Aging and Disease最新文献_第2页

GABA Levels Are Significantly Reduced in the Visual, Motor, and Auditory Cortex of Patients with Mild Cognitive Impairment. 轻度认知障碍患者的视觉、运动和听觉皮层中GABA水平显著降低。

IF 7 2区医学

Aging and Disease Pub Date : 2025-07-03 DOI: 10.14336/AD.2025.0334

Mark D Zuppichini, Abbey M Hamlin, Quan Zhou, Esther Kim, Kayla Wyatt, Noah Reardon, Benjamin M Hampstead, Thad A Polk

{"title":"GABA Levels Are Significantly Reduced in the Visual, Motor, and Auditory Cortex of Patients with Mild Cognitive Impairment.","authors":"Mark D Zuppichini, Abbey M Hamlin, Quan Zhou, Esther Kim, Kayla Wyatt, Noah Reardon, Benjamin M Hampstead, Thad A Polk","doi":"10.14336/AD.2025.0334","DOIUrl":"https://doi.org/10.14336/AD.2025.0334","url":null,"abstract":"One factor that might contribute to functional deterioration in patients with mild cognitive impairment (pwMCI) is a reduction in the brain's major inhibitory neurotransmitter, gamma-aminobutyric acid (GABA). Previous studies have reported reductions in GABA in pwMCI while others have not. Here we use magnetic resonance spectroscopy (MRS) to estimate GABA + macromolecules due to co-editing (GABA+) levels in six different brain regions in 37 pwMCI and 163 healthy controls. We estimate GABA+ levels using both creatine and water as reference molecules, and we analyze the effect of correcting for grey matter volume. When referenced to water, we found that GABA+ was significantly lower in pwMCI compared to controls in all six regions, even after tissue composition correction. When referenced to creatine, all but two regions exhibited lower amounts of GABA+ for pwMCI, even after controlling for tissue composition. Results suggest that pwMCI experience reductions in GABA+ throughout the brain, even in regions not typically associated with cognitive impairment.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-07-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144666793","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Complex Bidirectional Relationship Between Aging and Atherosclerosis: Mechanistic Insights and Translational Opportunities. 衰老与动脉粥样硬化之间复杂的双向关系：机制见解和转化机会。

IF 7 2区医学

Aging and Disease Pub Date : 2025-07-02 DOI: 10.14336/AD.2025.10620

Binquan You, Dong Yi, Bingyin Wang, Hua Yan

引用次数: 0

Mechanistic Role of Astrocytic Rac1 Protein in Alzheimer's Disease. 星形细胞Rac1蛋白在阿尔茨海默病中的机制作用。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-28 DOI: 10.14336/AD.2025.0502

Fengwen Jiang, Niya Wang, Qiang Meng

引用次数: 0

Regulatory and Influencing Factors of Digestive Function in Elderly People: Roles of the Gut Microbiota and Nutritional Interventions. 老年人消化功能的调节和影响因素：肠道菌群的作用和营养干预。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-27 DOI: 10.14336/AD.2025.0565

Ka Li, Safia Arbab, Qiujing Du, Jiao Zhou, Yuwen Chen, Yali Tian, Li Qijie, Hanif Ullah, Ben Zhang

{"title":"Regulatory and Influencing Factors of Digestive Function in Elderly People: Roles of the Gut Microbiota and Nutritional Interventions.","authors":"Ka Li, Safia Arbab, Qiujing Du, Jiao Zhou, Yuwen Chen, Yali Tian, Li Qijie, Hanif Ullah, Ben Zhang","doi":"10.14336/AD.2025.0565","DOIUrl":"https://doi.org/10.14336/AD.2025.0565","url":null,"abstract":"Aging is a natural and gradual biological process through which living organisms undergo physical, physiological, and sometimes psychological changes over time. Aging is commonly associated with a decline in gastrointestinal function, leading to various digestive disorders that impact the quality of life of older adults. The gut microbiota is a highly complex ecosystem that plays crucial roles in digestion, metabolic processes, immune functions, and overall health. However, emerging evidence indicates that many elderly individuals maintain relatively stable digestive health, suggesting the influence of modifiable regulatory factors. In this review, we describe the key physiological, microbial, and nutritional factors that regulate and influence digestive function in an aging population. Additionally, we explored the impact of age-associated alterations in the gut microbiota on digestive health challenges in older adults and emphasized the therapeutic potential of targeted nutritional intervention approaches, such as dietary modifications, prebiotics, probiotics, and symbiotic and fecal microbiota transplantation, which have shown promise in rebalancing the gut microbiome and reducing inflammation.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525985","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer. 揭示细胞衰老、表观遗传学和癌症之间的关系。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-27 DOI: 10.14336/AD.2025.0677

