest. Immersive contexts may offer more accurate representations of reality, potentially enhancing the usefulness of experimental information in multi-disciplinary modelling endeavours.</p><p><strong>Methods: </strong>This preregistered study, aimed directly at examining the effect of immersion on risk-taking in the context of migration decisions, and indirectly at informing a multi-disciplinary construction of an agent-based model of migration, presents a choice-based interactive fiction game in which players make migration decisions to advance through a story.</p><p><strong>Participants: </strong>(N = 1000 Prolific users) took part in one of four experimental conditions, three involving different renditions of the game attempting to create immersion, with the last condition presenting the decisions in standard survey format.</p><p><strong>Results: </strong>Although addressing the lack of ecological validity in survey data is important for improving agent-based modelling methodology, the experimental design used to tackle this issue, while responding directly to modelling needs, proved too complex. The created experimental conditions ended up too distinct from each other, involving stimuli that differed in quantity and content. This introduced several unintended and uncontrolled confounds, making it impossible to meaningfully interpret the results of this experiment on its own. Our results act as a cautionary tale for agent-based modellers, highlighting that the modelling needs should not override the principles of experimental design, and provide motivation for more rigorous research on this topic.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"3 ","pages":"34"},"PeriodicalIF":0.0,"publicationDate":"2024-10-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11525092/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559674","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Energy Transition in Northern Netherlands: seeking a balance between top-down and bottom-up initiatives. 荷兰北部的能源转型:寻求自上而下和自下而上倡议之间的平衡。
Open research Europe Pub Date : 2024-10-28 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.17431.2
Bas Oldenbroek, Ifigenia Psarra, Tineke van der Schoor, Cyril Tjahja
{"title":"Energy Transition in Northern Netherlands: seeking a balance between top-down and bottom-up initiatives.","authors":"Bas Oldenbroek, Ifigenia Psarra, Tineke van der Schoor, Cyril Tjahja","doi":"10.12688/openreseurope.17431.2","DOIUrl":"10.12688/openreseurope.17431.2","url":null,"abstract":"<p><p>This brief report focuses on top-down and bottom-up processes within the field of energy transition. It aims at gaining a better understanding of the needs of the local energy initiatives. On this basis, policy recommendations are formulated to help the municipality of Groningen to facilitate local energy initiatives, ultimately leading to a more balanced approach of the local energy transition. Thus, this study explored the (mutual) interests, barriers and expectations of the municipality and local citizen initiatives. The theoretical framework is the implementation analysis framework, distinguishing top-down and bottom-up approaches. Specifically, this qualitative (thematic analysis) research study investigates the mismatch in expectations between a number of local energy initiatives and the municipality of Groningen regarding their roles within the local energy transition context. To this end, semi-structured interviews have been conducted with members of the municipality of Groningen, Grunneger Power (a local energy intermediary), and four local energy initiatives. Need and expectation gaps have been identified and potential solutions have been explored. The main findings of the study illustrate the need of professional support for citizen initiatives, at both technical and organizational level, especially in the first phases of their development. Additionally, clear mutual communication on short and long-term planning and ambitions of the involved parties is of key importance for the alignment of the interests and the course of actions. Consequently, a clear context is needed, within which an exchange of feedback on the envisioned strategies, and the subsequent energy saving or generation interventions, can take place in an efficient and effective way. Additionally, such a context increases confidence and provides a clear understanding to the citizen initiatives regarding their role and the level and nature of support they can expect in their intended projects and activities. Based on these findings, policy implications have been drawn.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"139"},"PeriodicalIF":0.0,"publicationDate":"2024-10-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11739859/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143017858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transforming European Food Systems with multi-actor networks and Living Labs through the FoodSHIFT Approach. 通过 FoodSHIFT 方法,利用多行为体网络和生活实验室改造欧洲食品系统。
Open research Europe Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.17982.2
Luke John Schafer, Aida Anthouli, Alessandra Schmidt, Anita Beblek, Annika Fruehbeisser, Beatrice Walthall, Carla Mingolla, Catalina Rogozan, Damiano Petruzzella, Dirk Wascher, Francesca Volpe, Giordano Ruggeri, Gustavo Arciniegas, Jose Luis Vicente-Vicente, Katerina Riviou, Katerina Valta, Lena Marijke Wenzel, Lorenzo Labellarte, Maarten Crivits, Malgorzata Swiader, Marin Lysak, Marta Sylla, Poppy Eyre, Raluca Barbu, Stefano Corsi, Christian Bugge Henriksen
