利用床边弥漫性光学断层扫描提取新生儿脑损伤的新型成像生物标志物:一项前瞻性可行性研究方案。

IF 2 Q3 CLINICAL NEUROLOGY
NeuroSci Pub Date : 2025-06-30 DOI:10.3390/neurosci6030060
Sabrina Mastroianni, Anagha Vinod, Naiqi G Xiao, Heather Johnson, Lehana Thabane, Qiyin Fang, Ipsita Goswami
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引用次数: 0

摘要

新生儿缺氧缺血性脑病(HIE)的神经发育预后主要依赖于临床常规脑磁共振成像的结构评估。弥漫性光学断层扫描(DOT)可以在床边提供关于脑功能的补充信息,进一步提高预后的准确性。基于dot的神经影像学标记的预测准确性和普遍性尚不清楚。本研究的目的是在一项更大的研究中测试前瞻性招募和保留新生儿12个月的可行性,该研究调查了基于dot的HIE生物标志物的预后效用。该研究将招募25名患有HIE的新生儿超过一年,并在他们6个月和12个月大时随访至新生儿重症监护病房出院。研究对象将在生命的7天内进行静息状态DOT测量,持续30-45分钟,无镇静。一个定制的新生儿帽,每侧有10个源和8个检测器,将用于量化皮质功能连接,并使用基于matlab的软件(版本24.2)生成大脑网络。年龄和阶段问卷-第三版将用于随访时的标准化发展评估。这项可行性研究将有助于完善设计和样本量的计算,以进行更大规模的研究,以确定基于dot的神经成像在围产期脑损伤中的临床应用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。

Derivation of Novel Imaging Biomarkers of Neonatal Brain Injury Using Bedside Diffuse Optical Tomography: Protocol for a Prospective Feasibility Study.

Derivation of Novel Imaging Biomarkers of Neonatal Brain Injury Using Bedside Diffuse Optical Tomography: Protocol for a Prospective Feasibility Study.

Derivation of Novel Imaging Biomarkers of Neonatal Brain Injury Using Bedside Diffuse Optical Tomography: Protocol for a Prospective Feasibility Study.

Derivation of Novel Imaging Biomarkers of Neonatal Brain Injury Using Bedside Diffuse Optical Tomography: Protocol for a Prospective Feasibility Study.

Prognostication of neurodevelopmental outcomes for neonates with hypoxic-ischemic encephalopathy (HIE) is primarily reliant on structural assessment using conventional brain magnetic resonance imaging in the clinical setting. Diffuse optical tomography (DOT) can provide complementary information on brain function at the bedside, further enhancing prognostic accuracy. The predictive accuracy and generalizability of DOT-based neuroimaging markers are unknown. This study aims to test the feasibility of prospectively recruiting and retaining neonates for 12 months in a larger study that investigates the prognostic utility of DOT-based biomarkers of HIE. The study will recruit 25 neonates with HIE over one year and follow them beyond NICU discharge at 6 and 12 months of age. Study subjects will undergo resting-state DOT measurement within 7 days of life for a 30-45-min period without sedation. A customized neonatal cap with 10 sources and eight detectors per side will be used to quantify cortical functional connectivity and to generate brain networks using MATLAB-based software (version 24.2). The Ages and Stages Questionnaires-3rd edition will be used for standardized developmental assessments at follow-up. This feasibility study will help refine the design and sample-size calculation for an adequately powered larger study that determines the clinical utility of DOT-based neuroimaging in perinatal brain injury.

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