Pawel Kordowitzki, Arkadiusz Grzeczka

{"title":"Unveiling the Relation between Cellular Ageing, Epigenetics and Cancer.","authors":"Pawel Kordowitzki, Arkadiusz Grzeczka","doi":"10.14336/AD.2025.0677","DOIUrl":"https://doi.org/10.14336/AD.2025.0677","url":null,"abstract":"This Editorial article intends to unravel the relationships among cellular ageing, epigenetic changes, and tumorigenesis, thereby offering perspectives that could improve therapeutic approaches in cancer management and promote future research on these topics. Furthermore, selected fundamental principles concerning cellular ageing will be presented to elucidate how this process contributes to the comprehension of tumorigenesis. As humans age, there is a progressive decline in physiological functions, which significantly increases the risk of cancer. Epigenetic alterations-heritable yet reversible modifications of the genome without changes in DNA sequence-play a pivotal role in both ageing and tumorigenesis. Age-associated epigenetic drift, involving widespread DNA methylation changes, histone modification shifts, and chromatin remodelling, disrupts normal gene regulatory networks, leading to genomic instability and impaired cellular homeostasis. Additionally, the accumulation of senescent cells, driven by epigenetic dysregulation, fosters a pro-inflammatory environment that can promote tumorigenesis. Moreover, the epigenetic landscape of aged tissues resembles that of cancerous tissues, suggesting that ageing establishes a permissive environment for malignant transformation. Understanding the interplay between ageing, epigenetic regulation, and cancer is critical for the development of preventive strategies and novel therapeutics. Epigenetic reprogramming technologies, aiming to restore youthful epigenetic states, hold promise for delaying ageing and reducing cancer incidence. However, challenges remain in selectively targeting pathogenic epigenetic changes without disrupting essential cellular functions.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525990","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent Advances in Aging-Related Diseases: Accelerated Aging, Molecular Mechanisms, Interventions, and Therapies. 衰老相关疾病的最新进展：加速衰老、分子机制、干预和治疗。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-26 DOI: 10.14336/AD.2025.10618

Elham Sadat Afraz, Seyed Alireza Hoseinikhah, Nasrollah Moradikor

{"title":"Recent Advances in Aging-Related Diseases: Accelerated Aging, Molecular Mechanisms, Interventions, and Therapies.","authors":"Elham Sadat Afraz, Seyed Alireza Hoseinikhah, Nasrollah Moradikor","doi":"10.14336/AD.2025.10618","DOIUrl":"10.14336/AD.2025.10618","url":null,"abstract":"Aging is a multifaceted biological process influenced by cellular stress, mitochondrial dysfunction, and immune system alterations. This editorial commentary categorizes recent findings of Aging and Disease into three main areas: the acceleration of aging, prediction of age-related decline, and emerging therapeutic strategies. Research indicates that factors such as oxidative stress, chronic inflammation, and genetic predispositions contribute to premature cellular aging and the onset of age-related diseases. Recent advances in biomarkers and machine learning have improved our ability to predict biological age and associated risks, including sarcopenia and cardiovascular decline. Promising therapeutic interventions such as mitochondrial transplantation, immune system modulation, and targeted gene therapies show efficacy in decelerating aging processes and treating conditions such as Alzheimer's disease and tissue fibrosis. A deeper understanding of these interconnected mechanisms lays the groundwork for developing personalized interventions that promote healthy aging.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":"16 4","pages":"1785-1792"},"PeriodicalIF":7.0,"publicationDate":"2025-06-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12221415/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144551665","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Inflammasome-miR Axis in Alzheimer's Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities. 炎症小体- mir轴在阿尔茨海默病和慢性疼痛中的作用：分子机制和治疗机会。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-25 DOI: 10.14336/AD.2025.0353

Botond Gaál, Roland Takács, Csaba Matta, Krisztián Juhász, Béla Fülesdi, Zoltán Szekanecz, Szilvia Benkő, László Ducza

{"title":"The Inflammasome-miR Axis in Alzheimer's Disease and Chronic Pain: Molecular Mechanisms and Therapeutic Opportunities.","authors":"Botond Gaál, Roland Takács, Csaba Matta, Krisztián Juhász, Béla Fülesdi, Zoltán Szekanecz, Szilvia Benkő, László Ducza","doi":"10.14336/AD.2025.0353","DOIUrl":"https://doi.org/10.14336/AD.2025.0353","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder characterized by cognitive decline, synaptic dysfunction, and chronic neuroinflammation. Mounting evidence suggests that inflammasome activation plays a pivotal role in the onset and progression of AD by promoting neuronal damage, Tau pathology, and amyloid-β (Aβ) accumulation. Among the various inflammasome types expressed in the central nervous system (CNS), NLRP3 has received particular attention due to its strong association with both AD and pain-related neuroinflammation. Chronic pain, frequently observed in older adults and individuals with dementia, shares overlapping inflammatory mechanisms with AD, including glial activation and cytokine dysregulation. The inflammasome-microRNA (miR) axis has recently emerged as a key regulatory pathway modulating these neuroinflammatory responses. Specific inflammation-associated miRs, such as miR-22, miR-34a, miR-146a, miR-155, and miR-223, influence innate immune signaling and critically affect both neuronal homeostasis and pain sensitization. Emerging evidence also implicates dysfunction of the locus coeruleus-noradrenergic (LC-NE) system-an early target of AD pathology-in amplifying neuroinflammation and pain sensitivity, partly through interactions with dysregulated miRs. While previous studies have addressed the roles of inflamma-miRs in AD or chronic pain individually, this review uniquely examines their interconnected roles-highlighting how dysregulated miR expression and inflammasome activation may converge to drive persistent neuroinflammation across both conditions. By elucidating shared molecular pathways, we propose that targeting the inflammasome-miR axis may offer dual therapeutic potential: slowing AD progression while addressing pain-related neural dysfunction. As the prevalence of AD rises, such integrated insights are essential for the development of more precise, mechanism-based interventions.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525989","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases. 视网膜色素上皮吞噬与视网膜退行性疾病。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-25 DOI: 10.14336/AD.2025.0542

