NeuroSci最新文献_第10页

Pediatric Acute Disseminated Encephalomyelitis Triggered by Concurrent Administration of Seasonal and H1N1 Influenza Vaccines: A Case Report and Review. 同时接种季节性流感疫苗和H1N1流感疫苗引发小儿急性播散性脑脊髓炎：一例报告和回顾

IF 1.6

NeuroSci Pub Date : 2024-12-30 DOI: 10.3390/neurosci6010001

George Imataka, Hideaki Shiraishi, Shigemi Yoshihara

{"title":"Pediatric Acute Disseminated Encephalomyelitis Triggered by Concurrent Administration of Seasonal and H1N1 Influenza Vaccines: A Case Report and Review.","authors":"George Imataka, Hideaki Shiraishi, Shigemi Yoshihara","doi":"10.3390/neurosci6010001","DOIUrl":"10.3390/neurosci6010001","url":null,"abstract":"Background: Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated inflammatory disorder of the central nervous system (CNS), typically characterized by the acute onset of multifocal demyelination. The pathogenesis of ADEM remains unclear, but it is believed to be triggered by an autoimmune response, often following viral infections or vaccinations.Case report: This case report describes a 3-year-old child who developed ADEM after receiving two concurrent influenza vaccines: one for seasonal influenza and one for the 2009 H1N1 pandemic. The patient presented with motor regression, mild pleocytosis in cerebrospinal fluid (CSF), and typical MRI findings of ADEM. Steroid pulse therapy resulted in rapid improvement, and the patient recovered fully without sequelae.Results: Although the influenza vaccine has been linked to ADEM in some studies, it remains uncertain whether the simultaneous administration of both vaccines contributed to the onset of ADEM. While influenza vaccines are considered safe and effective by health organizations such as the CDC, data suggest that the incidence of ADEM and other neurological complications is significantly higher after natural influenza infections compared to vaccination. This highlights the importance of vaccination in preventing severe outcomes.Conclusions: This case underscores the importance of monitoring and reporting adverse events following vaccination to refine our understanding of rare complications like ADEM. While simultaneous vaccine administration warrants further research, the benefits of vaccination in preventing severe complications from natural infections far outweigh the risks. Continued vigilance and improved surveillance systems are essential for maintaining public confidence in vaccination programs.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development of Spatial Memory: A Behavioral Study. 空间记忆的发展：一项行为研究。

IF 1.6

NeuroSci Pub Date : 2024-12-19 DOI: 10.3390/neurosci5040050

Konstantinos Kostakos, Alexandra Pliakopanou, Vasileios Meimaridis, Ourania-Natalia Oriana Galanou, Aikaterini Argyro Anagnostou, Dimitra Sertidou, Panagiotis Katis, Periklis Anastasiou, Konstantinos Katsoulidis, Yannis Lykogiorgos, Dimitrios Mytilinaios, Andreas P Katsenos, Yannis V Simos, Stefanos Bellos, Spyridon Konitsiotis, Dimitrios Peschos, Konstantinos I Tsamis

{"title":"Development of Spatial Memory: A Behavioral Study.","authors":"Konstantinos Kostakos, Alexandra Pliakopanou, Vasileios Meimaridis, Ourania-Natalia Oriana Galanou, Aikaterini Argyro Anagnostou, Dimitra Sertidou, Panagiotis Katis, Periklis Anastasiou, Konstantinos Katsoulidis, Yannis Lykogiorgos, Dimitrios Mytilinaios, Andreas P Katsenos, Yannis V Simos, Stefanos Bellos, Spyridon Konitsiotis, Dimitrios Peschos, Konstantinos I Tsamis","doi":"10.3390/neurosci5040050","DOIUrl":"10.3390/neurosci5040050","url":null,"abstract":"Although spatial memory has been widely studied in rodents, developmental studies involving humans are limited in number and sample size. We designed and studied the validity of two simple experimental setups for the evaluation of spatial memory and navigation development. The dataset of this study was composed of 496 schoolchildren, from 4 to 15 years old. Participants were tested blindfolded on their ability to navigate in a square area between three stool stations while performing an item-collecting task, having observed the experimental space and procedure (Test 1) or having, in addition, executed the task open-eyed (Test 2). The performance times were analyzed to identify age-specific differences. Parametric methods, including the one-way ANOVA and independent samples t-test, were employed. Statistically significant differences were observed in the mean performance time among age groups, as well as within the same age groups when comparing Test 1 and Test 2. Our results revealed a performance improvement with aging for both functions and showed that spatial memory and spatial navigation develop throughout childhood and puberty and interact during development. When children integrate visual stimuli with other sensory inputs, they can form stronger spatial memories, thereby enhancing their navigation skills. The proposed experimental setup is considered feasible and can be used for behavioral studies of navigation-related memory in children and beyond with appropriate adaptations, allowing for large-scale assessment.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"713-728"},"PeriodicalIF":1.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Influence of Anesthesia on Neuromonitoring During Scoliosis Surgery: A Systematic Review. 麻醉对脊柱侧凸手术中神经监测的影响：系统综述。

