免疫细胞调控骨骼肌炎预后的研究进展。

IF 7 2区医学 Q1 GERIATRICS & GERONTOLOGY

Aging and Disease Pub Date : 2025-07-17 DOI:10.14336/AD.2025.0549

Shuxian Huang, Yongling Zhao, Yuanpeng Xin, Ziqi Yao, Yi Deng, Qihui Cai, Junyi Xie, Ruixue Wang, Zhaohong Liao

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引用次数: 0

摘要

骨骼肌炎的患病率每年都在增加，损害了活动能力，并可能导致急性器官衰竭。肌肉损伤后，受损肌肉内的各种因素引发免疫细胞从血液中渗出到损伤区域，影响疾病进展。本文综述了国内外关于骨骼肌炎细胞/分子机制的研究，探讨了外源性骨骼肌炎、营养不良性肌病和特发性炎症性肌病（IIM）中免疫细胞的调控作用。我们得出结论，来自肌内免疫细胞的细胞因子是临床管理和治疗发展的关键目标。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Advances in the Regulation by Immune Cells of Skeletal Myositis Outcomes.

Skeletal myositis prevalence is increasing annually, impairing mobility and potentially causing acute organ failure. Following muscle injury, various factors within damaged muscle trigger immune cell exudation from the bloodstream to the injured area, influencing disease progression. This paper synthesizes global research on cellular/molecular mechanisms in skeletal myositis, examining immune cell regulation in exogenous-induced skeletal myositis, dystrophic myopathy, and idiopathic inflammatory myopathy (IIM). We conclude that cytokines from intramuscular immune cells represent key targets for clinical management and therapeutic development.

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来源期刊

Aging and Disease GERIATRICS & GERONTOLOGY-

CiteScore

14.60

自引率

2.70%

发文量

138

审稿时长

10 weeks

期刊介绍： Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.