Aging and Disease最新文献

Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study. 神经丝-轻链和胶质纤维酸性蛋白作为基于血液的谵妄风险标志物：一项多队列研究。

IF 7 2区医学

Aging and Disease Pub Date : 2025-05-09 DOI: 10.14336/AD.2025.0107

Maria Cristina Ferrara, Lucía Lozano-Vicario, Beatrice Arosio, Cristina D'Orlando, Lara De Luca, Alice Margherita Ornago, Elena Pinardi, Paolo Mazzola, Chukwuma Okoye, Riccardo Gamberale, Francesca Remelli, Massimiliano Castellazzi, Giovanni Zatti, Giuseppe Foti, Ángel Javier Muñoz-Vázquez, Nicolás Martínez-Velilla, Stefano Volpato, Giuseppe Bellelli

{"title":"Neurofilament-Light Chain and Glial Fibrillary Acidic Protein as Blood-Based Delirium Risk Markers: A Multicohort Study.","authors":"Maria Cristina Ferrara, Lucía Lozano-Vicario, Beatrice Arosio, Cristina D'Orlando, Lara De Luca, Alice Margherita Ornago, Elena Pinardi, Paolo Mazzola, Chukwuma Okoye, Riccardo Gamberale, Francesca Remelli, Massimiliano Castellazzi, Giovanni Zatti, Giuseppe Foti, Ángel Javier Muñoz-Vázquez, Nicolás Martínez-Velilla, Stefano Volpato, Giuseppe Bellelli","doi":"10.14336/AD.2025.0107","DOIUrl":"https://doi.org/10.14336/AD.2025.0107","url":null,"abstract":"Postoperative delirium (POD) is often under-recognized in clinical practice. Blood-based markers could facilitate delirium detection and risk stratification. Neurofilament-Light chain (NfL) and Glial Fibrillary Acidic Protein (GFAP) are promising blood-based markers for neurodegenerative diseases and potential candidates for delirium. This study explored their role as blood-based risk markers for POD in older patients undergoing hip fracture surgery. In this prospective multicohort study, preoperative blood and intraoperative cerebrospinal fluid (CSF) samples were collected from patients aged ≥65 years with hip fractures. POD was assessed daily using the 4AT scale. NfL and GFAP concentrations in both blood and CSF were compared between POD and Non-POD groups, further stratifying by dementia status. Logistic regression models adjusted for covariates were used to assess associations. A total of 143 patients (median age, 85 years; 76.9% female) were included, with POD occurring in 38 patients (26.6%). Blood NfL and GFAP concentrations were significantly higher in the POD group than in Non-POD (64.55 vs. 44.6 pg/mL and 22 vs. 14.8 pg/mL, P&;lt0.001). CSF NfL levels were also elevated in POD (2154 vs. 1565 pg/mL, P=0.007), but no significant difference was observed for CSF GFAP levels. Higher preoperative blood NfL and GFAP levels independently predicted POD after adjusting for age, sex, dementia, frailty, and Interleukin-6 (Odds Ratio, OR: 3.21, 95% Confidence Interval, CI: 1.26-8.21, and OR: 3.66, 95% CI: 1.38-9.68, respectively). Although further research is needed, our findings support the role of NfL and GFAP as blood-based risk markers for POD in older patients undergoing hip fracture surgery.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143955493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Decoding Aging through iPSC Reprogramming: Advances and Challenges. 通过iPSC重编程解码衰老：进展与挑战。

