Aging and Disease最新文献_第5页

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future. 表观遗传时钟：超越生物年龄，用过去预测现在和未来。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-23 DOI: 10.14336/AD.2024.1495

Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu

引用次数: 0

Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease. 线粒体质量控制：慢性阻塞性肺疾病骨骼肌功能障碍的新视角。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-21 DOI: 10.14336/AD.2024.1129

Yanxia Song, Xiaoyu Han, Yingqi Wang, Kangxia Li, Huanping Li, Yizhu Tian, Xiaoqing Ma, Weibing Wu, Jihong Wang

{"title":"Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease.","authors":"Yanxia Song, Xiaoyu Han, Yingqi Wang, Kangxia Li, Huanping Li, Yizhu Tian, Xiaoqing Ma, Weibing Wu, Jihong Wang","doi":"10.14336/AD.2024.1129","DOIUrl":"https://doi.org/10.14336/AD.2024.1129","url":null,"abstract":"Skeletal muscle dysfunction (SMD), one of the extrapulmonary complications in patients with chronic obstructive pulmonary disease (COPD), considerably influences patient prognosis. Mitochondria regulates their dynamic networks through a mitochondria quality control (MQC) mechanism, involving mitochondrial biogenesis, mitochondrial dynamics, and mitophagy. The MQC is crucial for mitochondrial homeostasis and health, and disruption of it can lead to mitochondrial damage, which is a key factor in the structural and functional impairment of skeletal muscle in COPD. The mitochondria in the skeletal muscles of these patients undergo changes, mainly including decrease in mitochondrial density and biogenesis levels, imbalanced mitochondrial fission and fusion, and altered mitophagy status. However, the potential mechanisms linking MQC to the damaged structure and function of skeletal muscles in COPD have not been fully clarified. Therefore, this review highlights the effects and potential pathways of the MQC system on the dysfunction of skeletal muscle (muscle atrophy, impaired myogenesis and regeneration, and aerobic endurance) in patients with COPD, and summarizes potential interventions targeted MQC, intending to provide a theoretical basis for further research on COPD, improve SMD, and enhance the quality of life.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization. 有氧运动通过调节Annexin-A1-MAPK轴和星形胶质细胞极化改善慢性脑灌注不足小鼠的认知恢复。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-19 DOI: 10.14336/AD.2024.01213

Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang

{"title":"Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization.","authors":"Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang","doi":"10.14336/AD.2024.01213","DOIUrl":"https://doi.org/10.14336/AD.2024.01213","url":null,"abstract":"Vascular cognitive impairment and dementia (VCID), resulting from chronic cerebral hypoperfusion, represent the second most prevalent form of dementia globally. Aerobic exercise is widely acknowledged as an effective intervention for various cognitive disorders. This study utilized a bilateral common carotid artery stenosis (BCAS) model to investigate whether aerobic exercise promotes cognitive recovery through the Annexin-A1 (ANXA1)/mitogen-activated protein kinase (MAPK) axis in BCAS mice. Our findings demonstrate that aerobic exercise improved spatial memory in BCAS mice by enhancing white matter (WM) integrity and hippocampal function. WM integrity was confirmed through Luxol Fast Blue (LFB) staining and protein assays. Additionally, aerobic exercise mitigated BCAS-induced long-term potentiation (LTP) decay and upregulated hippocampal expression of key synaptic proteins, including N-methyl-D-aspartate receptor subunits NR2B and NR1, vesicular glutamate transporter 1 (vGluT1), and the synaptic scaffolding protein postsynaptic density protein 95 (PSD95). Furthermore, aerobic exercise enhanced the expression of the anti-inflammatory mediator ANXA1 through exosome secretion while simultaneously suppressing the MAPK signaling pathway. These molecular changes were associated with increased astrocyte proliferation and the polarization of astrocytes toward the A2 phenotype. These findings were further validated using an in vitro co-culture model of astrocytes (U251) and neurons (HT22). In summary, our study demonstrates that aerobic exercise improves WM integrity and hippocampal function by modulating the ANXA1/MAPK axis following astrocyte polarization. Thus, aerobic exercise emerges as a promising intervention for promoting functional recovery in VCID.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142919044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuroinflammation as a Link in Parkinson's and Alzheimer's Diseases: A Systematic Review and Meta-Analysis. 神经炎症与帕金森病和阿尔茨海默病的关系：一项系统综述和荟萃分析。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-18 DOI: 10.14336/AD.2024.1174

