Nanomedicine (London, England)最新文献

Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.

Nanomedicine (London, England) Pub Date : 2025-03-21 DOI: 10.1080/17435889.2025.2480046

Zheng Nie, Yongxuan Liu, Li Xu, Yang Wang, Mengzhu Wang, Wen Zhou, Huimin Zhu, Min Zhao, Shikun Wang, Hongjian Zhang, Meijing Geng, Mai Peng, Hao Zeng, Yuan Zhang, Pengxi Zhu, Wei Shen

{"title":"Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.","authors":"Zheng Nie, Yongxuan Liu, Li Xu, Yang Wang, Mengzhu Wang, Wen Zhou, Huimin Zhu, Min Zhao, Shikun Wang, Hongjian Zhang, Meijing Geng, Mai Peng, Hao Zeng, Yuan Zhang, Pengxi Zhu, Wei Shen","doi":"10.1080/17435889.2025.2480046","DOIUrl":"https://doi.org/10.1080/17435889.2025.2480046","url":null,"abstract":"Aim: This study aims to explore the mechanism by which selenium nanoparticles (SeNPs) inhibit retinal neovascularization (RNV) and to identify a more effective treatment for pathological RNV.Materials & methods: The characterization and identification of the synthesized selenium nanoparticles (SeNPs) were conducted to investigate their effects on the function of human umbilical vein endothelial cells (HUVECs), retinal blood vessel development in mice, and the impact on oxygen-induced retinopathy. Tritium-labeled thymine was utilized to label newly synthesized DNA both in vivo and in vitro, allowing for the observation of SeNPs' effects on cell proliferation. Additionally, flow cytometry, immunofluorescence, and western blotting techniques were employed to elucidate the mechanisms by which SeNPs inhibit retinal neovascularization.Results: SeNPs can significantly inhibit the functions of vascular endothelial cells, particularly their proliferation, both in vivo and in vitro. The SeNPs achieve this by modulating the expression of cell cycle-related proteins through the regulation of the PI3K-AKT-p21 axis, which in turn inhibits the transition of the cell cycle from the G1 phase to the S phase.Conclusion: SeNPs may be a novel treatment for the interference of retinal neovascularization.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-14"},"PeriodicalIF":0.0,"publicationDate":"2025-03-21","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Metal-based nanoplatforms for enhancing the biomedical applications of berberine: current progress and future directions.

Nanomedicine (London, England) Pub Date : 2025-03-20 DOI: 10.1080/17435889.2025.2480051

Isaac Baidoo, Paromita Sarbadhikary, Heidi Abrahamse, Blassan P George

{"title":"Metal-based nanoplatforms for enhancing the biomedical applications of berberine: current progress and future directions.","authors":"Isaac Baidoo, Paromita Sarbadhikary, Heidi Abrahamse, Blassan P George","doi":"10.1080/17435889.2025.2480051","DOIUrl":"https://doi.org/10.1080/17435889.2025.2480051","url":null,"abstract":"The isoquinoline alkaloid berberine, a bioactive compound derived from various plants, has demonstrated extensive therapeutic potential. However, its clinical application is hindered by poor water solubility, low bioavailability, rapid metabolism, and insufficient targeting. Metal-based nanoplatforms offer promising solutions, enhancing drug stability, controlled release, and targeted delivery. This review comprehensively explores the synthesis, physicochemical properties, and biomedical applications of metal-based nanocarriers, including gold, silver, iron oxide, zinc oxide, selenium, and magnetic nanoparticles, for berberine delivery to improve berberine's therapeutic efficacy. Recent advancements in metal-based nanocarrier systems have significantly improved berberine delivery by enhancing cellular uptake, extending circulation time, and enabling site-specific targeting. However, metal-based nanoplatforms encounter several limitations of potential toxicity, limited large-scale productions, and regulatory constraints. Addressing these limitations necessitates extensive studies on biocompatibility, long-term safety, and clinical translation. By summarizing the latest innovations and clinical perspectives, this review aims to guide future research toward optimizing berberine-based nanomedicine for improved therapeutic efficacy.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-18"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665624","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in the treatment of atherosclerotic plaque based on nanomaterials.