{"title":"Transforming European Food Systems with multi-actor networks and Living Labs through the FoodSHIFT Approach.","authors":"Luke John Schafer, Aida Anthouli, Alessandra Schmidt, Anita Beblek, Annika Fruehbeisser, Beatrice Walthall, Carla Mingolla, Catalina Rogozan, Damiano Petruzzella, Dirk Wascher, Francesca Volpe, Giordano Ruggeri, Gustavo Arciniegas, Jose Luis Vicente-Vicente, Katerina Riviou, Katerina Valta, Lena Marijke Wenzel, Lorenzo Labellarte, Maarten Crivits, Malgorzata Swiader, Marin Lysak, Marta Sylla, Poppy Eyre, Raluca Barbu, Stefano Corsi, Christian Bugge Henriksen","doi":"10.12688/openreseurope.17982.2","DOIUrl":"10.12688/openreseurope.17982.2","url":null,"abstract":"<p><p>Our current global Food System is facing extraordinary challenges in both size and severity, including a rise in unsustainable consumption behaviours, continued environmental degradation, growing food insecurity, and widening social inequalities. A Food System transformation is now both critically important and overwhelmingly complex, requiring nothing less than a complete overhaul of the entire value chain. Everyone is needed: Small Medium Enterprises (SMEs) with technological solutions, Non-Governmental Organisations (NGOs) with social innovations, researchers with novel methodologies, governments with food policy advancements, professionals with varying expertise, and last but not least, empowered and informed citizens with the ability and resources for better decision-making. Living Labs offer a holistic, place-based approach needed to facilitate multi-actor inputs on various levels, specifically Food System Living Labs (FSLLs) like the ones established as part of the FoodSHIFT 2030 Project. Nine front-runner Food System Living Labs were operationalised alongside a novel framework merging high-level interdisciplinary initiatives with a diverse set of innovative approaches towards more Sustainable Food Systems (SFS). The FoodSHIFT Approach concept was praised by external evaluators for its ground-breaking framework, and the nearly completed project has been listed as a best practice. However, positive applications alone will not ensure a cross-sector European-wide Food System transformation, and the following text offers a critical reflection coupled with experience-based solutions to further improve the FoodSHIFT Approach.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"151"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11535485/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142583584","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Assessment of the use of Open Educational Resources at five European Library and Information Science higher education institutions during and post-COVID-19 pandemic. 评估欧洲五所图书馆和信息科学高等教育机构在 COVID-19 大流行期间和之后使用开放教育资源的情况。
Open research Europe Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.17457.3
Gema Santos-Hermosa, Cristóbal Urbano, Sílvia Argudo, Juan-José Boté-Vericad, Anja Đurđevic, Milijana Micunovic, Lea Wöbbekind, Tania Todorova
{"title":"Assessment of the use of Open Educational Resources at five European Library and Information Science higher education institutions during and post-COVID-19 pandemic.","authors":"Gema Santos-Hermosa, Cristóbal Urbano, Sílvia Argudo, Juan-José Boté-Vericad, Anja Đurđevic, Milijana Micunovic, Lea Wöbbekind, Tania Todorova","doi":"10.12688/openreseurope.17457.3","DOIUrl":"10.12688/openreseurope.17457.3","url":null,"abstract":"<p><p>This article presents an analysis of the impact of Open Educational Resources (OER) during the COVID-19 pandemic, as well as their potential use in the post-pandemic, in Library and Information Science (LIS) higher education institutions. The research explored how OER were used and created, what were the main barriers and drivers in practice and some main lessons learned that can help to improve the quality and increase the use of OER beyond times of crisis. The research was based on fieldwork carried out in the LIS departments of the universities of Barcelona (Spain), Hildesheim (Germany), Osijek and Zagreb (Croatia) and the University of Library Studies and Information Technologies in Sofia (Bulgaria). The methodology approach was qualitative and was based on interviews with faculty and focus groups with students. Results show that faculty members were still hesitant to adopt OER since they generally did not consider them. Moreover, those who did use them did so on their own initiative and as additional resources. We discuss the different speeds of OER implementation that have been observed depending on the faculty's prior level of knowledge, and on whether their institutions and countries are prepared to support the use of OER. The promotion of post-pandemic OER involves greater capacity building, as well as collaboration and institutional support. Students' attitudes about the usefulness of OER focus on their availability. The large number of teachers and students who participated in the study, as well as the international scope of the study, constitute a strength in the treatment of a topic such as the use of OER where the user perspectives and LIS context have been little addressed in the literature.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"95"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523556/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142549410","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Modelling drift of cold-stunned Kemp's ridley turtles stranding on the Dutch coast. 为搁浅在荷兰海岸的冷惊蛰肯普氏脊龟建立漂流模型。
