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Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects. 化学合成的环丙沙星-PEG-FeO 纳米疗法具有很强的抗菌和可控细胞毒性作用。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-26 DOI: 10.2217/nnm-2023-0298
Hussan, Sobia Nisa, Syeda Asma Bano, Muhammad Zia
{"title":"Chemically synthesized ciprofloxacin-PEG-FeO nanotherapeutic exhibits strong antibacterial and controlled cytotoxic effects.","authors":"Hussan, Sobia Nisa, Syeda Asma Bano, Muhammad Zia","doi":"10.2217/nnm-2023-0298","DOIUrl":"10.2217/nnm-2023-0298","url":null,"abstract":"<p><p><b>Aim:</b> To develop a biocompatible conjugated ciprofloxacin-PEG-FeO nanodelivery system with increased efficacy of available therapeutics in a controlled manner. <b>Materials & methods:</b> FeO nanoparticles were synthesized by chemical and biological methods and modified as ciprofloxacin-PEG-FeO nanoformulations. After initial antibacterial and cytotoxicity studies, the effective and biocompatible nanoformulations was further fabricated as nanotherapeutics for <i>in vivo</i> studies in mouse models. <b>Results:</b> Chemically synthesized ciprofloxacin-PEG-FeO nanoformulations demonstrated boosted antibacterial activity against clinically isolated bacterial strains. Nanoformulations were also found to be compatible with baby hamster kidney 21 cells and red blood cells. In <i>in vivo</i> studies, nanotherapeutic showed wound-healing effects with eradication of <i>Staphylococcus aureus</i> infection. <b>Conclusion:</b> The investigations indicate that the developed nanotherapeutic can eradicate localized infections and enhance wound healing with controlled cytotoxicity.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advances in nanomedicines: a promising therapeutic strategy for ischemic cerebral stroke treatment. 纳米药物的进展：治疗缺血性脑中风的一种前景广阔的治疗策略。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI: 10.2217/nnm-2023-0266
Jun Li, Fei Xie, Xuemei Ma
{"title":"Advances in nanomedicines: a promising therapeutic strategy for ischemic cerebral stroke treatment.","authors":"Jun Li, Fei Xie, Xuemei Ma","doi":"10.2217/nnm-2023-0266","DOIUrl":"10.2217/nnm-2023-0266","url":null,"abstract":"<p><p>Ischemic stroke, prevalent among the elderly, necessitates attention to reperfusion injury post treatment. Limited drug access to the brain, owing to the blood-brain barrier, restricts clinical applications. Identifying efficient drug carriers capable of penetrating this barrier is crucial. Blood-brain barrier transporters play a vital role in nutrient transport to the brain. Recently, nanoparticles emerged as drug carriers, enhancing drug permeability via surface-modified ligands. This article introduces the blood-brain barrier structure, elucidates reperfusion injury pathogenesis, compiles ischemic stroke treatment drugs, explores nanomaterials for drug encapsulation and emphasizes their advantages over conventional drugs. Utilizing nanoparticles as drug-delivery systems offers targeting and efficiency benefits absent in traditional drugs. The prospects for nanomedicine in stroke treatment are promising.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041098","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Implantable celecoxib nanofibers made by electrospinning: fabrication and characterization. 利用电纺丝技术制造的可植入塞来昔布纳米纤维：制备与表征。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-02-02 DOI: 10.2217/nnm-2023-0314
Geng Lu, Chuangzan Yang, Kedi Chu, Yi Zhu, Sa Huang, Juying Zheng, Huanhuan Jia, Xiaofang Li, Junfeng Ban