Nanomedicine (London, England) Pub Date : 2025-03-20 DOI: 10.1080/17435889.2025.2480049

Pengyu Wang, Weiwei Chen, Jingfeng Zhang, Chunshu Pan, Yagui Lv, Yanzi Sun, Yanan Wang, Xuehua Ma, Changyong Gao, Tianxiang Chen, Aiguo Wu, Jianjun Zheng

{"title":"Advances in the treatment of atherosclerotic plaque based on nanomaterials.","authors":"Pengyu Wang, Weiwei Chen, Jingfeng Zhang, Chunshu Pan, Yagui Lv, Yanzi Sun, Yanan Wang, Xuehua Ma, Changyong Gao, Tianxiang Chen, Aiguo Wu, Jianjun Zheng","doi":"10.1080/17435889.2025.2480049","DOIUrl":"https://doi.org/10.1080/17435889.2025.2480049","url":null,"abstract":"Atherosclerosis is the leading cause of cardiovascular disease worldwide, posing not only a significant threat to cardiovascular health but also impairing the function of multiple organs, with severe cases potentially being life-threatening. Consequently, the effective treatment of atherosclerosis is of paramount importance in reducing the mortality associated with cardiovascular diseases. With the advancement of nanomedicine and a deeper understanding of the pathological mechanisms underlying atherosclerosis, nanomaterials have emerged as promising platforms for precise diagnosis and targeted therapeutic strategies. These materials offer notable advantages, including targeted drug delivery, enhanced bioavailability, improved drug stability, and controlled release. This review provides an overview of the mechanisms underlying atherosclerotic plaque development and examines nanomaterial-based therapeutic approaches for managing atherosclerotic plaques, including therapies targeting cholesterol metabolism, anti-inflammatory strategies, macrophage clearance, and immunotherapy. Additionally, the paper discusses the current technical challenges associated with the clinical transformation of these therapies. Finally, the potential future integration of nanomaterials, smart nanomaterials, and artificial intelligence in the treatment of atherosclerosis is also explored.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-03-20","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143665579","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

From innovation to application: safety concerns in nanomaterial implant coatings.

Nanomedicine (London, England) Pub Date : 2025-03-19 DOI: 10.1080/17435889.2025.2480045

Eileen Tabrizi, Bingyun Li

引用次数: 0

3D spheroid model reveals enhanced efficacy of mannose-decorated nanoparticles for TB treatment.

Nanomedicine (London, England) Pub Date : 2025-03-18 DOI: 10.1080/17435889.2025.2478806

Suyash M Patil, Apoorva Daram, Nitesh K Kunda

{"title":"3D spheroid model reveals enhanced efficacy of mannose-decorated nanoparticles for TB treatment.","authors":"Suyash M Patil, Apoorva Daram, Nitesh K Kunda","doi":"10.1080/17435889.2025.2478806","DOIUrl":"https://doi.org/10.1080/17435889.2025.2478806","url":null,"abstract":"Aims: Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a significant global health challenge aggravated by drug-resistant strains and prolonged treatment regimens. Innovative strategies to enhance treatment efficacy, improve patient adherence, and reduce adverse effects are urgently required.Methods: We explored a combination therapy using bedaquiline and pretomanid encapsulated in polymeric nanoparticles (pNPs). Further, active targeting was achieved through mannose-decorated nanoparticles (Man-pNPs) for macrophage-specific delivery. The drug-loaded pNPs and Man-pNPs were spray-dried into dry powder particles to improve drug solubility and enable local lung delivery via inhalation. Man-pNPs were prepared to target macrophages, wherein TB bacteria reside.Results: Formulations exhibited high drug loading and excellent aerosolization performance (MMAD 1-5 µm, FPF > 75%) for pNPs and Man-pNPs. Man-pNPs formulation enhanced macrophage targeting via receptor-mediated endocytosis and phagocytosis, improving bacterial inhibition. Man-pNPs demonstrated similar MIC in vitro and enhanced intracellular M.tb inhibition compared to free drug combination and pNPs. In addition, a TB spheroid model was developed for formulation screening, mimicking granulomas' physiological conditions. Man-pNPs formulation showed superior intracellular bacterial inhibition in TB spheroid model compared to free drug combination and pNPs.Conclusion: This research underscores the potential of combination therapy, particulate-based inhaled drug delivery, and active targeting to advance efficient and patient-friendly TB treatments.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-03-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Topical delivery of pterostilbene nanoemulgel ameliorates imiquimod-induced psoriasis-like skin inflammation in mice.

Nanomedicine (London, England) Pub Date : 2025-03-17 DOI: 10.1080/17435889.2025.2480047

