Npj mental health research最新文献

{"title":"Developing a suicide risk model for use in the Indian Health Service","authors":"Roy Adams, Emily E. Haroz, Paul Rebman, Rose Suttle, Luke Grosvenor, Mira Bajaj, Rohan R. Dayal, Dominick Maggio, Chelsea L. Kettering, Novalene Goklish","doi":"10.1038/s44184-024-00088-5","DOIUrl":"10.1038/s44184-024-00088-5","url":null,"abstract":"We developed and evaluated an electronic health record (EHR)-based model for suicide risk specific to an American Indian patient population. Using EHR data for all patients over 18 with a visit between 1/1/2017 and 10/2/2021, we developed a model for the risk of a suicide attempt or death in the 90 days following a visit. Features included demographics, medications, diagnoses, and scores from relevant screening tools. We compared the predictive performance of logistic regression and random forest models against existing suicide screening, which was augmented to include the history of previous attempts or ideation. During the study, 16,835 patients had 331,588 visits, with 490 attempts and 37 deaths by suicide. The logistic regression and random forest models (area under the ROC (AUROC) 0.83 [0.80–0.86]; both models) performed better than enhanced screening (AUROC 0.64 [0.61–0.67]). These results suggest that an EHR-based suicide risk model can add value to existing practices at Indian Health Service clinics.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2024-10-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00088-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142439133","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"28-country global study on associations between cultural characteristics and Recovery College fidelity","authors":"Yasuhiro Kotera, Amy Ronaldson, Daniel Hayes, Holly Hunter-Brown, Merly McPhilbin, Danielle Dunnett, Tesnime Jebara, Simran Takhi, Takahiko Masuda, Elizabeth Camacho, Ioannis Bakolis, Julie Repper, Sara Meddings, Vicky Stergiopoulos, Lisa Brophy, Clara De Ruysscher, Michail Okoliyski, Petra Kubinová, Lene Eplov, Charlotte Toernes, Dagmar Narusson, Aurélie Tinland, Bernd Puschner, Ramona Hiltensperger, Fabio Lucchi, Yuki Miyamoto, Stynke Castelein, Marit Borg, Trude Gøril Klevan, Roger Tan Boon Meng, Chatdanai Sornchai, Kruawon Tiengtom, Marianne Farkas, Hannah Moreland Jones, Edith Moore, Ann Butler, Richard Mpango, Samson Tse, Zsuzsa Kondor, Michael Ryan, Gianfranco Zuaboni, Dan Elton, Jason Grant-Rowles, Rebecca McNaughton, Charlotte Hanlon, Claire Harcla, Wouter Vanderplasschen, Simone Arbour, Denise Silverstone, Ulrika Bejerholm, Candice Powell, Susana Ochoa, Mar Garcia-Franco, Jonna Tolonen, Caroline Yeo, Ashleigh Charles, Claire Henderson, Mike Slade","doi":"10.1038/s44184-024-00092-9","DOIUrl":"10.1038/s44184-024-00092-9","url":null,"abstract":"Recovery Colleges (RCs) are learning-based mental health recovery communities, located globally. However, evidence on RC effectiveness outside Western, educated, industrialised, rich, and democratic (WEIRD) countries is limited. This study aimed to evaluate associations between cultural characteristics and RC fidelity, to understand how culture impacts RC operation. Service managers from 169 RCs spanning 28 WEIRD and non-WEIRD countries assessed the fidelity using the RECOLLECT Fidelity Measure, developed based upon key RC operation components. Hofstede’s cultural dimension scores were entered as predictors in linear mixed-effects regression models, controlling for GDP spent on healthcare and Gini coefficient. Higher Individualism and Indulgence, and lower Uncertainty Avoidance were associated with higher fidelity, while Long-Term Orientation was a borderline negative predictor. RC operations were predominantly aligned with WEIRD cultures, highlighting the need to incorporate non-WEIRD cultural perspectives to enhance RCs’ global impact. Findings can inform the refinement and evaluation of mental health recovery interventions worldwide.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2024-10-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00092-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142395783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Meta-correlation of the effect of ketamine and psilocybin induced subjective effects on therapeutic outcome","authors":"Jack D. C. Dahan, David Dadiomov, Tijmen Bostoen, Albert Dahan","doi":"10.1038/s44184-024-00091-w","DOIUrl":"10.1038/s44184-024-00091-w","url":null,"abstract":"There is some evidence that the subjective effects of ketamine and other psychedelics like psilocybin are crucial for their therapeutic outcomes, such as treatment of depression or substance use disorder (SUD). We performed a meta-analysis and systematic review on the