Aging and Disease最新文献

Alpha-Glucosidase Inhibitors in Aging and Aging-Related Diseases: Clinical Applications and Relevant Mechanisms.

IF 7 2区医学

Aging and Disease Pub Date : 2025-01-02 DOI: 10.14336/AD.2024.1477

Ling Zhong, Jielin Yang, Jibran Nehal Syed, Yuwei Zhang, Yan Tian, Xianghui Fu

引用次数: 0

Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-31 DOI: 10.14336/AD.2024.1499

Jianqiong Yin, Wei Peng, Lu Lu, Zhen Hong, Dong Zhou, Jinmei Li

{"title":"Mechanistic Insights and Emerging Therapeutic Targets of Alzheimer's Disease: From the Perspective of Inter-Organ Crosstalk.","authors":"Jianqiong Yin, Wei Peng, Lu Lu, Zhen Hong, Dong Zhou, Jinmei Li","doi":"10.14336/AD.2024.1499","DOIUrl":"https://doi.org/10.14336/AD.2024.1499","url":null,"abstract":"With complex pathogenesis, Alzheimer's disease (AD) is a neurological illness that has worsened over time. Inter-organ crosstalk, which is essential for coordinating organ function and maintaining homeostasis, is involved in multiple physiological and pathological events. Increasing evidence suggests that AD is closely associated with multiple diseases of peripheral organs, including the gut, adipose tissue, liver, and bone. Despite numerous studies on AD, the ambiguous role of pathological peripheral organ-brain crosstalk in the development of AD remains incompletely understood, and the potential mechanisms remain obscure. This review summarizes the current knowledge of the relationship between AD and disorders of various organs from clinical and preclinical evidence. Additionally, we elucidate the mechanisms underlying AD development from the perspective of \"organ-organ crosstalk\", including the gut-brain, adipose tissue-brain, liver-brain and bone-brain axes. On the basis of the peripheral organ-brain crosstalk, we emphasize promising therapeutic targets with the hope of providing novel perspectives for AD management.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Senescent Macrophages and the Lung Cancer Microenvironment: A New Perspective on Tumor Immune Evasion.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-31 DOI: 10.14336/AD.2024.1404

Lexin Qin, Tingting Liang, Xinyu Zhu, Wentao Hu, Bo Li, Meidan Wei, Jiaxin Zhang, Jianxiang Li, Jin Wang

引用次数: 0

Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-30 DOI: 10.14336/AD.2024.1293

Shokofeh Rahimpour, Briana L Clary, Sanaz Nasoohi, Yohanna S Berhanu, Candice M Brown

{"title":"Immunometabolism In Brain Aging and Neurodegeneration: Bridging Metabolic Pathways and Immune Responses.","authors":"Shokofeh Rahimpour, Briana L Clary, Sanaz Nasoohi, Yohanna S Berhanu, Candice M Brown","doi":"10.14336/AD.2024.1293","DOIUrl":"https://doi.org/10.14336/AD.2024.1293","url":null,"abstract":"The complex set of interactions between the immune system and metabolism, known as immunometabolism, has emerged as a critical regulator of disease outcomes in the central nervous system. Numerous studies have linked metabolic disturbances to impaired immune responses in brain aging, neurodegenerative disorders, and brain injury. In this review, we will discuss how disruptions in brain immunometabolism balance contribute to the pathophysiology of brain dysfunction. The first part of the review summarizes the contributions of critical immune cell populations such as microglia, astrocytes, and infiltrating immune cells in mediating inflammation and metabolism in CNS disorders. The remainder of the review addresses the impact of metabolic changes on immune cell activation and disease progression in brain aging, Alzheimer's disease, Parkinson's disease, multiple sclerosis, stroke, spinal cord injury, and traumatic brain injury. Furthermore, we also address the therapeutic potential of targeting immunometabolic pathways to reduce neuroinflammation and slow disease progression. By focusing on the interactions among brain immune cells and the metabolic mechanisms they recruit in disease, we present a comprehensive overview of brain immunometabolism in human health and disease.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918858","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-30 DOI: 10.14336/AD.2024.1538

Xiwei Fan, Hong Xu, Indira Prasadam, Antonia Rujia Sun, Xiaoxin Wu, Ross Crawford, Yanping Wang, Xinzhan Mao

