Nanomedicine (London, England)最新文献_第5页

Can automated gold nanoparticle synthesis drive the next wave of biomedical innovation? 自动化的金纳米粒子合成能推动下一波生物医学创新吗？

Nanomedicine (London, England) Pub Date : 2025-06-05 DOI: 10.1080/17435889.2025.2514424

Masoud Negahdary, Ngoc Nhu Vu, Samuel Mabbott

引用次数: 0

Diethyldithiocarbamate-Cu₄O₃ nanocomplex induced mitochondrial and telomerase dysfunction in non-small cell lung cancer. 二乙基二硫代氨基甲酸盐- cu4o3纳米复合物诱导非小细胞肺癌线粒体和端粒酶功能障碍。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI: 10.1080/17435889.2025.2502321

Marwa M Abu-Serie, María A Blasco

{"title":"Diethyldithiocarbamate-Cu4O3 nanocomplex induced mitochondrial and telomerase dysfunction in non-small cell lung cancer.","authors":"Marwa M Abu-Serie, María A Blasco","doi":"10.1080/17435889.2025.2502321","DOIUrl":"10.1080/17435889.2025.2502321","url":null,"abstract":"Background: Targeting cancer stem cells (CSCs)-mediated aggressive features of non-small cell lung cancer (NSCLC) is a promising anticancer approach. This can be accomplished via suppressing critical mediators, such as functional mitochondria, aldehyde dehydrogenase (ALDH)1A, and telomere protectors (telomerase reverse transcriptase (TERT) and telomere repeat binding factor (TRF)1).Materials & methods: Copper nanocomplexes (diethyldithiocarbamate (DE)-Cu4O3 nanoparticles (NPs) and DE-Cu NPs) were prepared using the simplest green chemistry method and assessed for inducing mitochondrial dysfunction-dependent non-apoptotic pathway (cuproptosis) and repressing CSC markers.Results: DE-Cu4O3 NPs had higher growth inhibition for NSCLC (A549, H520, and H1299) spheroids than DE-Cu NPs. DE-Cu4O3 NPs had higher uptake rate and prooxidant effect resulting in lower mitochondrial membrane potential and mitochondrial DNA copy number, as well as stronger inhibition of telomerase and ALDH1A than DE-Cu NPs. This caused dramatic redox imbalance and lowering AKT pathway (activator of telomere stabilizers and stemness)-mediated repression of TERT and TRF1 protein levels as well as phosphorylated NF-κB subunit (p65) led to collapsing telomeres, as evidenced by downregulating TERT regulators and confocal microscopy. In animal study, this active nanocomplex revealed powerful and selective therapeutic tumor-targeting effects, with no evidence of toxicity to healthy tissues.Conclusion: DE-Cu4O3 nanocomplex is deemed as promising nanomedicine for NSCLC.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1267-1280"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges. 用于癌症治疗的核酸纳米生物系统：新兴趋势和挑战的概述。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2501919

Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito

{"title":"Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges.","authors":"Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito","doi":"10.1080/17435889.2025.2501919","DOIUrl":"10.1080/17435889.2025.2501919","url":null,"abstract":"Different cancers remain major global health challenges due to their diverse biological behaviors and significant treatment hurdles. The aging of populations and lifestyle factors increase cancer occurrence and place increasing pressure on healthcare systems. Despite continuous advancements, many cancers remain fatal due to late-stage diagnosis, tumor heterogeneity, and drug resistance, thus necessitating urgent development of innovative treatment solutions. Therapeutic nucleic acids, a new class of biological drugs, offer a promising approach to overcoming these challenges. The recent Nucleic Acids and Nanobiosystems in Cancer Theranostics (NANCT) conference brought together internationally recognized experts from 15 countries to discuss cutting-edge research, spanning from oncolytic viruses to anticancer RNA nanoparticles and other emerging nanotechnologies. This review captures key insights and developments, emphasizing the need for interdisciplinary translation of scientific advancements into clinical practice and shaping the future of personalized cancer treatments for improved therapeutic outcomes.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1281-1298"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiotechnologies for stroke treatment. 纳米生物技术用于中风治疗。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2501514

Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

引用次数: 0

A drug delivery perspective on nanotechnology-based topical therapeutics for inflammatory skin diseases. 基于纳米技术的炎症性皮肤病局部疗法的药物递送前景。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-25 DOI: 10.1080/17435889.2025.2506347

Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Allana Carolina Leme de Almeida, Felipe Mota Tashiro, Isabel Rheinfranck Peleje, Marlus Chorilli

{"title":"A drug delivery perspective on nanotechnology-based topical therapeutics for inflammatory skin diseases.","authors":"Leonardo Delello Di Filippo, Jonatas Lobato Duarte, Allana Carolina Leme de Almeida, Felipe Mota Tashiro, Isabel Rheinfranck Peleje, Marlus Chorilli","doi":"10.1080/17435889.2025.2506347","DOIUrl":"10.1080/17435889.2025.2506347","url":null,"abstract":"Inflammatory skin diseases are chronic conditions that significantly affect patients' skin health and quality of life. Traditional treatments, including systemic immunosuppressants and topical therapies, often face limitations such as low efficacy, inadequate skin penetration, and severe side effects. Nanotechnology has emerged as a promising solution to tackle these challenges by providing innovative drug delivery systems that not only enhance therapeutic precision but also reduce systemic exposure. This review highlights the technological innovations and pre-clinical potential of nanotechnology-based therapies in managing inflammatory skin diseases, emphasizing their advantages over conventional treatments and their ability to overcome existing therapeutic limitations. Drug delivery nanosystems like lipid, polymeric, and metallic nanocarriers can be designed to penetrate the skin barrier and deliver drugs directly to the affected tissues. These nanocarriers improve drug stability, bioavailability, and retention in target areas while minimizing adverse effects. Furthermore, nanoparticles can be functionalized with bioadhesive molecules (e.g. hyaluronic acid) to achieve targeted and sustained drug release. In preclinical studies, such advanced formulations have demonstrated the potential to modulate immune responses and reduce inflammation by delivering therapeutics in a controlled and localized manner.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1441-1459"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12143682/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144144779","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing nanoparticles to minimize unintended inflammatory responses: a step toward safer and more effective precision nanomedicine. 设计纳米粒子以减少意外的炎症反应：迈向更安全、更有效的精密纳米医学的一步。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1080/17435889.2025.2476377

