Npj mental health research最新文献

Beyond discrete classifications: a computational approach to the continuum of cognition and behavior in children. 超越离散分类：儿童认知和行为连续体的计算方法。

Npj mental health research Pub Date : 2025-10-01 DOI: 10.1038/s44184-025-00163-5

Anthony Gagnon, Virginie Gillet, Anne-Sandrine Desautels, Jean-François Lepage, Andrea A Baccarelli, Jonathan Posner, Maxime Descoteaux, Marie A Brunet, Larissa Takser

{"title":"Beyond discrete classifications: a computational approach to the continuum of cognition and behavior in children.","authors":"Anthony Gagnon, Virginie Gillet, Anne-Sandrine Desautels, Jean-François Lepage, Andrea A Baccarelli, Jonathan Posner, Maxime Descoteaux, Marie A Brunet, Larissa Takser","doi":"10.1038/s44184-025-00163-5","DOIUrl":"10.1038/s44184-025-00163-5","url":null,"abstract":"Psychiatry is undergoing a shift toward precision medicine, demanding personalized approaches that capture the complexity of cognition and behavior. Here, we introduce a novel referential of four robust, replicable, and generalizable cognitive and behavioral profiles. These were derived from a large pediatric cohort (ABCD: n = 10,843) and validated in two independent cohorts (BANDA: n = 195 and GESTE: n = 271) regrouping children aged 9-17 years. We demonstrate the profiles' longitudinal stability and consistency with clinical diagnoses in the general population while exposing critical discrepancies across parent-reported, youth-reported, and expert-derived diagnoses. Beyond validation, we showcase the real-world utility of our approach by linking profiles to environmental factors, revealing associations between parental influences and youths' cognition and behavior. Our fuzzy profiling framework moves beyond discrete classification, offering a powerful tool to refine psychiatric evaluation and intervention. We provide an open-source framework, enabling researchers and clinicians to fast-track implementation and foster a data-driven, domain-based approach to diagnosis.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"48"},"PeriodicalIF":0.0,"publicationDate":"2025-10-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12489131/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145208392","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Associations between internet use, social participation, and cognitive function among middle-aged and older adults. 中老年人网络使用、社会参与和认知功能之间的关系。

Npj mental health research Pub Date : 2025-09-30 DOI: 10.1038/s44184-025-00162-6

Tongshuang Yuan, Kai Liu, Leilei Liang, Chengbin Zheng, Yujie Cui, Honghua Li, Mingtu Xu, Marhaba Kiyum, Jinshuo Zhang, Chaofan Zhang, Yaning Su, Songli Mei

{"title":"Associations between internet use, social participation, and cognitive function among middle-aged and older adults.","authors":"Tongshuang Yuan, Kai Liu, Leilei Liang, Chengbin Zheng, Yujie Cui, Honghua Li, Mingtu Xu, Marhaba Kiyum, Jinshuo Zhang, Chaofan Zhang, Yaning Su, Songli Mei","doi":"10.1038/s44184-025-00162-6","DOIUrl":"10.1038/s44184-025-00162-6","url":null,"abstract":"The evidence regarding the impact of internet use on cognitive function is inconsistent and lacks cross-national analysis. And prior studies have predominantly focused on global cognitive function. The present study aimed to examine the association between internet use and its transitions with cognitive function using five prospective cohorts from 32 countries. The linear mixed model results showed that internet use was associated with better memory, orientation, executive function, and global cognitive function. These associations were stronger among vulnerable populations (e.g., rural, low-education). When combined with social activities, internet use maximized its protective effects. Additionally, individual's cognitive function with continuous internet use were better than those who have stopped using it. The findings indicated that encouraging internet use among middle-aged and older adults, coupled with targeted training and guidance, could be an effective strategy to protect cognitive function. And social activity participation also benefited cognitive function for those without internet use.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"47"},"PeriodicalIF":0.0,"publicationDate":"2025-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12485158/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145202459","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying distinct service use phenotypes across levels of suicidality and self-harm: a UK Biobank study. 识别不同的服务使用表型跨越自杀和自残水平：英国生物银行的研究。

