Colleen Stiles-Shields, Giovanni Ramos, Adrian Ortega, Alexandra M. Psihogios
{"title":"Increasing digital mental health reach and uptake via youth partnerships","authors":"Colleen Stiles-Shields, Giovanni Ramos, Adrian Ortega, Alexandra M. Psihogios","doi":"10.1038/s44184-023-00030-1","DOIUrl":"10.1038/s44184-023-00030-1","url":null,"abstract":"Youth in the United States are facing an unprecedented mental health crisis. Yet, brick-and-mortar mental healthcare, such as face-to-face therapy, is overwhelmingly inaccessible to youth despite research advances in youth mental health. Digital Mental Health tools (DMH), the use of technologies to deliver mental health assessments and interventions, may help to increase mental healthcare accessibility. However, for a variety of reasons, evidence-based DMH have not been successful in reaching youth in real-world settings, particularly those who are most encumbered with access barriers to mental healthcare. This Comment therefore focuses on increasing DMH reach and uptake by young people, particularly among minoritized youth, by engaging in community-based youth partnerships. This idea recognizes and grows from decades’ worth of community-based participatory research and youth partnerships successfully conducted by other disciplines (e.g., social work, public health, urban planning, education). Increasing uptake and engagement is an issue that is unlikely to be solved by adult-driven theory and design. As such, we emphasize the necessity of reframing youth input into DMH design and deployment from one-time participants to integral community-based partners. Indeed, recognizing and valuing their expertise to equitably address DMH implementation challenges, youth should help to pose the very questions that they will help to answer throughout the design and implementation planning for DMH moving forward.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-4"},"PeriodicalIF":0.0,"publicationDate":"2023-06-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10361731/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10240093","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Macarena S. Aloi, Guillermo F. Poblete, John Oldham, Michelle A. Patriquin, David A. Nielsen, Thomas R. Kosten, Ramiro Salas
{"title":"miR-124-3p target genes identify globus pallidus role in suicide ideation recovery in borderline personality disorder","authors":"Macarena S. Aloi, Guillermo F. Poblete, John Oldham, Michelle A. Patriquin, David A. Nielsen, Thomas R. Kosten, Ramiro Salas","doi":"10.1038/s44184-023-00027-w","DOIUrl":"10.1038/s44184-023-00027-w","url":null,"abstract":"Borderline personality disorder (BPD) is characterized by patterns of unstable affect, unstable interpersonal relationships, and chronic suicidal tendencies. Research on the genetics, epigenetics, and brain function of BPD is lacking. MicroRNA-124-3p (miR-124-3p) was recently identified in a Genome-Wide Association Study as likely associated with BPD. Here, we identified the anatomical brain expression of genes likely modulated by miR-124-3p and compared morphometry in those brain regions in BPD inpatients vs. controls matched for psychiatric comorbidities. We isolated lists of targets likely modulated by miR-124-3p from TargetScan (v 8.0) by their preferentially conserved targeting (Aggregate PCT > 0.99, see Supplementary Table 1). We applied Process Genes List (PGL) to identify regions of interest associated with the co-expression of miR-124-3p target genes. We compared the gray matter volume of the top region of interest co-expressing those genes between BPD inpatients (n = 111, 46% female) and psychiatric controls (n = 111, 54% female) at The Menninger Clinic in Houston, Texas. We then correlated personality measures, suicidal ideation intensity, and recovery from suicidal ideation with volumetrics. Gene targets of miR-124-3p were significantly co-expressed in the left Globus Pallidus (GP), which was smaller in BPD than in psychiatric controls. Smaller GP volume was negatively correlated with agreeableness and with recovery from suicidal ideation post-treatment. In BPD, GP volume may be reduced through miR-124-3p regulation and suppression of its target genes. Importantly, we identified that a reduction of the GP in BPD could serve as a potential biomarker for recovery from suicidal ideation.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-06-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10500603/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10653948","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Mental health penalties of having a child: findings from the China family panel studies","authors":"Xinjie Shi, Yu Shen","doi":"10.1038/s44184-023-00026-x","DOIUrl":"10.1038/s44184-023-00026-x","url":null,"abstract":"In recent years, the birth rate in China has rapidly declined. While much research has been done on the penalties in earnings that women incur when they fall behind men in the labor market due to childbirth, there has been little to no research on the mental health effects. This study addresses the gap in current literature by examining the mental health penalties that women experience after having a child in comparison to men. We applied econometric modeling to data collected from China Family Panel Studies (CFPS) and found that women experienced a significant, immediate, and long-run decline (4.3%) in life satisfaction after their first child, while men were unaffected. We also found that women experienced a significant increase in depression after their first child. This suggests mental health penalties since the mental health risk proxied by these two measurements is only significant for women. This is likely related to child penalties in labor market performance and childbirth-related physical health issues. When countries adopt multiple tools to stimulate the birth rate for economic growth, they must consider the implicit burden on women—especially the long-term negative effects on mental health.