NeuroSci最新文献_第4页

Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis. 丙戊酸胚胎暴露对斑马鱼的影响：系统综述和荟萃分析。

IF 1.6

NeuroSci Pub Date : 2024-12-07 DOI: 10.3390/neurosci5040046

Bernardo Flores-Prieto, Jorge Manzo-Denes, María Elena Hernández-Aguilar, Genaro Alfonso Coria-Avila, Deissy Herrera-Covarrubias, Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, César Antonio Pérez-Estudillo, Jorge Suárez-Medellín, María Rebeca Toledo-Cárdenas

{"title":"Effects of Valproic Acid Embryonic Exposure on Zebrafish: A Systematic Review and Meta-Analysis.","authors":"Bernardo Flores-Prieto, Jorge Manzo-Denes, María Elena Hernández-Aguilar, Genaro Alfonso Coria-Avila, Deissy Herrera-Covarrubias, Gonzalo Emiliano Aranda-Abreu, Fausto Rojas-Durán, César Antonio Pérez-Estudillo, Jorge Suárez-Medellín, María Rebeca Toledo-Cárdenas","doi":"10.3390/neurosci5040046","DOIUrl":"10.3390/neurosci5040046","url":null,"abstract":"Exposure to valproic acid (VPA) during embryogenesis has become a valuable tool for modeling neurodevelopmental disorders in animal models such as zebrafish (Danio rerio). This article examines the effects of embryonic exposure to VPA in zebrafish on the basis of 39 articles sourced from PubMed and Google Scholar. We conducted a systematic review and meta-analysis to elucidate the common impacts of VPA exposure and reported that VPA significantly altered development at various levels. Behaviorally, zebrafish exposed to VPA exhibit notable changes in their social interaction patterns. Physiologically, VPA exposure leads to significant alterations, including decreased heart rates, increased mortality rates, and pronounced morphological abnormalities. Pharmacological exposure has been linked to neuroanatomical and neurochemical changes. At the genetic level, VPA exposure is associated with the differential expression of genes involved in neurodevelopment and neuronal function. The synthesized data from these studies underscore the utility of zebrafish as a model organism for investigating the effects of teratogen exposure on neurodevelopment.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"650-665"},"PeriodicalIF":1.6,"publicationDate":"2024-12-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678182/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Neuraxial Anesthesia and Risk of Root Damage: A 3D Ex Vivo Study. 轴向麻醉和根损伤的风险：一项3D离体研究。

IF 1.6

NeuroSci Pub Date : 2024-12-03 DOI: 10.3390/neurosci5040044

Hipólito Labandeyra, Xavier Sala-Blanch, Alberto Prats-Galino, Anna Puigdellívol-Sánchez

{"title":"Neuraxial Anesthesia and Risk of Root Damage: A 3D Ex Vivo Study.","authors":"Hipólito Labandeyra, Xavier Sala-Blanch, Alberto Prats-Galino, Anna Puigdellívol-Sánchez","doi":"10.3390/neurosci5040044","DOIUrl":"10.3390/neurosci5040044","url":null,"abstract":"Cauda equina nerve roots may become damaged during neuraxial anesthesia, and post-puncture headache may appear in the case of cerebrospinal fluid leakage if needle tips are deformed due to bone contact when several attempts are needed. Our aim was to verify the correlation between skin-transverse process distance (st) and skin-dural sac distance (d) for calculation of optimal angles in a free visual guide and as a reference for the maximal depth to be traversed by the needle. Randomly selected ex vivo samples (n = 10) were flexed to reproduce the position of the lumbosacral spine during spinal anesthesia. Spinal needles were inserted perpendicular to the skin either blindly or following the inferred paramedian angle corresponding to ultrasound-measured (d). After computed tomography and three-dimensional reconstruction, both (st) and (d) were measured, and the Pearson correlation index was calculated. A free 3D-PDF tool was used to illustrate the potential affectation of nerve cuffs by needles located lateral to the dural sac. Correlation between (d) and (st) was 0.84-0.93 at L4L5-L3L4 intervertebral levels, and most needle tips were located within the spinal canal, but some traversed the zone where nerve cuffs emerge. In conclusion, ultrasound may determine if a perpendicular needle insertion is viable at midline. If not, the optimal paramedian angle and maximal depth may be determined by measuring (st).","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"623-634"},"PeriodicalIF":1.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677341/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900982","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β-Myrcene, in Mice. 常见大麻萜类、芳樟醇和β-月桂烯抗焦虑性的性别差异。