Npj mental health research Pub Date : 2025-09-23 DOI: 10.1038/s44184-025-00160-8

Biya Tang, Fiona Shand, Helen Christensen, Alexis E Whitton

{"title":"Identifying distinct service use phenotypes across levels of suicidality and self-harm: a UK Biobank study.","authors":"Biya Tang, Fiona Shand, Helen Christensen, Alexis E Whitton","doi":"10.1038/s44184-025-00160-8","DOIUrl":"10.1038/s44184-025-00160-8","url":null,"abstract":"Mental health service use among individuals experiencing suicidality and self-harm is highly variable, with many individuals not seeking professional help. Using large-scale data from the UK Biobank, this study examined factors predictive of distinct service use phenotypes across varying levels of suicidality and self-harm. Male sex, the absence of psychological distress, and lower severity of suicide risk were the factors most strongly associated with reduced engagement with professional care. Additionally, although use of informal support predicted greater odds of service engagement, the type of support varied depending on suicidality severity: informal therapeutic strategies (e.g. yoga) were linked to service use among lower-risk individuals, whereas use of helplines was most strongly associated with service use among higher-risk individuals (e.g. those with a history of suicide attempts). These findings suggest that tailoring interventions to the unique needs and contexts of different subgroups may improve service engagement among individuals experiencing suicidality and/or self-harm.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"46"},"PeriodicalIF":0.0,"publicationDate":"2025-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12457640/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145133076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevalence and psychiatric correlates of loneliness in UK university students. 英国大学生孤独感的患病率和精神病学相关性

Npj mental health research Pub Date : 2025-09-16 DOI: 10.1038/s44184-025-00144-8

Umair Akram, Jennifer Drabble, Kamila Irvine, Sarah Allen, Asha Akram, Jodie C Stevenson, Maria Gardani

{"title":"Prevalence and psychiatric correlates of loneliness in UK university students.","authors":"Umair Akram, Jennifer Drabble, Kamila Irvine, Sarah Allen, Asha Akram, Jodie C Stevenson, Maria Gardani","doi":"10.1038/s44184-025-00144-8","DOIUrl":"10.1038/s44184-025-00144-8","url":null,"abstract":"University students remain vulnerable to the experience of loneliness and comorbid psychiatric difficulties, as evidenced in countries worldwide. In the present study, we examined the prevalence of loneliness among UK university students whilst assessing the association between multiple psychiatric risk factors. Here, N = 1408 students completed eight validated measures: Generalized Anxiety Disorder Scale; Patient Health Questionnaire; The Mood Disorder Questionnaire; The Sleep Condition Indicator; The Perceived Stress Scale; Suicidal Behaviours Questionnaire-Revised; The Prodromal Questionnaire 16; and the University of California Loneliness Scale. Moderate to severe levels of loneliness was reported by approximately two thirds of students (78.98%). Loneliness was significantly associated with each psychiatric symptom. After accounting for shared variance between symptoms, linear regression analyses determined loneliness to be significantly related to perceived stress, depression, psychotic like experiences and suicidal ideation. We demonstrate the exceedingly high prevalence of loneliness amongst large sample of UK university students, whilst highlighting the prominent role of depression, psychotic experiences, perceived stress, and suicidal ideation. Whilst highlighting the primacy of tailored interventions for lonely students, future work should explore contextual factors faced by UK university students.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"45"},"PeriodicalIF":0.0,"publicationDate":"2025-09-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12441134/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145076850","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Intron retention: a novel method for evaluating the response to ketamine in patients with treatment-resistant depression. 内含子保留：一种评估难治性抑郁症患者对氯胺酮反应的新方法。

