{"title":"通过细胞衰老解码组织纤维化：机制、治疗和新兴技术。","authors":"Wenjie Cai, Haoyu Zhang, Zhouzhou Li, Mingyun Cai, Shiwen Yu, Peng Chen, Xinyu Song","doi":"10.14336/AD.2025.0503","DOIUrl":null,"url":null,"abstract":"<p><p>Cellular senescence is one of the hallmarks of aging, and it is closely related to tissue fibrosis in various age-related diseases. By integrating multi-level and multi-dimensional data, emerging technologies can comprehensively analyze the complex mechanisms of aging and fibrosis diseases, discover new biomarkers and therapeutic targets, and promote the development of precision medicine. Most of the current reviews still focus on the molecular mechanisms of cellular senescence and fibrosis diseases, but lack a comprehensive summary of anti-aging drugs for the treatment of fibrosis-related diseases, and emerging technologies and integrated analysis of multi-omics data. This review discusses the latest evidence on the role of cellular senescence in tissue fibrosis, especially lungs, liver, and kidney fibrosis. In addition, we also introduce the application of anti-aging strategies in fibrotic diseases, especially drugs to eliminate senescent cells, and the latest application of emerging technologies in aging and fibrotic diseases.</p>","PeriodicalId":7434,"journal":{"name":"Aging and Disease","volume":" ","pages":""},"PeriodicalIF":6.9000,"publicationDate":"2025-07-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies.\",\"authors\":\"Wenjie Cai, Haoyu Zhang, Zhouzhou Li, Mingyun Cai, Shiwen Yu, Peng Chen, Xinyu Song\",\"doi\":\"10.14336/AD.2025.0503\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>Cellular senescence is one of the hallmarks of aging, and it is closely related to tissue fibrosis in various age-related diseases. By integrating multi-level and multi-dimensional data, emerging technologies can comprehensively analyze the complex mechanisms of aging and fibrosis diseases, discover new biomarkers and therapeutic targets, and promote the development of precision medicine. Most of the current reviews still focus on the molecular mechanisms of cellular senescence and fibrosis diseases, but lack a comprehensive summary of anti-aging drugs for the treatment of fibrosis-related diseases, and emerging technologies and integrated analysis of multi-omics data. This review discusses the latest evidence on the role of cellular senescence in tissue fibrosis, especially lungs, liver, and kidney fibrosis. In addition, we also introduce the application of anti-aging strategies in fibrotic diseases, especially drugs to eliminate senescent cells, and the latest application of emerging technologies in aging and fibrotic diseases.</p>\",\"PeriodicalId\":7434,\"journal\":{\"name\":\"Aging and Disease\",\"volume\":\" \",\"pages\":\"\"},\"PeriodicalIF\":6.9000,\"publicationDate\":\"2025-07-21\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Aging and Disease\",\"FirstCategoryId\":\"3\",\"ListUrlMain\":\"https://doi.org/10.14336/AD.2025.0503\",\"RegionNum\":2,\"RegionCategory\":\"医学\",\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"Q1\",\"JCRName\":\"GERIATRICS & GERONTOLOGY\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Aging and Disease","FirstCategoryId":"3","ListUrlMain":"https://doi.org/10.14336/AD.2025.0503","RegionNum":2,"RegionCategory":"医学","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"Q1","JCRName":"GERIATRICS & GERONTOLOGY","Score":null,"Total":0}
Tissue Fibrosis Decoded via Cellular Senescence: Mechanisms, Treatments, and Emerging Technologies.
Cellular senescence is one of the hallmarks of aging, and it is closely related to tissue fibrosis in various age-related diseases. By integrating multi-level and multi-dimensional data, emerging technologies can comprehensively analyze the complex mechanisms of aging and fibrosis diseases, discover new biomarkers and therapeutic targets, and promote the development of precision medicine. Most of the current reviews still focus on the molecular mechanisms of cellular senescence and fibrosis diseases, but lack a comprehensive summary of anti-aging drugs for the treatment of fibrosis-related diseases, and emerging technologies and integrated analysis of multi-omics data. This review discusses the latest evidence on the role of cellular senescence in tissue fibrosis, especially lungs, liver, and kidney fibrosis. In addition, we also introduce the application of anti-aging strategies in fibrotic diseases, especially drugs to eliminate senescent cells, and the latest application of emerging technologies in aging and fibrotic diseases.
期刊介绍：
Aging & Disease (A&D) is an open-access online journal dedicated to publishing groundbreaking research on the biology of aging, the pathophysiology of age-related diseases, and innovative therapies for conditions affecting the elderly. The scope encompasses various diseases such as Stroke, Alzheimer's disease, Parkinson’s disease, Epilepsy, Dementia, Depression, Cardiovascular Disease, Cancer, Arthritis, Cataract, Osteoporosis, Diabetes, and Hypertension. The journal welcomes studies involving animal models as well as human tissues or cells.
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