Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis.

IF 1.6 Q3 CLINICAL NEUROLOGY
NeuroSci Pub Date : 2024-12-07 DOI:10.3390/neurosci5040046
Bernardo Flores-Prieto, Jorge Manzo-Denes, María Elena Hernández-Aguilar, Genaro Alfonso Coria-Avila, Deissy Herrera-Covarrubias, Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, César Antonio Pérez-Estudillo, Jorge Suárez-Medellín, María Rebeca Toledo-Cárdenas
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引用次数: 0

Abstract

Exposure to valproic acid (VPA) during embryogenesis has become a valuable tool for modeling neurodevelopmental disorders in animal models such as zebrafish (Danio rerio). This article examines the effects of embryonic exposure to VPA in zebrafish on the basis of 39 articles sourced from PubMed and Google Scholar. We conducted a systematic review and meta-analysis to elucidate the common impacts of VPA exposure and reported that VPA significantly altered development at various levels. Behaviorally, zebrafish exposed to VPA exhibit notable changes in their social interaction patterns. Physiologically, VPA exposure leads to significant alterations, including decreased heart rates, increased mortality rates, and pronounced morphological abnormalities. Pharmacological exposure has been linked to neuroanatomical and neurochemical changes. At the genetic level, VPA exposure is associated with the differential expression of genes involved in neurodevelopment and neuronal function. The synthesized data from these studies underscore the utility of zebrafish as a model organism for investigating the effects of teratogen exposure on neurodevelopment.

丙戊酸胚胎暴露对斑马鱼的影响:系统综述和荟萃分析。
胚胎发生期间暴露于丙戊酸(VPA)已成为模拟斑马鱼(Danio rerio)等动物模型的神经发育障碍的有价值的工具。本文基于来自PubMed和谷歌Scholar的39篇文章,研究了斑马鱼胚胎暴露于VPA的影响。我们进行了一项系统回顾和荟萃分析,以阐明VPA暴露的共同影响,并报告VPA在不同水平上显著改变了发育。在行为上,暴露于VPA的斑马鱼表现出显著的社会互动模式变化。在生理上,VPA暴露会导致显著的改变,包括心率降低、死亡率增加和明显的形态学异常。药物暴露与神经解剖学和神经化学变化有关。在遗传水平上,VPA暴露与参与神经发育和神经元功能的基因的差异表达有关。这些研究的综合数据强调了斑马鱼作为研究致畸原暴露对神经发育影响的模式生物的效用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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