Npj mental health research Pub Date : 2025-09-14 DOI: 10.1038/s44184-025-00161-7

Norihiro Okada, Kenshiro Oshima, Akiko Maruko, Yoshinori Kobayashi

{"title":"Intron retention: a novel method for evaluating the response to ketamine in patients with treatment-resistant depression.","authors":"Norihiro Okada, Kenshiro Oshima, Akiko Maruko, Yoshinori Kobayashi","doi":"10.1038/s44184-025-00161-7","DOIUrl":"10.1038/s44184-025-00161-7","url":null,"abstract":"In response to stress, the body attempts to maintain protein homeostasis through intron retention (IR). By identifying the genes that undergo IR in response to stress, possibly we can identify what type of stress the body is experiencing. Using this principle, we reanalyzed RNA sequencing data of patients with treatment-resistant depression and examined IR genes to investigate their characteristics to ketamine. The ketamine nonresponders were characterized by a state of elevated viral infection. Several IR genes related to viral infection were restored to a healthy state by ketamine, regardless of whether the individual was a nonresponder or a responder. Accordingly, it was more reasonable to describe nonresponders not as individuals for whom ketamine is ineffective but rather as individuals for whom ketamine is insufficient to overcome the extremely elevated inflammatory state of these individuals. This study is pioneering in its exploration of the molecular underpinnings that differentiate between nonresponders and responders.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"44"},"PeriodicalIF":0.0,"publicationDate":"2025-09-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433452/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058749","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The impact of fine-tuning LLMs on the quality of automated therapy assessed by digital patients. 微调llm对数字化患者评估的自动化治疗质量的影响。

Npj mental health research Pub Date : 2025-09-13 DOI: 10.1038/s44184-025-00159-1

Stav Yosef, Moreah Zisquit, Ben Cohen, Anat Brunstein Klomek, Kfir Bar, Doron Friedman

{"title":"The impact of fine-tuning LLMs on the quality of automated therapy assessed by digital patients.","authors":"Stav Yosef, Moreah Zisquit, Ben Cohen, Anat Brunstein Klomek, Kfir Bar, Doron Friedman","doi":"10.1038/s44184-025-00159-1","DOIUrl":"10.1038/s44184-025-00159-1","url":null,"abstract":"The use of generative large language models (LLMs) in mental health applications is gaining traction, with some proposals even suggesting LLM-based automated therapists. In this study, we assess the impact of fine-tuning therapist LLMs to improve the quality of therapy sessions, addressing a critical question in LLM-based mental health research. Specifically, we demonstrate that fine-tuning with datasets focused on specific therapeutic techniques significantly enhances the performance of LLM therapists. To facilitate this assessment, we introduce a novel evaluation system based on digital patients, powered by LLMs, which engage in text-based therapy sessions and provide session evaluations through questionnaires designed for human patients. This method addresses the inadequacies of traditional text-similarity metrics, which are insufficient for assessing the quality of therapeutic interactions. This study centers on motivational interviewing (MI), a structured and goal-oriented therapeutic approach. However, our digital therapists and patients can be adapted to work in other forms of therapy. We believe that our digital therapists offer a standardized method for assessing automated therapists and showcasing the potential of LLMs in mental health care.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"43"},"PeriodicalIF":0.0,"publicationDate":"2025-09-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12433451/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145058705","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Objective risk and protective factors for momentary and daily loneliness:using digital phenotyping and temporal analysis. 瞬间和日常孤独的客观风险和保护因素：使用数字表型和时间分析。

Npj mental health research Pub Date : 2025-09-07 DOI: 10.1038/s44184-025-00148-4

Matthias Haucke, Stephan Heinzel, Shuyan Liu

{"title":"Objective risk and protective factors for momentary and daily loneliness:using digital phenotyping and temporal analysis.","authors":"Matthias Haucke, Stephan Heinzel, Shuyan Liu","doi":"10.1038/s44184-025-00148-4","DOIUrl":"10.1038/s44184-025-00148-4","url":null,"abstract":"Loneliness is a growing global health issue, yet real-time assessments of its objective risk and protective factors are limited. This study identifies momentary and daily predictors using digital phenotyping and temporal analysis. Analyzing 12788 momentary observations from social mobile sensing and actigraphy, we examined how they impact loneliness on average (between-person) and in daily fluctuations (within-person). Instant messenger app usage was associated with increased loneliness, both momentarily (B = 2.95, p = 0.017) and daily (B = 2.83, p = 0.018), within and between subjects. Social media usage was associated with higher within-person momentary loneliness (B = 0.53, p = 0.001). An exploratory network analysis suggested that physical activity is associated with in-person social interaction, which is negatively associated with loneliness, while social media may replace social interactions. Thus, objective risk factors include increased use of social media and instant messaging, whereas greater physical activity may serve as a protective factor.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"42"},"PeriodicalIF":0.0,"publicationDate":"2025-09-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12413993/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"145008671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Identifying therapeutic characteristics of digital social media narratives about suicide: a mixed methods investigation. 识别关于自杀的数字社交媒体叙事的治疗特征：一项混合方法调查。