IF 1.6

NeuroSci Pub Date : 2024-12-03 DOI: 10.3390/neurosci5040045

Jasmin K Wagner, Ella Gambell, Tucker Gibbons, Thomas J Martin, Joshua S Kaplan

{"title":"Sex Differences in the Anxiolytic Properties of Common Cannabis Terpenes, Linalool and β-Myrcene, in Mice.","authors":"Jasmin K Wagner, Ella Gambell, Tucker Gibbons, Thomas J Martin, Joshua S Kaplan","doi":"10.3390/neurosci5040045","DOIUrl":"10.3390/neurosci5040045","url":null,"abstract":"Volatile organic compounds, colloquially referred to as \"terpenes\", have been proposed to impact the therapeutic qualities that are traditionally ascribed to cannabis. However, the contribution of these terpenes in anxiety, at relevant levels and exposure methods common with cannabis use, is lacking empirical assessment. We tested the anxiolytic properties of two prominent cannabis terpenes, linalool and β-myrcene, in male and female mice using short duration vapor pulls to model human inhalation when combusting flower or vaping cannabis oil. We observed sex differences in the locomotor effects in the open field and anxiolytic properties in the elevated plus maze of these terpenes that depended on their exposure characteristics. Both linalool and β-myrcene had anxiolytic effects in female mice when delivered in discrete vapor pulls over the course of 30 min. In male mice, only a single vapor hit containing linalool or β-myrcene had anxiolytic effects. The combination of sub-effective levels of linalool and the phytocannabinoid, cannabidiol (CBD), had synergistic anxiolytic effects in females, but these entourage effects between CBD and terpenes were absent with β-myrcene for females and for either terpene in males. Together, our findings reveal sex differences in the anxiolytic properties of common cannabis terpenes and highlight the potential benefits of unique combinations of CBD and terpenes in expanding the therapeutic dose window.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"635-649"},"PeriodicalIF":1.6,"publicationDate":"2024-12-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900996","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immediate Effects of Distinct Intensities of Transcutaneous Spinal Direct Current Stimulation on Chronic Pain: A Randomized Controlled Trial. 不同强度的经皮脊髓直流电刺激对慢性疼痛的直接影响：一项随机对照试验。

IF 1.6

NeuroSci Pub Date : 2024-12-02 DOI: 10.3390/neurosci5040043

Kariny Realino do Rosário Ferreira, Maria de Cássia Souza Macedo, Ana Luiza Guimarães Alves, Arthur Ferreira Esquírio, Bianca Rossi Botim, Gabrielly Souza Jacob, Mayra Evelise Cunha Dos Santos, Gabriela Lopes Gama, Michelle Cristina Sales Almeida Barbosa, Alexandre Wesley Carvalho Barbosa

{"title":"Immediate Effects of Distinct Intensities of Transcutaneous Spinal Direct Current Stimulation on Chronic Pain: A Randomized Controlled Trial.","authors":"Kariny Realino do Rosário Ferreira, Maria de Cássia Souza Macedo, Ana Luiza Guimarães Alves, Arthur Ferreira Esquírio, Bianca Rossi Botim, Gabrielly Souza Jacob, Mayra Evelise Cunha Dos Santos, Gabriela Lopes Gama, Michelle Cristina Sales Almeida Barbosa, Alexandre Wesley Carvalho Barbosa","doi":"10.3390/neurosci5040043","DOIUrl":"10.3390/neurosci5040043","url":null,"abstract":"This study aimed to assess the immediate effects of transcutaneous spinal direct current stimulation (tsDCS) on pain outcomes, measured using the visual analog scale (VAS) and pressure pain thresholds in a cohort of 55 participants experiencing chronic pain using a controlled, randomized trial with 55 participants allocated into 2 groups: 2 mA and 0.5 mA of tsDCS for 20 min. Anodal stimulation was applied on the 12th thoracic vertebra, with the cathode positioned on the 7th cervical vertebra. Pain outcomes were assessed before and post intervention using the VAS and pressure algometry. Between- and within-group differences, along with chi-square tests, were used to determine the differences and responsiveness. Significance was established at p < 0.05. Findings showed significant temporal effects for both VAS (p < 0.001) and pressure algometry (p = 0.04). However, no between-group differences were noted for the time × group factor for VAS (p = 0.46) and pressure algometry (p = 0.78). No significant between-group differences were observed for the responsiveness analysis. The results indicate that a single 20-min session of 2 and 0.5 mA tsDCS improves pain scores for both intensities equally. However, there were no statistically significant between-group differences in pain perception or pressure pain threshold.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"614-622"},"PeriodicalIF":1.6,"publicationDate":"2024-12-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677310/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900979","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harmonization for Parkinson's Disease Multi-Dataset T1 MRI Morphometry Classification. 帕金森病多数据集T1 MRI形态学分类的协调。

