NeuroSci最新文献

{"title":"Association Between Stroke and Traumatic Brain Injury: A Systematic Review and Meta-Analysis.","authors":"Mohammed Maan Al-Salihi, Maryam Sabah Al-Jebur, Ahmed Abd Elazim, Ram Saha, Ahmed Saleh, Farhan Siddiq, Ali Ayyad, Adnan I Qureshi","doi":"10.3390/neurosci6010021","DOIUrl":"10.3390/neurosci6010021","url":null,"abstract":"<p><strong>Background: </strong>Stroke and traumatic brain injury (TBI) represent two major health concerns worldwide. There is growing evidence suggesting a potential association between TBI and stroke. In this systematic review and meta-analysis, we aim to explore the association between TBI and stroke risk, with a specific focus on overall stroke risk and subgroup variations based on stroke type, severity, and the post-TBI time period.</p><p><strong>Methods: </strong>PubMed, Web of Science (WOS), Scopus, and Cochrane Library were systematically searched for studies exploring the link between stroke and TBI. The pooled hazard ratios (HRs) with a 95% confidence interval (CI) were calculated. The Comprehensive Meta-Analysis (CMA) software was used for the analysis. Subgroup analyses were conducted based on stroke type, TBI severity, and post-TBI phase. The Newcastle-Ottawa Scale (NOS) was utilized for the quality assessment.</p><p><strong>Results: </strong>We included a total of 13 observational studies, with data from 8 studies used for quantitative analysis. A history of TBI was associated with a significantly higher odds of stroke compared to controls (HR = 2.3, 95% CI (1.79 to 2.958), <i>p</i> < 0.001). The risk was greater for hemorrhagic stroke (HR = 4.8, 95% CI (3.336 to 6.942), <i>p</i> < 0.001) than for ischemic stroke (HR = 1.56, 95% CI (1.28 to 1.9), <i>p</i> < 0.001). Both moderate-to-severe TBI (HR = 3.64, 95% CI (2.158 to 6.142), <i>p</i> < 0.001) and mild TBI (HR = 1.81, 95% CI (1.17 to 2.8), <i>p</i> = 0.007) were associated with a significantly higher risk of stroke. The risk was also higher in the early post-TBI phase (1-30 days) (HR = 4.155, 95% CI (2.25 to 7.67), <i>p</i> < 0.001) compared to later phases (HR = 1.68, 95% CI (1.089 to 2.59), <i>p</i> = 0.019) from 30 days to 1 year and (HR = 1.87, 95% CI (1.375 to 2.544), <i>p</i> < 0.001) after 1 year.</p><p><strong>Conclusions: </strong>This systematic review confirms a significant association between TBI and an increased risk of stroke, regardless of TBI severity, type, or timing of stroke. The findings highlight the need for early monitoring and advocating preventive strategies for stroke in patients with a history of TBI.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944542/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733503","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Impaired Regulation of Emotion in Bipolar I Disorder: Behavioral and Neurophysiological Signatures.","authors":"Mathilde Carminati, Frédéric Isel, Josselin Houenou, Michèle Wessa, Chantal Henry","doi":"10.3390/neurosci6010020","DOIUrl":"10.3390/neurosci6010020","url":null,"abstract":"<p><p>People with bipolar disorder (BD) present with mood instability resulting from more frequent and intense emotions in response to environmental conditions relative to healthy subjects. The aim of this study was to investigate the time course of emotion regulation strategies, distraction, and reappraisal in euthymic BD patients (i.e., normal mood range) using electroencephalography (EEG). Fourteen BD patients and 13 matched healthy controls took part in an experiment constituting three conditions, i.e., a passive viewing of positive, negative, and neutral pictures, and two regulation conditions, one with a reappraisal strategy and the other with a distraction strategy. Critically, the ERP results indicated that during passive viewing, the Late Positive Potential (LPP) was larger in BD patients compared with healthy controls, but only for neutral pictures. During emotion regulation, LPP amplitude was reduced in distraction conditions compared with viewing ones, especially for negative emotions in both patients and controls. Importantly, LPP was reduced in reappraisal conditions compared with passive viewing in an early time window for negative emotions and in a later time window for positive emotions in controls but not in patients. Our findings showed that the temporal dynamics of emotion regulation by reappraisal are faster for negative than for positive emotions in controls but not in BD patients.