白藜芦醇：利用自然的潜力缓解慢性疼痛。

IF 7 2区医学 Q1 GERIATRICS & GERONTOLOGY

Aging and Disease Pub Date : 2025-06-23 DOI:10.14336/AD.2025.0530

Hong Wu, Jia-Yi Wu, Shao-Jie Gao, Lin Liu, Xin-Yi Dai, Wen-Lu Song, Long-Qing Zhang, Dai-Qiang Liu, Ying-Xin Tang, Ya-Qun Zhou, Wei Mei

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引用次数: 0

摘要

白藜芦醇是一种具有抗炎、抗氧化和神经保护特性的天然多酚，在治疗慢性疼痛方面显示出巨大的潜力。本文综述了其镇痛机制，包括抑制神经炎症，增强抗氧化活性，诱导自噬，减少内质网应激，调节血清素系统，恢复肠道微生物群稳态，调节神经内分泌系统，促进线粒体生物发生。虽然其镇痛潜力相当大，但未来的研究应优先考虑提高其生物利用度，研究药物相互作用，并确认长期安全性，以开发更有效的慢性疼痛治疗方法。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Resveratrol: Harnessing Nature's Potential for Chronic Pain Relief.

Resveratrol, a natural polyphenol with anti-inflammatory, antioxidant, and neuroprotective properties, shows great potential in managing chronic pain. This review explores its analgesic mechanisms, including the inhibition of neuroinflammation, enhancement of antioxidant activity, induction of autophagy, reduction of endoplasmic reticulum stress, modulation of the serotonin system, restoration of gut microbiota homeostasis, regulation of the neuroendocrine system, and promotion of mitochondrial biogenesis. While its analgesic potential is considerable, future research should prioritize enhancing its bioavailability, investigating drug interactions, and confirming long-term safety to develop more effective therapies for chronic pain.

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来源期刊

Aging and Disease GERIATRICS & GERONTOLOGY-

CiteScore

14.60

自引率

2.70%

发文量

138

审稿时长

10 weeks

期刊介绍： Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.