IF 1.6

NeuroSci Pub Date : 2024-11-29 DOI: 10.3390/neurosci5040042

Mohammed Saqib, Silvina G Horovitz

{"title":"Harmonization for Parkinson's Disease Multi-Dataset T1 MRI Morphometry Classification.","authors":"Mohammed Saqib, Silvina G Horovitz","doi":"10.3390/neurosci5040042","DOIUrl":"10.3390/neurosci5040042","url":null,"abstract":"Classification of disease and healthy volunteer cohorts provides a useful clinical alternative to traditional group statistics due to individualized, personalized predictions. Classifiers for neurodegenerative disease can be trained on structural MRI morphometry, but require large multi-scanner datasets, introducing confounding batch effects. We test ComBat, a common harmonization model, in an example application to classify subjects with Parkinson's disease from healthy volunteers and identify common pitfalls, including data leakage. We used a multi-dataset cohort of 372 subjects (216 with Parkinson's disease, 156 healthy volunteers) from 11 identified scanners. We extracted both FreeSurfer and the determinant of Jacobian morphometry to compare single-scanner and multi-scanner classification pipelines. We confirm the presence of batch effects by running single scanner classifiers which could achieve wildly divergent AUCs on scanner-specific datasets (mean:0.651 ± 0.144). Multi-scanner classifiers that considered neurobiological batch effects between sites could easily achieve a test AUC of 0.902, though pipelines that prevented data leakage could only achieve a test AUC of 0.550. We conclude that batch effects remain a major issue for classification problems, such that even impressive single-scanner classifiers are unlikely to generalize to multiple scanners, and that solving for batch effects in a classifier problem must avoid circularity and reporting overly optimistic results.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"600-613"},"PeriodicalIF":1.6,"publicationDate":"2024-11-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678312/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900976","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring Music-Based Interventions for Executive Functioning and Emotional Well-Being in Stroke Rehabilitation: A Scoping Review. 探索基于音乐的脑卒中康复执行功能和情绪健康干预：范围综述。

IF 1.6

NeuroSci Pub Date : 2024-11-27 DOI: 10.3390/neurosci5040041

Camila F Pfeiffer, Wendy L Magee, Rebecca Fülöp, Travis C Nace, Candela Castro, Agustina Iturri, Jimena Franceschi, Gabriela Echauri, Liliana Gassull, María Julieta Russo

{"title":"Exploring Music-Based Interventions for Executive Functioning and Emotional Well-Being in Stroke Rehabilitation: A Scoping Review.","authors":"Camila F Pfeiffer, Wendy L Magee, Rebecca Fülöp, Travis C Nace, Candela Castro, Agustina Iturri, Jimena Franceschi, Gabriela Echauri, Liliana Gassull, María Julieta Russo","doi":"10.3390/neurosci5040041","DOIUrl":"10.3390/neurosci5040041","url":null,"abstract":"Purpose: Stroke is one of the leading causes of disability with life-long implications requiring assessment and treatment of several functional domains. This review identifies the results from research into music-based interventions (MBIs), including music therapy (MT), for executive functions (EFs) and emotional well-being (EWB) in adults with stroke and highlights opportunities for clinical practice and future research.Methods: APA PsycInfo (EBSCOhost), and CINAHL (EBSCOhost) were searched, in addition to grey literature.Results: A total of 49 studies were included and encompassed experimental, analytic, and descriptive observational studies, and case reports, involving a total of 1663 participants. In total, 32 studies included MT interventions, and 17 were MBIs. EFs were an outcome in 20.41%, and EWB in 61.22% of studies, for which active interventions were the most utilized. Overall, 73.47% of the studies reported positive results.Conclusions: This scoping review indicates that music interventions can be beneficial for the improvement of different aspects of EFs and EWB at different stages of stroke recovery. Further research may benefit clinical practice by including standardized protocols, outcome and self-reported measures, and brain imaging data to determine the effects of interventions and support evidence-based decisions for treatment policies for stroke survivors.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"565-599"},"PeriodicalIF":1.6,"publicationDate":"2024-11-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677499/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900965","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity. 衰老对外显记忆检索的影响：情感如何影响神经功能连接性

