NeuroSci最新文献_第4页

Sleep Deprivation in Rats Causes Dissociation of the Synaptic NMDA Receptor/D1 Dopamine Receptor Heterocomplex. 睡眠剥夺导致大鼠突触NMDA受体/D1多巴胺受体异复合体的分离。

IF 2

NeuroSci Pub Date : 2025-07-05 DOI: 10.3390/neurosci6030061

Natalia Kiknadze, Nana Narmania, Maia Sepashvili, Tamar Barbakadze, Elene Zhuravliova, Tamar Shetekauri, Nino Tkemaladze, Nikoloz Oniani, David Mikeladze

{"title":"Sleep Deprivation in Rats Causes Dissociation of the Synaptic NMDA Receptor/D1 Dopamine Receptor Heterocomplex.","authors":"Natalia Kiknadze, Nana Narmania, Maia Sepashvili, Tamar Barbakadze, Elene Zhuravliova, Tamar Shetekauri, Nino Tkemaladze, Nikoloz Oniani, David Mikeladze","doi":"10.3390/neurosci6030061","DOIUrl":"10.3390/neurosci6030061","url":null,"abstract":"Glutamate and dopamine receptors play a crucial role in regulating synaptic plasticity throughout the sleep-wake cycle. These receptors form various heterocomplexes in synaptic areas; however, the role of this protein interactome in sleep-wake cycles remains unclear. Co-immunoprecipitation experiments were conducted to observe the complexation of the NMDA glutamate receptor (NMDAR) subunits GluN2A and GluN2B, metabotropic glutamate receptors mGluR1/5, and dopamine receptors (D1R and D2R) with the scaffold protein Homer in the synaptic membranes of the hippocampus after six hours of sleep deprivation (SD) in rats. Our findings indicate that the level of Homer in the GluN2A/mGluR1/D1R interactome decreased during SD, while the content of Homer remained unchanged in the GluN2B/mGluR1/D2R heterocomplex. Moreover, Homer immunoprecipitated a reduced amount of inositol trisphosphate receptor (IP3R) in the microsomal and synaptic fractions, confirming the dissociation of the ternary supercomplex Homer/mGluR1/IP3R during SD. Additionally, our findings indicate that SD increases the synaptic content of the AMPA receptor (AMPAR) subunit GluA1. Unlike AMPAR, NMDAR subunits in synaptic membranes do not undergo significant changes. Furthermore, the G-to-F actin ratio decreases during SD. Changes in the assembly of actin filaments occur due to the dephosphorylation of cofilin. These results suggest that SD causes the dissociation of the GluN2A/mGluR1/D1R/Homer/IP3R heterocomplex in synaptic and endoplasmic membranes.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-07-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286143/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Derivation of Novel Imaging Biomarkers of Neonatal Brain Injury Using Bedside Diffuse Optical Tomography: Protocol for a Prospective Feasibility Study. 利用床边弥漫性光学断层扫描提取新生儿脑损伤的新型成像生物标志物：一项前瞻性可行性研究方案。

IF 2

NeuroSci Pub Date : 2025-06-30 DOI: 10.3390/neurosci6030060

Sabrina Mastroianni, Anagha Vinod, Naiqi G Xiao, Heather Johnson, Lehana Thabane, Qiyin Fang, Ipsita Goswami

{"title":"Derivation of Novel Imaging Biomarkers of Neonatal Brain Injury Using Bedside Diffuse Optical Tomography: Protocol for a Prospective Feasibility Study.","authors":"Sabrina Mastroianni, Anagha Vinod, Naiqi G Xiao, Heather Johnson, Lehana Thabane, Qiyin Fang, Ipsita Goswami","doi":"10.3390/neurosci6030060","DOIUrl":"10.3390/neurosci6030060","url":null,"abstract":"Prognostication of neurodevelopmental outcomes for neonates with hypoxic-ischemic encephalopathy (HIE) is primarily reliant on structural assessment using conventional brain magnetic resonance imaging in the clinical setting. Diffuse optical tomography (DOT) can provide complementary information on brain function at the bedside, further enhancing prognostic accuracy. The predictive accuracy and generalizability of DOT-based neuroimaging markers are unknown. This study aims to test the feasibility of prospectively recruiting and retaining neonates for 12 months in a larger study that investigates the prognostic utility of DOT-based biomarkers of HIE. The study will recruit 25 neonates with HIE over one year and follow them beyond NICU discharge at 6 and 12 months of age. Study subjects will undergo resting-state DOT measurement within 7 days of life for a 30-45-min period without sedation. A customized neonatal cap with 10 sources and eight detectors per side will be used to quantify cortical functional connectivity and to generate brain networks using MATLAB-based software (version 24.2). The Ages and Stages Questionnaires-3rd edition will be used for standardized developmental assessments at follow-up. This feasibility study will help refine the design and sample-size calculation for an adequately powered larger study that determines the clinical utility of DOT-based neuroimaging in perinatal brain injury.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286108/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700619","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

