NeuroSci最新文献_第5页

Emerging Therapies for Neurological Disorders: A Clinical Review of MANAGED (Music, Art, Nature-Based, Animal-Assisted, Game, Essential Oil, Dance) Care. 神经系统疾病的新疗法：管理（音乐、艺术、自然基础、动物辅助、游戏、精油、舞蹈）护理的临床回顾。

IF 1.6

NeuroSci Pub Date : 2025-06-04 DOI: 10.3390/neurosci6020051

Alyssa Wan-Chei Lee, Rahim Hirani, Jonathan Ogulnick, Raj K Tiwari, Mill Etienne

{"title":"Emerging Therapies for Neurological Disorders: A Clinical Review of MANAGED (Music, Art, Nature-Based, Animal-Assisted, Game, Essential Oil, Dance) Care.","authors":"Alyssa Wan-Chei Lee, Rahim Hirani, Jonathan Ogulnick, Raj K Tiwari, Mill Etienne","doi":"10.3390/neurosci6020051","DOIUrl":"10.3390/neurosci6020051","url":null,"abstract":"In the face of the limitations in pharmacological and surgical interventions for neurological conditions such as Parkinson's and Alzheimer's disease, patients are increasingly turning to non-pharmacological and alternative therapies to manage their symptoms and improve their quality of life. This shift underscores the urgent need for accessible, effective, and affordable treatments. This literature review examines a range of alternative and personalized therapies, including game therapy, animal-assisted therapy, dance therapy, art therapy, music therapy, aroma therapy, and shinrin-yoku therapy. These modalities have demonstrated promising results in mitigating symptoms and enhancing well-being among individuals grappling with neurological disorders. Moreover, these therapies offer a holistic approach that complements traditional medical interventions, underscoring the importance of integrating diverse treatment modalities. Despite their historical roots in non-clinical settings, their potential in modern clinical practice remains untapped. The findings suggest the necessity for further research, particularly large cohort studies, to validate the efficacy of these personalized therapies and advocate for their widespread adoption. In an era marked by escalating healthcare costs, the exploration of alternative therapies presents a compelling avenue for enhancing patient care while simultaneously addressing economic challenges within the healthcare system.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196375/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487382","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Isoforms of Phosphorylated Tau as Potential Biomarkers for Alzheimer's Disease: The Contribution of Mass Spectrometry-Based Proteomics. 磷酸化Tau亚型作为阿尔茨海默病的潜在生物标志物：基于质谱的蛋白质组学的贡献

IF 1.6

NeuroSci Pub Date : 2025-06-03 DOI: 10.3390/neurosci6020050

Marco Agostini, Pietro Traldi, Mahmoud Hamdan

{"title":"Isoforms of Phosphorylated Tau as Potential Biomarkers for Alzheimer's Disease: The Contribution of Mass Spectrometry-Based Proteomics.","authors":"Marco Agostini, Pietro Traldi, Mahmoud Hamdan","doi":"10.3390/neurosci6020050","DOIUrl":"10.3390/neurosci6020050","url":null,"abstract":"Alzheimer's disease (AD) is a progressive neurodegenerative disorder, heterogeneous at the molecular level and characterized by diverse and complex pathological features. Such features are known to accumulate silently in the brain over years or even decades before the onset of detectable symptoms. Despite long years of intense research activities, the disease remains orphaned of either disease-modifying therapies or a specific blood test capable of predicting the disease in the pre-symptomatic stages. This disappointing outcome of such efforts can be attributed to a number of factors. One of these factors is the failure of earlier research to capture the heterogeneity of the disease. Such failure has the direct consequence of poor patient stratification, which in turn impacts negatively on the development of specific and effective therapy. The second factor is the absence of detailed and accurate information on proteins and associated post-translational modifications, which may influence the initiation and progress of the disease. Recent studies have demonstrated that the quantification of various isoforms of phosphorylated tau protein in plasma and other biofluids can be considered as potential biomarkers for the early detection of Alzheimer's disease. Mass spectrometry-based proteomics and immunoassay-based multiplex proteomics are the two technologies in current use for probing the human proteome, both in tissues and biofluids. In the present review, we discuss the contribution of MS-based proteomics to efforts aimed at the identification and eventual characterization of the heterogeneity of the disease, and the key role of the same technique in the analysis of protein post-translational modifications associated with the disease is also discussed.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-06-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196459/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487384","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Rare Case of Cervical Solitary Fibrous Tumor in a Pediatric Patient: Case Report and Literature Review. 小儿宫颈孤立性纤维性肿瘤1例：病例报告及文献复习。