Npj mental health research Pub Date : 2025-09-03 DOI: 10.1038/s44184-025-00155-5

Jessica Stubbing, Peter J Franz, David Mou, Adam C Jaroszewski, Patrick Mair, Daniel Kessler, Sara Ray, Vy Cao-Silveira, Savannah Bachman, Sarah Schuster, Daniel Graupensperger, Mike Porath, Matthew K Nock

{"title":"Identifying therapeutic characteristics of digital social media narratives about suicide: a mixed methods investigation.","authors":"Jessica Stubbing, Peter J Franz, David Mou, Adam C Jaroszewski, Patrick Mair, Daniel Kessler, Sara Ray, Vy Cao-Silveira, Savannah Bachman, Sarah Schuster, Daniel Graupensperger, Mike Porath, Matthew K Nock","doi":"10.1038/s44184-025-00155-5","DOIUrl":"10.1038/s44184-025-00155-5","url":null,"abstract":"Recently, we found adults who received digital bibliotherapy featuring lived-experience narratives related to suicidal thoughts and behaviors reported lower suicidal thoughts, mediated by increased social connectedness and optimism. This study aimed to identify characteristics of narratives associated with decreased suicidal thinking and increased social connectedness and optimism. 1532 users of a social media platform responded to surveys before and after reading narratives. Mixed-methods content analysis and clustered multidimensional scaling tested whether clusters that shared narrative characteristics were related to suicidal thoughts, social connectedness and optimism. We identified three narrative clusters: Cluster 1: \"Encouraging Readers to Live,\" Cluster 2: \"Sharing Personal Stories,\" and Cluster 3: \"Detailed Accounts.\" Clusters 2 and 3 were associated with greatest reduction in suicidal thoughts, Cluster 2 with the greatest increase in social connectedness, and Cluster 3 with the greatest increase in optimism. Results suggest the optimal narratives for reducing suicidal thoughts are personal, detailed accounts.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"41"},"PeriodicalIF":0.0,"publicationDate":"2025-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12408815/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144994695","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The joint estimation of uncertainty and its relationship with psychotic-like traits and psychometric schizotypy. 不确定度的联合估计及其与精神病样特征和心理测量分裂型的关系。

Npj mental health research Pub Date : 2025-08-31 DOI: 10.1038/s44184-025-00146-6

Toni Gibbs-Dean, Teresa Katthagen, Ruixin Hu, Margaret L Westwater, Thomas Spencer, Kelly M J Diederen

{"title":"The joint estimation of uncertainty and its relationship with psychotic-like traits and psychometric schizotypy.","authors":"Toni Gibbs-Dean, Teresa Katthagen, Ruixin Hu, Margaret L Westwater, Thomas Spencer, Kelly M J Diederen","doi":"10.1038/s44184-025-00146-6","DOIUrl":"10.1038/s44184-025-00146-6","url":null,"abstract":"Learning involves reducing the uncertainty of incoming information-does it reflect meaningful change (volatility) or random noise? Normative accounts of learning capture the interconnectedness of this uncertainty: learning increases when changes are perceived as meaningful (volatility) and reduces when changes are seen as noise. Misestimating uncertainty-especially volatility-may contribute to psychotic symptoms, yet studies often overlook the interdependence of noise. We developed a block-design task that manipulated both noise and volatility using inputs from ground-truth distributions, with incentivised trial-wise estimates. Across three general population samples (online Ns = 580/147; in-person N = 19), participants showed normative learning overall. However, psychometric schizotypy and delusional ideation were linked to non-normative patterns. Paranoia was associated with poorer performance and reduced insight. All traits showed inflexible adaptation to changing uncertainty. Computational modelling suggested that non-normative learning may reflect difficulties inferring noise. This could lead one to misinterpret randomness as meaningful. Capturing joint uncertainty estimation offers insights into psychosis and supports clinically relevant computational phenotyping.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":"4 1","pages":"40"},"PeriodicalIF":0.0,"publicationDate":"2025-08-31","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12398549/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144981686","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unlocking deep relaxation: the power of rhythmic breathing on brain rhythms. 开启深度放松：有节奏的呼吸对大脑节奏的影响。

Npj mental health research Pub Date : 2025-08-23 DOI: 10.1038/s44184-025-00156-4

Vaibhav Tripathi, Lakshmi Bhaskar, Chhaya Kharya, Manvir Bhatia, Vinod Kochupillai

引用次数: 0