NeuroSci最新文献_第6页

Differences in Static and Dynamic Resting-State Functional Connectivity between Migraineurs with and without Photophobia, without Phonophobia or Osmophobia. 患有和不患有畏光症、畏声症或畏水症的偏头痛患者在静态和动态静息状态功能连接性方面的差异。

IF 1.6

NeuroSci Pub Date : 2024-06-23 eCollection Date: 2024-09-01 DOI: 10.3390/neurosci5030017

Noboru Imai, Asami Moriya, Eiji Kitamura

{"title":"Differences in Static and Dynamic Resting-State Functional Connectivity between Migraineurs with and without Photophobia, without Phonophobia or Osmophobia.","authors":"Noboru Imai, Asami Moriya, Eiji Kitamura","doi":"10.3390/neurosci5030017","DOIUrl":"10.3390/neurosci5030017","url":null,"abstract":"Background: We have previously shown that static and dynamic resting-state functional connectivity differ between migraineurs with and without photophobia, phonophobia, or osmophobia. Furthermore, some patients with photophobia also experience phonophobia or osmophobia. To investigate the functional connectivity specific to migraineurs with photophobia, we examined the differences in static and dynamic resting-state functional connectivity between patients with and without photophobia, with no phonophobia or osmophobia.Methods: Fifteen migraineurs with photophobia but without phonophobia or osmophobia, as well as 15 sex- and age-matched migraineurs without photophobia, phonophobia, or osmophobia, underwent 3-T functional magnetic resonance imaging during the interictal phase. Static and dynamic resting-state functional connectivity were compared using region-of-interest analyses of 91 cortical, 15 subcortical, and 26 cerebellar areas.Results: Static resting-state functional connectivity analysis revealed ten significant connectivity pairs in patients with photophobia, while dynamic resting-state functional connectivity analysis revealed six significant connectivity pairs in patients with photophobia. Migraineurs with photophobia had significantly lower connectivity between the cerebellar hemisphere and the temporal region than those without photophobia in both static and dynamic studies.Conclusions: Our results show that lower resting-state functional connectivity between the cerebellar hemisphere and the temporal region is specific to migraineurs with photophobia.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 3","pages":"222-229"},"PeriodicalIF":1.6,"publicationDate":"2024-06-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11469730/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559659","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

In the Brain, It Is Not All about Sugar. 在大脑中，糖并不是全部。

IF 1.6

NeuroSci Pub Date : 2024-06-19 eCollection Date: 2024-06-01 DOI: 10.3390/neurosci5020016

Bernardo C Antunes, Tomás Mateus, Vanessa A Morais

{"title":"In the Brain, It Is Not All about Sugar.","authors":"Bernardo C Antunes, Tomás Mateus, Vanessa A Morais","doi":"10.3390/neurosci5020016","DOIUrl":"10.3390/neurosci5020016","url":null,"abstract":"The maintenance of energetic homeostasis relies on a tight balance between glycolysis and mitochondrial oxidative phosphorylation. The case of the brain is a peculiar one, as although entailing a constant demand for energy, it is believed to rely mostly on glucose, particularly at the level of neurons. Nonetheless, this has been challenged by studies that show that alternatives such as lactate, ketone bodies, and glutamate can be used as fuels to sustain neuronal activity. The importance of fatty acid (FA) metabolism to this extent is still unclear, albeit sustaining a significant energetic output when compared to glucose. While several authors postulate a possible role of FA for the energetic homeostasis of the brain, several others point out the intrinsic features of this pathway that make its contribution difficult to explain in the context of neuronal bioenergetics. Moreover, fueling preference at the synapse level is yet to be uncovered. In this review, we discuss in detail the arguments for and against the brain usage of FA. Furthermore, we postulate that the importance of this fuel may be greater at the synapse, where local mitochondria possess a set of features that enable a more effective usage of this fuel source.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 2","pages":"209-221"},"PeriodicalIF":1.6,"publicationDate":"2024-06-19","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11493208/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559657","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Characterization of Anti-GAD65-Associated Neurological Syndromes: Clinical Features and Antibody Titers. 抗 GAD65 相关神经综合征的特征：临床特征和抗体滴度。

IF 1.6

NeuroSci Pub Date : 2024-06-17 eCollection Date: 2024-06-01 DOI: 10.3390/neurosci5020015

João Moura, Firmina Sambayeta, Ana Paula Sousa, Paula Carneiro, Esmeralda Neves, Raquel Samões, Ana Martins Silva, Ernestina Santos