IF 1.6

NeuroSci Pub Date : 2025-06-01 DOI: 10.3390/neurosci6020049

Eleonora Becattini, Lorenzo Sgarbanti, Giuseppina Bevacqua, Valentina Grespi, Carlo Conti

引用次数: 0

Psychosocial Correlates of Insomnia Symptoms Among Women and Men Receiving Buprenorphine Treatment for Opioid Use Disorder. 接受丁丙诺啡治疗阿片类药物使用障碍的女性和男性失眠症状的社会心理相关性

IF 1.6

NeuroSci Pub Date : 2025-05-30 DOI: 10.3390/neurosci6020048

Sajanee Chithranjan, Michelle Eglovitch, Madison M Marcus, Dace Svikis, Maha Alattar, Caitlin E Martin

{"title":"Psychosocial Correlates of Insomnia Symptoms Among Women and Men Receiving Buprenorphine Treatment for Opioid Use Disorder.","authors":"Sajanee Chithranjan, Michelle Eglovitch, Madison M Marcus, Dace Svikis, Maha Alattar, Caitlin E Martin","doi":"10.3390/neurosci6020048","DOIUrl":"10.3390/neurosci6020048","url":null,"abstract":"Insomnia is common in individuals with opioid use disorder (OUD). Biopsychosocial factors are important in sleep health, yet this intersection has yet to be fully elucidated in people on buprenorphine for OUD. The objective is to report on patient-reported biopsychosocial factors among people with and without insomnia, specifically among women and men in outpatient OUD treatment. The parent study enrolled adults stabilized on buprenorphine from February 2022-September 2023. Scores of ≥11 on the Insomnia Severity Index (ISI) indicated clinically significant insomnia. Differences were detected by the presence of insomnia, stratified by men and women, using chi-squared and Fisher's exact tests. Of the overall participants (N = 130), most (n = 77; 59.2%) met the criteria for clinically significant insomnia. Women with insomnia were more likely to report social stressors including discrimination for substance use (p = 0.040), food insecurity (p = 0.032), and transportation difficulties accessing healthcare (p = 0.043) than women without insomnia. Men with insomnia were more likely to report financial difficulties accessing healthcare (p = 0.023) than men without insomnia. These findings provide a unique perspective to consider in the development and implementation of sleep interventions for women and men receiving medication treatment for OUD.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12195933/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487387","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Functional Expression of NMDA Receptors in SH-SY5Y Neuroblastoma Cells Following Long-Term RA/BDNF-Induced Differentiation. RA/ bdnf诱导SH-SY5Y神经母细胞瘤细胞长期分化后NMDA受体的功能表达

IF 1.6

NeuroSci Pub Date : 2025-05-26 DOI: 10.3390/neurosci6020047

Ya-Jean Wang, Yun-Hsiang Chen, Eric Hwang, Che-Jui Yeh, You-Xuan Liu, Hwei-Hsien Chen, Sheng-Nan Wu

{"title":"Functional Expression of NMDA Receptors in SH-SY5Y Neuroblastoma Cells Following Long-Term RA/BDNF-Induced Differentiation.","authors":"Ya-Jean Wang, Yun-Hsiang Chen, Eric Hwang, Che-Jui Yeh, You-Xuan Liu, Hwei-Hsien Chen, Sheng-Nan Wu","doi":"10.3390/neurosci6020047","DOIUrl":"10.3390/neurosci6020047","url":null,"abstract":"SH-SY5Y neuroblastoma cells can be effectively differentiated into a neuronal phenotype using retinoic acid (RA) and brain-derived neurotrophic factor (BDNF), making them a valuable in vitro model for studying neuronal differentiation. This study aimed to investigate the electrophysiological properties of SH-SY5Y cells following prolonged differentiation, with a focus on membrane characteristics, evoked action potentials, and the functionality of cellular components such as N-methyl-D-aspartate (NMDA) receptor. Whole-cell patch-clamp recordings were employed to evaluate ionic currents and action potentials in embryonic mouse cortical neurons (mCNs) and in both differentiated and undifferentiated SH-SY5Y neuroblastoma cells. Differentiated SH-SY5Y cells exhibited neurite outgrowth, evoked action potential firing, and functional NMDA receptor-mediated currents. Notably, atorvastatin significantly modulated the duration and firing of action potentials as well as NMDA receptor-mediated currents in differentiated SH-SY5Y cells. These findings highlight that neuronally differentiated SH-SY5Y cells expressing functional NMDA receptor-mediated currents serve as a robust and convenient model for investigating the molecular mechanisms of NMDA receptor function and for screening pharmacological agents targeting these receptors.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12196125/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487383","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Meta-Analysis of Exercise Effects on Cognition in Persons with Parkinson's Disease. 帕金森病患者运动对认知影响的meta分析。