{"title":"Implantable celecoxib nanofibers made by electrospinning: fabrication and characterization.","authors":"Geng Lu, Chuangzan Yang, Kedi Chu, Yi Zhu, Sa Huang, Juying Zheng, Huanhuan Jia, Xiaofang Li, Junfeng Ban","doi":"10.2217/nnm-2023-0314","DOIUrl":"10.2217/nnm-2023-0314","url":null,"abstract":"<p><p><b>Background:</b> Osteoarthritis causes tremendous damage to the joints, reducing the quality of life and imposing significant financial burden. An implantable drug-delivery system can improve the symptomatic manifestations with low doses and frequencies. However, the free drug has short retention in the joint cavity. <b>Materials & methods:</b> This study used electrostatic spinning technology to create an implantable drug-delivery system loaded with celecoxib (celecoxib nanofibers [Cel-NFs]) to improve retention and bioavailability. <b>Results:</b> Cel-NFs exhibited good formability, hydrophilicity and tensile properties. Cel-NFs were able to continuously release drugs for 2 weeks and increase the uptake capacity of Raw 264.7 cells, ultimately ameliorating symptoms in osteoarthritis rats. <b>Conclusion:</b> These results suggest that Cel-NFs can effectively ameliorate cartilage damage, reduce joint pain and alleviate osteoarthritis progression.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139673808","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Futuristic senolytic drug incorporated nanomedicine therapy to treat osteoarthritis. 治疗骨关节炎的未来型溶老药物纳米医学疗法。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-01 DOI: 10.2217/nnm-2023-0348
Laxmi Akhileshwar Jha, Bhupendra Kumar, Saurav Kumar Jha, Keshav Raj Paudel
{"title":"Futuristic senolytic drug incorporated nanomedicine therapy to treat osteoarthritis.","authors":"Laxmi Akhileshwar Jha, Bhupendra Kumar, Saurav Kumar Jha, Keshav Raj Paudel","doi":"10.2217/nnm-2023-0348","DOIUrl":"10.2217/nnm-2023-0348","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998519","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Neutrophil and endothelial cell membranes coassembled roflumilast nanoparticles attenuate myocardial ischemia/reperfusion injury. 中性粒细胞和内皮细胞膜共同组装的罗氟司特纳米颗粒能减轻心肌缺血再灌注损伤。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-01 DOI: 10.2217/nnm-2023-0313
Ying Tan, Xun Wang, Yu Gu, Xue Bao, He Lu, Xuan Sun, Lina Kang, Biao Xu
{"title":"Neutrophil and endothelial cell membranes coassembled roflumilast nanoparticles attenuate myocardial ischemia/reperfusion injury.","authors":"Ying Tan, Xun Wang, Yu Gu, Xue Bao, He Lu, Xuan Sun, Lina Kang, Biao Xu","doi":"10.2217/nnm-2023-0313","DOIUrl":"10.2217/nnm-2023-0313","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to develop biomimetic nanoparticles (NPs) of roflumilast (ROF) for attenuating myocardial ischemia/reperfusion (MI/R) injury. <b>Materials & methods:</b> We synthesized biomimetic ROF NPs and assembled ROF NPs in neutrophil and endothelial cell membranes (NE/ROF NPs). The physical properties of NE/ROF NPs were characterized and biological functions of NE/ROF NPs were tested <i>in vitro</i>. Targeting characteristics, therapeutic efficacy and safety of NE/ROF NPs were examined in mice model of MI/R. <b>Results:</b> NE/ROF NPs exhibited significant anti-inflammatory and antiadhesion effects. Meanwhile, they was effective in reducing MI/R injury in mice. Furthermore, NE/ROF NPs exhibited stronger targeting capabilities and demonstrated good safety. <b>Conclusion:</b> NE/ROF NPs may be a versatile biomimetic drug-delivery system for attenuating MI/R injury.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139998520","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Plasma-treated collagen functionalized with chondroitin sulfate as bioactive and nanostructured extracellular matrix mimics. 经血浆处理的胶原蛋白与硫酸软骨素功能化，作为具有生物活性的纳米结构细胞外基质模拟物。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-02-22 DOI: 10.2217/nnm-2023-0310
Federica Barbugian, Francesca Cadamuro, Francesco Nicotra, Claudia Riccardi, Laura Russo