{"title":"Characterization of Anti-GAD65-Associated Neurological Syndromes: Clinical Features and Antibody Titers.","authors":"João Moura, Firmina Sambayeta, Ana Paula Sousa, Paula Carneiro, Esmeralda Neves, Raquel Samões, Ana Martins Silva, Ernestina Santos","doi":"10.3390/neurosci5020015","DOIUrl":"10.3390/neurosci5020015","url":null,"abstract":"Introduction: Anti-GAD65 antibodies are associated with several neurological phenotypes. Antibody titers are increasingly recognized as useful in diagnosis and prognosis.Objective: To describe a Portuguese cohort of patients with anti-GAD65-associated neurological syndromes.Methods: Retrospective analysis of all patients with positive anti-GAD65 antibodies and associated neurological syndromes followed in a tertiary referral center.Results: Nineteen anti-GAD65 antibody-positive neurological patients were identified, 62.3% female, with a mean age of onset of 56.0 (SD = 13.3) years. Comorbid autoimmune disorders were present in seven patients. Six patients had limbic encephalitis (31.6%), four had epilepsy (21.1%), four had cerebellar ataxia (21.1%), and three had stiff-person syndrome (15.8%). Two patients presented with isolated cognitive dysfunction (executive and mnesic) in the absence of other neurological symptoms. The mean follow-up time was 24.0 (14.0-42.0) months, at the end of which the mean modified Rankin Scale (mRS) value was 2.0 (1.0-4.0). Screening for malignancies was negative in all patients. Serum quantitative analysis was carried out in 18 patients, 10 of whom showed titers above previously defined cut-off points (>10,000 IU/L for ELISA and >20 mmol/L for RIA). Quantitative CSF analysis was performed in nine patients, with four showing above-threshold titers. There was no association between anti-GAD65 levels and clinical phenotype or the final mRS values. High-dose intravenous methylprednisolone and oral prednisolone were the most common acute and chronic treatment regimens, respectively.Conclusion: Anti-GAD65 antibodies are associated with varied neurological syndromes, and antibody titers alone should not be used to exclude a disease.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 2","pages":"201-208"},"PeriodicalIF":1.6,"publicationDate":"2024-06-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467970/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559655","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Frequency Domain Template Subtraction Approach to Attenuate Maternal Electrocardiogram in Fetal Electrocardiogram. 在胎儿心电图中减弱母体心电图的频域模板抽取法。

IF 1.6

NeuroSci Pub Date : 2024-05-25 eCollection Date: 2024-06-01 DOI: 10.3390/neurosci5020013

Susan Wang, Pooneh Roshanitabrizi, Anita Krishnan, R B Govindan

{"title":"Frequency Domain Template Subtraction Approach to Attenuate Maternal Electrocardiogram in Fetal Electrocardiogram.","authors":"Susan Wang, Pooneh Roshanitabrizi, Anita Krishnan, R B Govindan","doi":"10.3390/neurosci5020013","DOIUrl":"10.3390/neurosci5020013","url":null,"abstract":"We develop a frequency domain template subtraction approach to attenuate the maternal ECG in the abdominal ECG measured from pregnant women. The proposed approach was tested on five public fetal ECG datasets simultaneously measured with ECG from the fetal scalp. The method's performance was compared with the template subtraction approach in the time domain using the accuracy and association metrics. The accuracy was calculated by counting the number of fetal complexes in the processed data that coincided with the fetal complexes in the scalp fetal ECG. The association is quantified as the coherence between the processed data and the gold standard. The maximum coherence values calculated for each approach were compared using the paired t-test. Our results showed no difference in the accuracy between the frequency and time domain approach (p = 0.733). However, the association was higher between the frequency domain data and the gold standard compared to the template subtraction data and the gold standard (p = 0.049), indicating that the frequency domain approach yielded a signal that resembled that of the scalp ECG compared to the time domain approach.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 2","pages":"184-191"},"PeriodicalIF":1.6,"publicationDate":"2024-05-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11467962/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559656","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Role of Astrocytes and Alpha-Synuclein in Parkinson's Disease: A Review. 星形胶质细胞和阿尔法-突触核蛋白在帕金森病中的作用：综述。

IF 1.6

NeuroSci Pub Date : 2024-03-08 eCollection Date: 2024-03-01 DOI: 10.3390/neurosci5010005