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944531/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733507","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Liposomal Lactoferrin Reduces Brain Neuroinflammation in Rats and Alleviates Jetlag and Improves Sleep Quality After Long-Haul Travel.","authors":"Shoko Uesaki, Masanori Yamato, Atsushi Ishikado, Yutaka Suekawa, Yasuhisa Tamura, Yosky Kataoka","doi":"10.3390/neurosci6010019","DOIUrl":"10.3390/neurosci6010019","url":null,"abstract":"<p><p>Insufficient sleep and circadian misalignment increase inflammatory agents. This triggers neuroinflammation and can result in health issues including depression, dementia, lifestyle-related diseases, and industrial accidents. Lactoferrin (LF) confers neuroprotective effects, which are derived from its anti-inflammatory, antioxidant, and iron metabolic properties; however, its roles in acute neuroinflammation and circadian rhythm disruption are yet to be elucidated. Therefore, we aimed to test the effects of LF on rat neuroinflammation and sleep and jetlag in humans. Rats received 7 days of an oral liposomal bovine LF (L-bLF) or vehicle followed by polyriboinosinic:polyribocytidylic acid (poly I:C) peritoneal injections (n = 5-6). Compared with the rats given poly I:C only, the rats given L-bLF and poly I:C had lower Il1b, Tnf, Casp1, Nfe212, Gclm, and Sod2 expression in the hippocampus. This open-label pilot study was carried out on tour conductors performing regular international tour responsibilities, and the data were compared between the initial tour without L-bLF intake and the subsequent tour with L-bLF intake. In the tour with L-bLF intake, L-bLF administration started from one week before the trip and was continued during the trip. In both periods, the tour conductors experienced limited sleep; however, both subjective and objective sleep quality was significantly better with the oral L-bLF intake than without. Overall, we found that prophylactic L-bLF supplementation reduced neuroinflammation in rat hippocampi and improved sleep quality and jetlag in tour conductors.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11944617/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Open Midline Decompression with Ligament Reconstruction for Multiple-Level Spinal Stenosis in Elderly Patients.","authors":"Shin-Jae Kim, Sang-Ho Lee, Junseok Bae","doi":"10.3390/neurosci6010018","DOIUrl":"10.3390/neurosci6010018","url":null,"abstract":"<p><p>(1) Background: Multiple lumbar spinal stenosis (LSS) is a degenerative disease that is increasingly prevalent with global aging. Multilevel fusion surgery is burdensome to perform in elderly patients, especially with osteoporosis and underlying disease. This study introduces open midline decompression (OMD) with ligament reconstruction as an alternative stabilization technique for elderly patients with multilevel LSS. (2) Methods: A retrospective review included 42 elderly patients aged 70 or older diagnosed with LSS at three or more levels and who underwent OMD with ligament reconstruction. Pre- and postoperative clinical and radiologic data were analyzed. (3) Results: Thirty-three patients underwent three-level surgeries, and twelve patients underwent four-level surgeries. The mean operative time was 240 ± 42.2 min (74.6 ± 14.9 min per level) with a mean blood loss of 282.9 ± 167.1 cc. Clinical outcome (VAS) and quality of life parameters (SF-12) showed significant improvement after surgery. Postoperative MRI showed sufficient decompression. Dynamic X-rays showed improvement in instability after surgery, but it was statistically insignificant. (4) Conclusions: OMD with ligament reconstruction provides effective neural decompression while preserving the posterior arch and offers soft stabilization with artificial ligaments. It is a safe and viable surgical option for elderly patients with multilevel LSS.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11946262/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143733514","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Pain Pressure Threshold as a Non-Linear Marker of Neural Adaptation in Amputees: Evidence from the DEFINE Cohort.","authors":"Marta Imamura, Anna Carolyna Gianlorenço, Guilherme J M Lacerda, Linamara Rizzo Battistella, Felipe Fregni","doi":"10.3390/neurosci6010017","DOIUrl":"10.3390/neurosci6010017","url":null,"abstract":"<p><strong>Background: </strong>Amputation poses significant physical, psychological, and emotional challenges, with chronic pain being one of the most debilitating outcomes. Pain Pressure Threshold (PPT), a measure of nociceptive sensitivity, is a valuable tool for assessing changes in pain perception. Understanding PPT modulation in amputees is crucial for uncovering the mechanisms underlying pain and developing targeted interventions for pain management.</p><p><strong>Objective: </strong>This study aimed to evaluate PPT in amputees and identify factors associated with PPT variation in this population.