Advances in the Regulation by Immune Cells of Skeletal Myositis Outcomes.

Abstract

Skeletal myositis prevalence is increasing annually, impairing mobility and potentially causing acute organ failure. Following muscle injury, various factors within damaged muscle trigger immune cell exudation from the bloodstream to the injured area, influencing disease progression. This paper synthesizes global research on cellular/molecular mechanisms in skeletal myositis, examining immune cell regulation in exogenous-induced skeletal myositis, dystrophic myopathy, and idiopathic inflammatory myopathy (IIM). We conclude that cytokines from intramuscular immune cells represent key targets for clinical management and therapeutic development.