correlation of subjective symptoms and dissociation versus ketamine-induced therapeutic outcomes in patients with depression or SUD. A similar analysis was conducted for psilocybin-induced therapeutic improvement. We retrieved 23 papers studying ketamine (21 on depression, 2 on SUD) in 471 patients and 8 papers studying psilocybin (6 on depression, 2 on SUD) in 183 patients. Our study demonstrated a modest role for subjective effects mediating therapeutic outcomes, with R2-values ranging from 5–10% for ketamine and for psilocybine the R2 was 24%. A greater mediating effect for psilocybin compared to ketamine was detected, particularly when restricting the analysis to depression. Additionally there is a greater mediating effect in SUD than depression, irrespective of treatment.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2024-10-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00091-w.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142378668","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A Bayesian analysis of heart rate variability changes over acute episodes of bipolar disorder","authors":"Filippo Corponi, Bryan M. Li, Gerard Anmella, Clàudia Valenzuela-Pascual, Isabella Pacchiarotti, Marc Valentí, Iria Grande, Antonio Benabarre, Marina Garriga, Eduard Vieta, Stephen M. Lawrie, Heather C. Whalley, Diego Hidalgo-Mazzei, Antonio Vergari","doi":"10.1038/s44184-024-00090-x","DOIUrl":"10.1038/s44184-024-00090-x","url":null,"abstract":"Bipolar disorder (BD) involves autonomic nervous system dysfunction, detectable through heart rate variability (HRV). HRV is a promising biomarker, but its dynamics during acute mania or depression episodes are poorly understood. Using a Bayesian approach, we developed a probabilistic model of HRV changes in BD, measured by the natural logarithm of the Root Mean Square of Successive RR interval Differences (lnRMSSD). Patients were assessed three to four times from episode onset to euthymia. Unlike previous studies, which used only two assessments, our model allowed for more accurate tracking of changes. Results showed strong evidence for a positive lnRMSSD change during symptom resolution (95.175% probability of positive direction), though the sample size limited the precision of this effect (95% Highest Density Interval [−0.0366, 0.4706], with a Region of Practical Equivalence: [-0.05; 0.05]). Episode polarity did not significantly influence lnRMSSD changes.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-10-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00090-x.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142368735","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Evaluating a mobile app’s effects on depression and anxiety in medication-treated opioid use disorder","authors":"Michael V. Heinz, Damien Lekkas, Veronica Abreu, Camilla Lee, Lisa A. Marsch, Nicholas C. Jacobson","doi":"10.1038/s44184-024-00086-7","DOIUrl":"10.1038/s44184-024-00086-7","url":null,"abstract":"Depression and anxiety frequently co-occur with opioid use disorder (OUD) yet are often overlooked in standard OUD treatments. This study evaluated the feasibility, acceptability, and preliminary effectiveness of a mobile application designed to address these symptoms in individuals receiving medications for OUD (MOUD). A randomized controlled trial recruited N = 63 adults with OUD who received MOUD and screened positive for moderate depression or generalized anxiety. Participants were randomized to an app-based digital intervention or treatment-as-usual for 4 weeks, and completed follow-ups at 4 and 8 weeks. Primary outcomes were self-reported severity measures for depression and generalized anxiety, and urine drug screens (UDS). Secondary outcomes included self-reported OUD severity, craving intensity, and digital biomarkers derived from passive smartphone sensors. The application was well-received (median app rating = 4/5 stars). The intervention group showed significant reductions in depressive and generalized anxiety symptoms post-intervention and at 8 weeks follow-up (d > 0.70), with large (d = 0.78) and moderate (d = 0.38) effect sizes, respectively, compared to controls. Both groups exhibited substantial decreases in self-reported severity of opioid use symptoms (d > 2.50). UDS suggested similar between-group adherence to MOUD, with a marginal decrease in opioid (MOP) use in the intervention group and increase in controls, yielding medium between group effect sizes (d = 0.44). Passive sensor data suggested significant increases in social connectedness in the intervention group, evidenced by a significant rise in incoming and outgoing calls and text connections. Initial evidence supports the feasibility and acceptability of a digital intervention for treating anxiety and depressive symptoms in persons receiving MOUD. While underpowered to confidently determine statistical significance beyond directionality, the intervention showed promise in reducing depressive and anxiety symptoms, suggesting its potential as a cost-effective and scalable adjunctive therapy alongside standard OUD treatment. Due to the preliminary nature of this pilot study, further research with sample sizes permitting greater statistical power is needed to confirm findings and explore long-term effects.