</p><p><strong>Methods: </strong>This cross-sectional study analyzed neurophysiological, clinical, and demographic data from 86 amputee patients. PPT was assessed as the primary outcome, and its associations with demographic and clinical predictors were examined using both linear and quadratic regression models.</p><p><strong>Results: </strong>Multivariate analysis identified a significant association between PPT and biological sex, with females exhibiting lower PPT values than males. Quadratic regression analyses revealed inverted U-shaped associations between PPT and age, BMI, and duration since amputation. PPT increased with age, peaking at 45.8 years, followed by a decline. Similar patterns were observed for BMI, peaking at 27.0 kg/m², and for amputation duration, peaking at 26.6 months.</p><p><strong>Conclusions: </strong>Our findings indicate that sex, age, BMI, and time since amputation are significant factors influencing PPT in amputees, with nonlinear relationships observed for age, BMI, and amputation duration. These results suggest that physiological and disease-related factors (such as age, BMI, and duration of injury) have specific peaks for optimal PPT, highlighting their role in the brain's compensatory system and potential implications for targeted pain management strategies.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843867/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143469915","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Trends and Disparities in Alzheimer's Disease Mortality in the United States: The Impact of COVID-19.","authors":"Jasleen Chaddha, Eli Blaney, Ali Al-Salahat, Amna Noor, Taylor Billion, Yu-Ting Chen, Abubakar Tauseef, Akshat Sood, Ali Bin Abdul Jabbar","doi":"10.3390/neurosci6010016","DOIUrl":"10.3390/neurosci6010016","url":null,"abstract":"<p><p><b>Background:</b> Alzheimer's disease (AD) is the fifth leading cause of death for Americans older than 65. Though fluctuations have been noticed over the past two decades, the mortality of Alzheimer's patients increased considerably during the COVID-19 pandemic. This study aims to explore the temporal trends in AD-associated mortality (ADAM) and disparities in these trends, and we aim to discern changes to these trends during the COVID-19 pandemic. <b>Methods:</b> The CDC WONDER Multiple Cause-of-Death Public Use Records from 1999 to 2022 were used to extract population data on deaths related to AD and stratify them based on age, biological sex, race, ethnicity, place of death, census region, and state. ICD-10 codes G30.0, G30.1, G30.8, and G30.9 were used to identify AD-related mortality. Statistical analysis was performed using the Joinpoint Regression Program version 5.0.2. <b>Results:</b> We confirmed an increase in mortality rate in all races, sexes, places of death, age groups above 65, and states/census regions. Interestingly, the age-adjusted mortality rate (AAMR) of AD was consistently higher in females compared to males. Non-Hispanic whites had the highest AD mortality by race and ethnicity. At the intersection of race and biological sex, White females had the highest AAMR with AD. Lastly, we noted an increase in AD mortality at hospice facilities as compared to other places of death. <b>Conclusions:</b> Our findings demonstrate that the number of deaths due to AD was exacerbated by the recent pandemic and that White females were disproportionately affected. The disparities relating to ADAM uncovered in this study may assist healthcare administrators and policymakers in their decisions. Additionally, the findings might help initiate larger studies focusing on these disparities to explore novel risk/prognostic factors for AD.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843863/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470177","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"The Association of Pain Medication Usage and Quantitative Sensory Testing Outcomes in Fibromyalgia Patients: A Secondary Data Analysis.","authors":"Luana Gola Alves, Kevin Pacheco-Barrios, Guilherme J M Lacerda, Felipe Fregni","doi":"10.3390/neurosci6010015","DOIUrl":"10.3390/neurosci6010015","url":null,"abstract":"<p><strong>Background: </strong>Fibromyalgia syndrome (FMS), a chronic pain syndrome affecting 0.2-6.6% of the general population, is known for its challenging diagnosis and treatment. The known dysregulation in the Endogenous Pain Modulatory System (EPMS) characteristic of the pathology contributes to enhanced pain sensitivity. Fibromyalgia patients, who are often overmedicated, may experience, in addition to the drug-related known adverse effects, effects on fibromyalgia sensory-related outcomes. Therefore, the focus of this analysis is to explore the bidirectional drug-sensory outcome interactions, indexed by the conditioned pain modulation (CPM), an important assessment element in regard to an EPMS's efficacy.