IF 7 2区医学

Aging and Disease Pub Date : 2025-05-07 DOI: 10.14336/AD.2025.0438

Rui-Lin Li, Yun-Zeng Zou, Sheng Kang

{"title":"Decoding Aging through iPSC Reprogramming: Advances and Challenges.","authors":"Rui-Lin Li, Yun-Zeng Zou, Sheng Kang","doi":"10.14336/AD.2025.0438","DOIUrl":"https://doi.org/10.14336/AD.2025.0438","url":null,"abstract":"Aging is characterized by cellular senescence and increased susceptibility to age-related diseases. Induced pluripotent stem cell (iPSC) technology demonstrates the potential to reverse aging hallmarks, including telomere attrition, mitochondrial dysfunction, and oxidative stress. Reprogramming somatic cells using factors such as Oct4, Sox2, Klf4, and c-Myc (OSKM) restores pluripotency and reverses aging markers. Partial reprogramming, involving transient OSKM expression, rejuvenates cells by resetting epigenetic clocks, reducing senescence-associated secretory phenotypes (SASPs), and improving mitochondrial function, as evidenced by lifespan extension in progeroid mouse models. These advancements facilitate disease modeling and autologous therapies for neurodegeneration, etc. Critical challenges, including tumorigenicity risks associated with oncogenic reprogramming factors, have been mitigated through non-integrative delivery systems (e.g., mRNA, small molecules) and suicide genes. Persistent epigenetic memory and incomplete reprogramming impede iPSC differentiation, but CRISPR-based tools (e.g., dCas9-DNMT3A, CRISPRoff) allow precise epigenetic editing to erase residual somatic signatures. Variability in iPSC quality, influenced by cell source and culture conditions, necessitates standardized protocols and CRISPR-enhanced quality control. Ethical considerations, such as informed consent and genetic discrimination, highlight the need for governance frameworks that align innovation with societal values. Subsequent priorities include optimizing reprogramming efficiency, validating safety in preclinical models, and translating findings into therapies for age-related disorders. In conclusion, iPSC and CRISPR technologies collectively present transformative strategies to delay aging and restore cellular vitality, paving the way for rejuvenation therapies. Future studies should focus on improving the reprogramming efficiency, minimizing the risk of tumorigenicity, and exploring the optimized CRISPR-based epigenetic editing technique.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143952684","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

What do You Need to Know after Diabetes and before Diabetic Retinopathy? 糖尿病后和糖尿病视网膜病变前你需要知道什么？

IF 7 2区医学

Aging and Disease Pub Date : 2025-05-06 DOI: 10.14336/AD.2025.0289

Shiyu Zhang, Jia Liu, Heng Zhao, Yuan Gao, Changhong Ren, Xuxiang Zhang

{"title":"What do You Need to Know after Diabetes and before Diabetic Retinopathy?","authors":"Shiyu Zhang, Jia Liu, Heng Zhao, Yuan Gao, Changhong Ren, Xuxiang Zhang","doi":"10.14336/AD.2025.0289","DOIUrl":"https://doi.org/10.14336/AD.2025.0289","url":null,"abstract":"Diabetic retinopathy (DR) is a leading cause of vision impairment and blindness among individuals with diabetes mellitus. Current clinical diagnostic criteria mainly base on visible vascular structure changes, which are insufficient to identify diabetic patients without clinical DR (NDR) but with dysfunctional retinopathy. This review focuses on retinal endothelial cells (RECs), the first cells to sense and respond to elevated blood glucose. As blood glucose rises, RECs undergo compensatory and transitional phases, and the correspondingly altered molecules are likely to become biomarkers and targets for early prediction and treatment of NDR with dysfunctional retinopathy. This article elaborated the possible pathophysiological processes focusing on RECs and summarized recently published and reliable biomarkers for early screening and emerging intervention strategies for NDR patients with dysfunctional retinopathy. Additionally, references for clinical medication selection and lifestyle recommendations for this population are provided. This review aims to deepen the understanding of REC biology and NDR pathophysiology, emphasizes the importance of early detection and intervention, and points out future directions to improve the diagnosis and treatment of NDR with dysfunctional retinopathy and to reduce the occurrence of DR.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-05-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143964817","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Pericytes in the Development and Progression of Brain Diseases. 周细胞在脑部疾病发生发展中的作用。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-27 DOI: 10.14336/AD.2025.0028

Qingbin Wu, Xinyi Cui, Xiaochen Yuan, Jianqun Han, Hongwei Li, Ruijuan Xiu

引用次数: 0

Lanatoside C, a Novel Senolytic, Ameliorates Atherosclerosis in Mice. lanat苷C，一种新型的抗衰老药物，改善小鼠动脉粥样硬化。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-25 DOI: 10.14336/AD.2025.1219

Eok-Cheon Kim, Youlim Son, Seon-Hui Kim, Soo-Ji Kim, So-Young Park, Jae-Ryong Kim

引用次数: 0

Optic Atrophy 1: The Conductor of Cellular Harmony and Age-Related Pathologies. 视神经萎缩1：细胞和谐和年龄相关病理的传导。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-24 DOI: 10.14336/AD.2025.0017

Ye Xu, Jingwen Zhu, Qixiang Shao, Hui Wang

引用次数: 0

Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy. 溶酶体作为衰老过程中代谢信号和器官生理的动态调节因子：从机制到治疗。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-22 DOI: 10.14336/AD.2025.0275