David Brash-Arias, Luis I García, César Antonio Pérez-Estudillo, Fausto Rojas-Durán, Gonzalo Emiliano Aranda-Abreu, Deissy Herrera-Covarrubias, Donaji Chi-Castañeda

{"title":"The Role of Astrocytes and Alpha-Synuclein in Parkinson's Disease: A Review.","authors":"David Brash-Arias, Luis I García, César Antonio Pérez-Estudillo, Fausto Rojas-Durán, Gonzalo Emiliano Aranda-Abreu, Deissy Herrera-Covarrubias, Donaji Chi-Castañeda","doi":"10.3390/neurosci5010005","DOIUrl":"10.3390/neurosci5010005","url":null,"abstract":"The search for new therapies to reduce symptoms and find a cure for Parkinson's disease has focused attention on two key points: the accumulation of alpha-synuclein aggregates and astrocytes. The former is a hallmark of the disease, while the latter corresponds to a type of glial cell with an important role in both the prevention and development of this neurodegenerative disorder. Traditionally, research has focused on therapies targeting dopaminergic neurons. Currently, as more is known about the genetic and molecular factors and the neuroglial interaction in the disease, great emphasis has been placed on the neuroprotective role of astrocytes in the early stages of the disease and on the astrocytic capture of alpha-synuclein under both physiological and pathological conditions. This review aims to analyze the contribution of alpha-synuclein and astrocytes to the development and progression of Parkinson's disease, as well as to evaluate recent therapeutic proposals specifically focused on synucleopathies and astroglial cells as potential therapies for the disease.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"5 1","pages":"71-86"},"PeriodicalIF":1.6,"publicationDate":"2024-03-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11523690/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142559654","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recurrent Falls as the Only Clinical Sign of Cortical–Subcortical Myoclonus: A Case Report 反复跌倒是皮层-皮层下肌阵挛的唯一临床表现：一份病例报告

NeuroSci Pub Date : 2023-12-28 DOI: 10.3390/neurosci5010001

Giulia De Napoli, Jessica Rossi, F. Cavallieri, Matteo Pugnaghi, Romana Rizzi, Marco Russo, Federica Assenza, Giulia Di Rauso, Franco Valzania

{"title":"Recurrent Falls as the Only Clinical Sign of Cortical–Subcortical Myoclonus: A Case Report","authors":"Giulia De Napoli, Jessica Rossi, F. Cavallieri, Matteo Pugnaghi, Romana Rizzi, Marco Russo, Federica Assenza, Giulia Di Rauso, Franco Valzania","doi":"10.3390/neurosci5010001","DOIUrl":"https://doi.org/10.3390/neurosci5010001","url":null,"abstract":"Some authors use the term cortical–subcortical myoclonus to identify a specific type of myoclonus, which differs from classical cortical myoclonus in that the abnormal neuronal activity spreads between the cortical and subcortical circuits, producing diffuse excitation. The EEG shows generalized spike-and-wave discharges that correlate with the myoclonic jerks. We report the case of a 79-year-old patient with a history of right thalamic deep hemorrhagic stroke, with favorable evolution. Fifteen years later, he was readmitted to the emergency department for episodes characterized by sudden falls without loss of consciousness. An EEG with EMG recording channel on the right deltoid muscle was performed, which documented frequent diffuse spike–wave and polyspike–wave discharges, temporally related to myoclonic jerks in the lower limbs. Brain MRI showed the persistence of a small right thalamic hemosiderin residue at the site of the previous hemorrhage. Antiseizure treatment with levetiracetam was started, with rapid clinical and electroencephalographic improvement. Our case may represent a lesion model of generalized epilepsy with myoclonic seizures. Furthermore, it highlights that lower limb myoclonus of cortical–subcortical origin may be an underestimate cause of gait disturbances and postural instability. Then, it may be reasonable to include the EEG in the diagnostic work-up of patients with recurrent falls.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"24 48","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139148515","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

On the Cranial Nerves 关于颅神经

NeuroSci Pub Date : 2023-12-28 DOI: 10.3390/neurosci5010002

Hugo M. Libreros-Jiménez, Jorge Manzo, F. Rojas-Durán, G. Aranda-Abreu, L. I. García-Hernández, GA Coria-Avila, D. Herrera-Covarrubias, C. A. Pérez-Estudillo, M. R. Toledo-Cárdenas, M. Hernández-Aguilar

