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Natural and artificial phospholipid bilayer coatings on solid-state nanoparticles, current and future perspectives. 固态纳米粒子上的天然和人工磷脂双分子层涂层、现状与未来展望。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-02-26 DOI: 10.2217/nnm-2023-0358
Bianca Dumontel, Giada Rosso, Valentina Cauda
{"title":"Natural and artificial phospholipid bilayer coatings on solid-state nanoparticles, current and future perspectives.","authors":"Bianca Dumontel, Giada Rosso, Valentina Cauda","doi":"10.2217/nnm-2023-0358","DOIUrl":"10.2217/nnm-2023-0358","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139975498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Anticancer effect and laser photostability of ternary graphene oxide/chitosan/silver nanocomposites on various cancer cell lines. 三元氧化石墨烯/壳聚糖/银纳米复合材料对各种癌细胞株的抗癌效果和激光光稳定性。
Nanomedicine (London, England) Pub Date : 2024-04-01 Epub Date: 2024-02-07 DOI: 10.2217/nnm-2023-0264
Marwa A Ramadan, Marwa Sharaky, Sara Gad, Hoda A Ahmed, Mariusz Jaremko, Abdul-Hamid Emwas, Amna H Faid
{"title":"Anticancer effect and laser photostability of ternary graphene oxide/chitosan/silver nanocomposites on various cancer cell lines.","authors":"Marwa A Ramadan, Marwa Sharaky, Sara Gad, Hoda A Ahmed, Mariusz Jaremko, Abdul-Hamid Emwas, Amna H Faid","doi":"10.2217/nnm-2023-0264","DOIUrl":"10.2217/nnm-2023-0264","url":null,"abstract":"<p><p><b>Aims:</b> The development of nanocomposites (NCs) of antitumor activity provides a new paradigm for fighting cancer. Here, a novel NC of green synthetic silver nanoparticles (AgNPs), graphene oxide (GO) and chitosan (Cs) NPs was developed. <b>Materials & methods:</b> The prepared GO/Cs/Ag NCs were analyzed using various techniques. Cytotoxicity of the NCs was evaluated against different cancer cell lines by Sulforhodamine B (SRB) assay. <b>Results:</b> GO/Cs/Ag NCs are novel and highly stable. UV-Vis showed two peaks at 227 and 469 nm, indicating the decoration of AgNPs on the surface of GO/Cs NPs. All tested cell lines were affected by GO/Cs NPs and GO/Cs/Ag NCs. <b>Conclusion:</b> The results indicate that GO/Cs/Ag NCs were present on tested cell lines and are a promising candidate for cancer therapy.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139699089","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in Pseudomonas aeruginosa. 纳米配方美洛昔康和利福平：抑制铜绿假单胞菌的法定量感应和生物膜形成。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-02-13 DOI: 10.2217/nnm-2023-0268
Malihe Khorramdel, Fatemeh Peyravii Ghadikolaii, Seyed Isaac Hashemy, Hossein Javid, Masoud Homayouni Tabrizi
{"title":"Nanoformulated meloxicam and rifampin: inhibiting quorum sensing and biofilm formation in <i>Pseudomonas aeruginosa</i>.","authors":"Malihe Khorramdel, Fatemeh Peyravii Ghadikolaii, Seyed Isaac Hashemy, Hossein Javid, Masoud Homayouni Tabrizi","doi":"10.2217/nnm-2023-0268","DOIUrl":"10.2217/nnm-2023-0268","url":null,"abstract":"<p><p><b>Background:</b> We aimed to investigate the simultaneous effects of meloxicam and rifampin nanoformulations with solid lipid nanoparticle (SLN) and nanostructured lipid carrier (NLC) substrates on inhibiting the quorum-sensing system of <i>Pseudomonas aeruginosa</i> and preventing biofilm formation by this bacterium. <b>Methods:</b> Antimicrobial activity of rifampin and meloxicam encapsulated with SLNs and NLCs against <i>P. aeruginosa</i> PAO1 was assessed by disk diffusion, minimum inhibitory concentration (MIC) and minimum bactericidal concentration (MBC). <b>Results:</b> The SLN formulation was associated with lower doses for the MIC and minimum bactericidal concentration in comparison to NLC. Moreover, our results demonstrated that both nanoformulations were able to produce 100% inhibition of the biofilm formation of <i>P. aeruginosa</i> PAO1. <b>Conclusion:</b> All these findings suggest that meloxicam and rifampin encapsulated with SLNs could be the most effective formulation against <i>P. aeruginosa</i>.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139725221","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Engineering Iron-Based Nanomaterials for Breast Cancer Therapy Associated with Ferroptosis. 用于乳腺癌治疗的铁基纳米材料工程与铁变态反应有关。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.2217/nnm-2023-0270
