Applications of Chitosan and its Derivatives in the Treatment of Osteoarthritis.

IF 7 2区 医学 Q1 GERIATRICS & GERONTOLOGY
Xuexuan Fan, Guangze Chen, Sishu Wang, Xinhong Liu, Sai Huang, Cong Feng, Xiaolei Jiang
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引用次数: 0

Abstract

Osteoarthritis (OA) is a common joint disease, which is mainly characterized by the degeneration of articular cartilage, inflammation of the synovial membrane of the joint, and changes in the surrounding bone tissue. With the increase of age and weight, the incidence of OA gradually increases, which seriously affects the quality of life of patients. The primary pharmacological treatments for OA include analgesics and non-steroidal anti-inflammatory drugs. However, these medications primarily provide symptomatic relief and are associated with significant side effects. Chitosan, derived from the deacetylation of chitin, has excellent biocompatibility, biodegradability, anti-inflammatory and antioxidant properties, and can promote the repair of articular cartilage. Chitosan can be used as a viscosupplement, drug carrier, cartilage tissue engineering scaffold or other forms. In this review, we systematically summarize the applications of chitosan and its derivatives in the treatment of OA.

壳聚糖及其衍生物在骨关节炎治疗中的应用。
骨关节炎(OA)是一种常见的关节疾病,主要表现为关节软骨退行性变,关节滑膜炎症,周围骨组织发生改变。随着年龄和体重的增加,OA的发病率逐渐增加,严重影响患者的生活质量。OA的主要药物治疗包括镇痛药和非甾体抗炎药。然而,这些药物主要提供症状缓解,并伴有明显的副作用。壳聚糖是由几丁质去乙酰化而成,具有良好的生物相容性、生物可降解性、抗炎和抗氧化性能,并能促进关节软骨的修复。壳聚糖可作为黏液补充剂、药物载体、软骨组织工程支架或其他形式使用。本文就壳聚糖及其衍生物在OA治疗中的应用作一综述。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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来源期刊
Aging and Disease
Aging and Disease GERIATRICS & GERONTOLOGY-
CiteScore
14.60
自引率
2.70%
发文量
138
审稿时长
10 weeks
期刊介绍: Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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