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-05-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10184102/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9509130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
J. M. Tyron, R. Bluhm, E. D. Achtyes, A. M. McCright, L. Y. Cabrera
{"title":"The influence of prior awareness on views about psychiatric electroceutical interventions among non-clinician stakeholders","authors":"J. M. Tyron, R. Bluhm, E. D. Achtyes, A. M. McCright, L. Y. Cabrera","doi":"10.1038/s44184-023-00028-9","DOIUrl":"10.1038/s44184-023-00028-9","url":null,"abstract":"Psychiatric electroceutical interventions (PEIs) are emerging interventions in the treatment of depression and other mood disorders. The uptake of PEIs is strongly influenced by public, caregiver, and patient views. This study examines the influence of prior awareness and of trust in the medico-scientific establishment with respect to non-clinicians’ views on PEI among a cohort of U.S. respondents. About 3098 U.S. caregivers, patients, and members of the general public completed an online survey with an embedded experiment to evaluate PEI views by stakeholder, modality, and disease severity. ANOVA statistical tests and logistic regression models were used to identify significant differences between groups and moderating factors. Overall, respondents had greater awareness of antidepressant medication (73–84%) and psychotherapy (68–76%) than of any PEI, and ECT garnered the most prior awareness (29–40%) within each group. Non-clinical respondents most often used websites or social media as information sources, and the least trusted sources included those with notable financial interests. Considering the low awareness level among non-clinicians, the implementation of programs to target and advance awareness levels about the use of PEIs in depression among this population may contribute to reducing negative views around these interventions. Fostering trust in the medico-scientific establishment may also increase public support for PEIs as well as uptake of these treatment modalities.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-8"},"PeriodicalIF":0.0,"publicationDate":"2023-05-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-023-00028-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45656523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Zishan Jiwani, Raquel Tatar, Cortland J. Dahl, Christine D. Wilson-Mendenhall, Matthew J. Hirshberg, Richard J. Davidson, Simon B. Goldberg
{"title":"Examining equity in access and utilization of a freely available meditation app","authors":"Zishan Jiwani, Raquel Tatar, Cortland J. Dahl, Christine D. Wilson-Mendenhall, Matthew J. Hirshberg, Richard J. Davidson, Simon B. Goldberg","doi":"10.1038/s44184-023-00025-y","DOIUrl":"10.1038/s44184-023-00025-y","url":null,"abstract":"Digital interventions have the potential to alleviate mental health disparities for marginalized and minoritized communities. The current study examined whether disparities in access and utilization of meditation in the United States (US) were reduced for a freely available meditation app. We analyzed demographic and usage data from US-based users of the Healthy Minds Program (HMP; N = 66,482) between October 2019 and July 2022. College education was associated with a greater likelihood of accessing (65.0% of users vs. 32.9% of the US population) and continuing to utilize the app (β = 0.11–0.17). Conversely, identifying as African American was associated lower likelihood of accessing (5.3% vs. 13.4% of the US population) and continuing to utilize the app (β = −0.02–0.03). African Americans were more likely to access content from an African American meditation teacher, but this did not appear to increase utilization. Additional efforts are warranted to identify factors that might reduce disparities.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-10"},"PeriodicalIF":0.0,"publicationDate":"2023-04-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC10164442/pdf/nihms-1879395.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9450274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jinkun Zeng, Yaoyun Zhang, Yutao Xiang, Sugai Liang, Chuang Xue, Junhang Zhang, Ya Ran, Minne Cao, Fei Huang, Songfang Huang, Wei Deng, Tao Li