β2-Microglobulin Regulates Extracellular Matrix Dynamics During Peripheral Nerve Injury. β2-微球蛋白调节周围神经损伤时细胞外基质动力学。

IF 2

NeuroSci Pub Date : 2025-06-29 DOI: 10.3390/neurosci6030059

Eiki Shirasawa, Kentaro Uchida, Kenji Onuma, Gen Inoue, Koji Eshima, Masashi Satoh, Masayuki Miyagi, Yoji Toyomura, Akira Norisugi, Masashi Takaso

{"title":"β2-Microglobulin Regulates Extracellular Matrix Dynamics During Peripheral Nerve Injury.","authors":"Eiki Shirasawa, Kentaro Uchida, Kenji Onuma, Gen Inoue, Koji Eshima, Masashi Satoh, Masayuki Miyagi, Yoji Toyomura, Akira Norisugi, Masashi Takaso","doi":"10.3390/neurosci6030059","DOIUrl":"10.3390/neurosci6030059","url":null,"abstract":"Peripheral nerve injury initiates a complex cascade of events coordinating immune responses, extracellular matrix (ECM) remodeling, and neuronal repair. While β2-microglobulin (B2M) is well known for its role in MHC class I-mediated antigen presentation and CD8+ T-cell differentiation, its potential contributions to non-immune processes remain underexplored. In this study, we investigated the role of B2M in peripheral nerve regeneration using a chronic constriction injury (CCI) model in wild-type and B2M-deficient (B2M-KO) mice. Flow cytometry, RNA sequencing (RNA-seq), and quantitative PCR (qPCR) were performed to assess T-cell subset dynamics and gene expression following injury. Flow cytometric analysis showed that CD3+CD4+ and CD3+CD8+ T-cell populations increased by day 7 post-injury. While CD3+CD4+ T-cell expansion occurred in both groups, a significant increase in CD3+CD8+ T cells was observed only in wild-type mice. RNA-seq analysis at 3 days post-injury-prior to substantial T-cell accumulation-revealed marked downregulation of ECM-related genes in B2M-KO mice, including collagens, matrix-associated proteins, and other key ECM components. KEGG analysis identified suppression of ECM-receptor interaction, PI3K-Akt, and TGF-β signaling pathways. qPCR confirmed reduced expression of Thbs1 in B2M-KO mice. These findings suggest that B2M plays a critical, CD8+ T-cell-independent role in regulating ECM dynamics and regenerative signaling during early nerve repair, expanding the conceptual framework of B2M's function beyond classical immune roles.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 3","pages":""},"PeriodicalIF":2.0,"publicationDate":"2025-06-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12286088/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144700625","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Electrodiagnostic Evaluation of Meralgia Paresthetica. 触感异常痛的电诊断评价。

IF 2

NeuroSci Pub Date : 2025-06-22 DOI: 10.3390/neurosci6030058

Jernej Avsenik, Simon Podnar

引用次数: 0

14th Panhellenic Conference on Alzheimer's Disease and the 6th Mediterranean Conference on Neurodegenerative Diseases, 13 February-16 February, Thessaloniki, Greece. 第14届泛希腊阿尔茨海默病会议和第6届地中海神经退行性疾病会议，2月13日至16日，希腊塞萨洛尼基。

IF 2

NeuroSci Pub Date : 2025-06-20 DOI: 10.3390/neurosci6030057

Magda Tsolaki

引用次数: 0

Commentary: Treating Diseases from Alzheimer's to Parkinson's Using Transcranial Pulse Stimulation: Mechanistic Insights, Recent Evidence, and Ethical Considerations. 评论：使用经颅脉冲刺激治疗从阿尔茨海默病到帕金森病的疾病：机制见解，最新证据和伦理考虑。