IF 1.6

NeuroSci Pub Date : 2024-12-17 DOI: 10.3390/neurosci5040049

Malgorzata Reysner, Tomasz Reysner, Piotr Janusz, Grzegorz Kowalski, Alicja Geisler-Wojciechowska, Monika Grochowicka, Monika Pyszczorska, Aleksander Mularski, Katarzyna Wieczorowska-Tobis

{"title":"The Influence of Anesthesia on Neuromonitoring During Scoliosis Surgery: A Systematic Review.","authors":"Malgorzata Reysner, Tomasz Reysner, Piotr Janusz, Grzegorz Kowalski, Alicja Geisler-Wojciechowska, Monika Grochowicka, Monika Pyszczorska, Aleksander Mularski, Katarzyna Wieczorowska-Tobis","doi":"10.3390/neurosci5040049","DOIUrl":"10.3390/neurosci5040049","url":null,"abstract":"Background: Intraoperative neuromonitoring (IONM) is crucial for the safety of scoliosis surgery, providing real-time feedback on the spinal cord and nerve function, primarily through motor-evoked potentials (MEPs). The choice of anesthesia plays a crucial role in influencing the quality and reliability of these neuromonitoring signals. This systematic review evaluates how different anesthetic techniques-total intravenous anesthesia (TIVA), volatile anesthetics, and regional anesthesia approaches such as Erector Spinae Plane Block (ESPB), spinal, and epidural anesthesia-affect IONM during scoliosis surgery.Methods: A systematic review was conducted following PRISMA guidelines. PubMed, MEDLINE, EMBASE, and Cochrane databases were searched for studies published between 2017 and 2024 that examined the impact of anesthetic techniques on neuromonitoring during scoliosis surgery. The focus was on studies reporting MEP outcomes, anesthetic protocols, and postoperative neurological and analgesic effects.Results: The search initially identified 998 articles. After applying inclusion criteria based on relevance, recency, methodological quality, and citation frequency, 45 studies were selected for detailed review.Conclusion: The erector Spinae Plane Block (ESPB) provides distinct benefits over spinal and epidural anesthesia in scoliosis surgery, particularly in maintaining neuromonitoring accuracy, reducing hemodynamic instability, and minimizing complications. The ESPB's ability to deliver effective segmental analgesia without compromising motor function makes it a safer and more efficient option for postoperative pain management, enhancing patient outcomes.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"693-712"},"PeriodicalIF":1.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Concentric Needle Electromyography Findings in Patients with Ulnar Neuropathy at the Elbow. 肘部尺神经病变患者的同心针肌电图表现。

IF 1.6

NeuroSci Pub Date : 2024-12-10 DOI: 10.3390/neurosci5040047

Simon Podnar

{"title":"Concentric Needle Electromyography Findings in Patients with Ulnar Neuropathy at the Elbow.","authors":"Simon Podnar","doi":"10.3390/neurosci5040047","DOIUrl":"10.3390/neurosci5040047","url":null,"abstract":"In ulnar neuropathy at the elbow (UNE), the degree of neuropathic changes, the sensitivity of needle electromyography (EMG) in individual ulnar muscles, and the utility of individual EMG parameters are controversial. I compared qualitative needle EMG findings in two ulnar-innervated hands muscles and two ulnar-innervated forearm muscles in a group of previously reported UNE patients. Altogether, 170 UNE patients (175 arms) were studied. I found spontaneous denervation activity (SDA) most frequently in the first dorsal interosseus (FDI) (62%) and neuropathic changes in the abductor digiti minimi (ADM) muscle (88%). In the forearm muscles, SDA was more common (29% vs. 20%; p = 0.02), and neuropathic changes were similar in the flexor carpi ulnaris (FCU) and the flexor digitorum profundus (FDP) muscles. SDA and neuropathic changes were more common in the ulnar hand (88% and 77%) than in the ulnar forearm muscles (71% and 68%). Needle EMG is sensitive to diagnose UNE. For the detection of SDA FDI and neuropathic changes, ADM is the best muscle. Ulnar forearm muscles are less useful than ulnar hand muscles for UNE diagnosis.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"666-673"},"PeriodicalIF":1.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Temporal and Fronto-Central Auditory Evoked Responses in Children with Neurodevelopmental Disorders: A Scoping Review. 儿童神经发育障碍的颞叶和额-中枢听觉诱发反应：范围综述。