{"title":"Plasma-treated collagen functionalized with chondroitin sulfate as bioactive and nanostructured extracellular matrix mimics.","authors":"Federica Barbugian, Francesca Cadamuro, Francesco Nicotra, Claudia Riccardi, Laura Russo","doi":"10.2217/nnm-2023-0310","DOIUrl":"10.2217/nnm-2023-0310","url":null,"abstract":"<p><p><b>Aim:</b> Cell microenvironment contains a plethora of information that influences cell modulation. Indeed, the extracellular matrix plays a central role in tissue development. Reproducing the cell-extracellular matrix crosstalk able to recapitulate both physical and biochemical signals is crucial to obtain functional tissue models or regenerative strategies. <b>Materials & methods:</b> Here, a combined method is proposed to easily functionalize collagen surface films, tailoring morphological properties. Oxygen nonthermal plasma treatment and glyco-conjugation with chondroitin sulfate are used to modify surface properties. <b>Results:</b> It results in higher adhesion, proliferation and morphological organization of U87 glioblastoma cells. <b>Conclusion:</b> Our finding suggests new promising strategies for the development of collagen-based biomaterials, which can be employed for advanced <i>in vitro</i> models.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139934576","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Platelet-derived extracellular vesicles: a new-generation nanostructured tool for chronic wound healing. 血小板衍生细胞外囊泡：用于慢性伤口愈合的新一代纳米结构工具。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-06 DOI: 10.2217/nnm-2023-0344
Abdolreza Esmaeilzadeh, Pegah Moharrami Yeganeh, Mahdis Nazari, Kimia Esmaeilzadeh
{"title":"Platelet-derived extracellular vesicles: a new-generation nanostructured tool for chronic wound healing.","authors":"Abdolreza Esmaeilzadeh, Pegah Moharrami Yeganeh, Mahdis Nazari, Kimia Esmaeilzadeh","doi":"10.2217/nnm-2023-0344","DOIUrl":"10.2217/nnm-2023-0344","url":null,"abstract":"<p><p>Chronic nonhealing wounds pose a serious challenge to regaining skin function and integrity. Platelet-derived extracellular vesicles (PEVs) are nanostructured particles with the potential to promote wound healing since they can enhance neovascularization and cell migration and reduce inflammation and scarring. This work provides an innovative overview of the technical laboratory issues in PEV production, PEVs' role in chronic wound healing and the benefits and challenges in its clinical translation. The article also explores the challenges of proper sourcing, extraction techniques and storage conditions, and discusses the necessity of further evaluations and combinational therapeutics, including dressing biomaterials, M2-derived exosomes, mesenchymal stem cells-derived extracellular vesicles and microneedle technology, to boost their therapeutic efficacy as advanced strategies for wound healing.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041029","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Leveraging selective knockdown of Sost gene by polyethyleneimine-siRNA-chitosan reduced gold nanoparticles to promote osteogenesis in MC3T3-E1 & MEF cells. 利用聚乙烯亚胺-siRNA-壳聚糖还原金纳米粒子选择性敲除Sost基因，促进MC3T3-E1和MEF细胞的成骨过程。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-26 DOI: 10.2217/nnm-2023-0325
Karishma Niveria, Mohammad ZafarYab, Largee Biswas, Asiya Mahtab, Anita Kamra Verma
{"title":"Leveraging selective knockdown of <i>Sost</i> gene by polyethyleneimine-siRNA-chitosan reduced gold nanoparticles to promote osteogenesis in MC3T3-E1 & MEF cells.","authors":"Karishma Niveria, Mohammad ZafarYab, Largee Biswas, Asiya Mahtab, Anita Kamra Verma","doi":"10.2217/nnm-2023-0325","DOIUrl":"10.2217/nnm-2023-0325","url":null,"abstract":"<p><p><b>Aim:</b> Osteoporosis is a systemic skeletal disorder characterized by reduced osteoblast differentiation, predominantly by overexpression of the <i>Sost</i> gene. A layer-by-layer approach enabled encapsulation of <i>Sost</i> siRNA to enhance the short half-life and poor transfection capacity of siRNA. <b>Materials & methods:</b> Polyethyleneimine and siRNA on chitosan-coated gold nanoparticles (PEI/siRNA/Cs-AuNPs) were engineered using chitosan-reduced gold nanoparticles. They were characterized by dynamic light scattering, scanning electron microscopy, transmission electron microscopy, Fourier transform infrared and gel-mobility assays. Detailed <i>in vitro</i> experiments, gene silencing and western blots were performed. <b>Results:</b> A total of 80% knockdown of the target sclerostin protein was observed by PEI/siRNA/Cs-AuNPs, q-PCR showed threefold downregulation of the <i>Sost</i> gene. Osteogenic markers <i>RunX2</i> and <i>Alp</i> were significantly upregulated. <b>Conclusion:</b> We report a safe, biocompatible nanotherapeutic strategy to enhance siRNA protection and subsequent silencing to augment bone formation.