Ruixue Wei, Gaoliang Fu, Zhe Li, Yang Liu, Mengzhou Xue
{"title":"Engineering Iron-Based Nanomaterials for Breast Cancer Therapy Associated with Ferroptosis.","authors":"Ruixue Wei, Gaoliang Fu, Zhe Li, Yang Liu, Mengzhou Xue","doi":"10.2217/nnm-2023-0270","DOIUrl":"10.2217/nnm-2023-0270","url":null,"abstract":"<p><p>Ferroptosis has received increasing attention as a novel nonapoptotic programmed death. Recently, iron-based nanomaterials have been extensively exploited for efficient tumor ferroptosis therapy, as they directly release high concentrations of iron and increase intracellular reactive oxygen species levels. Breast cancer is one of the commonest malignant tumors in women; inhibiting breast cancer cell proliferation through activating the ferroptosis pathway could be a potential new target for patient treatment. Here, we briefly introduce the background of ferroptosis and systematically review the current cancer therapeutic strategies based on iron-based ferroptosis inducers. Finally, we summarize the advantages of these various ferroptosis inducers and shed light on future perspectives. This review aims to provide better guidance for the development of iron-based nanomaterial ferroptosis inducers.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643524","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanoemulsions: Summary of a Decade of Research and Recent Advances. 纳米乳剂：十年研究总结和最新进展。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.2217/nnm-2023-0199
Vivek P Chavda, Pankti C Balar, Rajashri Bezbaruah, Dixa A Vaghela, Damanbhalang Rynjah, Bedanta Bhattacharjee, Vrashabh V Sugandhi, Ana Cláudia Paiva-Santos
{"title":"Nanoemulsions: Summary of a Decade of Research and Recent Advances.","authors":"Vivek P Chavda, Pankti C Balar, Rajashri Bezbaruah, Dixa A Vaghela, Damanbhalang Rynjah, Bedanta Bhattacharjee, Vrashabh V Sugandhi, Ana Cláudia Paiva-Santos","doi":"10.2217/nnm-2023-0199","DOIUrl":"10.2217/nnm-2023-0199","url":null,"abstract":"<p><p>Nanoemulsions consist of a combination of several components such as oil, water, emulsifiers, surfactants and cosurfactants. Various techniques for producing nanoemulsions include high-energy and low-energy approaches such as high-pressure homogenization, microfluidization, jet disperser and phase inversion methods. The properties of a formulation can be influenced by elements such as the composition, concentration, size and charge of droplets, which in turn can affect the technique of manufacture. Characterization is conducted by the assessment of several factors such as physical properties, pH analysis, viscosity measurement and refractive index determination. This article offers a thorough examination of the latest developments in nanoemulsion technology, with a focus on their wide-ranging applications and promising future possibilities. It also discusses the administration of nanoemulsions through several methods.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643527","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Heating tumors with tumor cell-derived nanoparticles to enhance chemoimmunotherapy for colorectal cancer. 用肿瘤细胞衍生的纳米粒子加热肿瘤，加强结直肠癌的化疗免疫疗法。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-24 DOI: 10.2217/nnm-2023-0332