{"title":"Optimizing multi-domain hematologic biomarkers and clinical features for the differential diagnosis of unipolar depression and bipolar depression","authors":"Jinkun Zeng, Yaoyun Zhang, Yutao Xiang, Sugai Liang, Chuang Xue, Junhang Zhang, Ya Ran, Minne Cao, Fei Huang, Songfang Huang, Wei Deng, Tao Li","doi":"10.1038/s44184-023-00024-z","DOIUrl":"10.1038/s44184-023-00024-z","url":null,"abstract":"There is a lack of objective features for the differential diagnosis of unipolar and bipolar depression, especially those that are readily available in practical settings. We investigated whether clinical features of disease course, biomarkers from complete blood count, and blood biochemical markers could accurately classify unipolar and bipolar depression using machine learning methods. This retrospective study included 1160 eligible patients (918 with unipolar depression and 242 with bipolar depression). Patient data were randomly split into training (85%) and open test (15%) sets 1000 times, and the average performance was reported. XGBoost achieved the optimal open-test performance using selected biomarkers and clinical features—AUC 0.889, sensitivity 0.831, specificity 0.839, and accuracy 0.863. The importance of features for differential diagnosis was measured using SHapley Additive exPlanations (SHAP) values. The most informative features include (1) clinical features of disease duration and age of onset, (2) biochemical markers of albumin, low density lipoprotein (LDL), and potassium, and (3) complete blood count-derived biomarkers of white blood cell count (WBC), platelet-to-lymphocyte ratio (PLR), and monocytes (MONO). Overall, onset features and hematologic biomarkers appear to be reliable information that can be readily obtained in clinical settings to facilitate the differential diagnosis of unipolar and bipolar depression.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2023-04-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-023-00024-z.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"49448169","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Carsten Langholm, Andrew Jin Soo Byun, Janet Mullington, John Torous
{"title":"Monitoring sleep using smartphone data in a population of college students","authors":"Carsten Langholm, Andrew Jin Soo Byun, Janet Mullington, John Torous","doi":"10.1038/s44184-023-00023-0","DOIUrl":"10.1038/s44184-023-00023-0","url":null,"abstract":"Sleep is fundamental to all health, especially mental health. Monitoring sleep is thus critical to delivering effective healthcare. However, measuring sleep in a scalable way remains a clinical challenge because wearable sleep-monitoring devices are not affordable or accessible to the majority of the population. However, as consumer devices like smartphones become increasingly powerful and accessible in the United States, monitoring sleep using smartphone patterns offers a feasible and scalable alternative to wearable devices. In this study, we analyze the sleep behavior of 67 college students with elevated levels of stress over 28 days. While using the open-source mindLAMP smartphone app to complete daily and weekly sleep and mental health surveys, these participants also passively collected phone sensor data. We used these passive sensor data streams to estimate sleep duration. These sensor-based sleep duration estimates, when averaged for each participant, were correlated with self-reported sleep duration (r = 0.83). We later constructed a simple predictive model using both sensor-based sleep duration estimates and surveys as predictor variables. This model demonstrated the ability to predict survey-reported Pittsburgh Sleep Quality Index (PSQI) scores within 1 point. Overall, our results suggest that smartphone-derived sleep duration estimates offer practical results for estimating sleep duration and can also serve useful functions in the process of digital phenotyping.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-6"},"PeriodicalIF":0.0,"publicationDate":"2023-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-023-00023-0.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"46604567","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Preventing comorbidity between distress and suicidality: a network analysis","authors":"Alvin Junus, Paul S. F. Yip","doi":"10.1038/s44184-023-00022-1","DOIUrl":"10.1038/s44184-023-00022-1","url":null,"abstract":"Suicidality among individuals between 10 and 35 years of age may be poised to exert massive burdens on society through decreased economic productivity and increased incidence of chronic physical conditions in the individuals’ later years, thereby necessitating early prevention of suicide. While research suggests that the pathway to suicidality may begin from episodes of psychological distress, such pathway may involve complex interplays between intermediary psychiatric symptoms and external stimuli that are not easily delineated through conventional means. This study applies the network approach to psychopathology to elucidate this complexity. Comorbidity between psychological distress and suicidality in 1968 community-dwelling individuals is analyzed with regularized partial correlation networks to identify their bridge symptoms and links. Temporal relationships between symptoms are analyzed through temporal symptom network formed from 453 individuals who completed subsequent follow-up surveys. Network analysis shows that feelings of hopelessness and the presence of suicidal ideation are the strongest bridge symptoms in the comorbidity symptom network, and form the only prominent link that bridges psychological distress and suicidality. Effects of sleep troubles, anxiety, and poor social relationships on suicidal ideation appear to be mediated by hopelessness. The same observations hold among individuals with and without diagnoses of psychiatric disorders, as well as young people (10–24 year-olds) and young adults (25–35 year-olds). The edge between hopelessness and suicidal ideation remains the strongest bridge link after controlling for effects of symptoms from the previous time point. Findings here provide an evidence base for both professional training in caregiving professions as well as gatekeeper training in community members to emphasize more on how to effectively recognize hopelessness, and instill hope, in young people and young adults for various types of distress.