IF 1.6

NeuroSci Pub Date : 2024-12-10 DOI: 10.3390/neurosci5040048

Zohreh Ahmadi, Fauve Duquette-Laplante, Shanna Kousaie, Benjamin Rich Zendel, Amineh Koravand

{"title":"Temporal and Fronto-Central Auditory Evoked Responses in Children with Neurodevelopmental Disorders: A Scoping Review.","authors":"Zohreh Ahmadi, Fauve Duquette-Laplante, Shanna Kousaie, Benjamin Rich Zendel, Amineh Koravand","doi":"10.3390/neurosci5040048","DOIUrl":"10.3390/neurosci5040048","url":null,"abstract":"At the cortical level, the central auditory neural system (CANS) includes primary and secondary areas. So far, much research has focused on recording fronto-central auditory evoked potentials/responses (P1-N1-P2), originating mainly from the primary auditory areas, to explore the neural processing in the auditory cortex. However, less is known about the secondary auditory areas. This review aimed to investigate and compare fronto-central and T-complex responses in populations at risk of auditory dysfunction, such as individuals with neurodevelopmental disorders. After searching the electronic databases (PubMed, Web of Science, Scopus, and Ovid), ten studies encompassing six neurodevelopmental disorders were included for the analysis. All experimental populations had atypical T-complexes, manifesting as an absence of evoked responses, shorter latency, and/or smaller amplitude. Moreover, in two experimental groups, dyslexia and attention deficit/hyperactivity disorder (ADHD), abnormal T-complex responses were observed despite the presence of normal fronto-central responses. The presence of abnormal T-complex responses in combination with normal fronto-central responses in the same population, using the same experiment, may highlight the advantage of the T-complex for indexing deficits in distinct auditory processes or regions, which the fronto-central response may not track.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"674-692"},"PeriodicalIF":1.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis. 丙戊酸胚胎暴露对斑马鱼的影响：系统综述和荟萃分析。

IF 1.6

NeuroSci Pub Date : 2024-12-07 DOI: 10.3390/neurosci5040046

Bernardo Flores-Prieto, Jorge Manzo-Denes, María Elena Hernández-Aguilar, Genaro Alfonso Coria-Avila, Deissy Herrera-Covarrubias, Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, César Antonio Pérez-Estudillo, Jorge Suárez-Medellín, María Rebeca Toledo-Cárdenas

{"title":"Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis.","authors":"Bernardo Flores-Prieto, Jorge Manzo-Denes, María Elena Hernández-Aguilar, Genaro Alfonso Coria-Avila, Deissy Herrera-Covarrubias, Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, César Antonio Pérez-Estudillo, Jorge Suárez-Medellín, María Rebeca Toledo-Cárdenas","doi":"10.3390/neurosci5040046","DOIUrl":"10.3390/neurosci5040046","url":null,"abstract":"Exposure to valproic acid (VPA) during embryogenesis has become a valuable tool for modeling neurodevelopmental disorders in animal models such as zebrafish (Danio rerio). This article examines the effects of embryonic exposure to VPA in zebrafish on the basis of 39 articles sourced from PubMed and Google Scholar. We conducted a systematic review and meta-analysis to elucidate the common impacts of VPA exposure and reported that VPA significantly altered development at various levels. Behaviorally, zebrafish exposed to VPA exhibit notable changes in their social interaction patterns. Physiologically, VPA exposure leads to significant alterations, including decreased heart rates, increased mortality rates, and pronounced morphological abnormalities. Pharmacological exposure has been linked to neuroanatomical and neurochemical changes. At the genetic level, VPA exposure is associated with the differential expression of genes involved in neurodevelopment and neuronal function. The synthesized data from these studies underscore the utility of zebrafish as a model organism for investigating the effects of teratogen exposure on neurodevelopment.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"650-665"},"PeriodicalIF":1.6,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuraxial Anesthesia and Risk of Root Damage: A 3D Ex Vivo Study. 轴向麻醉和根损伤的风险：一项3D离体研究。