IF 1.6

NeuroSci Pub Date : 2025-05-23 DOI: 10.3390/neurosci6020046

Syed O Ahmad, Dana Stiles, Kaylee Brown, Leah Dillon, Eliza Shroba

{"title":"Meta-Analysis of Exercise Effects on Cognition in Persons with Parkinson's Disease.","authors":"Syed O Ahmad, Dana Stiles, Kaylee Brown, Leah Dillon, Eliza Shroba","doi":"10.3390/neurosci6020046","DOIUrl":"10.3390/neurosci6020046","url":null,"abstract":"Background: Parkinson's disease (PD) is a debilitating neurodegenerative disorder affecting millions of people worldwide. PD results in motor and cognitive dysfunction. While there is no proven cure for PD, it is widely agreed that aerobic exercises and occupations can help slow the progression of the disease and keep some motor-related symptoms from developing. The most effective forms of exercise to slow the progression of motor symptoms in Parkinson's disease have also been studied.Research question: This research article aims to compare the differences in outcomes of exercise on cognitive outcomes in Parkinson's Disease, as evaluated by meta-analysis.Methods: Key terms were Parkinson's Disease and exercise terms. These search terms were then entered to electronic databases-Ovid MEDLINE, SCOPUS, and CINAHL-from March 2018 to May 2023. An ancestral bibliography was also performed.Results: Two reviewers screened the title and abstract records (n = 528) found in the initial search. Our review identified 18 studies which met inclusion criteria for meta-analysis. The meta-analysis found an effect of exercise on cognition of patients with PD (d = -0.03) which was not significant (CI95% of -0.13 < µ < 0.08; p > 0.05, as the CI includes zero). Additionally, the homogeneity analysis was not significant (Q (17) = 2.83; p > 0.05).","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12195965/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144487385","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

A Confirmatory Factor Analysis of the Dementia Attitude Scale (DAS) in a European Case Series of Caregivers of People with Dementia Enrolled in the RECage Study. 一项验证性因素分析痴呆态度量表（DAS）在欧洲病例系列的痴呆症患者的照顾者登记在RECage研究。

IF 1.6

NeuroSci Pub Date : 2025-05-20 DOI: 10.3390/neurosci6020045

Bruno Mario Cesana, Eleni Poptsi, Magda Tsolaki, Sverre Bergh, Andrea Fabbo, Lutz Frölich, Maria Cristina Jori, Carlo Alberto Defanti

{"title":"A Confirmatory Factor Analysis of the Dementia Attitude Scale (DAS) in a European Case Series of Caregivers of People with Dementia Enrolled in the RECage Study.","authors":"Bruno Mario Cesana, Eleni Poptsi, Magda Tsolaki, Sverre Bergh, Andrea Fabbo, Lutz Frölich, Maria Cristina Jori, Carlo Alberto Defanti","doi":"10.3390/neurosci6020045","DOIUrl":"10.3390/neurosci6020045","url":null,"abstract":"Background: The Dementia Attitude Scale (DAS) is a validated instrument used to capture the affective, behavioural, and cognitive components of attitudes toward people living with dementia (PLwD). This study conducts confirmatory and exploratory factor analyses (CFA and EFA) of the DAS assessed by caregivers of PLwD and BPSD enrolled in the RECage multicentre clinical trial.Methods: The baseline questionnaire was completed by 485 caregivers (29.7% male, 70.3% female), from six European countries, reflecting diverse cultural contexts. CFA tested the two-factor structure of the original model, while EFA thoroughly explored the factor structure.Results: The CFA results showed a poor model fit, with significant deviations from ideal values for RMSEA (0.0861), SRMSR (0.0781), and CFI (0.7117), showcasing an inadequate representation of the data. EFA revealed a three-factor structure, explaining the 45.2% variance for social comfort, 28.8% for social discomfort, and 25.9% for dementia knowledge. The social comfort items reflected positive caregiver attitudes toward PLwD, while social discomfort captured feelings of discomfort and uncertainty about caregiving. Dementia knowledge included items related to understanding dementia's symptoms and needs.Conclusions: The three-factor model highlights the importance of emotional comfort, knowledge of dementia, and social discomfort as key dimensions in caregiver attitudes.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101286/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129672","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