IF 1.6

NeuroSci Pub Date : 2025-06-17 DOI: 10.3390/neurosci6020056

Lars Wojtecki

{"title":"Commentary: Treating Diseases from Alzheimer's to Parkinson's Using Transcranial Pulse Stimulation: Mechanistic Insights, Recent Evidence, and Ethical Considerations.","authors":"Lars Wojtecki","doi":"10.3390/neurosci6020056","DOIUrl":"10.3390/neurosci6020056","url":null,"abstract":"Transcranial pulse stimulation (TPS) is a non-invasive neuromodulation method that uses, high-intensity acoustic shockwaves to deliver focused mechanical stimulation to neural tissue with minimal thermal effects. The mechanism of action includes but is not limited to promotion of blood flow and angiogenesis through mechanotransduction. Clinical data to date are limited and preliminary. In Alzheimer's disease (AD), TPS has demonstrated cognitive and mood improvements in pilot studies and secondary endpoint analysis in first randomized trials. The enhancement of gamma-band oscillations and network connectivity has been reported. Clinical observations in Parkinson's disease (PD) suggest TPS as a hypothesis-generating approach to address non-motor symptoms-such as depression, cognitive decline, and the freezing of gait-through theoretical modulation of basal ganglia-cortical circuits. TPS is CE-marked in Europe for AD and shows a favorable safety profile; however, ethical considerations arise from the limited evidence base, potential impairment of patient autonomy and judgment in dementia, and the risk of withholding established treatments. TPS should only be offered under structured scientific protocols or within patient registries to ensure rigorous oversight. Ensuring that consent processes account for cognitive capacity, and that TPS is applied as adjunct rather than replacement therapy, is paramount. Future research must include large-scale randomized controlled trials (RCTs), standardize stimulation protocols, deepen mechanistic insight, and embed robust ethical frameworks.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12195775/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Romantic Partners with Mismatched Relationship Satisfaction Showed Greater Interpersonal Neural Synchrony When Co-Viewing Emotive Videos: An Exploratory Pilot fNIRS Hyperscanning Study. 关系满意度不匹配的恋人在共同观看情感视频时表现出更大的人际神经同步性：一项探索性试点fNIRS超扫描研究。

IF 1.6

NeuroSci Pub Date : 2025-06-12 DOI: 10.3390/neurosci6020055

Wen Xiu Heng, Li Ying Ng, Zen Ziyi Goh, Gianluca Esposito, Atiqah Azhari

{"title":"Romantic Partners with Mismatched Relationship Satisfaction Showed Greater Interpersonal Neural Synchrony When Co-Viewing Emotive Videos: An Exploratory Pilot fNIRS Hyperscanning Study.","authors":"Wen Xiu Heng, Li Ying Ng, Zen Ziyi Goh, Gianluca Esposito, Atiqah Azhari","doi":"10.3390/neurosci6020055","DOIUrl":"10.3390/neurosci6020055","url":null,"abstract":"Emotional attunement, or emotional co-regulation in a relationship, can manifest as interpersonal neural synchrony, where partners exhibit similar anti-phase or phase-shifted brain activity. In adult romantic relationships, emotional attunement may differ according to relationship satisfaction. No study has examined how relationship satisfaction difference influences interpersonal neural synchrony. This exploratory pilot study on 17 couples (unmarried Chinese undergraduate couples in a Southeast Asian university) investigated whether relationship satisfaction difference influenced interpersonal neural synchrony during a shared emotive experience. Each couple wore an fNIRS cap to measure brain activity in their prefrontal cortex (PFC) while co-viewing seven videos intended to evoke positive, negative or neutral emotions. We found preliminary evidence that relationship satisfaction difference modulated interpersonal neural synchrony in the right ventral PFC regions, including the right ventromedial PFC (involved in the encoding of emotional values to stimuli and emotional regulation), right ventrolateral PFC (involved in voluntary emotional regulation) and the right orbitofrontal cortex (involved in processing of emotional experiences and regulation of emotions). This suggested that couples with mismatched relationship satisfaction displayed greater interpersonal neural synchrony, possibly due to mutual social cognitive processes when viewing emotive videos together. Further studies can replicate the findings with larger, diverse samples.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196001/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487388","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing Neurosurgical Oncology and AI Innovations in Latin American Brain Cancer Care: Insights from a Center of Excellence. 拉丁美洲脑癌护理中推进神经外科肿瘤学和人工智能创新：来自卓越中心的见解。

IF 1.6

NeuroSci Pub Date : 2025-06-10 DOI: 10.3390/neurosci6020054

José E Valerio, Immanuel O Olarinde, Guillermo de Jesus Aguirre Vera, Jorge Zumaeta, Noe Santiago Rea, Maria P Fernandez Gomez, Penelope Mantilla-Farfan, Andrés M Alvarez-Pinzon

