NeuroSciPub Date : 2025-01-15DOI: 10.3390/neurosci6010006
Henry Weresh, Kallin Hermann, Ali Al-Salahat, Amna Noor, Taylor Billion, Yu-Ting Chen, Abubakar Tauseef, Ali Bin Abdul Jabbar
{"title":"Trends and Disparities in Parkinson's Disease Mortality in the United States with Predictions Using Machine Learning.","authors":"Henry Weresh, Kallin Hermann, Ali Al-Salahat, Amna Noor, Taylor Billion, Yu-Ting Chen, Abubakar Tauseef, Ali Bin Abdul Jabbar","doi":"10.3390/neurosci6010006","DOIUrl":"10.3390/neurosci6010006","url":null,"abstract":"<p><strong>Background: </strong>Parkinson's disease (PD) is a progressive neurodegenerative condition characterized by the degradation of dopaminergic pathways in the brain. As the population in the United States continues to age, it is essential to understand the trends in mortality related to PD. This analysis of PD's mortality characterizes temporal shifts, examines demographic and regional differences, and provides machine-learning predictions.</p><p><strong>Methods: </strong>PD-related deaths in the United States were gathered from CDC WONDER. Age-adjusted mortality rates (AAMR) were collected, and trends were analyzed based on gender, race, region, age, and place of death. Annual percent change and average annual percent change were calculated using Joinpoint Regression program. Forecasts were obtained using the optimal Autoregressive Integrated Moving Average (ARIMA) model.</p><p><strong>Results: </strong>Overall mortality rate due to Parkinson's increased from 1999 to 2022. Male gender, White race, Southern region, and older ages were associated with higher mortality compared to other groups. Deaths at home decreased and hospice deaths increased during the study period.</p><p><strong>Conclusions: </strong>This study highlights the increasing rate of PD AAMR and how it may become even more prevalent with time, emphasizing the value of increasing knowledge surrounding the disease and its trends to better prepare health systems and individual families for the burden of PD.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755521/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025378","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroSciPub Date : 2025-01-13DOI: 10.3390/neurosci6010005
Sara Veggi, Fausto Roveta
{"title":"Neurodegenerative Disorders in Criminal Offending and Cognitive Decline Among Aging Inmates.","authors":"Sara Veggi, Fausto Roveta","doi":"10.3390/neurosci6010005","DOIUrl":"10.3390/neurosci6010005","url":null,"abstract":"<p><p>Dementia, including Alzheimer's disease (AD) and frontotemporal dementia (FTD), presents critical challenges for correctional systems, particularly as global populations age. AD, affecting 60-80% of dementia cases, primarily impairs memory and cognition in individuals over 65. In contrast, FTD, rarer than AD but not uncommon in those under 65, affects the frontal and temporal brain regions, leading to deficits in social behavior, language, and impulse control, often resulting in antisocial actions and legal consequences. Behavioral variant FTD is especially associated with socially inappropriate and impulsive behaviors due to frontal lobe degeneration. The prevalence of cognitive impairment in incarcerated populations is high, exacerbated by prison environments that compound distress and limited access to specialized healthcare. Studies indicate that up to 11% of United States state prison inmates over the age of 55 exhibit cognitive impairments, often undiagnosed, resulting in punitive rather than rehabilitative responses to symptoms like disinhibition and aggression. Ethical concerns around criminal responsibility for individuals with dementia are increasingly prominent, particularly regarding their ability to comprehend and engage in legal proceedings. The growing elderly prison population necessitates reform in correctional healthcare to include early cognitive assessment, targeted intervention, and tailored post-release programs. Addressing these needs is essential to ensure appropriate treatments, alleviate healthcare demands, and support reintegration for cognitively impaired inmates.