Nanomedicine (London, England)最新文献_第5页

The potential of nanoparticle-based siRNA delivery in breast cancer treatment. 基于纳米颗粒的siRNA递送在乳腺癌治疗中的潜力。

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1080/17435889.2024.2440302

Athirah Bakhtiar, Xi-Yuen Kuan, Ezharul Hoque Chowdhury

引用次数: 0

Synergistic anti-cancer effects of piezoelectric hexagonal boron nitride nanocarriers for controlled doxorubicin release.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1080/17435889.2025.2459055

Nilay Cicek, Zehra Cobandede, Sevin Adiguzel, Hulya Yilmaz, Mustafa Culha

{"title":"Synergistic anti-cancer effects of piezoelectric hexagonal boron nitride nanocarriers for controlled doxorubicin release.","authors":"Nilay Cicek, Zehra Cobandede, Sevin Adiguzel, Hulya Yilmaz, Mustafa Culha","doi":"10.1080/17435889.2025.2459055","DOIUrl":"10.1080/17435889.2025.2459055","url":null,"abstract":"Aims: This study aims to develop a piezoelectric drug delivery system based on hexagonal boron nitride nanosheets (hBNs).Materials and methods: hBNs were synthesized using the chemical vapor deposition (CVD) method and characterized through imaging and spectroscopic techniques. Their piezoelectric properties were evaluated to confirm their functionality. Subsequently, the potential of hBNs as nanocarriers was assessed through in vitro experiments with doxorubicin (Dox) as a model drug.Results: The piezoelectric hBNs were successfully synthesized and exhibited efficient loading and controlled release of Dox. In vitro experiments conducted on PC3 (human prostate cancer) and PNT1A (normal adult prostate epithelial) cell lines demonstrated that ultrasound (US)-induced Dox-loaded hBNs (hBN-Dox) significantly inhibited the proliferation of prostate cancer cells, achieving efficacy at a much lower Dox concentration compared to conventional methods. The system enhanced reactive oxygen species (ROS) generation, impaired cancer cell colony formation, and induced both early and late apoptosis.Conclusions: These findings highlight the potential of piezoelectric hBNs as nanocarriers for efficient drug delivery, leveraging the synergistic effect of piezoelectricity-induced drug release and the degradation products of hBNs in biological media. Their ability to enhance drug efficacy while reducing the required dose holds promise for advanced cancer therapies.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"455-466"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in nanoultrasonography for the diagnosis and treatment of gastrointestinal diseases.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1080/17435889.2025.2457319

Weiping Wan, Haina Tao, Zhixiao Chen, Fangming Guo, Yun Tian

引用次数: 0

The potential of nanofibrous matrices in muscular regeneration. 纳米纤维基质在肌肉再生中的潜力。

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-17 DOI: 10.1080/17435889.2025.2454893

Moon Sung Kang, Dong-Wook Han

引用次数: 0

Aminofullerenes as targeted inhibitors of EGFR: from pancreatic cancer inhibitors to Drosophila m. Toxicology.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-07 DOI: 10.1080/17435889.2025.2461985

Katarzyna Malarz, Julia Korzuch, Anna Mrozek-Wilczkiewicz, Magdalena Szubka, Patryk Rurka, Karol Małota, Aitor Herraiz, Dominik Dreszer, Karina Kocot, Fernando Herranz, Magdalena Rost-Roszkowska, Tao Sun, Robert Musioł, Maciej Serda

{"title":"Aminofullerenes as targeted inhibitors of EGFR: from pancreatic cancer inhibitors to Drosophila m. Toxicology.","authors":"Katarzyna Malarz, Julia Korzuch, Anna Mrozek-Wilczkiewicz, Magdalena Szubka, Patryk Rurka, Karol Małota, Aitor Herraiz, Dominik Dreszer, Karina Kocot, Fernando Herranz, Magdalena Rost-Roszkowska, Tao Sun, Robert Musioł, Maciej Serda","doi":"10.1080/17435889.2025.2461985","DOIUrl":"10.1080/17435889.2025.2461985","url":null,"abstract":"Aim: Pancreatic ductal adenocarcinoma (PDAC) is recognized as one of the most formidable cancers, largely due to its distinct microenvironment characterized predominantly by extensive desmoplastic stroma. In this study, we synthesized three novel water-soluble fullerene-based nanomaterials targeting EGFR protein.Methods: The direct amination of fullerene carbon atoms, was followed by conjugation with a modified derivative of the EGFR inhibitor-erlotinib, resulting in the formation of novel water-soluble fullerene derivatives.Results: Further investigation into PAN02 and AsPC-1 cell lines revealed that these fullerene nanomaterials could induce cell cycle arrest in the G0/G1 phase, corroborated by alterations in the expression levels of the p27 and cyclin E1 proteins. Additionally, mechanisms of cell death were identified as autophagy for C60BUT and C70BUT-ERL, and apoptosis for Gd@C82EDA-ERL nanomaterials.Conclusions: Crucially, the study uncovered the efficacy of synthesized aminofullerenes in inhibiting the EGFR signaling pathway. The further toxicological studies of Gd@C82EDA-ERL fullerene on Drosophila melanogaster, underscored its potential for theranostic applications.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"585-601"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881853/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143366960","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotechnology-driven EGCG: bridging antioxidant and therapeutic roles in metabolic and cancer pathways.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-09 DOI: 10.1080/17435889.2025.2462521