Anna Tylutka, Piotr Żabiński, Łukasz Walas, Agnieszka Zembron-Lacny

{"title":"Neuroinflammation as a Link in Parkinson's and Alzheimer's Diseases: A Systematic Review and Meta-Analysis.","authors":"Anna Tylutka, Piotr Żabiński, Łukasz Walas, Agnieszka Zembron-Lacny","doi":"10.14336/AD.2024.1174","DOIUrl":"https://doi.org/10.14336/AD.2024.1174","url":null,"abstract":"Neuroinflammation plays a critical role in Alzheimer's (AD) and Parkinson's diseases (PD) onset, pathophysiology, and progression. The aim of our meta-analysis was to review the available literature to assess the role of neuroinflammation in the pathogenesis of the two most common neurological diseases: Parkinson's disease and Alzheimer's disease. Two medical databases were searched: Web of Science and PubMed in the period from 2009-2023, where a total of 37 publications that met the inclusion criteria were selected for further evaluation. Both patients with AD and with PD showed statistically significantly higher levels of interleukin IL-6 compared to the control group: p-value of 0.0034 for AD (SMD, 1.17; 95% CI, 0.39-1.96) and p-value of 0.0487 for PD (SMD 0.29 95% Cl 0.00-0.59). In AD patients, statistical significance (for random effect) was also observed for IL-1β, where higher values of this cytokine were recorded in patients compared to controls (p-value <0.001). In turn, in patients with PD, apart from IL-6, statistical significance was also observed for tumor necrosis factor-α (TNF-α) (p= 0.0431, SMD 0.52 95%Cl 0.02-1.02). Significant heterogeneity was also recorded (Q =85.48; P < 0.01; I2 = 87%). In both study groups, significant differences in common effect were observed for the anti-inflammatory cytokine IL-10, which could suggest a protective effect of this cytokine in patients with neurodegenerative diseases. The obtained results reinforce the existing clinical evidence that Alzheimer's and Parkinson's diseases are accompanied by an inflammatory response, with considerably higher blood levels observed for pro-inflammatory cytokines: IL-6, TNF-α and IL-1β.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exposure of Young Mice to Atmospherically Relevant PM_2.5 Has Sex-Dependent Long-Lasting Impacts on the Skeletal Muscle System. 幼年小鼠暴露于与大气相关的PM2.5对骨骼肌系统具有性别依赖性的长期影响。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-16 DOI: 10.14336/AD.2024.1047

Wenduo Liu, Zilin Wang, Min-Hye Kim, Yu Gu, Hyun-Jaung Sim, Jeong-Chae Lee, Sung-Ho Kook, Sang Hyun Kim