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140295483","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoparticles integrated with mild photothermal therapy and oxaliplatin for tumor chemotherapy and immunotherapy. 集成温和光热疗法和奥沙利铂的纳米颗粒用于肿瘤化疗和免疫疗法。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-04 DOI: 10.2217/nnm-2023-0335
Qiong Yi, Shumin He, Kai Liao, Zongxiang Yue, Ling Mei
{"title":"Nanoparticles integrated with mild photothermal therapy and oxaliplatin for tumor chemotherapy and immunotherapy.","authors":"Qiong Yi, Shumin He, Kai Liao, Zongxiang Yue, Ling Mei","doi":"10.2217/nnm-2023-0335","DOIUrl":"10.2217/nnm-2023-0335","url":null,"abstract":"<p><p><b>Aims:</b> Preparation and evaluation of nanoparticles for tumor chemotherapy and immunotherapy mild photothermal therapy and oxaliplatin. <b>Methods:</b> The double emulsion method was used for nanoparticle preparations. Polydopamine was deposited on the surface, which was further modified with folic acid. Cytotoxicity assays were carried out by cell counting kit-8. <i>In vivo</i> antitumor assays were carried out on 4T1 tumor-bearing mice. <b>Results:</b> The nanoparticles exhibited a 190 nm-diameter pomegranate-like sphere, which could increase temperature to 43-46°C. <i>In vivo</i> distribution showed enhanced accumulation. The nanoparticles generated stronger immunogenic cell death effects. By stimulating the maturation of dendritic cells, mild photothermal therapy combined with oxaliplatin significantly increased the antitumor effect by a direct killing effect and activation of immunotherapy. <b>Conclusion:</b> This study provided a promising strategy of combination therapy for tumors.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140023607","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Development of erlotinib-loaded nanotransferosomal gel for the topical treatment of ductal carcinoma in situ. 开发用于局部治疗乳腺导管原位癌的厄洛替尼负载纳米转运体凝胶。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-03-05 DOI: 10.2217/nnm-2023-0260
Bharti Mangla, Priya Mittal, Pankaj Kumar, Shamama Javed, Waquar Ahsan, Geeta Aggarwal
{"title":"Development of erlotinib-loaded nanotransferosomal gel for the topical treatment of ductal carcinoma <i>in situ</i>.","authors":"Bharti Mangla, Priya Mittal, Pankaj Kumar, Shamama Javed, Waquar Ahsan, Geeta Aggarwal","doi":"10.2217/nnm-2023-0260","DOIUrl":"10.2217/nnm-2023-0260","url":null,"abstract":"<p><p><b>Aims:</b> This study was aimed to formulate erlotinib (ERL)-loaded transferosomal gel (ERL@TG) intended for topical application for the treatment of ductal carcinoma <i>in situ</i>. <b>Materials & methods:</b> The optimized process involved a thin-film hydration method to generate ERL-loaded transferosomes (ERL@TFS), which was incorporated into a carbopol gel matrix to generate ERL@TG. The optimized formulation was characterized <i>in vitro</i> followed by cytotoxicity evaluation on MCF-7 breast cancer cell lines and acute toxicity and skin irritation studies was performed <i>in vivo</i>. <b>Results:</b> In a comparative assessment against plain ERL, ERL@TG displayed enhanced efficacy against MCF-7 cell lines, reflected in considerably lower IC<sub>50</sub> values with an enhanced safety profile. <b>Conclusion:</b> Optimized ERL@TG was identified as a promising avenue for addressing ductal carcinoma <i>in situ</i> breast cancer.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140029677","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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