Open research Europe Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.16913.2
Darshika Manral, Ilse Bos, Mark de Boer, Erik van Sebille
{"title":"Modelling drift of cold-stunned Kemp's ridley turtles stranding on the Dutch coast.","authors":"Darshika Manral, Ilse Bos, Mark de Boer, Erik van Sebille","doi":"10.12688/openreseurope.16913.2","DOIUrl":"10.12688/openreseurope.16913.2","url":null,"abstract":"<p><strong>Background: </strong>Every few years, juvenile Kemp's ridley turtles ( <i>Lepidochelys kempii</i>) are stranded on the Dutch coasts. The main population distribution of this critically endangered species primarily inhabits the Gulf of Mexico and the east coast of the United States. This study focuses on five reports from the Netherlands between 2007 and 2022, where juvenile turtles were reported to strand alive during the winter, albeit in a hypothermic state. At ambient ocean temperatures between 10°C and 13°C, Kemp's ridley turtles begin to show an inability to actively swim and remain afloat on the ocean's surface, a condition termed <i>'cold stunning'</i>. Understanding their transport in cold-stunned state can help improve the rehabilitation process of stranded turtles.</p><p><strong>Methods: </strong>Cold-stunned turtles are back-tracked as passive, virtual particles from their stranding location using Lagrangian flow modelling. This study investigates when and where these juvenile turtles cross the threshold temperatures between 10° C and 14° C before stranding by tracking the temperature along the trajectories.</p><p><strong>Results: </strong>As expected, the simulations show the transport of the cold-stunned turtles via the English Channel. More surprisingly, the analysis suggests they likely experience cold-stunning in the southern North Sea region and encounter temperatures below 10°C for only a few days to up to three weeks, and below 12°C for up to a month before stranding.</p><p><strong>Conclusions: </strong>The estimate of cold-stunned drift duration of the turtles provides additional knowledge about their health status at the time of stranding. Adherence to rehabilitation protocols for Kemp's ridley and post-release monitoring are recommended to improve their long-term survival.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11415756/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142302833","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Co-creation of the Digital Democracy and Data Commons Manifesto: alternative sociotechnical visions of data. 共同创建数字民主和数据公共宣言:数据的替代性社会技术愿景。
Open research Europe Pub Date : 2024-10-25 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.17020.2
Enric Senabre Hidalgo, Antonio Calleja, Ricard Espelt, Sara Suárez Gonzalo, Mayo Fuster Morell, Andreu Belsunces
{"title":"Co-creation of the Digital Democracy and Data Commons Manifesto: alternative sociotechnical visions of data.","authors":"Enric Senabre Hidalgo, Antonio Calleja, Ricard Espelt, Sara Suárez Gonzalo, Mayo Fuster Morell, Andreu Belsunces","doi":"10.12688/openreseurope.17020.2","DOIUrl":"10.12688/openreseurope.17020.2","url":null,"abstract":"<p><p>Amid public concern surrounding the proprietary and exploitative use of personal data by corporations and public institutions, and its consequences from a sociotechnical perspective, narratives around digital commons have recently emerged, framing potential alternatives. This paper presents the co-creation of the Digital Democracy and Data Commons Manifesto through a collaborative writing sprint, drawing on principles of openness, diversity, and inclusivity. The manifesto articulates a technopolitical vision for data governance that prioritizes community control over data. We analyze the manifesto's evolution throughout the process, demonstrating its capacity to address contemporary concerns such as data extractivism and algorithmic governance. Our approach is based on participatory design methods, more concretely on a collaborative writing sprint, to co-create a manifesto on alternatives to current datafication, digital inequalities, and lack of citizen control over personal data. On the one hand, we describe the process of implementing a sprint approach for collaboratively writing a topic-specific manifesto, in the context of the broader EU project DECODE (Decentralised Citizen Owned Data Ecosystems). On the other hand, we present and analyse the main results from the content structure of the manifesto over its initial and final versions, which moved progressively as a cohesive text away from a scholarly and policy-oriented tone.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"45"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11589416/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142735227","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication of hydrogel mini-capsules as carrier systems. 水凝胶微胶囊载体体系的制备。
Open research Europe Pub Date : 2024-10-25 eCollection Date: 2023-01-01 DOI: 10.12688/openreseurope.16723.2