Yu Sun, Jin Wei, Shiyin Ma, Chang He, Liutao Sui, Xudong Pan, Xiaoyan Zhu

{"title":"Lysosomes as Dynamic Regulators of Metabolic Signaling and Organ Physiology in Aging: From Mechanism to Therapy.","authors":"Yu Sun, Jin Wei, Shiyin Ma, Chang He, Liutao Sui, Xudong Pan, Xiaoyan Zhu","doi":"10.14336/AD.2025.0275","DOIUrl":"https://doi.org/10.14336/AD.2025.0275","url":null,"abstract":"Lysosomes are degradation centers and signaling hubs that in cells and play important roles in cellular homeostasis, development, and aging. Growing evidence has also implicated the role of lysosome-related mechanisms in the aging process. Meanwhile, the potential impact of lysosomal dysfunction on the production of inflammatory molecules, cellular metabolic status, and mitochondrial function is becoming increasingly significant. In this review, we provide a comprehensive overview of the physiological roles of lysosomes and their association with aging. At the cellular level, lysosomal dysfunction and cellular senescence show strong correlations. Herein, we elucidated the precise mechanisms by which lysosomal dysfunction contributes to various cellular physiological processes, as well as its potential implications in age-related hallmarks. More importantly, we discuss how lysosomal homeostasis is disrupted in several age-related diseases, including atherosclerosis, heart diseases, cancer, neurodegenerative diseases, metabolic disorders, and motor system diseases. Thus, a deeper understanding of lysosomal function may provide fundamental insights into human physiology and age-related diseases. Furthermore, these discoveries emphasize the role of the lysosome in the development of novel therapeutic strategies.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-22","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143959005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments. 缺氧预处理减轻急性缺氧诱导的MS/VDB胆碱能细胞丧失和记忆障碍。

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-21 DOI: 10.14336/AD.2025.0175

Linhui Qin, Yong Yang, Houdi Zhang, Sijie Li, Xi Wu, Minjie Wang, Simeng Liu, Heguan Fu, Xunming Ji, Cong Han, Changhong Ren

{"title":"Hypoxic Preconditioning Mitigates Acute Hypoxia Induced MS/VDB Cholinergic Cell Loss and Memory Impairments.","authors":"Linhui Qin, Yong Yang, Houdi Zhang, Sijie Li, Xi Wu, Minjie Wang, Simeng Liu, Heguan Fu, Xunming Ji, Cong Han, Changhong Ren","doi":"10.14336/AD.2025.0175","DOIUrl":"https://doi.org/10.14336/AD.2025.0175","url":null,"abstract":"Cholinergic cells originating from the medial septal nucleus (MS) and the vertical and horizontal limbs of the diagonal band of Broca (VDB and HDB, respectively) are critical for supporting a variety of memory and cognitive functions. However, the viability of cholinergic cells has not been explored in the context of acute hypoxia (AH). This study aimed to investigate the effects of AH on cholinergic cells in these nuclei and to test whether hypoxic preconditioning (HPC)-a previously established neuroprotective therapy-could prevent cholinergic cell loss, cognitive dysfunction, and hippocampal synaptic dysfunction in mice exposed to AH. We found that cholinergic cell loss occurred in the MS/DB after AH. HPC prevented this effect and also improved AH-induced cognitive dysfunction and hippocampal synaptic dysfunction. Overall, our findings highlight the significant role of cholinergic cells in AH-induced memory impairments and suggest that the preservation of cholinergic cell viability may provide a mechanism by which HPC improves memory impairments and preserves the function of memory-processing brain structures after AH.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-04-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143956970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

OPA1 Enhances Microglial Amyloid-β Clearance and Alleviates Cognitive Impairments in an Alzheimer's Disease Model. 在阿尔茨海默病模型中，OPA1增强小胶质淀粉样蛋白-β清除并减轻认知障碍

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-20 DOI: 10.14336/AD.2025.0082

Qing Wang, Mengqi Dong, Xue Xia, Xinyu Bao, Mengsha Hu, Lei Ye, Yun Xu

引用次数: 0

PCSK9 in Vascular Aging and Age-Related Diseases. PCSK9在血管老化和年龄相关疾病中的作用

IF 7 2区医学

Aging and Disease Pub Date : 2025-04-18 DOI: 10.14336/AD.2024.1713

Dong Tan, Xin Yang, Jing Yang, Gang Fan, Guozuo Xiong

引用次数: 0