Aging and Disease最新文献_第4页

Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies. 迈向精确衰老生物学：单细胞多组学和先进的人工智能驱动策略。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-17 DOI: 10.14336/AD.2025.0218

Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu

{"title":"Towards Precision Aging Biology: Single-Cell Multi-Omics and Advanced AI-Driven Strategies.","authors":"Sijia Xie, Xinwei Luo, Feitong Hong, Yijie Wei, Yuduo Hao, Xueqin Xie, Xiaolong Li, Guangbo Xie, Fuying Dao, Hao Lyu","doi":"10.14336/AD.2025.0218","DOIUrl":"https://doi.org/10.14336/AD.2025.0218","url":null,"abstract":"Individual aging is a complex biological process involving multiple levels, with molecular changes existing in heterogeneity across different cell types and tissues, being regulated by both internal and external factors. Traditional senescence markers, including p16, cell morphological changes, and cell cycle arrest, can only partially reflect the complexity of senescence. Single-cell omics technology facilitates the integration of multi-faceted data, including gene expression profiles, spatial dynamics, chromatin accessibility and metabolic pathways. This comprehensive approach enhances the development of biomarkers, granting us a more profound insight into the heterogeneity inherent within senescent cell populations. In this review, we summarize the application of single cell multi-omics approaches in analyzing senescence mechanisms and potential intervention targets from the perspectives of transcriptomics, epigenetics, metabolomics, and proteomics, explore the potential of developing new senescence markers at the cellular level using machine learning algorithms and artificial intelligence in bioinformatics analysis. Finally, we further discuss the challenges and prospective trajectories within this research domain to provide a more comprehensive perspective on dissecting the regulatory networks of senescence cells.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735532","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Targeting T-cell Aging to Remodel the Aging Immune System and Revitalize Geriatric Immunotherapy. 靶向t细胞老化，重塑老化免疫系统，振兴老年免疫治疗。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-15 DOI: 10.14336/AD.2025.0061

Mi Chen, Zhou Su, Jianxin Xue

引用次数: 0

Immunosenescence in Sepsis: Molecular Mechanisms and Potential Therapeutic Targets. 脓毒症的免疫衰老：分子机制和潜在的治疗靶点。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-14 DOI: 10.14336/AD.2025.0039

Heyang Sun, Qianya Hong, Chenning Li, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo

{"title":"Immunosenescence in Sepsis: Molecular Mechanisms and Potential Therapeutic Targets.","authors":"Heyang Sun, Qianya Hong, Chenning Li, Shuainan Zhu, Ying Yu, Hao Zhang, Kefang Guo","doi":"10.14336/AD.2025.0039","DOIUrl":"https://doi.org/10.14336/AD.2025.0039","url":null,"abstract":"Sepsis is a systemic inflammatory response triggered by infection that can result in immune regulation disruption and organ dysfunction. As an individual age, a phenomenon known as immunosenescence occurs. Immunosenescence is characterized by the deterioration of immune cells and organs. This decline leads to immune dysfunction, which is closely associated with an increased mortality rate among elderly sepsis patients. Recent studies have revealed that various responses during sepsis can induce premature aging of immune organs and cells in younger individuals, a process referred to as premature immunosenescence, which further accelerates the progression of sepsis and contributes to adverse outcomes. There is a significant correlation between immunosenescence and sepsis; therefore, understanding the specific manifestations and underlying mechanisms of immunosenescence induced by sepsis is imperative. Additionally, treatment strategies aimed at reversing or alleviating both immune aging and immune suppression in septic patients are worthwhile exploring and will also improve understanding of the concept of immunosenescence.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735630","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

1953-2023. Seventy Years of the Nerve Growth Factor: A Potential Novel Treatment in Neurological Diseases? 1953 - 2023。神经生长因子的70年：神经系统疾病的潜在新疗法？

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-14 DOI: 10.14336/AD.2024.0573

Davide Norata, Fioravante Capone, Francesco Motolese, Massimo Marano, Mariagrazia Rossi, Rosalinda Calandrelli, Marta Sacchetti, Flavio Mantelli, Vincenzo Di Lazzaro, Fabio Pilato