Elisa Roberti, Gaia Petrucci, Francesco Bianciardi, Stefano Palagi
{"title":"Fabrication of hydrogel mini-capsules as carrier systems.","authors":"Elisa Roberti, Gaia Petrucci, Francesco Bianciardi, Stefano Palagi","doi":"10.12688/openreseurope.16723.2","DOIUrl":"10.12688/openreseurope.16723.2","url":null,"abstract":"<p><p>Conventional drug administration often results in systemic action, thus needing high dosages and leading to potentially pronounced side effects. Targeted delivery, employing carriers like nanoparticles, aims to release drugs at a target site, but only a small fraction of nanoparticles actually reaches it. Microrobots have been proposed to overcome this issue since they can be guided to hard-to-reach sites and locally deliver payloads. To enhance their functionality, we propose microrobots made as deformable capsules with hydrogel shells and aqueous cores, having the potential added advantages of biocompatibility, permeability, and stimulus-responsiveness. Endowing microrobots with deformability could allow them to navigate inside capillaries and cross barriers to finally reach the target site. In this study, we present a cost-effective method for fabricating core-shell structures without the use of organic solvents, surfactants, or extreme pH conditions unlike other techniques (e.g. Layer by Layer). The process begins with the dripping of a mixture of hydrogels, agarose and alginate, into a solution to gelate the drops into beads. After they are loaded with calcium ions at different concentrations, they are immersed in an alginate solution to form the shell. Finally, the beads are heated to let the agarose melt and diffuse out, leaving a liquid core. By varying the concentration of calcium ions, we obtain shells of different thicknesses. To estimate it, we have developed a method using the colour intensity from microscope images. This allowed us to observe that lowering the calcium ions concentration below a threshold does not lead to the formation of continuous shells. For higher concentrations, although the core may remain partially gelled, continuous shells successfully form. Therefore, our fabrication process could find applications in drug delivery, encapsulation systems, and microrobotics.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"3 ","pages":"191"},"PeriodicalIF":0.0,"publicationDate":"2024-10-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11605173/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775367","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Oriented artificial nanofibers and laser induced periodic surface structures as substrates for Schwann cells alignment. 定向人造纳米纤维和激光诱导周期性表面结构作为许旺细胞排列的基底。
Open research Europe Pub Date : 2024-10-22 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.17370.3
Sebastian Lifka, Cristina Plamadeala, Agnes Weth, Johannes Heitz, Werner Baumgartner
{"title":"Oriented artificial nanofibers and laser induced periodic surface structures as substrates for Schwann cells alignment.","authors":"Sebastian Lifka, Cristina Plamadeala, Agnes Weth, Johannes Heitz, Werner Baumgartner","doi":"10.12688/openreseurope.17370.3","DOIUrl":"https://doi.org/10.12688/openreseurope.17370.3","url":null,"abstract":"<p><p>People with injuries to the peripheral nervous system suffer from paralysis of the facial muscles, fingers and hands or toes and feet, often for the rest of their lives, due to its poor functional regeneration. Therefore, to improve patients' quality of life, there is an urgent need for conduits that effectively support the healing of large defects in nerve pathways through specific guidance of nerve cells. This paper describes two specific methods for achieving directed growth of Schwann cells, a type of glial cells that can support the regeneration of the nerve pathway by guiding the neuronal axons in the direction of their alignment. One method uses aligned polyamide-6 (PA-6) nanofibers produced via electrospinning on a very fast rotating structured collector, which enables easy nanofiber detachment, without additional effort. The other method implies the exposure of a poly(ethylene terephthalate) (PET) foil to a KrF* laser beam, that renders a nanorippled surface topography. Schwann cell growth on these substrates was inspected after one week of cultivation by means of scanning electron microscopy (SEM). For both methods we show that Schwann cells grow in a certain direction, predetermined by nanofiber and nanoripple orientation. In contrast, cells cultivated on randomly oriented nanofibers or unstructured surfaces, show an omnidirectional growth behavior. These two methods can be used to produce nerve conduits for the treatment of injuries to the peripheral nervous system.</p>","PeriodicalId":74359,"journal":{"name":"Open research Europe","volume":"4 ","pages":"80"},"PeriodicalIF":0.0,"publicationDate":"2024-10-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11541076/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142607060","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enriching Earth observation datasets through semantics for climate change applications: The EIFFEL ontology. 通过语义丰富地球观测数据集,促进气候变化应用:EIFFEL 本体论。
Open research Europe Pub Date : 2024-10-18 eCollection Date: 2024-01-01 DOI: 10.12688/openreseurope.17992.2
Benjamin Molina, Carlos E Palau, Jaime Calvo-Gallego
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