{"title":"生菜叶绿体中可食用mRNA疫苗","authors":"Carson Campbell, Esteban Azagra","doi":"10.1038/s44222-025-00299-1","DOIUrl":null,"url":null,"abstract":"Messenger RNA (mRNA) vaccines hold promise for creating new and improved immunizations; however, their delivery is challenging in terms of compliance, reactogenicity, cost and scalability. In response to ‘the ultimate bioengineering challenge’ competition, we propose an edible mRNA vaccine platform using lettuce chloroplasts.","PeriodicalId":74248,"journal":{"name":"Nature reviews bioengineering","volume":"3 4","pages":"264-266"},"PeriodicalIF":37.6000,"publicationDate":"2025-04-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":"{\"title\":\"Edible mRNA vaccine in lettuce chloroplasts\",\"authors\":\"Carson Campbell, Esteban Azagra\",\"doi\":\"10.1038/s44222-025-00299-1\",\"DOIUrl\":null,\"url\":null,\"abstract\":\"Messenger RNA (mRNA) vaccines hold promise for creating new and improved immunizations; however, their delivery is challenging in terms of compliance, reactogenicity, cost and scalability. In response to ‘the ultimate bioengineering challenge’ competition, we propose an edible mRNA vaccine platform using lettuce chloroplasts.\",\"PeriodicalId\":74248,\"journal\":{\"name\":\"Nature reviews bioengineering\",\"volume\":\"3 4\",\"pages\":\"264-266\"},\"PeriodicalIF\":37.6000,\"publicationDate\":\"2025-04-14\",\"publicationTypes\":\"Journal Article\",\"fieldsOfStudy\":null,\"isOpenAccess\":false,\"openAccessPdf\":\"\",\"citationCount\":\"0\",\"resultStr\":null,\"platform\":\"Semanticscholar\",\"paperid\":null,\"PeriodicalName\":\"Nature reviews bioengineering\",\"FirstCategoryId\":\"1085\",\"ListUrlMain\":\"https://www.nature.com/articles/s44222-025-00299-1\",\"RegionNum\":0,\"RegionCategory\":null,\"ArticlePicture\":[],\"TitleCN\":null,\"AbstractTextCN\":null,\"PMCID\":null,\"EPubDate\":\"\",\"PubModel\":\"\",\"JCR\":\"\",\"JCRName\":\"\",\"Score\":null,\"Total\":0}","platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nature reviews bioengineering","FirstCategoryId":"1085","ListUrlMain":"https://www.nature.com/articles/s44222-025-00299-1","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"","PubModel":"","JCR":"","JCRName":"","Score":null,"Total":0}
Messenger RNA (mRNA) vaccines hold promise for creating new and improved immunizations; however, their delivery is challenging in terms of compliance, reactogenicity, cost and scalability. In response to ‘the ultimate bioengineering challenge’ competition, we propose an edible mRNA vaccine platform using lettuce chloroplasts.
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