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2023-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9984753/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"9910241","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The impact of working alliance in managing youth anxiety and depression: a scoping review","authors":"Jermaine M. Dambi, Webster Mavhu, Rhulani Beji-Chauke, Malinda Kaiyo-Utete, Rhiana Mills, Ruvimbo Shumba, Sidney Muchemwa, Rosemary Musesengwa, Ruth Verhey, Melanie Abas, Colette R. Hirsch, Dixon Chibanda","doi":"10.1038/s44184-023-00021-2","DOIUrl":"10.1038/s44184-023-00021-2","url":null,"abstract":"A working alliance (WA) is a multidimensional construct signifying a collaborative relationship between a client and a therapist. Systematic reviews of therapies to treat depression and anxiety, almost exclusively in adults, show WA is essential across psychotherapies. However, there are critical gaps in our understanding of the importance of WA in low-intensity therapies for young people with depression and anxiety. Here, we describe an initiative to explore the effect of WA on anxiety and depression outcomes in youth aged 14–24 years through a scoping review and stakeholders’ consultations (N = 32). We analysed 27 studies; most were done in high-income countries and evaluated one-on-one in-person therapies (18/27). The review shows that optimal WA is associated with improvements in: relationships, self-esteem, positive coping strategies, optimism, treatment adherence, and emotional regulation. Young people with lived experience expressed that: a favourable therapy environment, regular meetings, collaborative goal setting and confidentiality were vital in forming and maintaining a functional WA. For a clinician, setting boundaries, maintaining confidentiality, excellent communication skills, being non-judgmental, and empathy were considered essential for facilitating a functional WA. Overall, a functional WA was recognised as an active ingredient in psychotherapies targeting anxiety and depression in young people aged 14–24. Although more research is needed to understand WA’s influence in managing anxiety and depression in young people, we recommend routine evaluation of WA. Furthermore, there is an urgent need to identify strategies that promote WA in psychotherapies to optimise the treatment of anxiety and depression in young people.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2023-01-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9885927/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"10285332","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Adam S. Miner, Scott L. Fleming, Albert Haque, Jason A. Fries, Tim Althoff, Denise E. Wilfley, W. Stewart Agras, Arnold Milstein, Jeff Hancock, Steven M. Asch, Shannon Wiltsey Stirman, Bruce A. Arnow, Nigam H. Shah
{"title":"A computational approach to measure the linguistic characteristics of psychotherapy timing, responsiveness, and consistency","authors":"Adam S. Miner, Scott L. Fleming, Albert Haque, Jason A. Fries, Tim Althoff, Denise E. Wilfley, W. Stewart Agras, Arnold Milstein, Jeff Hancock, Steven M. Asch, Shannon Wiltsey Stirman, Bruce A. Arnow, Nigam H. Shah","doi":"10.1038/s44184-022-00020-9","DOIUrl":"10.1038/s44184-022-00020-9","url":null,"abstract":"Although individual psychotherapy is generally effective for a range of mental health conditions, little is known about the moment-to-moment language use of effective therapists. Increased access to computational power, coupled with a rise in computer-mediated communication (telehealth), makes feasible the large-scale analyses of language use during psychotherapy. Transparent methodological approaches are lacking, however. Here we present novel methods to increase the efficiency of efforts to examine language use in psychotherapy. We evaluate three important aspects of therapist language use - timing, responsiveness, and consistency - across five clinically relevant language domains: pronouns, time orientation, emotional polarity, therapist tactics, and paralinguistic style. We find therapist language is dynamic within sessions, responds to patient language, and relates to patient symptom diagnosis but not symptom severity. Our results demonstrate that analyzing therapist language at scale is feasible and may help answer longstanding questions about specific behaviors of effective therapists.","PeriodicalId":74321,"journal":{"name":"Npj mental health research","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2022-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.com/articles/s44184-022-00020-9.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"45352617","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}