Nature reviews bioengineering最新文献

{"title":"Wild bat targeted vaccines","authors":"Tonie E. Rocke","doi":"10.1038/s44222-026-00450-6","DOIUrl":"10.1038/s44222-026-00450-6","url":null,"abstract":"Oro-topical vaccines for wild bats could reduce the spread of disease to humans and domestic animals, as well as aid the conservation of endangered species.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 7","pages":"587-588"},"PeriodicalIF":42.7,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-026-00450-6.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434174","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Bioengineering the path to clinical xenotransplantation","authors":"","doi":"10.1038/s44222-026-00443-5","DOIUrl":"10.1038/s44222-026-00443-5","url":null,"abstract":"Xenotransplantation is driven as much by bioengineering as by clinical science. The field relies on engineering platforms, from gene editing and immunomodulation tools to in vitro tissue models, to translate its promise into routine clinical practice.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 5","pages":"387-387"},"PeriodicalIF":37.6,"publicationDate":"2026-05-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.nature.comhttps://www.nature.com/articles/s44222-026-00443-5.pdf","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147968204","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Thinking is not only writing","authors":"Brian D. Earp, Anne-Sophie Guernon, Sebastian Porsdam Mann","doi":"10.1038/s44222-026-00447-1","DOIUrl":"10.1038/s44222-026-00447-1","url":null,"abstract":"Generative artificial intelligence (AI) raises valid concerns about the loss of cognitive work embedded in scholarly writing. However, universally dismissing AI-assisted drafting mistakenly conflates writing with thinking itself and reinforces existing inequities in who can transform their ideas into polished text. Academic authorship should depend more on the depth and creativity of human intellectual engagement than on the medium through which first drafts are produced.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 6","pages":"479-480"},"PeriodicalIF":42.7,"publicationDate":"2026-05-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262030","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Endocrine effects in cell culture","authors":"Alison Marieann Veintimilla, Erika Moore","doi":"10.1038/s44222-026-00452-4","DOIUrl":"10.1038/s44222-026-00452-4","url":null,"abstract":"Cell culture work is crucial to biomedical innovation, yet established laboratory practices often overlook the endocrine effects of culture components. To improve the translatability and rigor of preclinical research, greater transparency, disclosure and consideration of endocrine effects is essential.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 8","pages":"697-698"},"PeriodicalIF":42.7,"publicationDate":"2026-05-12","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148704521","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Organoids as platforms for infectious disease research","authors":"Kuan Liu, Yilan Zhao, Erika M. Joloya, Benedetta Artegiani, Sina Bartfeld, Young Ki Choi, Yuling Han, Delilah Hendriks, Martin J. Hoogduijn, James E. Hudson, Luc J. W. van der Laan, Cun Li, Valeria V. Orlova, Jianhua Qin, Karine Raymond, Lisa E. Wagar, Jie Zhou, Mart M. Lamers, Qiuwei Pan","doi":"10.1038/s44222-026-00445-3","DOIUrl":"10.1038/s44222-026-00445-3","url":null,"abstract":"Endemic and emerging infectious diseases pose major public health, economic and societal challenges. To advance our understanding of infectious disease pathophysiology and develop effective interventions, experimental models are required that closely mimic human biology. In particular, organoid platforms have begun to address key limitations of 2D cell line cultures and animal models in infectious disease research. In this Review, we explore the diverse applications of human organoids in investigating organ-specific infections and disease manifestations across major physiological systems, including the respiratory, digestive, nervous, cardiovascular, integumentary, urinary, reproductive and lymphatic systems, with a primary emphasis on viral pathogens. We further discuss the importance of immune-competent and vascularized organoids for modelling complex host–pathogen interactions, and we examine organoid-on-a-chip platforms as tools to investigate dynamic processes and inter-organ mechanisms. In addition, we outline how organoid technologies can support vaccine and therapeutic development, enable the study of zoonotic transmission and contribute to pandemic preparedness. Finally, we underscore key priorities for the field, including enhancing tissue-like complexity and maturity, improving standardization, and increasing the scalability and throughput of organoid models. Human organoids offer experimental models that closely replicate human biology, enabling the investigation of infectious disease mechanisms across diverse organ systems, especially for viral pathogens. This Review highlights their applications in studying host–virus interactions, supporting therapeutic and vaccine development, and improving pandemic preparedness, while emphasizing the need for greater complexity, standardization and scalability.