Xin-Ying Li, Rong-Hui Li, Jun-Zi Cong, Wen-Shang Liu, Yang Zhang, Hui-Lin Guan, Ling-Ling Zhu, Kai Chen, Li-Ying Pang, Hong Jin
{"title":"Heating tumors with tumor cell-derived nanoparticles to enhance chemoimmunotherapy for colorectal cancer.","authors":"Xin-Ying Li, Rong-Hui Li, Jun-Zi Cong, Wen-Shang Liu, Yang Zhang, Hui-Lin Guan, Ling-Ling Zhu, Kai Chen, Li-Ying Pang, Hong Jin","doi":"10.2217/nnm-2023-0332","DOIUrl":"10.2217/nnm-2023-0332","url":null,"abstract":"<p><p><b>Aim:</b> To investigate the mechanism of doxorubicin (DOX)-induced immunogenic cell death (ICD) and to improve immunotherapy efficacy. <b>Materials & methods:</b> In this study, hybrid vesicles containing DOX (HV-DOX) were prepared by thin-film hydration with extrusion, and the formulated nanoparticles were characterized physically. Furthermore, <i>in vitro</i> experiments and animal models were used to investigate the efficacy and new mechanisms of chemotherapy combined with immunotherapy. <b>Results:</b> DOX improved tumor immunogenicity by alkalinizing lysosomes, inhibiting tumor cell autophagy and inducing ICD. HVs could activate dendritic cell maturation, synergistically enhancing chemotherapeutic immunity. <b>Conclusion:</b> The mechanism of DOX-induced ICD was explored, and antitumor immunity was synergistically activated by HV-DOX to improve chemotherapeutic drug loading and provide relevant antigenic information.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139542131","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Near infrared-responsive quinacrine-gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR+ breast cancer stem cells. 近红外响应喹啉-金杂交纳米粒子能解除ER/PR+乳腺癌干细胞中HSP-70/P300介导的H3K14乙酰化。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.2217/nnm-2023-0269
Somya Ranjan Dash, Chinmay Das, Biswajit Das, Atala Bihari Jena, Subarno Paul, Saptarshi Sinha, Jasaswini Tripathy, Chanakya Nath Kundu
{"title":"Near infrared-responsive quinacrine-gold hybrid nanoparticles deregulate HSP-70/P300-mediated H3K14 acetylation in ER/PR+ breast cancer stem cells.","authors":"Somya Ranjan Dash, Chinmay Das, Biswajit Das, Atala Bihari Jena, Subarno Paul, Saptarshi Sinha, Jasaswini Tripathy, Chanakya Nath Kundu","doi":"10.2217/nnm-2023-0269","DOIUrl":"10.2217/nnm-2023-0269","url":null,"abstract":"<p><p><b>Aim:</b> This study aimed to determine if quinacrine-gold hybrid nanoparticles (QAuNPs) + near-infrared (NIR) deregulate HSP-70/P300 complex-mediated H3K14 acetylation in estrogen receptor/progesterone receptor (ER/PR+) breast cancer stem cells (CSCs). <b>Materials & methods:</b> Various cells and mouse-based systems were used as models. <b>Results:</b> QAuNP + NIR treatment reduced the nuclear translocation of HSP-70, affected the histone acetyltransferase activity of P300 and specifically decreased H3K14 acetylation in ER/PR+ breast CSCs. Finally, HSP-70 knockdown showed a reduction in P300 histone acetyltransferase activity, decreased H3K14 acetylation and inhibited activation of the <i>TGF-β</i> gene. <b>Conclusion:</b> This study revealed that QAuNP + NIR irradiation inhibits oncogenic activation of the <i>TGF-β</i> gene by decreasing H3K14 acetylation mediated through the HSP-70/P300 nuclear complex in ER/PR+ breast CSCs.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643528","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Evaluation of Novel Dendrimer-Gold Complex Nanoparticles for Theranostic Application in Oncology. 评估新型树枝状聚合物-金复合物纳米粒子在肿瘤治疗中的应用。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-26 DOI: 10.2217/nnm-2023-0355
Nevena Milivojević, Mariana R Carvalho, David Caballero, Snežana Radisavljević, Marija Radoićić, Marko Živanović, Subhas C Kundu, Rui L Reis, Nenad Filipović, Joaquim M Oliveira