</p><p><strong>Methods: </strong>Baseline data from a randomized, double-blind, single-center (Boston-based tertiary hospital) clinical trial (NCT03371225) were analyzed. Participants aged 18-65 with an FMS diagnosis and resistance to common analgesics were included. Demographic, clinical, and sensory variables, including CPM, temporal summation, and Pain-60 outcomes, were collected alongside a pain medication diary. Multivariable regression models adjusted for confounders were applied to explore associations between medication classes and quantitative sensory outcomes.</p><p><strong>Results: </strong>Out of 101 recruited FMS patients, we categorized the use of the following medications: antidepressants with 50% use (<i>n</i> = 50), muscle relaxants with 26% use (<i>n</i> = 26), and gabapentin with 25% use (<i>n</i> = 25). The results showed that antidepressant use correlated with worsened CPM, Odds Ratio = 0.39 (95% CI = 0.17-0.91), while muscle relaxants were linked to increased TSPS, β coefficient = 0.72 (95% CI = 0.0021-1.4431). On the other hand, gabapentin use was associated with elevated Pain-60, OR = 2.68 (95% CI = 0.98-7.31). Interestingly, the use of low doses of opioids was not associated with altered sensory measures.</p><p><strong>Conclusion: </strong>This cross-sectional analysis suggests that common pain medications may affect quantitative sensory outcomes in FMS patients. We provided important insights into bidirectional drug-sensory outcome interactions and their influence on pain medicine.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843844/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"High Body Mass Index Disrupts the Homeostatic Relationship Between Pain Inhibitory Control and the Symptomatology in Patients with Knee Osteoarthritis-A Cross-Sectional Analysis from the DEFINE Study.","authors":"Guilherme J M Lacerda, Felipe Fregni, Linamara R Battistella, Marta Imamura","doi":"10.3390/neurosci6010014","DOIUrl":"10.3390/neurosci6010014","url":null,"abstract":"<p><strong>Objective: </strong>As outlined in our previous study, this study aims to investigate the role of body mass index (BMI) as an effect modifier in the relationship between conditioned pain modulation (CPM) and clinical outcomes, including depression, quality of life, and pain in individuals with knee osteoarthritis (KOA).</p><p><strong>Methods: </strong>This cross-sectional analysis is part of the DEFINE Study in Rehabilitation. A total of 113 participants with KOA, admitted to the Instituto de Medicina Física e Reabilitação (IMREA) rehabilitation program, were included. Clinical and neurophysiological assessments were conducted, focusing on CPM, the Hamilton Depression Rating Scale (HDRS), and the SF-36 health survey. BMI was stratified into two categories based on the mean BMI of 31.99 kg/m², and linear regression models were used to evaluate BMI as an effect modifier in the relationship between CPM and clinical outcomes. <i>p</i>-values below 0.10 for interaction terms (CPM × BMI) indicated effect modification.</p><p><strong>Results: </strong>In participants with BMI < 31.99 kg/m², increased CPM was significantly associated with improved depression scores (lower HDRS) and enhanced physical functioning, emotional well-being, and reduced limitations due to emotional problems (SF-36). In contrast, no significant associations between CPM and these outcomes were found in participants with BMI ≥ 31.99 kg/m². The results suggest that a higher BMI disrupts the salutogenic effects of endogenous pain control, diminishing the beneficial associations between CPM and both physical and psychological outcomes, as previously observed in fibromyalgia patients.</p><p><strong>Conclusions: </strong>BMI acts as an effect modifier in the relationship between CPM and clinical outcomes in individuals with KOA. Obesity appears to hinder the beneficial relationships between clinical symptoms and CPM, leading to a less favorable link between physical and emotional functioning and CPM. These findings highlight the importance of considering BMI in treatment strategies for KOA, particularly when addressing the impact of lifestyle and other modifiable factors that influence pain modulation.