Nanomedicine (London, England)最新文献_第4页

Synthesis and biocompatibility studies of 2D molybdenum carbide (MXene) nanosheets and their potential uses. 二维碳化钼（MXene）纳米片的合成、生物相容性研究及其应用前景。

Nanomedicine (London, England) Pub Date : 2025-05-26 DOI: 10.1080/17435889.2025.2509473

Sesuraj Balasamy, Preethi Sakthivelan, Vasanth Magesh, Ashok K Sundramoorthy

{"title":"Synthesis and biocompatibility studies of 2D molybdenum carbide (MXene) nanosheets and their potential uses.","authors":"Sesuraj Balasamy, Preethi Sakthivelan, Vasanth Magesh, Ashok K Sundramoorthy","doi":"10.1080/17435889.2025.2509473","DOIUrl":"https://doi.org/10.1080/17435889.2025.2509473","url":null,"abstract":"Aims: This study aims to evaluate the biocompatibility and explore the potential biomedical applications of two-dimensional (2D) molybdenum carbide (Mo₂CTх) MXene.Methods: Mo₂CTх MXene was synthesized by etching Mo₂Ga₂C using a Minimally Intensive Layer Delamination (MILD) method combined with hydrofluoric acid (HF). The structural and functional characteristics of the resulting material were characterized using UV-Vis, FT-IR, XRD, and FESEM. Antimicrobial activity was assessed against Staphylococcus aureus and Shigella sonnei, while biocompatibility was evaluated through in vitro testing on A549 lung epithelial cells and in vivo analysis using zebrafish embryos.Results: UV-Vis analysis showed characteristic absorption peaks at 220 nm and 550 nm. FT-IR confirmed the presence of surface functional groups. XRD results indicated high phase purity, and FESEM revealed a typical layered 2D morphology. Antimicrobial testing demonstrated a concentration-dependent response, with stronger inhibitory effects against S. aureus than S. sonnei. Biocompatibility studies showed high cell viability at low concentrations and no significant toxicity or morphological abnormalities in zebrafish embryos.Conclusion: Mo₂CTх MXene exhibits strong antimicrobial activity alongside excellent biocompatibility, highlighting its promise for biomedical applications. However, further studies focusing on long-term safety and functional surface modifications are needed to support its use in targeted therapeutic interventions.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144787","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Development and in vivo biodistribution of folate-targeted nanolipid system for erlotinib in breast cancer treatment. 厄洛替尼治疗乳腺癌的叶酸靶向纳米脂系统的开发和体内生物分布。

Nanomedicine (London, England) Pub Date : 2025-05-26 DOI: 10.1080/17435889.2025.2508135

Bharti Mangla, Tabish Pathan, Pankaj Kumar, Geeta Aggarwal

{"title":"Development and in vivo biodistribution of folate-targeted nanolipid system for erlotinib in breast cancer treatment.","authors":"Bharti Mangla, Tabish Pathan, Pankaj Kumar, Geeta Aggarwal","doi":"10.1080/17435889.2025.2508135","DOIUrl":"https://doi.org/10.1080/17435889.2025.2508135","url":null,"abstract":"Aim: The aim of the study was to develop folate targeted nanolipid carrier system (FA-ERT-NLCs) and study its in vivo oral biodistribution study for its absorption mechanism.Materials & methods: Folic acid was conjugated through pyridine and EDC chemistry. FA-ERT-NLCs was developed by high-pressure homogenization and parameters were optimized through design expert software. FA-ERT-NLCs were evaluated through in vitro characterization, Ex vivo and in vivo biodistribution studies. Moreover, female Wistar rats were used in this study.Results: Findings showed that targeted NLCs were found in nanometric range (182.34 nm) with negatively charge surface and PDI was found to be -16.2 mV and 0.203. The folate content in the conjugate was measured and found to be 71.33%. The depth of ERT and FC-ERT-NLCs was found to be 20 µm and 80.2 µm in rat intestine. Developed formulation was effective against MCF-7 cell lines. The IC50 values were found to be 526.2 µg/mL for ERT and 333.7 µg/mL for FC-ERT-NLCs. FA-ERT-NLCs are absorbed through intestine by lymphatic system.Conclusion: This study showed a promising targeted strategy for effective and safer breast cancer treatment.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-05-26","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144783","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Miktoarm polymers: past, present and future. 军工聚合物：过去，现在和未来。