Yuxiang Du, Yong Xia

{"title":"Retinal Pigment Epithelium Phagocytosis and Retinal Degenerative Diseases.","authors":"Yuxiang Du, Yong Xia","doi":"10.14336/AD.2025.0542","DOIUrl":"https://doi.org/10.14336/AD.2025.0542","url":null,"abstract":"In the mammalian retina, photoreceptors rely on the continuous renewal of their outer segments to preserve their function as light-sensing cells, thereby ensuring lifelong vision. This process entails the routine phagocytosis of shed photoreceptor outer segments (POS) by the retinal pigment epithelium (RPE). Phagocytosis of POS by RPE is a highly circadian-regulated process that is dependent on intricate and tightly controlled cellular signaling pathways. This article provides a systematic review of the research on the regulation and functional implications of the RPE phagocytic signaling system. Therefore, a deeper understanding of the role of retinal pigment epithelial phagocytosis in the pathogenesis of retinal degeneration can inform the development of potential therapeutic targets to prevent the irreversible loss of retinal pigment epithelium and photoreceptor cells, thereby preventing retinal degenerative diseases. This article summarizes the soluble and membrane-bound molecules produced by the RPE that are associated with phagocytosis and discusses their specific roles in POS phagocytosis and retinal degenerative disorders, potentially aiding in the prevention or treatment of retinal degenerative diseases.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525987","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Glucose Metabolism, Lactate, Lactylation and Alzheimer's Disease. 葡萄糖代谢，乳酸，乳酸化和阿尔茨海默病。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-25 DOI: 10.14336/AD.2025.0338

Shuangshuang Hai, Yadan Hou, Meiyan Zhang, Xiaoyan Gao, Tuo Yang, Xiuli Shang, Xiaohong Sun

{"title":"Glucose Metabolism, Lactate, Lactylation and Alzheimer's Disease.","authors":"Shuangshuang Hai, Yadan Hou, Meiyan Zhang, Xiaoyan Gao, Tuo Yang, Xiuli Shang, Xiaohong Sun","doi":"10.14336/AD.2025.0338","DOIUrl":"https://doi.org/10.14336/AD.2025.0338","url":null,"abstract":"Alzheimer's disease (AD) is a neurodegenerative disorder primarily characterized by cognitive decline; however, its pathogenesis remains incompletely understood. In recent years, the role of lactate metabolism and its derived lactylation modifications in AD has received increasing attention. As a product of glycolysis, lactate is not only a key molecule in energy metabolism but also regulates gene expression and protein function through lactylation modifications. Studies have shown that in the brains of AD patients, glucose metabolism is significantly reduced, while glycolysis is upregulated, and lactate levels are elevated. Nevertheless, the research regarding the relationship between lactylation and AD remains limited. Building on recent advances in understanding lactylation in neurodegenerative diseases and related conditions, we analyze and explore the potential relationships between lactylation and AD from the perspectives of β-amyloid (Aβ) deposition, tau protein pathology, and neuroinflammation. In summary, lactylation, as a novel post-translational modification holds significant promise in elucidating the pathological mechanisms and advancing the treatment of AD. A deeper investigation into its molecular mechanisms and regulatory networks may open new avenues for the diagnosis and treatment of AD.","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":7.0,"publicationDate":"2025-06-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144525983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief. 白藜芦醇：利用自然的潜力缓解慢性疼痛。

IF 7 2区医学

Aging and Disease Pub Date : 2025-06-23 DOI: 10.14336/AD.2025.0530

Hong Wu, Jia-Yi Wu, Shao-Jie Gao, Lin Liu, Xin-Yi Dai, Wen-Lu Song, Long-Qing Zhang, Dai-Qiang Liu, Ying-Xin Tang, Ya-Qun Zhou, Wei Mei

引用次数: 0