IF 1.6

NeuroSci Pub Date : 2024-12-03 DOI: 10.3390/neurosci5040044

Hipólito Labandeyra, Xavier Sala-Blanch, Alberto Prats-Galino, Anna Puigdellívol-Sánchez

{"title":"Neuraxial Anesthesia and Risk of Root Damage: A 3D Ex Vivo Study.","authors":"Hipólito Labandeyra, Xavier Sala-Blanch, Alberto Prats-Galino, Anna Puigdellívol-Sánchez","doi":"10.3390/neurosci5040044","DOIUrl":"10.3390/neurosci5040044","url":null,"abstract":"Cauda equina nerve roots may become damaged during neuraxial anesthesia, and post-puncture headache may appear in the case of cerebrospinal fluid leakage if needle tips are deformed due to bone contact when several attempts are needed. Our aim was to verify the correlation between skin-transverse process distance (st) and skin-dural sac distance (d) for calculation of optimal angles in a free visual guide and as a reference for the maximal depth to be traversed by the needle. Randomly selected ex vivo samples (n = 10) were flexed to reproduce the position of the lumbosacral spine during spinal anesthesia. Spinal needles were inserted perpendicular to the skin either blindly or following the inferred paramedian angle corresponding to ultrasound-measured (d). After computed tomography and three-dimensional reconstruction, both (st) and (d) were measured, and the Pearson correlation index was calculated. A free 3D-PDF tool was used to illustrate the potential affectation of nerve cuffs by needles located lateral to the dural sac. Correlation between (d) and (st) was 0.84-0.93 at L4L5-L3L4 intervertebral levels, and most needle tips were located within the spinal canal, but some traversed the zone where nerve cuffs emerge. In conclusion, ultrasound may determine if a perpendicular needle insertion is viable at midline. If not, the optimal paramedian angle and maximal depth may be determined by measuring (st).","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"623-634"},"PeriodicalIF":1.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β-Myrcene, in Mice. 常见大麻萜类、芳樟醇和β-月桂烯抗焦虑性的性别差异。

IF 1.6

NeuroSci Pub Date : 2024-12-03 DOI: 10.3390/neurosci5040045

Jasmin K Wagner, Ella Gambell, Tucker Gibbons, Thomas J Martin, Joshua S Kaplan

{"title":"Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β-Myrcene, in Mice.","authors":"Jasmin K Wagner, Ella Gambell, Tucker Gibbons, Thomas J Martin, Joshua S Kaplan","doi":"10.3390/neurosci5040045","DOIUrl":"10.3390/neurosci5040045","url":null,"abstract":"Volatile organic compounds, colloquially referred to as \"terpenes\", have been proposed to impact the therapeutic qualities that are traditionally ascribed to cannabis. However, the contribution of these terpenes in anxiety, at relevant levels and exposure methods common with cannabis use, is lacking empirical assessment. We tested the anxiolytic properties of two prominent cannabis terpenes, linalool and β-myrcene, in male and female mice using short duration vapor pulls to model human inhalation when combusting flower or vaping cannabis oil. We observed sex differences in the locomotor effects in the open field and anxiolytic properties in the elevated plus maze of these terpenes that depended on their exposure characteristics. Both linalool and β-myrcene had anxiolytic effects in female mice when delivered in discrete vapor pulls over the course of 30 min. In male mice, only a single vapor hit containing linalool or β-myrcene had anxiolytic effects. The combination of sub-effective levels of linalool and the phytocannabinoid, cannabidiol (CBD), had synergistic anxiolytic effects in females, but these entourage effects between CBD and terpenes were absent with β-myrcene for females and for either terpene in males. Together, our findings reveal sex differences in the anxiolytic properties of common cannabis terpenes and highlight the potential benefits of unique combinations of CBD and terpenes in expanding the therapeutic dose window.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"635-649"},"PeriodicalIF":1.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate Effects of Distinct Intensities of Transcutaneous Spinal Direct Current Stimulation on Chronic Pain: A Randomized Controlled Trial. 不同强度的经皮脊髓直流电刺激对慢性疼痛的直接影响：一项随机对照试验。