{"title":"Spatiotemperal Dynamics of Osteoarthritis: Bridging Insights from Bench to Bedside.","authors":"Xiwei Fan, Hong Xu, Indira Prasadam, Antonia Rujia Sun, Xiaoxin Wu, Ross Crawford, Yanping Wang, Xinzhan Mao","doi":"10.14336/AD.2024.1538","DOIUrl":"https://doi.org/10.14336/AD.2024.1538","url":null,"abstract":"Osteoarthritis (OA) is a multifaceted degenerative joint disorder affected by various risk factors such as age, mechanical stress, inflammation, and metabolic influences. These elements contribute to its diverse phenotypes and endotypes, underscoring the disease's inherent complexity. The involvement of multiple tissues and their interplay further complicates OA's investigation. The current limitations in spatial phenotyping technologies, coupled with the intricate web of multifactorial interactions, have hindered the discovery of reliable early diagnostic markers and the development of tailored therapeutic strategies. However, recent advances in spatiotemporal analysis have revolutionised researchers' capacity to explore OA's spatiotemporal dynamics. These advancements provide unprecedented insights into the disease's progression, revealing patient-specific clinical presentations, tissue and joint structure alterations, and microscopic to molecular changes in tissue cell populations and extracellular matrices. This paper summarises the latest developments in utilising state-of-the-art technologies for the deep phenotyping of OA's spatiotemporal variations, emphasising their critical role in elucidating OA's pathophysiology and how this can change clinical practice and advancing personalised treatment approaches, and finally lead to better clinical outcomes.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918873","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Bone Health and Physical Activity - The Complex Mechanism.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-30 DOI: 10.14336/AD.2024.1316

Alicja Nowak, Małgorzata Ogurkowska

{"title":"Bone Health and Physical Activity - The Complex Mechanism.","authors":"Alicja Nowak, Małgorzata Ogurkowska","doi":"10.14336/AD.2024.1316","DOIUrl":"https://doi.org/10.14336/AD.2024.1316","url":null,"abstract":"This review summarizes the mechanism and role of physical activity in maintaining the proper functioning of the musculoskeletal system. Bone adaptation to the mechanical environment occurs in skeletal regions subjected to the greatest stresses resulting from the nature of exercise, however, there is a varied response of bone tissue to mechanical loads depending on its material and structural properties (trabecular and cortical). The regulation of bone tissue metabolism during physical exercise is influenced by factors associated with mechanical stress (gravitational forces, impact loading, and muscular contractions) as well as by systemic mechanisms (hormones, myokines, cytokines). The presence of insulin receptors and glucose transporters in osteoblasts indicates that these cells consume large amounts of glucose. Therefore, when energy demand during physical activity increases, nutritional factors play an important role in bone response. On the other hand, the musculoskeletal system participates in the regulation of energy metabolism. To maintain bone homeostasis, an optimized form of physical activity should be used (e.g. intensity, duration, training session frequency). The complexity of factors modulating the sensitivity of bones to mechanical stimuli causes the results of physical training are age- and sex-dependent. Moreover, when selecting exercises to improve bone health, it is important to take into account metabolic and musculoskeletal system conditions. In addition, exercise should be safe and adapted to the health and fitness level so as not to increase the risk of fractures. Participation in regular physical activity should continue after the training program to maintain bone mass.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142919097","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Revisiting the Benefits of Exercise for Alzheimer's Disease through the Lens of Ferroptosis: A New Perspective.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-24 DOI: 10.14336/AD.2024.1560

Zikang Hao, Xinmeng Guo, Jiawen Wu, Guang Yang

{"title":"Revisiting the Benefits of Exercise for Alzheimer's Disease through the Lens of Ferroptosis: A New Perspective.","authors":"Zikang Hao, Xinmeng Guo, Jiawen Wu, Guang Yang","doi":"10.14336/AD.2024.1560","DOIUrl":"https://doi.org/10.14336/AD.2024.1560","url":null,"abstract":"Ferroptosis, an iron-dependent form of programmed cell death driven by oxidative stress, plays a crucial role in the progression of Alzheimer's disease (AD). Aging diminishes antioxidant systems that maintain iron homeostasis, particularly affecting the glutathione peroxidase (GPX) system, leading to increased ferroptosis and exacerbated neurodegeneration and neuroinflammation in AD. Nuclear factor erythroid 2-related factor 2 (Nrf2) is a key transcription factor regulating genes involved in antioxidant defense and ferroptosis. In this review, we examine the interconnected roles of Nrf2 signaling, iron metabolism, and ferroptosis in AD, and discuss how regular physical exercise-known to enhance antioxidant capacity-might influence these processes. Despite evidence linking exercise to improved cognitive function in AD and its role in modulating oxidative stress, there is a paucity of research specifically addressing how exercise affects ferroptosis in the AD brain. To address this gap, we utilized bioinformatics techniques to identify potential pathways and mechanisms by which exercise may mitigate ferroptosis in AD through Nrf2 signaling. Analyzing gene expression profiles from the GEO database, we identified differentially expressed ferroptosis-related genes in the hippocampus following exercise intervention. Hub genes like SLC2A1, TXN, MEF2C, and KRAS were significantly upregulated, suggesting that exercise may activate a network enhancing antioxidant defenses and regulating iron metabolism via Nrf2. Our findings propose a novel mechanism whereby exercise alleviates abnormal ferroptosis in the AD brain through modulation of Nrf2 signaling. This study highlights the need for further research to validate these findings and explore exercise as a therapeutic strategy for AD by targeting ferroptosis.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918870","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Epigenetic Clocks: Beyond Biological Age, Using the Past to Predict the Present and Future.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-23 DOI: 10.14336/AD.2024.1495

