Nanomedicine (London, England)最新文献

Regulating nanomedicines: challenges, opportunities, and the path forward. 监管纳米药物：挑战、机遇和前进的道路。

Nanomedicine (London, England) Pub Date : 2025-07-14 DOI: 10.1080/17435889.2025.2533107

Bharti Mangla, Pankaj Kumar, Shamama Javed, Tabish Pathan, Waquar Ahsan, Geeta Aggarwal

{"title":"Regulating nanomedicines: challenges, opportunities, and the path forward.","authors":"Bharti Mangla, Pankaj Kumar, Shamama Javed, Tabish Pathan, Waquar Ahsan, Geeta Aggarwal","doi":"10.1080/17435889.2025.2533107","DOIUrl":"https://doi.org/10.1080/17435889.2025.2533107","url":null,"abstract":"Over the past decade, nanomedicines have witnessed significant advancements, with various nanocarriers being introduced into clinical practice. Despite this progress, the absence of a well-defined regulatory framework presents major challenges for stakeholders in the pharmaceutical and healthcare industries. Challenges in biocompatibility, nanotoxicology, and regulatory oversight limit the clinical translation of nanomedicines. This review discusses the key challenges and emphasizes on the lack of clear and effective regulations in nanotechnology, which creates obstacles for manufacturers while also leaving legislators, medical practitioners, and the general public unable to properly assess the risk and safety measures associated with the nanomedicines. This review highlights the existing regulatory gaps by analyzing the clinical applications of nanomedicine, discussing the significance of regulatory frameworks. The barriers to the regulatory systems of various countries are compared to identify the multifaceted challenges associated with ensuring the safety and efficacy of nanomedicine interventions. The lack of consensus not only impedes the research and development (R&D) efforts in nanoparticle-based therapies but also affects the future adoption of nanomedicines. There is an urgent need to establish and implement a coherent and globally synchronized regulatory framework to facilitate the innovation and advancements of nanomedicines.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-07-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144627970","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Unveiling the toxicological mechanisms and biological impacts of copper sulfide nanoparticles on zebrafish. 揭示硫化铜纳米颗粒对斑马鱼的毒理学机制和生物学影响。

Nanomedicine (London, England) Pub Date : 2025-07-07 DOI: 10.1080/17435889.2025.2529774

Chandrasekaran Sneka, Dyah Ika Krisnawati, Muhamad Khafid, Hendra Susanto, Chinmaya Mutalik, Chih-Yu Chen, Tsung-Rong Kuo

{"title":"Unveiling the toxicological mechanisms and biological impacts of copper sulfide nanoparticles on zebrafish.","authors":"Chandrasekaran Sneka, Dyah Ika Krisnawati, Muhamad Khafid, Hendra Susanto, Chinmaya Mutalik, Chih-Yu Chen, Tsung-Rong Kuo","doi":"10.1080/17435889.2025.2529774","DOIUrl":"https://doi.org/10.1080/17435889.2025.2529774","url":null,"abstract":"Aim: Nanoparticles (NPs) are increasingly released into the environment, posing risks to living organisms. While copper sulfide NPs have been extensively studied, the toxicity of copper sulfide (CuS) NPs remains underexplored. Owing to their widespread use, it is crucial to assess their biological effects.Materials & methods: In this study, we used zebrafish embryos and larvae to evaluate CuS NP toxicity. Embryos were exposed to 20-100 µg/mL of CuS NPs under both dark and light conditions.Results: Concentrations ≥60 µg/mL caused up to 85% mortality, along with developmental abnormalities such as bent tails and pericardial edema. Under light irradiation, CuS NPs significantly elevated reactive oxygen species (ROS) production. This was evidenced by upregulated expression of antioxidant genes sod1, sod2, cat, and gpx1 in exposed embryos.Conclusions: Our findings demonstrate a photoreactive toxicity mechanism: CuS NPs generate ROS under light, disrupting redox balance. This underscores the importance of environmental factors, like sunlight, in nanomaterial risk assessment. By revealing how CuS NPs affect aquatic organisms under realistic conditions, our study contributes to understanding the ecological risks these particles pose and highlights their potential implications for human health.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-07-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577192","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Research progress on mRNA drug delivery strategies in the nervous system. 神经系统mRNA给药策略的研究进展。

Nanomedicine (London, England) Pub Date : 2025-07-07 DOI: 10.1080/17435889.2025.2530242

Bo Yang, Anqi Liu, Xiaojing Li, Zhigang Miao

引用次数: 0

Topical insulin meets nanomedicine: a synergy for enhanced skin regeneration. 局部胰岛素与纳米药物：增强皮肤再生的协同作用。

Nanomedicine (London, England) Pub Date : 2025-07-07 DOI: 10.1080/17435889.2025.2527579

Sofia O D Duarte, Pedro Fonte

引用次数: 0

Emerging immunomodulatory nanosystems for remodeling of cancer-associated fibroblasts. 用于癌症相关成纤维细胞重塑的新兴免疫调节纳米系统。

Nanomedicine (London, England) Pub Date : 2025-07-06 DOI: 10.1080/17435889.2025.2530376

