The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity.

Abstract

Age-related decline in episodic memory is often linked to structural and functional changes in the brain. Here, we investigated how these alterations might affect functional connectivity during memory retrieval following exposure to emotional stimuli. Using functional magnetic resonance imaging (fMRI), participants viewed images with varying emotional valences (positive, negative, and neutral) followed by unrelated non-arousing videos and were then asked to retrieve an episodic detail from the previously shown video. We conducted Multivariate Pattern Analysis (MVPA) to identify regions with divergent responses between age groups, which then served as seeds in Seed-Based Connectivity (SBC) analyses. The results revealed an age-related decline in behavioural performance following exposure to negative stimuli but preserved performance following positive stimuli. Young adults exhibited increased functional connectivity following negative valence. Conversely, old adults displayed increased connectivity more scarcely, and only following positive valence. These findings point to an adaptive response of the impact of emotions on task performance that depends on neural adaptations related to ageing. This suggests that age-related changes in functional connectivity might underlie how emotions influence memory, highlighting the need to tailor memory support strategies in older adulthood.