{"title":"On the Cranial Nerves","authors":"Hugo M. Libreros-Jiménez, Jorge Manzo, F. Rojas-Durán, G. Aranda-Abreu, L. I. García-Hernández, GA Coria-Avila, D. Herrera-Covarrubias, C. A. Pérez-Estudillo, M. R. Toledo-Cárdenas, M. Hernández-Aguilar","doi":"10.3390/neurosci5010002","DOIUrl":"https://doi.org/10.3390/neurosci5010002","url":null,"abstract":"The twelve cranial nerves play a crucial role in the nervous system, orchestrating a myriad of functions vital for our everyday life. These nerves are each specialized for particular tasks. Cranial nerve I, known as the olfactory nerve, is responsible for our sense of smell, allowing us to perceive and distinguish various scents. Cranial nerve II, or the optic nerve, is dedicated to vision, transmitting visual information from the eyes to the brain. Eye movements are governed by cranial nerves III, IV, and VI, ensuring our ability to track objects and focus. Cranial nerve V controls facial sensations and jaw movements, while cranial nerve VII, the facial nerve, facilitates facial expressions and taste perception. Cranial nerve VIII, or the vestibulocochlear nerve, plays a critical role in hearing and balance. Cranial nerve IX, the glossopharyngeal nerve, affects throat sensations and taste perception. Cranial nerve X, the vagus nerve, is a far-reaching nerve, influencing numerous internal organs, such as the heart, lungs, and digestive system. Cranial nerve XI, the accessory nerve, is responsible for neck muscle control, contributing to head movements. Finally, cranial nerve XII, the hypoglossal nerve, manages tongue movements, essential for speaking, swallowing, and breathing. Understanding these cranial nerves is fundamental in comprehending the intricate workings of our nervous system and the functions that sustain our daily lives.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"77 3","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-28","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139151954","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correlation between Blood Monocytes and CSF Tau in Alzheimer’s Disease: The Effect of Gender and Cognitive Decline 阿尔茨海默病患者血液单核细胞与脑脊液 Tau 之间的相关性：性别和认知衰退的影响

NeuroSci Pub Date : 2023-12-12 DOI: 10.3390/neurosci4040026

Carlotta Ginevra Valentina Cimiotti, Paolo Paganetti, Stefania Rossi, Emiliano Soldini, L. Sacco

{"title":"Correlation between Blood Monocytes and CSF Tau in Alzheimer’s Disease: The Effect of Gender and Cognitive Decline","authors":"Carlotta Ginevra Valentina Cimiotti, Paolo Paganetti, Stefania Rossi, Emiliano Soldini, L. Sacco","doi":"10.3390/neurosci4040026","DOIUrl":"https://doi.org/10.3390/neurosci4040026","url":null,"abstract":"Neuroinflammation is one of the main mechanisms contributing to the pathogenesis of Alzheimer’s disease (AD), although its key role and the immune cells involved have not yet been identified. Blood monocytes appear to play a role in the clearance of AD-related amyloid-β (Aβ) and tau protein. This retrospective study evaluated a possible correlation between blood monocytes; the concentrations of Aβ, total tau (t-Tau), and phosphorylated tau (p-Tau) in the cerebrospinal fluid (CSF); and cognitive decline assessed according to the Montreal Cognitive Assessment (MoCA). We collected data from 33 patients with AD or mild cognitive impairment (MCI) due to AD (15 men and 18 women) and found, along with a significant reduction in the concentration of blood monocytes in women (p-value = 0.083),significant correlations between the number of blood monocytes and the concentration of t-Tau in CSF (p-value = 0.045) and between blood monocytes and MoCA score (p-value = 0.037). These results confirm the role of blood monocytes in the pathogenesis of AD, provide further evidence of a gender difference in the neuroinflammatory process underlying AD, and show that blood monocyte count may reflect the cognitive impairment of AD patients.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"30 19","pages":""},"PeriodicalIF":0.0,"publicationDate":"2023-12-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139009073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The Effects of Zinc on Proprioceptive Sensory Function and Nerve Conduction 锌对本体感觉功能及神经传导的影响

NeuroSci Pub Date : 2023-11-10 DOI: 10.3390/neurosci4040025

Elizabeth R. Elliott, Kaitlyn E. Brock, Alaina C. Taul, Artin Asadipooya, Devin Bocook, Tessa Burnette, Isha V. Chauhan, Bilal Chhadh, Ryan Crane, Ashley Glover, Joshua Griffith, JayLa A. Hudson, Hassan Kashif, Samuel O. Nwadialo, Devan M. Neely, Adel Nukic, Deep R. Patel, Gretchen L. Ruschman, Johnathan C. Sales, Terra Yarbrough, Robin L. Cooper