{"title":"Exposure of Young Mice to Atmospherically Relevant PM2.5 Has Sex-Dependent Long-Lasting Impacts on the Skeletal Muscle System.","authors":"Wenduo Liu, Zilin Wang, Min-Hye Kim, Yu Gu, Hyun-Jaung Sim, Jeong-Chae Lee, Sung-Ho Kook, Sang Hyun Kim","doi":"10.14336/AD.2024.1047","DOIUrl":"https://doi.org/10.14336/AD.2024.1047","url":null,"abstract":"The negative effects of particulate matter up to 2.5 μm in diameter (PM2.5) and their mediating mechanisms have been studied in various tissues. However, little is known about the mechanism and long-term tracking underlying the sex-dependent effects of PM2.5 on skeletal muscle system modulation. During youth, skeletal muscle grows rapidly and develops at its highest rate. Here we explore how exposure to atmospherically relevant levels of artificial PM2.5 affects the skeletal muscle system in 4-week-old C57BL6 mice according to sex and track the effects for 15 months post-exposure. We found that PM2.5 retarded muscle fiber growth and caused mitochondrial damage by modulating factors related to mitochondrial kinetics. However, the effects of PM2.5 on the modulation of the skeletal muscle system differed by sex and post-exposure time. The negative impacts of PM2.5 on skeletal muscle continued until they were overwhelmed by aging-related oxidative stress and inflammation, which were more severe in older PM2.5-exposed female mice compared with male mice. Older PM2.5-exposed female mice, but not older PM2.5-exposed male mice, exhibited obesity-related phenotypes in the form of increased weight and fat mass. Overall, initial exposure to PM2.5 affected the skeletal muscle system with long-lasting impacts that differed according to sex.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142919102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis. 壳聚糖及其衍生物在骨关节炎治疗中的应用。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-16 DOI: 10.14336/AD.2024.1080

Xuexuan Fan, Guangze Chen, Sishu Wang, Xinhong Liu, Sai Huang, Cong Feng, Xiaolei Jiang

引用次数: 0

Multi-Omics Research on Angina Pectoris: A Novel Perspective. 心绞痛的多组学研究：新视角。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-10 DOI: 10.14336/AD.2024.1298

Haiyang Chen, Lijun Zhang, Meiyan Liu, Yanwei Li, Yunpeng Chi

{"title":"Multi-Omics Research on Angina Pectoris: A Novel Perspective.","authors":"Haiyang Chen, Lijun Zhang, Meiyan Liu, Yanwei Li, Yunpeng Chi","doi":"10.14336/AD.2024.1298","DOIUrl":"https://doi.org/10.14336/AD.2024.1298","url":null,"abstract":"Angina pectoris (AP), a clinical syndrome characterized by paroxysmal chest pain, is caused by insufficient blood supply to the coronary arteries and sudden temporary myocardial ischemia and hypoxia. Long-term AP typically induces other cardiovascular events, including myocardial infarction and heart failure, posing a serious threat to patient safety. However, AP's complex pathological mechanisms and developmental processes introduce significant challenges in the rapid diagnosis and accurate treatment of its different subtypes, including stable angina pectoris (SAP), unstable angina pectoris (UAP), and variant angina pectoris (VAP). Omics research has contributed significantly to revealing the pathological mechanisms of various diseases with the rapid development of high-throughput sequencing approaches. The application of multi-omics approaches effectively interprets systematic information on diseases from the perspective of genes, RNAs, proteins, and metabolites. Integrating multi-omics research introduces novel avenues for identifying biomarkers to distinguish different AP subtypes. This study reviewed articles related to multi-omics and AP to elaborate on the research progress in multi-omics approaches (including genomics, transcriptomics, proteomics, and metabolomics), summarized their applications in screening biomarkers employed to discriminate multiple AP subtypes, and delineated integration methods for multi-omics approaches. Finally, we discussed the advantages and disadvantages of applying a single-omics approach in distinguishing diverse AP subtypes. Our review demonstrated that the integration of multi-omics technologies is preferable for quick and precise diagnosis of the three AP types, namely SAP, UAP, and VAP.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications. 健康和神经退行性疾病中肠道微生物群与免疫系统的相互作用：洞察分子机制和治疗应用。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-07 DOI: 10.14336/AD.2024.1362

Rengasamy Balakrishnan, Shin-Il Kang, Ji-Yeon Lee, Yang-Kook Rho, Byoung-Kook Kim, Dong-Kug Choi