Feng Yuan, Zhong-Da Li, Qi Li, Yanqiao Zeng, Guofang Zhang, Yang Li

引用次数: 0

Drug-loaded nanoparticles induce immunogenic cell death and efficiently target cells from glioblastoma patients. 载药纳米颗粒诱导免疫原性细胞死亡并有效靶向胶质母细胞瘤患者的细胞。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2497747

Ada Tushe, Elena Marinelli, Beatrice Musca, Annavera Ventura, Sara Zumerle, Olga Slukinova, Giulia Zampardi, Francesco Volpin, Camilla Bonaudo, Alessandro Della Puppa, Mathieu Repellin, Giulia Guerriero, Giovanna Lollo, Susanna Mandruzzato

{"title":"Drug-loaded nanoparticles induce immunogenic cell death and efficiently target cells from glioblastoma patients.","authors":"Ada Tushe, Elena Marinelli, Beatrice Musca, Annavera Ventura, Sara Zumerle, Olga Slukinova, Giulia Zampardi, Francesco Volpin, Camilla Bonaudo, Alessandro Della Puppa, Mathieu Repellin, Giulia Guerriero, Giovanna Lollo, Susanna Mandruzzato","doi":"10.1080/17435889.2025.2497747","DOIUrl":"10.1080/17435889.2025.2497747","url":null,"abstract":"Aim: Glioblastoma multiforme (GBM) is characterized by a highly immunosuppressive tumor microenvironment (TME), posing significant challenges for efficient therapy's outcomes. Nanomedicine combined with immunotherapy holds the potential to modulate the TME and reactivate immune responses. This study proposes a polymeric nanosystem (NPs) encapsulating diaminocyclohexane-platinum II (DACHPt), an oxaliplatin derivative, to induce immunogenic cell death (ICD) in GBM cells.Materials & methods: An ionic-gelation technique was employed to generate polymeric nanoparticles (NPs) with an approximate size of 200 nm. NPs internalization was analyzed in GBM cell lines, in vitro-derived macrophages, and in leukocytes and tumor cells from GBM patient via flow cytometry and confocal imaging. ICD was assessed by measuring two of its main markers: adenosine triphosphate (ATP) and high-mobility group box 1 (HMGB1).Results: NPs were efficiently incorporated by myeloid and tumor cells, but not by lymphocytes. DACHPt-loaded NPs demonstrated enhanced cytotoxicity compared to free drug, with increased ATP and HMGB1 release from GBM cells, confirming ICD induction.Conclusions: Our findings suggest that DACHPt-loaded NPs represent a promising therapeutic strategy capable of targeting both tumor cells and tumor-promoting immune cells while inducing ICD.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1223-1234"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140489/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of erythrocyte-mimic nanoparticles in the treatment of cardiovascular diseases. 红细胞模拟纳米颗粒治疗心血管疾病的潜力。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-04-01 DOI: 10.1080/17435889.2025.2485674

Ni Zhu, Jing Yang

引用次数: 0

The potential of single-walled carbon nanotube-based therapeutic platforms targeting astrocytes. 靶向星形胶质细胞的单壁碳纳米管治疗平台的潜力。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-03-10 DOI: 10.1080/17435889.2025.2476376

Kristina Pilipović, Vladimir Parpura

引用次数: 0

Recent advances in smart gold nanoparticles for photothermal therapy. 光热治疗用智能金纳米颗粒的研究进展。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2500912

André F Moreira, Hugo A L Filipe, Sónia P Miguel, Maximiano J Ribeiro, Paula Coutinho

{"title":"Recent advances in smart gold nanoparticles for photothermal therapy.","authors":"André F Moreira, Hugo A L Filipe, Sónia P Miguel, Maximiano J Ribeiro, Paula Coutinho","doi":"10.1080/17435889.2025.2500912","DOIUrl":"10.1080/17435889.2025.2500912","url":null,"abstract":"Gold nanoparticles (AuNPs) possess unique properties, including low toxicity and excellent optical characteristics, making them highly appealing for biomedical applications. The plasmonic photothermal effect of AuNPs has been explored to trigger localized hyperthermia. Four commonly explored gold nanoparticles (spheres, rods, stars, and cages) are produced and optimized to present the localized surface plasmon resonance effect in the near-infrared region, exploiting the increased penetration in the human body. Additionally, the production of hybrid AuNPs, combining them with other materials, such as silica, graphene, zinc oxide, polymers, and small molecules has been explored to amplify the photothermal effect (T ≥ 45ºC). This review provides an overview of AuNPs' application in photothermal therapy, describing the general synthesis processes and the main particle parameters that affect their application in photothermal therapy, including the hybrid nanomaterials. Associated with this rapid progress, surface functionalization can also improve colloidal stability, safety, and therapeutic outcomes. In this regard, we also highlight the emerging trend of applying cell-derived vesicles as biomimetic coatings, capable of evading immune recognition, increasing blood circulation, and targeting specific tissues. In addition, the challenges and future developments of AuNPs for accelerating the clinical translations are discussed in light of their therapeutic and theragnostic potential.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1339-1353"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140457/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0