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755462/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026242","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Nutritional Intervention in Patients with Multiple Sclerosis, Correlation with Quality of Life and Disability-A Prospective and Quasi-Experimental Study.","authors":"Konstantina Metaxouli, Chrysoula Tsiou, Eleni Dokoutsidou, Nikoletta Margari","doi":"10.3390/neurosci6010004","DOIUrl":"10.3390/neurosci6010004","url":null,"abstract":"<p><p>Multiple sclerosis (MS) is a multifactorial disease, with diet and lifestyle playing an important role in its development. The Mediterranean diet has been considered to be particularly beneficial for MS patients. The aim of the present study was to investigate the relationship between diet and MS, as well as evaluate the effect of the Mediterranean diet on patients' quality of life and level of disability. The six-month study included 130 patients, divided into a control and intervention group. Data collection instruments were used for the collection of demographic and medical characteristics of the participants, as well as data regarding disability [(Multiple Sclerosis Rating Scale-Revised (MSRS-R) and Multiple Sclerosis Impact Scale-29 (MSIS-29)], nutrition [Mediterranean Diet Score (MedDiet Score) and Mini Nutritional Assessment (MNA)], and quality of life [Multiple Sclerosis Quality of Life-54 (MSQOL-54)]. The results indicated that the demographic characteristics of the groups were similar. The MNA score was positively associated with physical (<i>p</i> = 0.002) and mental health (<i>p</i> = 0.001). The intervention group reported an improvement in adherence to the Mediterranean diet, an increase in the MedDiet Score, and a decrease in the MSRS-R Score, indicating an improvement in functional capacity, nutritional status, and quality of life. In conclusion, the Mediterranean diet can improve the functionality and quality of life of patients with MS. Nutrition education is therefore deemed critical, and further research is required to reinforce these findings.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-06","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755478/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143024796","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroSciPub Date : 2025-01-04DOI: 10.3390/neurosci6010003
Krzysztof S Malinowski, Magdalena Wszędybył-Winklewska, Paweł J Winklewski
{"title":"Sex Influence on Trigeminal Nerve Stimulation and Breath-Hold Diving Performance: Examination of the Autonomic Regulation of Cardiovascular Responses to Facial Cooling and Apnoea Across Sex and Varied Factors.","authors":"Krzysztof S Malinowski, Magdalena Wszędybył-Winklewska, Paweł J Winklewski","doi":"10.3390/neurosci6010003","DOIUrl":"10.3390/neurosci6010003","url":null,"abstract":"<p><p>This review emphasises the importance of the cardiovascular response to facial cooling (FC) and breath holding in both sexes. The trigemino-cardiac reflex, triggered by FC, reduces heart rate (HR) and constricts blood vessels. When combined with breath holding, this effect intensifies, enhancing the cardiodepressive impact. The cardiovascular reaction to this combination, known as the cold-water face immersion or simulated diving test, varies among individuals and depends on their cardiovascular regulatory profiles, which differ between men and women. Despite extensive research on the cardiovascular response to FC and apnoea, most studies did not categorise participants by sex, leading to a limited understanding of how it influences trigeminal nerve stimulation (TGS) and breath-hold diving (BHD). Despite attempts to address this, the existing findings remain inconsistent due to intra- and inter-individual variability. Key factors influencing the diving response include the influence of the parasympathetic system on HR, vascular sympathetic activity affecting total peripheral resistance (TPR), sensitivity to CO<sub>2</sub>, lung capacity, training, physical performance, duration of apnoea, and the stimulation of metaboreceptors in working muscles. These factors differ between men and women, potentially contributing to variations in the effectiveness of the response to the FC combined with breath holding.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755585/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025015","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroSciPub Date : 2025-01-02DOI: 10.3390/neurosci6010002
Catarina Carvalho Senra, Adriana Conceição Soares Sampaio, Olivia Morgan Lapenta