{"title":"1953-2023. Seventy Years of the Nerve Growth Factor: A Potential Novel Treatment in Neurological Diseases?","authors":"Davide Norata, Fioravante Capone, Francesco Motolese, Massimo Marano, Mariagrazia Rossi, Rosalinda Calandrelli, Marta Sacchetti, Flavio Mantelli, Vincenzo Di Lazzaro, Fabio Pilato","doi":"10.14336/AD.2024.0573","DOIUrl":"10.14336/AD.2024.0573","url":null,"abstract":"Rita Levi-Montalcini's 1953 discovery of nerve growth factor (NGF) in mouse sarcoma tumors marked a groundbreaking moment in neuroscience. NGF, a key signaling molecule, became the first identified neurotrophic factor, influencing the growth, differentiation, and survival of neurons in both peripheral and central nervous systems. NGF and related neurotrophic factors hold therapeutic potential for various neurological disorders, such as Alzheimer's Disease, Parkinson's Disease, Huntington's Disease, amyotrophic lateral sclerosis, spinal cord injuries, neuropathies, traumatic brain injuries, and stroke. However, despite promising in vitro studies and animal models findings, NGF efficacy in patients remains unproven. Indeed, its use as a therapeutic agent faces challenges in delivery and clinical translation. This review delves into these challenges, exploring ongoing research on refined delivery methods, dosages, and safety profiles. Innovative strategies, including molecular mimicking, combination therapies, gene therapy, and coupling with neuromodulation techniques like transcranial magnetic stimulation and vagal nerve stimulation, are discussed. Incorporating nerve growth factor (NGF) into a comprehensive strategy may prove beneficial, particularly in non-neurodegenerative conditions such as stroke, trauma, and neuropathies. In these instances, NGF holds promise for promoting tissue regeneration and repair. Challenges persist in addressing the complexity of neurodegenerative pathologies for a combined therapeutic approach.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735621","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Emerging Targets, Novel Directions, and Innovative Approaches in Thrombosis Therapy. 血栓治疗的新靶点、新方向和创新方法。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-13 DOI: 10.14336/AD.2024.1688

Weiyue Zhang, Baoqing Pei, Yifan Zhou, Hui Li, Wei Ma, Bing Zhou, Chen Zhou, Huimin Jiang, Xunming Ji

{"title":"Emerging Targets, Novel Directions, and Innovative Approaches in Thrombosis Therapy.","authors":"Weiyue Zhang, Baoqing Pei, Yifan Zhou, Hui Li, Wei Ma, Bing Zhou, Chen Zhou, Huimin Jiang, Xunming Ji","doi":"10.14336/AD.2024.1688","DOIUrl":"https://doi.org/10.14336/AD.2024.1688","url":null,"abstract":"In clinical practice, antiplatelet, anticoagulant and fibrinolytic drugs are the mainstay of thrombosis treatment, but their potential bleeding side effects limit their widespread use. Therefore, modifying these existing drugs or developing new therapies that mitigate bleeding risks while maintaining their efficacy and utilization is necessary. Since the critical role of platelets in thrombosis is closely related to their cell surface receptors, intracellular signaling pathways and metabolism, current research focuses on these three major classes of platelet targets to develop new antithrombotic drugs. The coagulation cascade has always been the main target of anticoagulant drugs, but since the role of molecules of the contact system is more critical in thrombosis than in hemostasis, molecules targeting the contact system, such as FXIa and FXIIa, have become the main direction of anticoagulant drug research at present. Moreover, since the inflammatory response has been found to be significantly associated with thrombosis in recent years, the development of drugs that target inflammatory pathways, such as inflammasome, has also become a hot topic. This article provides a detailed description of these targets or drug formulations that are currently being investigated, including their mode of action and antithrombotic efficiency, and also points out their existing shortcomings. Moreover, antithrombotic nanomedicines can achieve precise release of drugs, which can greatly improve the thrombolytic efficiency and reduce side effects. In conclusion, this review focuses on summarizing the current new targets and new methods of antithrombotic drug research, hoping to provide a little reference for future related research.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143735625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways. 槲皮素覆盖的硒纳米粒子通过miR206/Connexin43、WNT和BMP信号通路促进骨再生。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-11 DOI: 10.14336/AD.2025.0025