Ankita Sood, Kulbhushan Tikoo

{"title":"Topical delivery of pterostilbene nanoemulgel ameliorates imiquimod-induced psoriasis-like skin inflammation in mice.","authors":"Ankita Sood, Kulbhushan Tikoo","doi":"10.1080/17435889.2025.2480047","DOIUrl":"https://doi.org/10.1080/17435889.2025.2480047","url":null,"abstract":"Aim: This study evaluates the therapeutic potential of Pterostilbene (PTN), a natural stilbenoid, in an imiquimod (IMQ)-induced psoriasis model. Due to PTN's poor solubility and bioavailability, a pterostilbene nano-emulsion gel (PTN-NEG) formulation (0.1% and 0.2% w/w) was developed to enhance its therapeutic efficacy.Methods: Psoriasis was induced in C57BL/6J mice by applying IMQ (62.5 mg/day) on a 5 cm2 shaved dorsal skin area for 7 days. PTN-NEG was topically applied, and its effects on oxidative stress, inflammatory cytokines (IL-17, TNF-α, IL-22), NF-κB pathway activation, and keratinocyte proliferation markers (Ki-67, Bcl-xL) were assessed. The expression of dual-specificity phosphatase-1 (DUSP-1) and its role in modulating mitogen-activated protein kinase (MAPK) signaling were evaluated. Additionally, DNA methyltransferase-1 (DNMT-1) inhibition was examined to explore PTN's epigenetic impact.Results: PTN-NEG restored antioxidant balance, reduced pro-inflammatory cytokines, inhibited NF-κB activation, and suppressed keratinocyte proliferation. It unregulated DUSP-1, modulating MAPK signaling and preventing psoriasis progression. PTN-NEG also improved epidermal structure, reduced hyperplasia, and prevented splenomegaly. Notably, PTN inhibited DNMT-1, suggesting a novel epigenetic mechanism for psoriasis.Conclusion: To our knowledge, this study is the first to demonstrate that PTN-NEG mitigates psoriasis through anti-inflammatory, antioxidant, and epigenetic regulatory mechanisms, highlighting its therapeutic potential in psoriasis management.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-03-17","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143652542","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could selection of biomolecular corona constituents through nanoparticle design produce more effective localized therapies?

Nanomedicine (London, England) Pub Date : 2025-03-15 DOI: 10.1080/17435889.2025.2480048

Antonietta Greco, Claudia Corbo

引用次数: 0

Femtosecond laser-ablative aqueous synthesis of multi-drug antiviral nanoparticles.

Nanomedicine (London, England) Pub Date : 2025-03-13 DOI: 10.1080/17435889.2025.2473307

Rebecca R Schmitt, Bruce A Davidson, Dihua He, Guang S He, Julia C Bulmahn, Suryaprakash Sambhara, Paul R Knight, Paras N Prasad

{"title":"Femtosecond laser-ablative aqueous synthesis of multi-drug antiviral nanoparticles.","authors":"Rebecca R Schmitt, Bruce A Davidson, Dihua He, Guang S He, Julia C Bulmahn, Suryaprakash Sambhara, Paul R Knight, Paras N Prasad","doi":"10.1080/17435889.2025.2473307","DOIUrl":"https://doi.org/10.1080/17435889.2025.2473307","url":null,"abstract":"Background: Nanomedicine offers a number of innovative strategies to address major public health burdens, including complex respiratory illnesses. In this work, we introduce a multi-drug nanoparticle fabricated using femtosecond laser ablation for the treatment of influenza, SARS-CoV-2, and their co-infections.Methods: The SARS-CoV-2 antiviral, remdesivir; the influenza antiviral, baloxavir marboxil; and the anti-inflammatory, dexamethasone, were co-crystalized and then ablated in aqueous media using a femtosecond pulsed laser and subsequently surface modified with the cationic polymer, chitosan, or poly-d-lysine. Physical and chemical properties were then characterized using multiple complimentary techniques. Finally, a clinically relevant in vitro primary mouse trachea epithelial cell-air-liquid interface culture model was used to analyze the antiviral effect of our nanoparticles against Influenza Virus A.Results: Our final nanoparticle exhibited a positive zeta potential with a diameter of ~73 nm. Remdesivir, baloxavir marboxil, and dexamethasone were all present in the nanoparticle suspension at a 1:1:1 ratio. Notably, these particles exhibited a potent anti-influenza effect, decreasing the viral titer by ≈ 4 logs in comparison to vehicle controls.Conclusion: Overall, these findings demonstrate great promise both for the use of laser ablation to generate multi-drug nanoparticles and for the anti-viral effects of our nanoformulation against respiratory illness.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-9"},"PeriodicalIF":0.0,"publicationDate":"2025-03-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143618018","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing nanoparticles to minimize unintended inflammatory responses: a step toward safer and more effective precision nanomedicine.

Nanomedicine (London, England) Pub Date : 2025-03-11 DOI: 10.1080/17435889.2025.2476377

Feng Yuan, Zhong-Da Li, Qi Li, Yanqiao Zeng, Guofang Zhang, Yang Li

引用次数: 0

The potential of single-walled carbon nanotube-based therapeutic platforms targeting astrocytes.

Nanomedicine (London, England) Pub Date : 2025-03-10 DOI: 10.1080/17435889.2025.2476376

Kristina Pilipović, Vladimir Parpura

引用次数: 0