{"title":"细胞外囊泡表面工程的化学工具箱","authors":"Leila Pourtalebi Jahromi, Gregor Fuhrmann","doi":"10.1038/s44222-025-00310-9","DOIUrl":null,"url":null,"abstract":"Surface engineering enhances the pharmacokinetics and pharmacodynamics of extracellular vesicles (EVs) by improving their stability, immune evasion, tracking and targeting. Advancing scalable chemical approaches that preserve the integrity and functionality of EVs and efficient purification methods are key to unlocking their full potential.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 8","pages":"617-619"},"PeriodicalIF":37.6000,"publicationDate":"2025-04-25","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"A chemical toolbox for surface engineering of extracellular vesicles\",\"authors\":\"Leila Pourtalebi Jahromi, Gregor Fuhrmann\",\"doi\":\"10.1038/s44222-025-00310-9\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Surface engineering enhances the pharmacokinetics and pharmacodynamics of extracellular vesicles (EVs) by improving their stability, immune evasion, tracking and targeting. Advancing scalable chemical approaches that preserve the integrity and functionality of EVs and efficient purification methods are key to unlocking their full potential.\",\"PeriodicalId\":74248,\"journal\":{\"name\":\"Nature reviews bioengineering\",\"volume\":\"3 8\",\"pages\":\"617-619\"},\"PeriodicalIF\":37.6000,\"publicationDate\":\"2025-04-25\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature reviews bioengineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44222-025-00310-9\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44222-025-00310-9","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
A chemical toolbox for surface engineering of extracellular vesicles
Surface engineering enhances the pharmacokinetics and pharmacodynamics of extracellular vesicles (EVs) by improving their stability, immune evasion, tracking and targeting. Advancing scalable chemical approaches that preserve the integrity and functionality of EVs and efficient purification methods are key to unlocking their full potential.