IF 1.6

NeuroSci Pub Date : 2024-12-02 DOI: 10.3390/neurosci5040043

Kariny Realino do Rosário Ferreira, Maria de Cássia Souza Macedo, Ana Luiza Guimarães Alves, Arthur Ferreira Esquírio, Bianca Rossi Botim, Gabrielly Souza Jacob, Mayra Evelise Cunha Dos Santos, Gabriela Lopes Gama, Michelle Cristina Sales Almeida Barbosa, Alexandre Wesley Carvalho Barbosa

{"title":"Immediate Effects of Distinct Intensities of Transcutaneous Spinal Direct Current Stimulation on Chronic Pain: A Randomized Controlled Trial.","authors":"Kariny Realino do Rosário Ferreira, Maria de Cássia Souza Macedo, Ana Luiza Guimarães Alves, Arthur Ferreira Esquírio, Bianca Rossi Botim, Gabrielly Souza Jacob, Mayra Evelise Cunha Dos Santos, Gabriela Lopes Gama, Michelle Cristina Sales Almeida Barbosa, Alexandre Wesley Carvalho Barbosa","doi":"10.3390/neurosci5040043","DOIUrl":"10.3390/neurosci5040043","url":null,"abstract":"This study aimed to assess the immediate effects of transcutaneous spinal direct current stimulation (tsDCS) on pain outcomes, measured using the visual analog scale (VAS) and pressure pain thresholds in a cohort of 55 participants experiencing chronic pain using a controlled, randomized trial with 55 participants allocated into 2 groups: 2 mA and 0.5 mA of tsDCS for 20 min. Anodal stimulation was applied on the 12th thoracic vertebra, with the cathode positioned on the 7th cervical vertebra. Pain outcomes were assessed before and post intervention using the VAS and pressure algometry. Between- and within-group differences, along with chi-square tests, were used to determine the differences and responsiveness. Significance was established at p < 0.05. Findings showed significant temporal effects for both VAS (p < 0.001) and pressure algometry (p = 0.04). However, no between-group differences were noted for the time × group factor for VAS (p = 0.46) and pressure algometry (p = 0.78). No significant between-group differences were observed for the responsiveness analysis. The results indicate that a single 20-min session of 2 and 0.5 mA tsDCS improves pain scores for both intensities equally. However, there were no statistically significant between-group differences in pain perception or pressure pain threshold.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"614-622"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harmonization for Parkinson's Disease Multi-Dataset T1 MRI Morphometry Classification. 帕金森病多数据集T1 MRI形态学分类的协调。

IF 1.6

NeuroSci Pub Date : 2024-11-29 DOI: 10.3390/neurosci5040042

Mohammed Saqib, Silvina G Horovitz

{"title":"Harmonization for Parkinson's Disease Multi-Dataset T1 MRI Morphometry Classification.","authors":"Mohammed Saqib, Silvina G Horovitz","doi":"10.3390/neurosci5040042","DOIUrl":"10.3390/neurosci5040042","url":null,"abstract":"Classification of disease and healthy volunteer cohorts provides a useful clinical alternative to traditional group statistics due to individualized, personalized predictions. Classifiers for neurodegenerative disease can be trained on structural MRI morphometry, but require large multi-scanner datasets, introducing confounding batch effects. We test ComBat, a common harmonization model, in an example application to classify subjects with Parkinson's disease from healthy volunteers and identify common pitfalls, including data leakage. We used a multi-dataset cohort of 372 subjects (216 with Parkinson's disease, 156 healthy volunteers) from 11 identified scanners. We extracted both FreeSurfer and the determinant of Jacobian morphometry to compare single-scanner and multi-scanner classification pipelines. We confirm the presence of batch effects by running single scanner classifiers which could achieve wildly divergent AUCs on scanner-specific datasets (mean:0.651 ± 0.144). Multi-scanner classifiers that considered neurobiological batch effects between sites could easily achieve a test AUC of 0.902, though pipelines that prevented data leakage could only achieve a test AUC of 0.550. We conclude that batch effects remain a major issue for classification problems, such that even impressive single-scanner classifiers are unlikely to generalize to multiple scanners, and that solving for batch effects in a classifier problem must avoid circularity and reporting overly optimistic results.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"600-613"},"PeriodicalIF":1.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0