{"title":"Visual Noise Mask for Human Point-Light Displays: A Coding-Free Approach.","authors":"Catarina Carvalho Senra, Adriana Conceição Soares Sampaio, Olivia Morgan Lapenta","doi":"10.3390/neurosci6010002","DOIUrl":"10.3390/neurosci6010002","url":null,"abstract":"<p><p>Human point-light displays consist of luminous dots representing human articulations, thus depicting actions without pictorial information. These stimuli are widely used in action recognition experiments. Because humans excel in decoding human motion, point-light displays (PLDs) are often masked with additional moving dots (noise masks), thereby challenging stimulus recognition. These noise masks are typically found within proprietary programming software, entail file format restrictions, and demand extensive programming skills. To address these limitations, we present the first user-friendly step-by-step guide to develop visual noise to mask PLDs using free, open-source software that offers compatibility with various file formats, features a graphical interface, and facilitates the manipulation of both 2D and 3D videos. Further, to validate our approach, we tested two generated masks in a pilot experiment with 12 subjects and demonstrated that they effectively jeopardised human agent recognition and, therefore, action visibility. In sum, the main advantages of the presented methodology are its cost-effectiveness and ease of use, making it appealing to novices in programming. This advancement holds the potential to stimulate young researchers' use of PLDs, fostering further exploration and understanding of human motion perception.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-01-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755652/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143025526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroSciPub Date : 2024-12-30DOI: 10.3390/neurosci6010001
George Imataka, Hideaki Shiraishi, Shigemi Yoshihara
{"title":"Pediatric Acute Disseminated Encephalomyelitis Triggered by Concurrent Administration of Seasonal and H1N1 Influenza Vaccines: A Case Report and Review.","authors":"George Imataka, Hideaki Shiraishi, Shigemi Yoshihara","doi":"10.3390/neurosci6010001","DOIUrl":"10.3390/neurosci6010001","url":null,"abstract":"<p><strong>Background: </strong>Acute disseminated encephalomyelitis (ADEM) is a rare, immune-mediated inflammatory disorder of the central nervous system (CNS), typically characterized by the acute onset of multifocal demyelination. The pathogenesis of ADEM remains unclear, but it is believed to be triggered by an autoimmune response, often following viral infections or vaccinations.</p><p><strong>Case report: </strong>This case report describes a 3-year-old child who developed ADEM after receiving two concurrent influenza vaccines: one for seasonal influenza and one for the 2009 H1N1 pandemic. The patient presented with motor regression, mild pleocytosis in cerebrospinal fluid (CSF), and typical MRI findings of ADEM. Steroid pulse therapy resulted in rapid improvement, and the patient recovered fully without sequelae.</p><p><strong>Results: </strong>Although the influenza vaccine has been linked to ADEM in some studies, it remains uncertain whether the simultaneous administration of both vaccines contributed to the onset of ADEM. While influenza vaccines are considered safe and effective by health organizations such as the CDC, data suggest that the incidence of ADEM and other neurological complications is significantly higher after natural influenza infections compared to vaccination. This highlights the importance of vaccination in preventing severe outcomes.</p><p><strong>Conclusions: </strong>This case underscores the importance of monitoring and reporting adverse events following vaccination to refine our understanding of rare complications like ADEM. While simultaneous vaccine administration warrants further research, the benefits of vaccination in preventing severe complications from natural infections far outweigh the risks. Continued vigilance and improved surveillance systems are essential for maintaining public confidence in vaccination programs.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 1","pages":""},"PeriodicalIF":1.6,"publicationDate":"2024-12-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11755601/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143026224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroSciPub Date : 2024-12-19DOI: 10.3390/neurosci5040050
Konstantinos Kostakos, Alexandra Pliakopanou, Vasileios Meimaridis, Ourania-Natalia Oriana Galanou, Aikaterini Argyro Anagnostou, Dimitra Sertidou, Panagiotis Katis, Periklis Anastasiou, Konstantinos Katsoulidis, Yannis Lykogiorgos, Dimitrios Mytilinaios, Andreas P Katsenos, Yannis V Simos, Stefanos Bellos, Spyridon Konitsiotis, Dimitrios Peschos, Konstantinos I Tsamis