{"title":"Evaluation of Novel Dendrimer-Gold Complex Nanoparticles for Theranostic Application in Oncology.","authors":"Nevena Milivojević, Mariana R Carvalho, David Caballero, Snežana Radisavljević, Marija Radoićić, Marko Živanović, Subhas C Kundu, Rui L Reis, Nenad Filipović, Joaquim M Oliveira","doi":"10.2217/nnm-2023-0355","DOIUrl":"10.2217/nnm-2023-0355","url":null,"abstract":"<p><strong>Aim: </strong>Despite some successful examples of therapeutic nanoparticles reaching clinical stages, there is still a significant need for novel formulations in order to improve the selectivity and efficacy of cancer treatment.</p><p><strong>Methods: </strong>The authors developed two novel dendrimer-gold (Au) complex-based nanoparticles using two different synthesis routes: complexation method (formulation A) and precipitation method (formulation B). Using a biomimetic cancer-on-a-chip model, the authors evaluated the possible cytotoxicity and internalization by colorectal cancer cells of dendrimer-Au complex-based nanoparticles.</p><p><strong>Results: </strong>The results showed promising capabilities of these nanoparticles for selectively targeting cancer cells and delivering drugs, particularly for the formulation A nanoparticles.</p><p><strong>Conclusion: </strong>This work highlights the potential of dendrimer-Au complex-based nanoparticles as a new strategy to improve the targeting of anticancer drugs.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563910","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Microfluidic Generation of Diverse Lipid Nanoparticle Libraries. 微流控生成多样化的脂质纳米粒子库。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-19 DOI: 10.2217/nnm-2023-0345
Andrew R Hanna, Sarah J Shepherd, David Issadore, Michael J Mitchell
{"title":"Microfluidic Generation of Diverse Lipid Nanoparticle Libraries.","authors":"Andrew R Hanna, Sarah J Shepherd, David Issadore, Michael J Mitchell","doi":"10.2217/nnm-2023-0345","DOIUrl":"10.2217/nnm-2023-0345","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139492918","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Biopolymer-based tumor microenvironment-responsive nanomedicine for targeted cancer therapy. 基于生物聚合物的肿瘤微环境响应型纳米药物，用于癌症靶向治疗。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-03-06 DOI: 10.2217/nnm-2023-0302
Abhishek Jha, Manish Kumar, Kanchan Bharti, Manjit Manjit, Brahmeshwar Mishra
{"title":"Biopolymer-based tumor microenvironment-responsive nanomedicine for targeted cancer therapy.","authors":"Abhishek Jha, Manish Kumar, Kanchan Bharti, Manjit Manjit, Brahmeshwar Mishra","doi":"10.2217/nnm-2023-0302","DOIUrl":"10.2217/nnm-2023-0302","url":null,"abstract":"<p><p>Nanomedicine has opened up new avenues for cancer treatment by enhancing drug solubility, permeability and targeted delivery to cancer cells. Despite its numerous advantages over conventional therapies, nanomedicine may exhibit off-target drug distribution, harming nontarget regions. The increased permeation and retention effect of nanomedicine in tumor sites also has its limitations, as abnormal tumor vasculature, dense stroma structure and altered tumor microenvironment (TME) may result in limited intratumor distribution and therapeutic failure. However, TME-responsive nanomedicine has exhibited immense potential for efficient, safe and precise delivery of therapeutics utilizing stimuli specific to the TME. This review discusses the mechanistic aspects of various TME-responsive biopolymers and their application in developing various types of TME-responsive nanomedicine.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"140041028","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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