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2024-09-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00086-7.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142329403","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A systematic review on passive sensing for the prediction of suicidal thoughts and behaviors","authors":"Rebekka Büscher, Tanita Winkler, Jacopo Mocellin, Stephanie Homan, Natasha Josifovski, Marketa Ciharova, Ward van Breda, Sam Kwon, Mark E. Larsen, John Torous, Joseph Firth, Lasse B. Sander","doi":"10.1038/s44184-024-00089-4","DOIUrl":"10.1038/s44184-024-00089-4","url":null,"abstract":"Passive sensing data from smartphones and wearables may help improve the prediction of suicidal thoughts and behaviors (STB). In this systematic review, we explored the feasibility and predictive validity of passive sensing for STB. On June 24, 2024, we systematically searched Medline, Embase, Web of Science, PubMed, and PsycINFO. Studies were eligible if they investigated the association between STB and passive sensing, or the feasibility of passive sensing in this context. From 2107 unique records, we identified eleven prediction studies, ten feasibility studies, and seven protocols. Studies indicated generally lower model performance for passive compared to active data, with three out of four studies finding no incremental value. PROBAST ratings revealed major shortcomings in methodology and reporting. Studies suggested that passive sensing is feasible in high-risk populations. In conclusion, there is limited evidence on the predictive value of passive sensing for STB. We highlight important quality characteristics for future research.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2024-09-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00089-4.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142309304","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Efficacy of a cognitive-behavioral digital therapeutic on psychosocial outcomes in rheumatoid arthritis: randomized controlled trial","authors":"Linda T. Betz, Gitta A. Jacob, Johannes Knitza, Michaela Koehm, Frank Behrens","doi":"10.1038/s44184-024-00085-8","DOIUrl":"10.1038/s44184-024-00085-8","url":null,"abstract":"Cognitive behavioral therapy improves psychosocial outcomes in rheumatoid arthritis (RA), but access is limited. We conducted a randomized controlled trial to evaluate the efficacy of a cognitive-behavioral digital therapeutic, reclarit, on psychosocial outcomes in adult RA patients with impaired health-related quality of life. Participants were randomized to reclarit plus treatment as usual (TAU) or TAU plus educational and informational material (active control). The primary outcome was SF-36 mental (MCS) and physical (PCS) component summary scores at 3 months, with additional assessments at 6 months. reclarit significantly improved SF-36 MCS scores compared to control (mean difference 3.3 [95% CI 0.7, 5.9]; p = 0.014), with high user satisfaction and sustained improvements at 6 months. Depression, anxiety, fatigue, and social/work functioning also improved significantly, while SF-36 PCS, pain, and disability scores did not differ. In conclusion, reclarit offers immediate, effective, evidence-based and personalized psychological support for RA patients.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00085-8.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127495","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Adapting the Parent Connector program for caregivers of adults with SMI: the Family Connector experience","authors":"Paige E. Cervantes, Charlotte Gendler, Lori Markowitz, Meggin Rose, Priscilla Shorter, Sally Mason, Tanya Hernandez, Kimberly E. Hoagwood","doi":"10.1038/s44184-024-00079-6","DOIUrl":"10.1038/s44184-024-00079-6","url":null,"abstract":"Caregivers play an essential role in the recovery of their adult loved ones with serious mental illness (SMI). Promoting caregiver empowerment and well-being is critical but has often been overlooked. Family peer interventions are well-suited to fill this need; however, research is limited supporting their use with caregivers of adults with