TRPC6 in Human Peripheral Nerves-An Investigation Using Immunohistochemistry. 人周围神经TRPC6的免疫组化研究。

IF 1.6

NeuroSci Pub Date : 2025-05-19 DOI: 10.3390/neurosci6020044

Cedric Raming, Carola Meier, Thomas Tschernig

{"title":"TRPC6 in Human Peripheral Nerves-An Investigation Using Immunohistochemistry.","authors":"Cedric Raming, Carola Meier, Thomas Tschernig","doi":"10.3390/neurosci6020044","DOIUrl":"10.3390/neurosci6020044","url":null,"abstract":"Since its discovery, TRPC6 has been associated with a variety of physiological and pathophysiological processes in different tissues. It functions as a non-selective cation channel and belongs to the group of TRP channels. Its importance in the development of pain hypersensitivity is becoming increasingly apparent. This condition has already been associated with increased expression of TRPC6 in dorsal root ganglia. Apart from the fact that most of the evidence has been obtained from samples of animal origin, it remains unclear whether the channel is also expressed in peripheral nerves outside the dorsal root ganglia. The aim of this work was therefore to examine peripheral nerves from human samples for TRPC6. For this purpose, samples of both the sciatic and ulnar nerves were taken from a total of eight body donors and analyzed by immunohistochemistry. Both longitudinal and transverse sections were obtained from the samples and stained. In total, 43 of 48 histological sections showed a positive immunosignal. There were no major differences between the sciatic and ulnar nerves with regard to staining. There was a slight difference in the staining intensity of transverse and longitudinal sections. The longitudinal sections of both nerves were consistently colored slightly more intensely. However, the inter-individual differences between the donors were more pronounced. Interestingly, the samples of a donor who suffered from chronic pain syndrome during his lifetime were particularly strongly stained. This is consistent with the knowledge gained to date, largely from animal experiments, that the channel shows increased expression in pain conditions in dorsal root ganglia. In the future, TRPC6 could therefore be a target in pain therapy.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101367/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129768","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Paraneoplastic LGI1 Encephalitis Associated with Lung Adenocarcinoma: A Case Report. 副肿瘤性LGI1脑炎伴肺腺癌1例报告。

IF 1.6

NeuroSci Pub Date : 2025-05-15 DOI: 10.3390/neurosci6020043

Francesco Rossato, Andrea Porsio, Diego Cecchin, Matteo Atzori, Anna Maria Basile, Marco Zoccarato

引用次数: 0

Proprioceptive Resonance and Multimodal Semiotics: Readiness to Act, Embodied Cognition, and the Dynamics of Meaning. 本体感觉共振与多模态符号学：行动准备、具身认知与意义动态。

IF 1.6

NeuroSci Pub Date : 2025-05-12 DOI: 10.3390/neurosci6020042

Marco Sanna

{"title":"Proprioceptive Resonance and Multimodal Semiotics: Readiness to Act, Embodied Cognition, and the Dynamics of Meaning.","authors":"Marco Sanna","doi":"10.3390/neurosci6020042","DOIUrl":"10.3390/neurosci6020042","url":null,"abstract":"This paper proposes a theoretical model of meaning-making grounded in proprioceptive awareness and embodied imagination, arguing that human cognition is inherently multimodal, anticipatory, and sensorimotor. Drawing on Peircean semiotics, Lotman's model of cultural cognition, and current research in neuroscience, we show that readiness to act-a proprioceptively grounded anticipation of movement-plays a fundamental role in the emergence of meaning, from perception to symbolic abstraction. Contrary to traditional approaches that reduce language to a purely symbolic or visual system, we argue that meaning arises through the integration of sensory, motor, and affective processes, structured by axial proprioceptive coordinates (vertical, horizontal, sagittal). Using Peirce's triadic model of interpretants, we identify proprioception as the modulatory interface between sensory stimuli, emotional response, and logical reasoning. A study on skilled pianists supports this view, showing that mental rehearsal without physical execution improves performance via motor anticipation. We define this process as proprioceptive resonance, a dynamic synchronization of embodied states that enables communication, language acquisition, and social intelligence. This framework allows for a critique of linguistic abstraction and contributes to ongoing debates in semiotics, enactive cognition, and the origin of syntax, challenging the assumption that symbolic thought precedes embodied experience.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"6 2","pages":""},"PeriodicalIF":1.6,"publicationDate":"2025-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12101425/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144129742","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0