{"title":"结构纳米医学的新时代。","authors":"Chad A Mirkin, Milan Mrksich, Natalie Artzi","doi":"10.1038/s44222-025-00306-5","DOIUrl":null,"url":null,"abstract":"<p><p>The lack of structural definition in nanomedicines limits therapeutic efficacy and complicates regulatory approval. Here, we emphasize that defining, designing and optimizing the structures of nanomedicine are critical to developing effective therapies because their architectures - not just the identity of their components - determines potency.</p>","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 7","pages":"526-528"},"PeriodicalIF":37.6000,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263095/pdf/","citationCount":"0","resultStr":"{\"title\":\"The emerging era of structural nanomedicine.\",\"authors\":\"Chad A Mirkin, Milan Mrksich, Natalie Artzi\",\"doi\":\"10.1038/s44222-025-00306-5\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"<p><p>The lack of structural definition in nanomedicines limits therapeutic efficacy and complicates regulatory approval. Here, we emphasize that defining, designing and optimizing the structures of nanomedicine are critical to developing effective therapies because their architectures - not just the identity of their components - determines potency.</p>\",\"PeriodicalId\":74248,\"journal\":{\"name\":\"Nature reviews bioengineering\",\"volume\":\"3 7\",\"pages\":\"526-528\"},\"PeriodicalIF\":37.6000,\"publicationDate\":\"2025-07-01\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12263095/pdf/\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature reviews bioengineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://doi.org/10.1038/s44222-025-00306-5\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"2025/4/25 0:00:00\",\"PubModel\":\"Epub\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1038/s44222-025-00306-5","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/4/25 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
The lack of structural definition in nanomedicines limits therapeutic efficacy and complicates regulatory approval. Here, we emphasize that defining, designing and optimizing the structures of nanomedicine are critical to developing effective therapies because their architectures - not just the identity of their components - determines potency.
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