SMI. Our team is currently engaged in a study evaluating an adapted version of the evidenced-based Parent Connectors program1,2, renamed Family Connectors (FC), for caregivers of young adults recently discharged from the First Episode Psychosis program in New York (OnTrackNY). This paper, written collaboratively with family peer professionals, describes the adaptation process we followed to systematically document the family peer professional experience one year into delivering the FC program to this novel population. Modifications made to improve intervention fit included tailoring the content of the intervention, incorporating an outside approach into the program, lengthening the service in some cases, and adding a weekly peer supervision meeting. We hope that these insights are used to inform future efforts to advance support for families of loved ones with SMI, and more broadly, that our approach serves as a model for effective collaboration to improve the application of peer support services for unique groups.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-08-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11330961/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142001519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Childhood maltreatment and its associations with trauma-related psychopathology: disentangling two classification approaches","authors":"Shilat Haim-Nachum, Doron Amsalem, Amit Lazarov, Soraya Seedat, Yuval Neria, Xi Zhu","doi":"10.1038/s44184-024-00082-x","DOIUrl":"10.1038/s44184-024-00082-x","url":null,"abstract":"Childhood maltreatment (CM) is associated with various mental health disorders, including PTSD, depression, and anxiety. This study explores how specific classifications – dichotomous (abuse versus neglect) and dimensional (physical, emotional, sexual) – relate to distinct psychopathologies. We recruited 642 individuals, screening them for CM history and symptoms. ANOVA, regression, and SEM analyses compared CM approaches and symptom associations. The dichotomous approach showed significant effects of abuse and neglect on all symptoms. In the dimensional approach, sexual and physical CM were primary features for PTSD, while sexual and emotional CM were primary for depression and anxiety. Overall, the dimensional approach outperformed the dichotomous approach in capturing symptoms, suggesting its importance in understanding psychopathologies and guiding therapeutic interventions. Our findings highlight the differential associations of CM experiences with PTSD, depression, and anxiety symptoms. The findings suggest the importance of a dimensional CM approach for understanding psychopathologies and possibly informing targeted therapeutic interventions.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-7"},"PeriodicalIF":0.0,"publicationDate":"2024-08-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11329716/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141997049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Immediate and evolving emotions among directly exposed survivors 7 years after the Oklahoma City bombing","authors":"E. Whitney Pollio, Helena Zhang, Alex Gajewski, Samir Abu-Hamad, Katy McDonald, David E. Pollio, Carol S. North","doi":"10.1038/s44184-024-00081-y","DOIUrl":"10.1038/s44184-024-00081-y","url":null,"abstract":"The Oklahoma City bombing in 1995 was one of the most devastating incidents of terrorism in America at that time. Existing research has not examined changes in emotional responses outside of psychopathology to disaster over time. The sample for this study consisted of adult participants randomly selected from a state registry of survivors who were directly exposed to the 1995 bombing in Oklahoma City. The Disaster Supplement to the Diagnostic Interview Schedule was used to collect participants’ demographic information and qualitative details of their disaster experience, perceptions, and feelings. A total of 315 items resulted from the coding of responses pertaining to emotions (125 immediately after the disaster event, 140 in the following week, and 50 at approximately seven years postdisaster). The most common emotions in the immediate postdisaster period were shock, fear, and anxiety. In the following week, the most common were sorrow and anger. At seven years, sorrow was the most frequently expressed of all emotions. Understanding the progression of these feelings across time enhances the ability to anticipate responses at different postdisaster timeframes and to intervene in a timely manner.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-024-00081-y.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141980511","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}