{"title":"Gut Microbiota-Immune System Interactions in Health and Neurodegenerative Diseases: Insights into Molecular Mechanisms and Therapeutic Applications.","authors":"Rengasamy Balakrishnan, Shin-Il Kang, Ji-Yeon Lee, Yang-Kook Rho, Byoung-Kook Kim, Dong-Kug Choi","doi":"10.14336/AD.2024.1362","DOIUrl":"https://doi.org/10.14336/AD.2024.1362","url":null,"abstract":"The human body contains approximately 100 trillion microorganisms, predominantly within the gastrointestinal tract, collectively called the gut microbiota. Investigations have revealed the bidirectional communication between the gut microbiota and the brain, characterized as the \"microbiota-gut-brain axis.\" This axis represents an important regulator of brain development and function, immune system development, and nutrient metabolism, making it a target for efforts to alleviate the development and progression of neurodegenerative diseases (NDDs). Despite extensive biomedical and clinical research, our understanding of the causes, optimal treatment, and progression of NDDs remains limited. This paper aims to summarize the available knowledge on the role played by gut microbiota and how it is connected to the progression of neurodegenerative conditions; in particular, the relationship between the microbiota and gut-brain communications and the gut microbiota and neuro-immune conditions is reviewed. We discuss how and why the gut immune system communicates with the brain and how this communication impacts neurodegeneration. Next, we examine the alterations in the gut microbiota, immune response, and brain changes associated with gut dysbiosis. Finally, we highlight the preclinical and clinical evidence for probiotics, prebiotics, fecal microbiota transplantation, dietary supplements, natural drugs, and exercise intervention as potential therapeutic approaches that could lead to a new treatment paradigm for NDDs.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Response to Letter to the Editor, "Senolytic Treatment Improve Small Intestine Regeneration in Aging". 回复致编辑的信，“抗衰老治疗促进衰老小肠再生”。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-04 DOI: 10.14336/AD.2024.1262R

Dong Tan, Chun Xu, Qing Zhu, Gang Fan, Qing-Tian Luo

引用次数: 0

Brain Resident Ly6C^hi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis. 脑内Ly6Chi单核细胞是维持成年海马神经发生所必需的。

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-03 DOI: 10.14336/AD.2024.0835

Yiran Huang, Nan Gao, Boren Liu, Weili Luo, Jianfei Chen, Yan Chen, Yong Bi, Zikai Zhou

{"title":"Brain Resident Ly6Chi Monocytes Are Necessary for Maintaining Adult Hippocampal Neurogenesis.","authors":"Yiran Huang, Nan Gao, Boren Liu, Weili Luo, Jianfei Chen, Yan Chen, Yong Bi, Zikai Zhou","doi":"10.14336/AD.2024.0835","DOIUrl":"https://doi.org/10.14336/AD.2024.0835","url":null,"abstract":"Adult hippocampal neurogenesis (AHN) is crucial to various brain functions. Neurodegeneration, neuroinflammation and stress can impair AHN, contributing to the development of neurological and psychiatric disorders. Stress is known to extensively affect both the brain and peripheral immune system. However, the cellular and molecular mechanisms underlying stress-induced impairments in AHN remain unclear. In this study, we found that, unlike neuroinflammatory conditions, stress significantly inhibited AHN independently of microglial activation, suggesting a novel mechanism mediating stress-impaired AHN. Since stress modulates peripheral immune cells, we examined the distribution of immune cells infiltrating the brain. We found a significant decrease of infiltrated Ly6Chi monocytes in the brain parenchyma. In the blood, adoptively transferred ZsGreen+ Ly6Chi monocytes drastically reduced due to stress-induced homing to the bone marrow. Adrenalectomy (ADX) experiments revealed that monocyte homing is regulated by glucocorticoid and may cause impairments in AHN. Depleting peripheral circulating monocytes reduced brain-resident Ly6Chi monocytes and replicated the stress-induced inhibition of AHN, independent of microglia activation. RNA sequencing analysis of Ly6Chi monocytes revealed a stress-induced transcriptional profile, suggesting their supportive role in neuronal functions. Together, these findings demonstrate a novel and essential role of brain resident Ly6Chi monocytes in maintaining AHN at basal level, which is important for brain functions.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142799047","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0