Runyu Liang, Qiang Tang, Jia Chen, Luwen Zhu

引用次数: 0

Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-21 DOI: 10.14336/AD.2024.1129

Yanxia Song, Xiaoyu Han, Yingqi Wang, Kangxia Li, Huanping Li, Yizhu Tian, Xiaoqing Ma, Weibing Wu, Jihong Wang

{"title":"Mitochondrial Quality Control: A New Perspective in Skeletal Muscle Dysfunction of Chronic Obstructive Pulmonary Disease.","authors":"Yanxia Song, Xiaoyu Han, Yingqi Wang, Kangxia Li, Huanping Li, Yizhu Tian, Xiaoqing Ma, Weibing Wu, Jihong Wang","doi":"10.14336/AD.2024.1129","DOIUrl":"https://doi.org/10.14336/AD.2024.1129","url":null,"abstract":"Skeletal muscle dysfunction (SMD), one of the extrapulmonary complications in patients with chronic obstructive pulmonary disease (COPD), considerably influences patient prognosis. Mitochondria regulates their dynamic networks through a mitochondria quality control (MQC) mechanism, involving mitochondrial biogenesis, mitochondrial dynamics, and mitophagy. The MQC is crucial for mitochondrial homeostasis and health, and disruption of it can lead to mitochondrial damage, which is a key factor in the structural and functional impairment of skeletal muscle in COPD. The mitochondria in the skeletal muscles of these patients undergo changes, mainly including decrease in mitochondrial density and biogenesis levels, imbalanced mitochondrial fission and fusion, and altered mitophagy status. However, the potential mechanisms linking MQC to the damaged structure and function of skeletal muscles in COPD have not been fully clarified. Therefore, this review highlights the effects and potential pathways of the MQC system on the dysfunction of skeletal muscle (muscle atrophy, impaired myogenesis and regeneration, and aerobic endurance) in patients with COPD, and summarizes potential interventions targeted MQC, intending to provide a theoretical basis for further research on COPD, improve SMD, and enhance the quality of life.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142918863","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization.

IF 7 2区医学

Aging and Disease Pub Date : 2024-12-19 DOI: 10.14336/AD.2024.01213

Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang

{"title":"Aerobic Exercise Improves Cognitive Recovery in Mice with Chronic Cerebral Hypoperfusion by Modulating the Annexin-A1-MAPK Axis and Astrocyte Polarization.","authors":"Wei Zhang, Jing He, Yuxin Wang, Xiaozhen Wang, He Jin, Xu Zhang, Ling Kong, Yanchuan Wu, Yong Yang, Rong Wang","doi":"10.14336/AD.2024.01213","DOIUrl":"https://doi.org/10.14336/AD.2024.01213","url":null,"abstract":"Vascular cognitive impairment and dementia (VCID), resulting from chronic cerebral hypoperfusion, represent the second most prevalent form of dementia globally. Aerobic exercise is widely acknowledged as an effective intervention for various cognitive disorders. This study utilized a bilateral common carotid artery stenosis (BCAS) model to investigate whether aerobic exercise promotes cognitive recovery through the Annexin-A1 (ANXA1)/mitogen-activated protein kinase (MAPK) axis in BCAS mice. Our findings demonstrate that aerobic exercise improved spatial memory in BCAS mice by enhancing white matter (WM) integrity and hippocampal function. WM integrity was confirmed through Luxol Fast Blue (LFB) staining and protein assays. Additionally, aerobic exercise mitigated BCAS-induced long-term potentiation (LTP) decay and upregulated hippocampal expression of key synaptic proteins, including N-methyl-D-aspartate receptor subunits NR2B and NR1, vesicular glutamate transporter 1 (vGluT1), and the synaptic scaffolding protein postsynaptic density protein 95 (PSD95). Furthermore, aerobic exercise enhanced the expression of the anti-inflammatory mediator ANXA1 through exosome secretion while simultaneously suppressing the MAPK signaling pathway. These molecular changes were associated with increased astrocyte proliferation and the polarization of astrocytes toward the A2 phenotype. These findings were further validated using an in vitro co-culture model of astrocytes (U251) and neurons (HT22). In summary, our study demonstrates that aerobic exercise improves WM integrity and hippocampal function by modulating the ANXA1/MAPK axis following astrocyte polarization. Thus, aerobic exercise emerges as a promising intervention for promoting functional recovery in VCID.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142919044","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0