{"title":"Development of Spatial Memory: A Behavioral Study.","authors":"Konstantinos Kostakos, Alexandra Pliakopanou, Vasileios Meimaridis, Ourania-Natalia Oriana Galanou, Aikaterini Argyro Anagnostou, Dimitra Sertidou, Panagiotis Katis, Periklis Anastasiou, Konstantinos Katsoulidis, Yannis Lykogiorgos, Dimitrios Mytilinaios, Andreas P Katsenos, Yannis V Simos, Stefanos Bellos, Spyridon Konitsiotis, Dimitrios Peschos, Konstantinos I Tsamis","doi":"10.3390/neurosci5040050","DOIUrl":"10.3390/neurosci5040050","url":null,"abstract":"<p><p>Although spatial memory has been widely studied in rodents, developmental studies involving humans are limited in number and sample size. We designed and studied the validity of two simple experimental setups for the evaluation of spatial memory and navigation development. The dataset of this study was composed of 496 schoolchildren, from 4 to 15 years old. Participants were tested blindfolded on their ability to navigate in a square area between three stool stations while performing an item-collecting task, having observed the experimental space and procedure (Test 1) or having, in addition, executed the task open-eyed (Test 2). The performance times were analyzed to identify age-specific differences. Parametric methods, including the one-way ANOVA and independent samples <i>t</i>-test, were employed. Statistically significant differences were observed in the mean performance time among age groups, as well as within the same age groups when comparing Test 1 and Test 2. Our results revealed a performance improvement with aging for both functions and showed that spatial memory and spatial navigation develop throughout childhood and puberty and interact during development. When children integrate visual stimuli with other sensory inputs, they can form stronger spatial memories, thereby enhancing their navigation skills. The proposed experimental setup is considered feasible and can be used for behavioral studies of navigation-related memory in children and beyond with appropriate adaptations, allowing for large-scale assessment.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"713-728"},"PeriodicalIF":1.6,"publicationDate":"2024-12-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677432/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900957","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroSciPub Date : 2024-12-17DOI: 10.3390/neurosci5040049
Malgorzata Reysner, Tomasz Reysner, Piotr Janusz, Grzegorz Kowalski, Alicja Geisler-Wojciechowska, Monika Grochowicka, Monika Pyszczorska, Aleksander Mularski, Katarzyna Wieczorowska-Tobis
{"title":"The Influence of Anesthesia on Neuromonitoring During Scoliosis Surgery: A Systematic Review.","authors":"Malgorzata Reysner, Tomasz Reysner, Piotr Janusz, Grzegorz Kowalski, Alicja Geisler-Wojciechowska, Monika Grochowicka, Monika Pyszczorska, Aleksander Mularski, Katarzyna Wieczorowska-Tobis","doi":"10.3390/neurosci5040049","DOIUrl":"10.3390/neurosci5040049","url":null,"abstract":"<p><strong>Background: </strong>Intraoperative neuromonitoring (IONM) is crucial for the safety of scoliosis surgery, providing real-time feedback on the spinal cord and nerve function, primarily through motor-evoked potentials (MEPs). The choice of anesthesia plays a crucial role in influencing the quality and reliability of these neuromonitoring signals. This systematic review evaluates how different anesthetic techniques-total intravenous anesthesia (TIVA), volatile anesthetics, and regional anesthesia approaches such as Erector Spinae Plane Block (ESPB), spinal, and epidural anesthesia-affect IONM during scoliosis surgery.</p><p><strong>Methods: </strong>A systematic review was conducted following PRISMA guidelines. PubMed, MEDLINE, EMBASE, and Cochrane databases were searched for studies published between 2017 and 2024 that examined the impact of anesthetic techniques on neuromonitoring during scoliosis surgery. The focus was on studies reporting MEP outcomes, anesthetic protocols, and postoperative neurological and analgesic effects.</p><p><strong>Results: </strong>The search initially identified 998 articles. After applying inclusion criteria based on relevance, recency, methodological quality, and citation frequency, 45 studies were selected for detailed review.