Nanomedicine (London, England) Pub Date : 2025-05-26 DOI: 10.1080/17435889.2025.2510195

Ashok Kakkar

引用次数: 0

Unlocking new frontiers: DNA nanotechnology's impact on acute kidney injury diagnosis and treatment. 开启新领域：DNA纳米技术对急性肾损伤诊断和治疗的影响。

Nanomedicine (London, England) Pub Date : 2025-05-23 DOI: 10.1080/17435889.2025.2510192

Xue Zhou, Jingrui Yao, Liping Fan, Ning Wang, Yuanqing Tian

{"title":"Unlocking new frontiers: DNA nanotechnology's impact on acute kidney injury diagnosis and treatment.","authors":"Xue Zhou, Jingrui Yao, Liping Fan, Ning Wang, Yuanqing Tian","doi":"10.1080/17435889.2025.2510192","DOIUrl":"https://doi.org/10.1080/17435889.2025.2510192","url":null,"abstract":"Acute kidney injury (AKI) serves as an independent risk factor for chronic kidney disease (CKD) and hastens its progression. However, effective early diagnosis and treatment methods for AKI are still limited in clinical practice. There is a pressing need to develop fast, effective, and noninvasive diagnostic methods for AKI, as well as treatments that reduce nephrotoxicity. DNA nanotechnology, utilizing the programmable properties of DNA to engineer nanostructures and nanodevices, has achieved significant advancements in disease diagnosis and treatment. The application of DNA nanotechnology for kidney disease, particularly AKI, has been increasingly explored. This review encompasses the advancement of rapid and highly sensitive detection methods for AKI biomarkers, alongside the development of targeted drug delivery systems to the kidneys. These innovations facilitate precise treatment while minimizing adverse drug effects. The review underscores the progress in employing DNA nanotechnology for AKI diagnosis and treatment. Initially, we examine DNA nanotechnology-based strategies for AKI diagnosis, with an emphasis on biomarker detection. Subsequently, we delve into the therapeutic applications of DNA nanotechnology in AKI, highlighting targeted drug delivery and reduced toxicity. Finally, we offer insights into the challenges and opportunities associated with the clinical application of DNA nanotechnology in AKI management.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-05-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144133366","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Non-viral gene delivery systems in the treatment of oral cancers: a promising future. 非病毒基因传递系统在口腔癌治疗中的应用前景广阔。

Nanomedicine (London, England) Pub Date : 2025-05-14 DOI: 10.1080/17435889.2025.2503693

Seiichi Yamano, Kenji Inoue

引用次数: 0

The benefits of emerging alternatives to PEG for lipid nanoparticle RNA delivery systems. 新兴的替代品PEG脂质纳米颗粒RNA递送系统的好处。

Nanomedicine (London, England) Pub Date : 2025-05-10 DOI: 10.1080/17435889.2025.2500917

Manon Berger, Manon Degey, Alicia Curnel, Brigitte Evrard, Géraldine Piel

引用次数: 0

How can nanotechnology be leveraged to produce multifunctional contrast agents to improve imaging and diagnostics? 如何利用纳米技术生产多功能造影剂来改善成像和诊断？

Nanomedicine (London, England) Pub Date : 2025-05-08 DOI: 10.1080/17435889.2025.2501515

Junxi Yi, Yun-Sheng Chen

引用次数: 0

How could the affordable, reliable and continuous production of lipid nanoparticles revolutionize healthcare? 脂质纳米颗粒的可负担、可靠和连续生产是如何彻底改变医疗保健的？

Nanomedicine (London, England) Pub Date : 2025-05-06 DOI: 10.1080/17435889.2025.2500911

Luke Burroughs, Diane J Burgess

引用次数: 0

Harnessing extracellular vesicles to deliver genetic medicine for cardiac repair. 利用细胞外囊泡为心脏修复提供基因药物。

Nanomedicine (London, England) Pub Date : 2025-05-06 DOI: 10.1080/17435889.2025.2500913

Songpu Xie, Nazma F Ilahibaks, Zhiyong Lei, Joost P G Sluijter

引用次数: 0

Can nanoparticulate formulations of vancomycin and vancomycin derivatives improve antibiotic therapy? 万古霉素和万古霉素衍生物的纳米粒制剂能改善抗生素治疗吗？

Nanomedicine (London, England) Pub Date : 2025-05-05 DOI: 10.1080/17435889.2025.2500905

Eric Mühlberg, Gert Fricker, Philipp Uhl

引用次数: 0