Islam A Hassanin, Ahmed O Elzoghby

引用次数: 0

Applying drug-loaded electrospun nanofibers to antimicrobial-resistant skin infections. 载药电纺纳米纤维在抗微生物耐药皮肤感染中的应用。

Nanomedicine (London, England) Pub Date : 2025-07-03 DOI: 10.1080/17435889.2025.2528592

Noura G Eissa, Mahmoud Elsabahy

引用次数: 0

Emerging nanocarrier systems for the enhanced delivery of active pharmaceutical ingredients to the intestine. 用于增强活性药物成分到肠道的递送的新兴纳米载体系统。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-06-27 DOI: 10.1080/17435889.2025.2520157

Francesca Re, Sara Pelucchi, Francesco Pettini, Antonella Prantera, Fabiola Troisi, Rayan Mahmoud Ali Mahmoud, Roberto Giovannoni, Donatella Barisani

{"title":"Emerging nanocarrier systems for the enhanced delivery of active pharmaceutical ingredients to the intestine.","authors":"Francesca Re, Sara Pelucchi, Francesco Pettini, Antonella Prantera, Fabiola Troisi, Rayan Mahmoud Ali Mahmoud, Roberto Giovannoni, Donatella Barisani","doi":"10.1080/17435889.2025.2520157","DOIUrl":"10.1080/17435889.2025.2520157","url":null,"abstract":"This review explores the recent advancements in nanodelivery systems designed to improve intestinal delivery, focusing on inflammatory bowel diseases (IBDs) and colorectal cancer (CRC). It outlines the challenges associated with conventional drug therapies, including poor bioavailability, systemic side effects, and nonspecific targeting, which often limit therapeutic outcomes. Nanotechnology-based delivery platforms, such as lipid-based or polymeric nanoparticles, offer promising alternatives due to their ability to enhance drug stability, enable site-specific delivery, and reduce toxicity.It highlights how these nanosystems can be engineered to respond to the unique physiological and biochemical conditions of the inflamed gut, such as pH, enzymes, and reactive oxygen species. It also discusses various strategies to achieve active targeting through ligand-receptor interactions, thereby improving the precision of drug delivery to inflamed tissues.Despite the progress, the review notes that challenges remain in translating these technologies into clinical practice. Regulatory hurdles, manufacturing scalability, long-term safety, and the complexity of disease pathogenesis continue to pose significant obstacles. Overall, nanodelivery systems targeting the intestine represent a transformative approach with the potential to significantly improve IBD and CRC management, though further research and development are essential for clinical implementation.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1549-1572"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233719/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144509861","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Precision oncology through SERS: emerging approaches for improved cancer diagnosis and prognosis. 通过SERS精确肿瘤学：改善癌症诊断和预后的新方法。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-04-28 DOI: 10.1080/17435889.2025.2497745

Eduardo Garcia-Rico, Miguel A Correa-Duarte, Ramon A Alvarez-Puebla

引用次数: 0

Cancer therapy with engineered nanozymes: from molecular design to tumour-responsive catalysis. 用工程纳米酶治疗癌症：从分子设计到肿瘤反应性催化。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-06-18 DOI: 10.1080/17435889.2025.2520736

Austine Ofondu Chinomso Iroegbu, Moipone Linda Teffo, Emmanuel Rotimi Sadiku

{"title":"Cancer therapy with engineered nanozymes: from molecular design to tumour-responsive catalysis.","authors":"Austine Ofondu Chinomso Iroegbu, Moipone Linda Teffo, Emmanuel Rotimi Sadiku","doi":"10.1080/17435889.2025.2520736","DOIUrl":"10.1080/17435889.2025.2520736","url":null,"abstract":"Nanozymes, engineered nanomaterials that mimic natural enzyme activity, have emerged as powerful tools in precision cancer therapy due to their ability to generate reactive oxygen species (ROS), modulate the tumor microenvironment (TME), and facilitate cascade catalytic reactions. This review presents a comprehensive evaluation of recent innovations in nanozyme structural engineering aimed at improving catalytic performance, substrate specificity, and biocompatibility. Key design strategies, including dimensional tailoring, valence state tuning, and surface functionalisation, are discussed in the context of tumor-targeted therapies. Special focus is given to multifunctional and stimuli-responsive nanozymes that adapt to TME conditions or external triggers like light and pH. Despite significant progress, barriers such as biosafety, delivery efficiency, and lack of standardized catalytic performance metrics remain. This review critically addresses these challenges and highlights state-of-the-art nanozyme platforms, such as single-atom catalysts and cascade systems, which are leading the field toward clinical translation. Finally, it proposes strategic directions to bridge current knowledge gaps and advance nanozymes from bench to bedside, positioning them as next-generation catalytic platforms for personalized oncology.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1799-1817"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239811/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

KRAS mutation-driven enhanced macropinocytosis: using albumin as a trojan horse for delivering nanomedicine. KRAS突变驱动的增强型巨噬细胞：利用白蛋白作为传递纳米药物的特洛伊木马。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1080/17435889.2025.2524312

Drishti Rathod, Mukti Vats, Poonam Gawali, Osaretin Otagho, Bhoomi Dholariya, Ketan Patel

引用次数: 0