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Intratympanic injections of emulsion-like dispersions to augment cinnarizine amount in a healthy rabbit inner ear model. 在健康兔内耳模型中鼓膜内注射乳剂样分散体以增加辛那利嗪的用量。
Nanomedicine (London, England) Pub Date : 2024-07-23 DOI: 10.1080/17435889.2024.2373042
Abhinab Goswami, Syed Nazrin Ruhina Rahman, Srikanth Ponneganti, Vijayakumar Gangipangi, Hariprasad Vavialala, Pullapanthula Radhakrishnanand, Sudhagar Selvaraju, Srinivasa Rao Mutheneni, Shreekant Bharti, Tamilvanan Shunmugaperumal
{"title":"Intratympanic injections of emulsion-like dispersions to augment cinnarizine amount in a healthy rabbit inner ear model.","authors":"Abhinab Goswami, Syed Nazrin Ruhina Rahman, Srikanth Ponneganti, Vijayakumar Gangipangi, Hariprasad Vavialala, Pullapanthula Radhakrishnanand, Sudhagar Selvaraju, Srinivasa Rao Mutheneni, Shreekant Bharti, Tamilvanan Shunmugaperumal","doi":"10.1080/17435889.2024.2373042","DOIUrl":"https://doi.org/10.1080/17435889.2024.2373042","url":null,"abstract":"<p><p><b>Aim:</b> To investigate eutectic liquid-based emulsion-like dispersions for intratympanic injections to augment cinnarizine permeability across round window membrane in a healthy rabbit inner ear model. <b>Methods:</b> Two-tier systematic optimization was used to get the injection formula. The drug concentrations in perilymph and plasma were analyzed via. Ultra-performance liquid chromatography-tandem mass spectrometry method after 30-, 60-, 90- and 120-min post intratympanic injection time points in rabbits. <b>Results:</b> A shear-thinning behavior, immediate drug release (∼98.80%, 10 min) and higher cell viability (>97.86%, 24 h) were observed in dispersions. The cinnarizine level of 8168.57 ± 1236.79 ng/ml was observed in perilymph at 30 min post intratympanic injection in rabbits. <b>Conclusion:</b> The emulsion-like dispersions can augment drug permeability through round window membrane.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749875","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Therapeutic effect of E-Lip-siRNA-sFlt1 on pre-eclampsia: targeted gene silencing and improved pregnancy outcomes. E-Lip-siRNA-sFlt1 对先兆子痫的治疗效果：靶向基因沉默和改善妊娠结局。
Nanomedicine (London, England) Pub Date : 2024-07-17 DOI: 10.1080/17435889.2024.2368449
Jinhua Dong, Yingying Zhang, Jingsheng Zhou, Shuhui Mao, Jianfen Tang, Suping Li, Qiang Ma, Ling Ai, Wei Wang, Guanghao Zhu, Huijing Shao, Yingdi Meng, Huaiwen Chen, Danqing Chen
{"title":"Therapeutic effect of E-Lip-siRNA-sFlt1 on pre-eclampsia: targeted gene silencing and improved pregnancy outcomes.","authors":"Jinhua Dong, Yingying Zhang, Jingsheng Zhou, Shuhui Mao, Jianfen Tang, Suping Li, Qiang Ma, Ling Ai, Wei Wang, Guanghao Zhu, Huijing Shao, Yingdi Meng, Huaiwen Chen, Danqing Chen","doi":"10.1080/17435889.2024.2368449","DOIUrl":"https://doi.org/10.1080/17435889.2024.2368449","url":null,"abstract":"<p><p><b>Aim:</b> To evaluate a liposome complex conjugated with anti-epidermal growth factor receptor (EGFR) antibodies for the treatment of pre-eclampsia (PE). <b>Methods:</b> In <i>in vitro</i> experiments, the transfection rate, silencing effect and cytotoxicity were determined. In the <i>in vivo</i> PE model, the siRNA distribution, mean arterial pressure, 24-h urine protein concentration, serum sFlt1 concentration, number of viable fetuses and placental weight were measured. <b>Results:</b> The nanomedicine effectively reduced the expression of sFIt1 and had a strong ability to target placental tissues. It could significantly reduce the symptoms of pre-eclampsia and improve pregnancy outcomes in PE model rats. <b>Conclusion:</b> The constructed nanomedicine can improve pregnancy outcomes in a rat model of pre-eclampsia and provides a new strategy for the treatment of pre-eclampsia.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141629476","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhanced biosafety, anticancer and antibacterial photodynamic activities using silver-pyropheophorbide-a nanoconjugates. 利用银-pyropheophorbide-a 纳米共轭物增强生物安全性、抗癌和抗菌光动力活性。