Garima Sharma, Yeon Hee Lee, Jin-Chul Kim, Ashish Ranjan Sharma, Sang-Soo Lee

{"title":"Bone Regeneration Enhanced by Quercetin-Capped Selenium Nanoparticles via miR206/Connexin43, WNT, and BMP signaling pathways.","authors":"Garima Sharma, Yeon Hee Lee, Jin-Chul Kim, Ashish Ranjan Sharma, Sang-Soo Lee","doi":"10.14336/AD.2025.0025","DOIUrl":"https://doi.org/10.14336/AD.2025.0025","url":null,"abstract":"Age-related alterations in the skeletal system are linked to decreased bone mass, a reduction in bone strength and density, and an increased risk of fractures and osteoporosis. Therapeutics are desired to stimulate bone regeneration and restore imbalance in the bone remodeling process. Quercetin (Qu), a naturally occurring flavonoid, induces osteogenesis; however, its solubility, stability, and bioavailability limit its therapeutic use. Nanoformulation can improve the physical properties of Qu and enhance its bioactivity and bioavailability. Further, localized delivery of Qu nanoformulations at the site of bone defects could ensure high local concentration, augmenting its osteogenic properties. Thus, this study aims to synthesize selenium nanoparticles-based Qu nanoformulation (Qu-SeNPs) and evaluate their osteogenic stimulation ability along with localized bone regeneration ability. Here, the spontaneously synthesized Qu-SeNPs showed uniform size distribution and rough flower-shaped morphology. The confocal images indicate improved cellular uptake and even cellular distribution of Qu-SeNPs in osteoblasts, resulting in increased osteogenic activity as indicated by enhanced expression of early and late osteoprogenitor differentiation markers. Qu-SeNPs also decreased osteoblasts' RANKL/OPG ratio and inhibited osteoclast formation. Mechanistically, Qu-SeNPs activate critical signaling pathways, including WNT and BMP, and utilize the miR-206/Connexin43 pathway to enhance osteogenesis. In vivo, experiments utilizing a drill-hole bone defect model in mice indicate that hydrogel-mediated localized delivery of Qu-SeNPs significantly accelerates bone defect healing. Thus, well-characterized and mechanistic, detailed synthesized Qu-SeNPs can restore bone remodeling, and Qu-SeNPs embedded in hydrogels may improve Qu cellular uptake and bioavailability in clinical settings, enabling innovative orthopedic and regenerative therapies for bone loss/defects.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603397","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiota Modulation of Dementia Related Complications. 肠道菌群调节痴呆相关并发症。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-08 DOI: 10.14336/AD.2025.0108

Xiaoqing Su, Yinghua Chen, Xingxing Yuan

{"title":"Gut Microbiota Modulation of Dementia Related Complications.","authors":"Xiaoqing Su, Yinghua Chen, Xingxing Yuan","doi":"10.14336/AD.2025.0108","DOIUrl":"https://doi.org/10.14336/AD.2025.0108","url":null,"abstract":"Recent advances in microbial pathogen research have highlighted the potential of gut microbe-based microbial medicine. One of the most extensively studied biological pathways is the gut-brain axis, which has been shown to reverse neurological disorders. Evidence from animal-based studies of dysbiosis suggest complex behavioral changes, such as alterations in sociability and anxiety, can be modulated through gut microbiota. Specifically, mental disorders include major depression, bipolar disorder, and schizophrenia. Gastrointestinal diseases can be reversed by modulating gut microbiota. Dementia and its related mechanisms are also amenable to modulation of the gut microbiota. This review focuses on the role of gut microbiota in dementia by discussing the effects on depressive symptoms, cognitive function, mood, behavioral changes, chronic stress, and the prospects of the microbiota-gut-brain axis for dementia. Although animal models have revealed promising approaches for treating dementia through the modulation of the gut microbiota, it may be premature to incorporate these interventions into standard clinical practice. The heterogeneity of findings from clinical trials and randomized control trials has yet to convincingly demonstrate the efficacy of modulation in reversing dementia and its related complications.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603417","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis. 光反应纳米材料在骨关节炎中的诊断和治疗潜力。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-07 DOI: 10.14336/AD.2025.0166