</p><p><strong>Conclusion: </strong>The erector Spinae Plane Block (ESPB) provides distinct benefits over spinal and epidural anesthesia in scoliosis surgery, particularly in maintaining neuromonitoring accuracy, reducing hemodynamic instability, and minimizing complications. The ESPB's ability to deliver effective segmental analgesia without compromising motor function makes it a safer and more efficient option for postoperative pain management, enhancing patient outcomes.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"693-712"},"PeriodicalIF":1.6,"publicationDate":"2024-12-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11677770/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901003","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
NeuroSciPub Date : 2024-12-10DOI: 10.3390/neurosci5040047
Simon Podnar
{"title":"Concentric Needle Electromyography Findings in Patients with Ulnar Neuropathy at the Elbow.","authors":"Simon Podnar","doi":"10.3390/neurosci5040047","DOIUrl":"10.3390/neurosci5040047","url":null,"abstract":"<p><p>In ulnar neuropathy at the elbow (UNE), the degree of neuropathic changes, the sensitivity of needle electromyography (EMG) in individual ulnar muscles, and the utility of individual EMG parameters are controversial. I compared qualitative needle EMG findings in two ulnar-innervated hands muscles and two ulnar-innervated forearm muscles in a group of previously reported UNE patients. Altogether, 170 UNE patients (175 arms) were studied. I found spontaneous denervation activity (SDA) most frequently in the first dorsal interosseus (FDI) (62%) and neuropathic changes in the abductor digiti minimi (ADM) muscle (88%). In the forearm muscles, SDA was more common (29% vs. 20%; <i>p</i> = 0.02), and neuropathic changes were similar in the flexor carpi ulnaris (FCU) and the flexor digitorum profundus (FDP) muscles. SDA and neuropathic changes were more common in the ulnar hand (88% and 77%) than in the ulnar forearm muscles (71% and 68%). Needle EMG is sensitive to diagnose UNE. For the detection of SDA FDI and neuropathic changes, ADM is the best muscle. Ulnar forearm muscles are less useful than ulnar hand muscles for UNE diagnosis.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"666-673"},"PeriodicalIF":1.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11676381/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900889","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Temporal and Fronto-Central Auditory Evoked Responses in Children with Neurodevelopmental Disorders: A Scoping Review.","authors":"Zohreh Ahmadi, Fauve Duquette-Laplante, Shanna Kousaie, Benjamin Rich Zendel, Amineh Koravand","doi":"10.3390/neurosci5040048","DOIUrl":"10.3390/neurosci5040048","url":null,"abstract":"<p><p>At the cortical level, the central auditory neural system (CANS) includes primary and secondary areas. So far, much research has focused on recording fronto-central auditory evoked potentials/responses (P1-N1-P2), originating mainly from the primary auditory areas, to explore the neural processing in the auditory cortex. However, less is known about the secondary auditory areas. This review aimed to investigate and compare fronto-central and T-complex responses in populations at risk of auditory dysfunction, such as individuals with neurodevelopmental disorders. After searching the electronic databases (PubMed, Web of Science, Scopus, and Ovid), ten studies encompassing six neurodevelopmental disorders were included for the analysis. All experimental populations had atypical T-complexes, manifesting as an absence of evoked responses, shorter latency, and/or smaller amplitude. Moreover, in two experimental groups, dyslexia and attention deficit/hyperactivity disorder (ADHD), abnormal T-complex responses were observed despite the presence of normal fronto-central responses. The presence of abnormal T-complex responses in combination with normal fronto-central responses in the same population, using the same experiment, may highlight the advantage of the T-complex for indexing deficits in distinct auditory processes or regions, which the fronto-central response may not track.</p>","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 4","pages":"674-692"},"PeriodicalIF":1.6,"publicationDate":"2024-12-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11678494/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142901000","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}