Nanomedicine (London, England) Pub Date : 2024-07-16 DOI: 10.1080/17435889.2024.2370226
Tabbisa Namulinda, Zhi-Bing Song, Yi-Jia Yan, Min Zhang, Gennady A Meerovich, Davor Margetic, Zhi-Long Chen
{"title":"Enhanced biosafety, anticancer and antibacterial photodynamic activities using silver-pyropheophorbide-a nanoconjugates.","authors":"Tabbisa Namulinda, Zhi-Bing Song, Yi-Jia Yan, Min Zhang, Gennady A Meerovich, Davor Margetic, Zhi-Long Chen","doi":"10.1080/17435889.2024.2370226","DOIUrl":"https://doi.org/10.1080/17435889.2024.2370226","url":null,"abstract":"<p><p><b>Aim:</b> A study of the enhancement of photodynamic activities of pyropheophorbide-a using PG-Ag-PPa nanoconjugates. <b>Materials & methods:</b> The nanoconjugates were formulated from silver nanoparticles and PPa via amide linkage, then characterized, and their photodynamic activities were examined. <b>Results:</b> The nanoconjugates displayed a higher rate of reactive oxygen species generation, commendable cellular uptake by Eca-109 cancer cells, higher photocytotoxicity toward the cancer cells and better bio-safety. They revealed strong antibacterial activity against <i>Escherichia coli</i> following internal reactive oxygen species generation and membrane disintegration. The <i>in vivo</i> anticancer studies confirmed higher cytotoxicity of the nanoconjugates toward cancer cells and better safety than PPa. <b>Conclusion</b>: Therefore, PG-Ag-PPa nanoconjugates could be considered potential nano photosensitizers for photodynamic therapy of tumors and bacterial infection with good bio-safety.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fluorescent carbon dots for sensing therapeutic moieties. 用于感知治疗分子的荧光碳点。
Nanomedicine (London, England) Pub Date : 2024-07-16 DOI: 10.1080/17435889.2024.2373679
Gaurav Gopal Naik, Vijay A Jagtap
{"title":"Fluorescent carbon dots for sensing therapeutic moieties.","authors":"Gaurav Gopal Naik, Vijay A Jagtap","doi":"10.1080/17435889.2024.2373679","DOIUrl":"10.1080/17435889.2024.2373679","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621885","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advancements in nanomedicine delivery systems: unraveling immune regulation strategies for tumor immunotherapy. 纳米药物传输系统的进展：揭示肿瘤免疫疗法的免疫调节策略。
Nanomedicine (London, England) Pub Date : 2024-07-16 DOI: 10.1080/17435889.2024.2374230
Yi Zhang, Xi Chen, Binbin Hu, Bingwen Zou, Yong Xu
{"title":"Advancements in nanomedicine delivery systems: unraveling immune regulation strategies for tumor immunotherapy.","authors":"Yi Zhang, Xi Chen, Binbin Hu, Bingwen Zou, Yong Xu","doi":"10.1080/17435889.2024.2374230","DOIUrl":"https://doi.org/10.1080/17435889.2024.2374230","url":null,"abstract":"<p><p>This review highlights the significant role of nanodrug delivery systems (NDDS) in enhancing the efficacy of tumor immunotherapy. Focusing on the integration of NDDS with immune regulation strategies, it explores their transformative impacts on the tumor microenvironment and immune response dynamics. Key advancements include the optimization of drug delivery through NDDS, targeting mechanisms like immune checkpoint blockade and modulating the immunosuppressive tumor environment. Despite the progress, challenges such as limited clinical efficacy and complex manufacturing processes persist. The review emphasizes the need for further research to optimize these systems, potentially revolutionizing cancer treatment by improving delivery efficiency, reducing toxicity and overcoming immune resistance.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction. 将 RGD 修饰的 ZIF-8 纳米粒子作为药物载体，用于心肌梗塞的磁共振成像和靶向给药。
Nanomedicine (London, England) Pub Date : 2024-07-16 DOI: 10.1080/17435889.2024.2365623
Yingxu Li, Maisituremu Tuerhan, Bing Li, Shuangling Chen, Yuji Wang, Yuanyuan Zheng