Zahra Esmaeili, Parisa Shavali Gilani, Masood Khosravani, Maral Motamedi, Shokofeh Maleknejad, Mahdi Adabi, Parisa Sadighara

引用次数: 0

C₆₀ fullerene promotes post-traumatic recovery of the rat muscle gastrocnemius.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-11 DOI: 10.1080/17435889.2025.2461988

Yuriy Prylutskyy, Dmytro Nozdrenko, Olexandr Motuziuk, Svitlana Prylutska, Igor Vareniuk, Natalia Nurishchenko, Daria Franskevych, Vasil Soroсa, Kateryna Bogutska, Uwe Ritter

{"title":"C60 fullerene promotes post-traumatic recovery of the rat muscle gastrocnemius.","authors":"Yuriy Prylutskyy, Dmytro Nozdrenko, Olexandr Motuziuk, Svitlana Prylutska, Igor Vareniuk, Natalia Nurishchenko, Daria Franskevych, Vasil Soroсa, Kateryna Bogutska, Uwe Ritter","doi":"10.1080/17435889.2025.2461988","DOIUrl":"10.1080/17435889.2025.2461988","url":null,"abstract":"Aim: The remarkable antioxidant capabilities of biocompatible and safe C60 fullerenes have extensive applications in biomedicine. This study is the first to present an investigation into the effect of water-soluble C60 fullerenes on post-traumatic recovery of the muscle gastrocnemius in rats.Methods: Tensometry was used to investigate the biomechanical parameters of muscle contraction, specifically the times of reaching and holding the maximum force response of the muscle, and the return of muscle contraction force to the initial value after cessation of stimulation. Blood biochemical indicators were assessed, including concentrations of c-reactive protein, lactate, creatinine, and reduced glutathione, as well as superoxide dismutase and catalase activities 5, 10, and 15 days after initiating open muscle injury. Histopathological analysis was also performed to examine the rat muscle gastrocnemius damage on day 15 after the onset of injury.Results: It was found that C60 fullerenes reduced the stiffness of injured skeletal muscle, thereby slowing the development of fibrosis, and inhibiting the inflammatory process due to their antioxidant properties. There was also a reduction in histopathological features of muscle damage.Conclusion: These findings suggest using of carbon nanoparticles to correct pathological conditions that may occur during the physiological repair of damaged muscle tissues.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"571-584"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881861/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400950","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in nanotherapeutics for HIV-associated neurocognitive disorders and substance use disorders.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-18 DOI: 10.1080/17435889.2025.2461984

Christia Lomas, Ravi Chandra Dubey, Gabriela Perez-Alvarez, Yesenia Lopez Hernandez, Aorzala Atmar, Adriana Yndart Arias, Atul Vashist, Saurabh Aggarwal, Pandiaraj Manickam, Madepalli Krishnappa Lakshmana, Arti Vashist

{"title":"Recent advances in nanotherapeutics for HIV-associated neurocognitive disorders and substance use disorders.","authors":"Christia Lomas, Ravi Chandra Dubey, Gabriela Perez-Alvarez, Yesenia Lopez Hernandez, Aorzala Atmar, Adriana Yndart Arias, Atul Vashist, Saurabh Aggarwal, Pandiaraj Manickam, Madepalli Krishnappa Lakshmana, Arti Vashist","doi":"10.1080/17435889.2025.2461984","DOIUrl":"10.1080/17435889.2025.2461984","url":null,"abstract":"Substance use disorders (SUD) and HIV-associated neurocognitive disorders (HAND) work synergistically as a significant cause of cognitive decline in adults and adolescents globally. Current therapies continue to be limited due to difficulties crossing the blood-brain barrier (BBB) leading to limited precision and effectiveness, neurotoxicity, and lack of co-treatment options for both HAND and SUD. Nanoparticle-based therapeutics have several advantages over conventional therapies including more precise targeting, the ability to cross the BBB, and high biocompatibility which decreases toxicity and optimizes sustainability. These advantages extend to other neurological disorders such as Alzheimer's disease (AD) and amyotrophic lateral sclerosis (ALS). This review summarizes recent advances in nanotechnology for application to HAND, SUD, and co-treatment, as well as other neurological disorders. This review also highlights the potential challenges these therapies face in clinical translation and long-term safety.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"603-619"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11902879/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a cure for type 1 diabetes: the innovative potential of Phosphatidylserine-rich liposomes.

Nanomedicine (London, England) Pub Date : 2025-02-28 DOI: 10.1080/17435889.2025.2473872

Bruna Barneda-Zahonero, Lidia Almenara-Fuentes, David Perna-Barrull, Marta Vives-Pi

引用次数: 0

Realizing the potential of nanomedicines to treat breast cancer liver metastasis.

Nanomedicine (London, England) Pub Date : 2025-02-27 DOI: 10.1080/17435889.2025.2469491

Biana Godin, Hermann B Frieboes

引用次数: 0