Yanlei Zhang, Jiachun Song, Yuxuan Li, Quanbo Ji

{"title":"Diagnostic and Therapeutic Potential of Photo-Responsive Nanomaterials in Osteoarthritis.","authors":"Yanlei Zhang, Jiachun Song, Yuxuan Li, Quanbo Ji","doi":"10.14336/AD.2025.0166","DOIUrl":"https://doi.org/10.14336/AD.2025.0166","url":null,"abstract":"Osteoarthritis (OA) is the most common musculoskeletal disease globally and is the main reason for the chronic pain and disability in people over sixty-five worldwide. Degradation of the articular cartilage, synovial inflammation and osteophyte formation are widely acknowledged as the primary pathological manifestations of OA. OA affects more than 300 million people all over the world, bringing extremely large socioeconomic burden. Unfortunately, there's so far, no disease-modified drugs to treat it, and techniques for early detection are absent. Photoacoustic imaging is a promising imaging method based on photothermal effects, which shows enormous potential in precisely monitoring the development of OA and tracking the drug treatment progress. Photothermal therapy is a non-invasive treatment curing diseases by converting the energy from light to heat through tissue absorption. Ample research evidence verifies the efficacy of photothermal therapy in treating OA. This narrative review covered recent advances of photosensitive nanomaterials applied in OA and illustrated the potential of them in diagnosing and treating OA, hoping it could pave the way for the following theranostics and clinical transition of OA.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603412","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila. 迷迭香和生姜提取物对果蝇衰老和健康的影响。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-07 DOI: 10.14336/AD.2024.1558

Ricardo Aparicio, Anna M Salazar, Edward T Schmid, Armen Khanbabaei, Arun Rajgopal, R Keith Randolph, David W Walker

{"title":"The Impact of Rosemary and Ginger Extracts on Aging and Healthspan in Drosophila.","authors":"Ricardo Aparicio, Anna M Salazar, Edward T Schmid, Armen Khanbabaei, Arun Rajgopal, R Keith Randolph, David W Walker","doi":"10.14336/AD.2024.1558","DOIUrl":"https://doi.org/10.14336/AD.2024.1558","url":null,"abstract":"Aging leads to a decline in physiological functions and increased risk of mortality, yet therapeutic avenues are limited. Dietary phytochemicals provide an attractive approach to counteract age-related health decline. Here, we have examined the impact of feeding extracts of rosemary and ginger, prepared via three different extraction methods, on markers of aging and healthspan in the fruit fly Drosophila. We observed that certain, but not all, extracts of ginger produce modest prolongevity effects. Feeding extracts of rosemary, produced via the three different methods, each produced prolongevity effects. We observe that feeding combinations of both rosemary and ginger extracts leads to robust lifespan extension. We find that the prolongevity effects of rosemary and ginger extracts are linked to improved intestinal barrier function in aged flies. Importantly, we show that the anti-aging effects observed are not linked to reduced food intake. Interestingly, we observe several instances where the combination of rosemary plus ginger produces effects which are more pronounced or not seen for either extract alone. In terms of cellular hallmarks of aging, rosemary plus ginger feeding leads to AMPK activation and improved markers of autophagy and proteostasis in aged flies. Furthermore, feeding the combination of rosemary plus ginger feeding improves cognitive function in aged flies. Our results demonstrate that rosemary and ginger extracts can counteract aging and prolong healthspan in flies.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143603430","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Cellular Senescence in the Regenerative Niche Hampers Skeletal Muscle Repair. 再生生态位中的细胞衰老阻碍骨骼肌修复。

IF 7 2区医学

Aging and Disease Pub Date : 2025-03-06 DOI: 10.14336/AD.2024.1501

MingYu Qiu, YangYang Li, QiSen Wang, XiaoTing Jian, JingWen Huang, WeiChao Gui, Jijie Hu, Hua Liao

引用次数: 0