{"title":"RGD-modified ZIF-8 nanoparticles as a drug carrier for MR imaging and targeted drug delivery in myocardial infarction.","authors":"Yingxu Li, Maisituremu Tuerhan, Bing Li, Shuangling Chen, Yuji Wang, Yuanyuan Zheng","doi":"10.1080/17435889.2024.2365623","DOIUrl":"https://doi.org/10.1080/17435889.2024.2365623","url":null,"abstract":"<p><p><b>Aim:</b> A multifunctional nanoplatform has been developed to enhance the targeting capability and biosafety of drug/siRNA for better diagnosis and treatment of myocardial infarction (MI). <b>Materials & methods:</b> The nanoplatform's chemical properties, biodistribution, cardiac magnetic resonance imaging (MRI) capabilities, therapeutic effects and biocompatibility were investigated. <b>Results:</b> The nanoplatform exhibited MI-targeting properties and pH-sensitivity, allowing for effective cardiac MRI and delivery of drugs to the infarcted myocardium. The GCD/Qt@ZIF-RGD demonstrated potential as a reliable MRI probe for MI diagnosis. Moreover, the GCD/si-SHP1/Qt@ZIF-RGD effectively suppressed SHP-1 expression, increased pro-angiogenesis gene expression and reduced cell apoptosis in HUVECs exposed to hypoxia/reoxygenation. <b>Conclusion:</b> Our newly developed multifunctional drug delivery system shows promise as a nanoplatform for both the diagnosis and treatment of MI.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621891","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Green-synthesized copper oxide nanoparticles induce apoptosis and up-regulate HOTAIR and HOTTIP in pancreatic cancer cells. 绿色合成的氧化铜纳米粒子可诱导胰腺癌细胞凋亡并上调 HOTAIR 和 HOTTIP。
Nanomedicine (London, England) Pub Date : 2024-07-16 DOI: 10.1080/17435889.2024.2367958
Zahra Hosseini, Amirhossein Ahmadi, Ahmad Shadi, Seyed Javad Hosseini, Hossein Nikmanesh
{"title":"Green-synthesized copper oxide nanoparticles induce apoptosis and up-regulate <i>HOTAIR</i> and <i>HOTTIP</i> in pancreatic cancer cells.","authors":"Zahra Hosseini, Amirhossein Ahmadi, Ahmad Shadi, Seyed Javad Hosseini, Hossein Nikmanesh","doi":"10.1080/17435889.2024.2367958","DOIUrl":"https://doi.org/10.1080/17435889.2024.2367958","url":null,"abstract":"<p><p><b>Aim:</b> Cu<sub>2</sub>O nanoparticles were synthesized using an extract from <i>S. latifolium</i> algae (SLCu<sub>2</sub>O NPs). Their effect on PANC-1 cells and the expression of two drug resistance-related lncRNAs were evaluated in comparison with Arsenic trioxide. <b>Materials & methods:</b> SLCu<sub>2</sub>O NPs were characterized using XRD, SEM, and TEM microscopies. The effects of SLCu<sub>2</sub>O NPs on cell cytotoxicity, cell cycle, and apoptosis, and expression of two drug resistance-related lncRNAs were examined using MTT assay, flow cytometry, and real-time PCR, respectively. <b>Results:</b> SLCu<sub>2</sub>O NPs demonstrated anti-cancer properties against PANC-1 cells comparable to Arsenic trioxide, and the expression of lncRNAs increased upon treatment with them. <b>Conclusion:</b> SLCu<sub>2</sub>O NPs demonstrate anti-cancer properties against PANC-1 cells; however, using gene silencing strategies along with SLCu<sub>2</sub>O NPs is suggested.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-16","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621886","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Transcriptome changes in humans acutely exposed to nanoparticles during grinding of dental nanocomposites. 人类在研磨牙科纳米复合材料过程中急性暴露于纳米粒子的转录组变化。
Nanomedicine (London, England) Pub Date : 2024-07-14 Epub Date: 2024-07-02 DOI: 10.1080/17435889.2024.2362611
Zuzana Simova, Michal Sima, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Jaroslav Schwarz, Ludmila Maskova, Pavel Bradna, Adela Roubickova, Zdenek Krejcik, Jiri Klema, Pavel Rossner, Andrea Rossnerova