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 6","pages":"503-522"},"PeriodicalIF":42.7,"publicationDate":"2026-05-11","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262027","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"A practice-based framework for point-of-care chronic disease management","authors":"Jillian Chan, Kate Qi, Jianhao Bai","doi":"10.1038/s44222-026-00441-7","DOIUrl":"10.1038/s44222-026-00441-7","url":null,"abstract":"Point-of-care solutions are required to shift healthcare upstream from disease treatment towards prevention and early intervention. Here, we examine the implementation of point-of-care testing for chronic disease management, sharing insights from real-world community-based deployment, and introduce STRIDE, a practice-based framework designed to strengthen continuity of care and enhance preventive impact.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 7","pages":"591-593"},"PeriodicalIF":42.7,"publicationDate":"2026-05-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148434176","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Enzymes to energize microelectronics","authors":"Marie R. Berthuel-Hammond, Jules L. Hammond","doi":"10.1038/s44222-026-00448-0","DOIUrl":"10.1038/s44222-026-00448-0","url":null,"abstract":"Bioenzymatic fuel cells provide a metal-free alternative to power the next generation of microelectronic devices that will rely solely on widely available ingredients: carbon, cellulose, sugar and enzymes. Applicable to logistics trackers, wearable biosensors and single-use medical devices, bioenzymatic fuel cells enable the development of smart systems while reducing the environmental footprint.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 6","pages":"487-489"},"PeriodicalIF":42.7,"publicationDate":"2026-05-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Digital twins and digital models of the human circulatory system","authors":"Runxin Wu, Guinevere Ferreira, Nusrat Sadia Khan, Samreen T. Mahmud, Jorik Stoop, Lydia L. Sohn, Jane A. Leopold, Amanda Randles","doi":"10.1038/s44222-026-00427-5","DOIUrl":"10.1038/s44222-026-00427-5","url":null,"abstract":"Digital models and digital twins of human circulatory transport could transform the way cardiovascular and haematological diseases are understood, monitored and treated. Digital twins are dynamic virtual representations of physical systems that continuously assimilate real-world data to simulate and predict system behaviour. However, translating digital twins into clinical practice remains challenging owing to the complexity of human physiology and the need for continuous bidirectional coupling between virtual models and their physical counterparts. Advances in medical-grade sensors, wearable devices, microfluidics, artificial intelligence and high-performance computing are accelerating the evolution of digital models into clinically meaningful digital twins. In this Review, we examine how digital twins can model the human circulatory system across scales, from macroscopic blood flow to molecular and cellular transport. We outline the essential components of a circulatory-transport digital twin, describe the pathophysiological conditions that can be digitally represented, and discuss approaches for acquiring and integrating physiological data, computational modelling strategies and model-based inference. We further survey applications of digital models and digital twins across various types of model inferences, from mechanistic insights to clinical decisions such as disease diagnosis, risk stratification, surgical planning and treatment planning. Finally, we identify key challenges and opportunities for next-generation circulatory digital twins capable of real-time monitoring, predictive simulation and closed-loop therapeutic control. Digital twins of the human circulatory system aim to integrate real-time physiological data with computational models to understand, monitor and treat cardiovascular and haematological diseases. This Review outlines the components, clinical applications and emerging technologies enabling such digital twins, highlighting the remaining challenges to achieving real-time, predictive and closed-loop clinical use.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 7","pages":"594-613"},"PeriodicalIF":42.7,"publicationDate":"2026-04-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148254875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"DNA logic gates direct selective drug delivery","authors":"Christine-Maria Horejs","doi":"10.1038/s44222-026-00442-6","DOIUrl":"10.1038/s44222-026-00442-6","url":null,"abstract":"An article in Nature Biotechnology reports a modular strategy in which affibody–DNA–drug and aptamer–DNA–drug conjugates are engineered to perform Boolean logic operations on combinations of biomarkers for amplified and selective intracellular delivery of therapeutic payloads.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 5","pages":"401-401"},"PeriodicalIF":37.6,"publicationDate":"2026-04-29","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"147968214","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

{"title":"Engineered cells as programmable mRNA delivery vehicles","authors":"Felix Horns, Victoria Tobin, Michael B. Elowitz","doi":"10.1038/s44222-026-00438-2","DOIUrl":"10.1038/s44222-026-00438-2","url":null,"abstract":"Delivering mRNA to specific cell types remains challenging. Recent work opens the possibility of using synthetic RNA transfer pathways to engineer mRNA ‘delivery cells’. These cells could home to disease sites, locally produce and deliver mRNA to target cells, and thereby enable targeted editing, reprogramming or elimination of selected cells for therapeutic benefit.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"4 6","pages":"477-478"},"PeriodicalIF":42.7,"publicationDate":"2026-04-24","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"148262045","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}