{"title":"Advancing Neurosurgical Oncology and AI Innovations in Latin American Brain Cancer Care: Insights from a Center of Excellence.","authors":"José E Valerio, Immanuel O Olarinde, Guillermo de Jesus Aguirre Vera, Jorge Zumaeta, Noe Santiago Rea, Maria P Fernandez Gomez, Penelope Mantilla-Farfan, Andrés M Alvarez-Pinzon","doi":"10.3390/neurosci6020054","DOIUrl":"10.3390/neurosci6020054","url":null,"abstract":"Background: Disparities in neuro-oncological care between high-income and low- and middle-income countries (LMICs) are well documented, yet region-specific data from Latin America remain limited. This review evaluates epidemiologic trends, access to care, and systemic challenges in brain tumor management across Latin American LMICs, using Argentina as a case study. Methods: A systematic review of peer-reviewed literature was conducted focusing on brain tumor incidence, mortality, risk factors, and availability of diagnostics and treatments in Latin America. Socioeconomic, cultural, and systemic barriers were also analyzed. Results: Latin America exhibits some of the highest global brain tumor mortality rates, with Brazil reporting age-standardized rates exceeding 4.5 per 100,000. Glioblastomas are frequently diagnosed at younger ages, often in the fifth decade of life, compared to the global average. Meningioma incidence has increased by 15-20% over the last decade, yet region-wide data remain fragmented. Access to neuroimaging, neurosurgery, radiotherapy, and chemotherapy is limited, with up to 60% of patients relying solely on under-resourced public health systems. Less than 30% of hospitals in rural areas have MRI availability, and continuous professional training is infrequent. Innovative adaptations, such as awake craniotomy, are used in some LMIC centers in response to equipment scarcity. Conclusions: Brain tumor care in Latin America is hindered by limited epidemiological data, restricted access to diagnostics and treatment, and insufficient workforce training. Targeted investments in healthcare infrastructure, international educational collaborations, and policy-level reforms are critical to reducing disparities and improving outcomes in neuro-oncology across the region.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196093/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

An Endocrine-Disrupting Chemical, Bisphenol A Diglycidyl Ether (BADGE), Accelerates Neuritogenesis and Outgrowth of Cortical Neurons via the G-Protein-Coupled Estrogen Receptor. 一种内分泌干扰化学物质，双酚A二甘油酯（BADGE），通过g蛋白偶联雌激素受体加速神经细胞的发生和皮质神经元的生长。

IF 1.6

NeuroSci Pub Date : 2025-06-06 DOI: 10.3390/neurosci6020053

Ikuko Miyazaki, Chiharu Nishiyama, Takeru Nagoshi, Akane Miyako, Suzuka Ono, Ichika Misawa, Aika Isse, Kana Tomimoto, Kaori Masai, Kazumasa Zensho, Masato Asanuma

{"title":"An Endocrine-Disrupting Chemical, Bisphenol A Diglycidyl Ether (BADGE), Accelerates Neuritogenesis and Outgrowth of Cortical Neurons via the G-Protein-Coupled Estrogen Receptor.","authors":"Ikuko Miyazaki, Chiharu Nishiyama, Takeru Nagoshi, Akane Miyako, Suzuka Ono, Ichika Misawa, Aika Isse, Kana Tomimoto, Kaori Masai, Kazumasa Zensho, Masato Asanuma","doi":"10.3390/neurosci6020053","DOIUrl":"10.3390/neurosci6020053","url":null,"abstract":"Bisphenol A diglycidyl ether (BADGE) is the main component of epoxy resin and is used for the inner coating of canned foods and plastic food containers. BADGE can easily migrate from containers and result in food contamination; the compound is known as an endocrine-disrupting chemical. We previously reported that maternal exposure to bisphenol A bis (2,3-dihydroxypropyl) ether (BADGE·2H2O), which is the most detected BADGE derivative not only in canned foods but also in human specimens, during gestation and lactation, could accelerate neuronal differentiation in the cortex of fetuses and induce anxiety-like behavior in juvenile mice. In this study, we investigated the effects of low-dose BADGE·2H2O (1-100 pM) treatment on neurites and the mechanism of neurite outgrowth in cortical neurons. BADGE·2H2O exposure significantly increased the number of dendrites and neurite length in cortical neurons; these accelerating effects were inhibited by estrogen receptor (ER) antagonist ICI 182,780 and G-protein-coupled estrogen receptor (GPER) antagonist G15. BADGE·2H2O down-regulated Hes1 expression, which is a transcriptional repressor, and increased levels of neuritogenic factor neurogenin-3 (Ngn3) in the cortical neurons; the changes were significantly blocked by G15. These data suggest that direct BADGE·2H2O exposure can accelerate neuritogenesis and outgrowth in cortical neurons through down-regulation of Hes1 and by increasing Ngn3 levels through ERs, particularly GPER.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196484/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487465","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Natural Compounds That Target Glioma Stem Cells. 针对神经胶质瘤干细胞的天然化合物。

IF 1.6

NeuroSci Pub Date : 2025-06-05 DOI: 10.3390/neurosci6020052

Mariia Yaroshenko, Monika Christoff, Mateusz Ścibiorski, Karolina Surowiec, Joanna Jakubowicz-Gil, Joanna Sumorek-Wiadro

引用次数: 0