{"title":"Transcriptome changes in humans acutely exposed to nanoparticles during grinding of dental nanocomposites.","authors":"Zuzana Simova, Michal Sima, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Jaroslav Schwarz, Ludmila Maskova, Pavel Bradna, Adela Roubickova, Zdenek Krejcik, Jiri Klema, Pavel Rossner, Andrea Rossnerova","doi":"10.1080/17435889.2024.2362611","DOIUrl":"10.1080/17435889.2024.2362611","url":null,"abstract":"<p><p><b>Aim:</b> Today, there is a lack of research studies concerning human acute exposure to nanoparticles (NPs). Our investigation aimed to simulate real-world acute inhalation exposure to NPs released during work with dental nanocomposites in a dental office or technician laboratory. <b>Methods:</b> Blood samples from female volunteers were processed before and after inhalation exposure. Transcriptomic mRNA and miRNA expression changes were analyzed. <b>Results:</b> We detected large interindividual variability, 90 significantly deregulated mRNAs, and 4 miRNAs when samples of participants before and after dental nanocomposite grinding were compared. <b>Conclusion:</b> The results suggest that inhaled dental NPs may present an occupational hazard to human health, as indicated by the changes in the processes related to oxidative stress, synthesis of eicosanoids, and cell division.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321414/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494467","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesenchymal stem cell membrane-coated nanoconstructs: why have they not yet found a home in clinical practice? 间充质干细胞膜包裹的纳米结构：为何尚未在临床实践中找到用武之地？
Nanomedicine (London, England) Pub Date : 2024-07-14 Epub Date: 2024-07-02 DOI: 10.1080/17435889.2024.2369495
Saurav Kumar Jha, Mohammad Imran, Shoaib Anwaar, Philip M Hansbro, Keshav Raj Paudel, Yousuf Mohammed
{"title":"Mesenchymal stem cell membrane-coated nanoconstructs: why have they not yet found a home in clinical practice?","authors":"Saurav Kumar Jha, Mohammad Imran, Shoaib Anwaar, Philip M Hansbro, Keshav Raj Paudel, Yousuf Mohammed","doi":"10.1080/17435889.2024.2369495","DOIUrl":"10.1080/17435889.2024.2369495","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321396/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141494464","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Design and in vitro evaluation of 223Ra/99mTc-loaded spherical nano-hydroxyapatite in bone tumor therapy. 用于骨肿瘤治疗的 223Ra/99mTc 负载球形纳米羟基磷灰石的设计与体外评估
Nanomedicine (London, England) Pub Date : 2024-07-14 Epub Date: 2024-07-16 DOI: 10.1080/17435889.2024.2365127
Yumei Wang, Yue Zhou, Dongliang Zhai, Hao Deng, Xiaoliang Chen
{"title":"Design and <i>in vitro</i> evaluation of <sup>223</sup>Ra/<sup>99m</sup>Tc-loaded spherical nano-hydroxyapatite in bone tumor therapy.","authors":"Yumei Wang, Yue Zhou, Dongliang Zhai, Hao Deng, Xiaoliang Chen","doi":"10.1080/17435889.2024.2365127","DOIUrl":"10.1080/17435889.2024.2365127","url":null,"abstract":"<p><p><b>Aim:</b> Nano-hydroxyapatite (nHA) is a good nanocarrier to load <sup>223</sup>Ra, but the low specific activity (sp.act.) of <sup>223</sup>Ra@nHA limits its application in medicine. <b>Methods:</b> We proposed a method for preparing nHA using PEG as a template, which significantly increases the sp.act of <sup>223</sup>Ra@nHA and a new method to loaded <sup>99m</sup>Tc for <i>in vivo</i> tracking. <b>Results:</b> The nHA synthesized using PEG as a template was associated with higher sp.act for <sup>223</sup>Ra in comparison to nHA with identical particle size and without PEG. The nHA load <sup>99m</sup>Tc-MDP was associated with higher labeling rate and stability in comparison to <sup>99m</sup>Tc. <b>Conclusion:</b> All these findings suggest that using PEG as a template and <sup>99m</sup>Tc-MDP could be the most effective of synthetic <sup>223</sup>Ra/<sup>99m</sup>Tc@nHA.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11321400/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141621883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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