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843865/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470248","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Contextual Influence on Pattern Separation During Encoding.","authors":"Laura García-Rueda, Claudia Poch, Joaquín Macedo-Pascual, Pablo Campo","doi":"10.3390/neurosci6010013","DOIUrl":"10.3390/neurosci6010013","url":null,"abstract":"<p><p>Pattern separation is considered a crucial process that allows us to distinguish among the highly similar and overlapping experiences that constitute our episodic memory. Not only do different episodes share common features, but it is often the case that they share the context in which they occurred. While there have been a great number of studies investigating pattern separation and its behavioral counterpart, a process known as mnemonic discrimination, surprisingly, research exploring the influence of context on pattern separation or mnemonic discrimination has been less common. The available evidence shows that similar items with similar contexts led to a failure in pattern separation due to high similarity that triggers overlap between events. On the other hand, others have shown that pattern separation can take place even under these conditions, allowing humans to distinguish between events with similar items and contexts, as different hippocampal subfields would play complementary roles in enabling both pattern separation and pattern completion. In the present study, we were interested in testing how stability in context influenced pattern separation. Despite the fact that pattern separation is by definition an encoding computation, the existing literature has focused on the retrieval phase. Here, we used a subsequent memory paradigm in which we manipulated the similarity of context during the encoding of visual objects selected from diverse categories. Thus, we manipulated the encoded context of each object category (four items within a category), so that some categories had the same context and others had a different context. This approach allowed us to test not only the items presented but also to include the conditions that entail the greatest demand on pattern separation. After a 20 min period, participants performed a visual mnemonic discrimination task in which they had to differentiate between old, similar, and new items by providing one of the three options for each tested item. Similarly to previous studies, we found no interaction between judgments and contexts, and participants were able to discriminate between old and lure items at the behavioral level in both conditions. Moreover, when averaging the ERPs of all the items presented within a category, a significant SME emerged between hits and new misses, but not between hits and old false alarms or similar false alarms. These results suggest that item recognition emerges from the interaction with subsequently encoded information, and not just between item memory strength and retrieval processes.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843873/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470244","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Stress-Induced Hyperglycemia Predicts Poor Outcomes in Primary Intracerebral Hemorrhage Patients.","authors":"Kevin Gilotra, Jade Basem, Melissa Janssen, Sujith Swarna, Racheed Mani, Benny Ren, Reza Dashti","doi":"10.3390/neurosci6010012","DOIUrl":"10.3390/neurosci6010012","url":null,"abstract":"<p><strong>Introduction: </strong>The current literature suggests hyperglycemia can predict poor outcomes in patients with primary intracerebral hemorrhage (ICH). Chronic hyperglycemia is seen in patients with pre-existing diabetes (DM); however, acute hyperglycemia in non-diabetic patients is defined as stress-induced hyperglycemia (SIH). This study explored the influence of hyperglycemia on outcomes of primary ICH patients both in the presence and absence of pre-existing DM.</p><p><strong>Methods: </strong>Data regarding admission glucose, pre-existing DM, inpatient mortality, and modified Rankin Scale (mRS) scores at discharge were available for 636 patients admitted to Stony Brook Hospital from January 2011 to December 2022 with a primary diagnosis of ICH. Regression models were used to compare outcomes between patients with admission hyperglycemia and/or pre-existing DM to a control group of normoglycemic and non-diabetic ICH patients.</p><p><strong>Results: </strong>Patients with SIH had higher inpatient mortality rates and worse mRS scores at discharge (<i>p</i> < 0.001). An association with higher mortality and worse mRS scores at discharge was also seen in patients with hyperglycemia secondary to DM, although the strength of this association was weaker when compared to patients with SIH.</p><p><strong>Conclusions: </strong>Our findings suggest that SIH may play a greater role in predicting poor outcomes at discharge rather than a history of poorly controlled DM with chronic hyperglycemia. To develop a more thorough understanding of this topic, prospective studies evaluating the effect of changes in serum glucose during hospital stay on short and long-term outcomes is needed.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-02-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11843840/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143470170","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}