IF 1.6

NeuroSci Pub Date : 2024-11-11 DOI: 10.3390/neurosci5040040

Marianna Constantinou, Anna Pecchinenda, Hana Burianová, Ala Yankouskaya

{"title":"The Impact of Ageing on Episodic Memory Retrieval: How Valence Influences Neural Functional Connectivity.","authors":"Marianna Constantinou, Anna Pecchinenda, Hana Burianová, Ala Yankouskaya","doi":"10.3390/neurosci5040040","DOIUrl":"10.3390/neurosci5040040","url":null,"abstract":"Age-related decline in episodic memory is often linked to structural and functional changes in the brain. Here, we investigated how these alterations might affect functional connectivity during memory retrieval following exposure to emotional stimuli. Using functional magnetic resonance imaging (fMRI), participants viewed images with varying emotional valences (positive, negative, and neutral) followed by unrelated non-arousing videos and were then asked to retrieve an episodic detail from the previously shown video. We conducted Multivariate Pattern Analysis (MVPA) to identify regions with divergent responses between age groups, which then served as seeds in Seed-Based Connectivity (SBC) analyses. The results revealed an age-related decline in behavioural performance following exposure to negative stimuli but preserved performance following positive stimuli. Young adults exhibited increased functional connectivity following negative valence. Conversely, old adults displayed increased connectivity more scarcely, and only following positive valence. These findings point to an adaptive response of the impact of emotions on task performance that depends on neural adaptations related to ageing. This suggests that age-related changes in functional connectivity might underlie how emotions influence memory, highlighting the need to tailor memory support strategies in older adulthood.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"542-564"},"PeriodicalIF":1.6,"publicationDate":"2024-11-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587483/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142712005","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Concept-Value Network as a Brain Model. 作为大脑模型的概念-价值网络

IF 1.6

NeuroSci Pub Date : 2024-11-07 DOI: 10.3390/neurosci5040039

Kieran Greer

引用次数: 0

Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review. 重复经颅磁刺激治疗本质性震颤的潜力有限：系统回顾

IF 1.6

NeuroSci Pub Date : 2024-11-05 DOI: 10.3390/neurosci5040038

Andrew A E D Bishay, Anton Guo, Rhea Desai, Samuel Mushinski, Andy Au, Andrew J Swenson, Marco Iacoboni, Alexander Bystritsky, Norman M Spivak

{"title":"Limited Potential of Repetitive Transcranial Magnetic Stimulation for Treatment of Essential Tremor: A Systematic Review.","authors":"Andrew A E D Bishay, Anton Guo, Rhea Desai, Samuel Mushinski, Andy Au, Andrew J Swenson, Marco Iacoboni, Alexander Bystritsky, Norman M Spivak","doi":"10.3390/neurosci5040038","DOIUrl":"10.3390/neurosci5040038","url":null,"abstract":"Essential tremor (ET) is a prevalent movement disorder characterized by action tremors, predominantly affecting the upper limbs. While various pharmacological and non-pharmacological interventions have shown efficacy in managing ET, the therapeutic role of repetitive transcranial magnetic stimulation (rTMS) remains uncertain. This systematic review synthesizes evidence from clinical trials investigating rTMS as a treatment for ET. Despite some open-label trials reporting reductions in tremor severity, double-blinded studies revealed no significant difference between active and sham rTMS, suggesting a strong placebo effect. The findings indicate that while rTMS can reduce tremor scores, its therapeutic efficacy in ET remains unproven. Future research should focus on improving sham designs and conducting larger, rigorously controlled trials to clarify rTMS's role in ET management. Current evidence supports considering alternative treatments, such as deep brain stimulation, over rTMS for ET.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"523-533"},"PeriodicalIF":1.6,"publicationDate":"2024-11-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587431/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711974","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Can Phonemic Verbal Fluency Be Used to Predict Alzheimer's Disease? 音位言语流畅性可用于预测阿尔茨海默病吗？

IF 1.6

NeuroSci Pub Date : 2024-11-04 DOI: 10.3390/neurosci5040036

Sara García-González

{"title":"Can Phonemic Verbal Fluency Be Used to Predict Alzheimer's Disease?","authors":"Sara García-González","doi":"10.3390/neurosci5040036","DOIUrl":"10.3390/neurosci5040036","url":null,"abstract":"Background: Among the cognitive markers, the deterioration of semantic and phonemic verbal fluency seems to be an early indicator of Alzheimer's disease (AD). The aims of this study are (1) to evaluate both types of verbal fluency in the early stages of AD in order to know which of them deteriorates earlier and (2) to investigate if verbal fluency tasks can help to differentiate between patients with Mild Cognitive Impairment (MCI) who will progress to AD two years later (progress) and those who will not (non-progress).Method: A verbal fluency task was administered to 25 patients with MCI and their respective control subjects. All patients underwent a neuropsychological evaluation twice in order for us to follow up on their global cognitive status. The second time, eight of them converted to AD.Results: On the one hand, phonemic verbal fluency deteriorates earlier than semantic verbal fluency in MCI patients; on the other hand, although we found statistically significant differences between patients with MCI and AD in both types of fluency tasks, none were found when comparing the performance of progress and non-progress.Conclusions: These results point to a greater impairment in phonemic verbal fluency in MCI patients and its potential capacity to predict conversion to AD.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"501-508"},"PeriodicalIF":1.6,"publicationDate":"2024-11-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11587474/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142711967","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0