{"title":"The Effects of Zinc on Proprioceptive Sensory Function and Nerve Conduction","authors":"Elizabeth R. Elliott, Kaitlyn E. Brock, Alaina C. Taul, Artin Asadipooya, Devin Bocook, Tessa Burnette, Isha V. Chauhan, Bilal Chhadh, Ryan Crane, Ashley Glover, Joshua Griffith, JayLa A. Hudson, Hassan Kashif, Samuel O. Nwadialo, Devan M. Neely, Adel Nukic, Deep R. Patel, Gretchen L. Ruschman, Johnathan C. Sales, Terra Yarbrough, Robin L. Cooper","doi":"10.3390/neurosci4040025","DOIUrl":"https://doi.org/10.3390/neurosci4040025","url":null,"abstract":"Zinc (Zn2+) is an essential element that can promote proper organ function, cell growth, and immune response; it can also, however, be present in too great a quantity. Zinc toxicity caused by overexposure may result in both minor and major physiological effects, with chronic exposure at low levels and acute exposure at high levels being harmful or even toxic. This investigation examines the effects of acute exposure to relatively high concentrations of Zn2+ on sensory nerve function and nerve conduction. A proprioceptive nerve in marine crab (Callinectes sapidus) limbs was used as a model to assess the effects of Zn2+ on stretch-activated channels (SACs) and evoked nerve conduction. Exposure to Zn2+ slowed nerve condition rapidly; however, several minutes were required before the SACs in sensory endings were affected. A depression in conduction speed and an increase followed by a decrease in amplitude were observed for the evoked compound action potential, while the frequency of nerve activity upon joint movement and stretching of the chordotonal organ significantly decreased. These altered responses could be partially reversed via extensive flushing with fresh saline to remove the zinc. This indicates that subtle, long-term exposure to Zn2+ may alter an organism’s SAC function for channels related to proprioception and nerve conduction.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":" April","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-10","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135186653","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Association of Circulating Levels of Inflammatory Cytokines and Chemotherapy-Associated Subjective Cognitive Impairment in a South African Cohort of Breast Cancer Patients 在南非乳腺癌患者队列中，循环炎症细胞因子水平与化疗相关的主观认知障碍的关联

NeuroSci Pub Date : 2023-11-07 DOI: 10.3390/neurosci4040024

Nicholas Keetile, Elzbieta Osuch, Antonio G. Lentoor, Tsakani Rasakanya

{"title":"Association of Circulating Levels of Inflammatory Cytokines and Chemotherapy-Associated Subjective Cognitive Impairment in a South African Cohort of Breast Cancer Patients","authors":"Nicholas Keetile, Elzbieta Osuch, Antonio G. Lentoor, Tsakani Rasakanya","doi":"10.3390/neurosci4040024","DOIUrl":"https://doi.org/10.3390/neurosci4040024","url":null,"abstract":"Background: The evidence links chemotherapy to cognitive impairment in breast cancer patients. This study assessed the link between subjective chemotherapy-related cognitive impairment and neuroinflammation in breast cancer patients. Methods: In a correlational study, 113 patients aged 21 to 60 years on chemotherapy regimens completed the Functional Assessment of Cancer Therapy-Cognition Test (FACT-Cog) as a measure of subjective cognitive functioning at three time points (baseline- T0, third cycle- T1, and sixth cycle- T2). The levels of inflammatory cytokines (interleukin-1 beta (IL-1β), interleukin-6 (IL-6), interleukin-8 (IL-8), and tumour necrosis factor-alpha (TNF-α)) were measured using an assay method and compared with the subjective cognitive impairment. Results: Midway through chemotherapy, higher levels of TNF-α were inversely linked with self-perceived cognitive performance, while higher levels of IL-1β were positively associated (p = 0.030). However, at the end of chemotherapy, only IL-8 (p = 0.50) was associated with higher self-perceived cognitive problems. Conclusions: The specific roles that various cytokines and their interactions may play in neuroinflammation or neuroprotection require further investigation.","PeriodicalId":74294,"journal":{"name":"NeuroSci","volume":"1 1","pages":"0"},"PeriodicalIF":0.0,"publicationDate":"2023-11-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"135476145","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0