Nanomedicine (London, England)最新文献

Nanoparticle-delivered quercetin exhibits enhanced efficacy in eliminating iron-overloaded senescent chondrocytes. 纳米颗粒递送的槲皮素在消除铁负荷过重的衰老软骨细胞方面表现出更强的功效。

Nanomedicine (London, England) Pub Date : 2024-09-04 DOI: 10.1080/17435889.2024.2393074

Asima Karim, Rizwan Qaisar, Savitha Suresh, Jayalakshmi Jagal, Mutasem Rawas-Qalaji

{"title":"Nanoparticle-delivered quercetin exhibits enhanced efficacy in eliminating iron-overloaded senescent chondrocytes.","authors":"Asima Karim, Rizwan Qaisar, Savitha Suresh, Jayalakshmi Jagal, Mutasem Rawas-Qalaji","doi":"10.1080/17435889.2024.2393074","DOIUrl":"https://doi.org/10.1080/17435889.2024.2393074","url":null,"abstract":"Aim: The therapeutic potential of senolytic drugs in osteoarthritis (OA) is poorly known. Quercetin, a senolytic agent exhibits promising potential to treat OA, having limited bioavailability. We investigated the effects of Quercetin-loaded nanoparticles (Q-NP) with enhanced bioavailability in human chondrocytes mimicking OA phenotype.Materials & methods: The C-20/A4 chondrocytes were exposed to ferric ammonium citrate to induce OA phenotype, followed by treatment with free Quercetin/Q-NP for 24 and 48-h. Q-NP were synthesized by nanoprecipitation method. Following treatment chondrocytes were assessed for drug cellular bioavailability, viability, cell cycle, apoptosis, oxidative stress and expression of key senescence markers.Results: Q-NP exhibited 120.1 ± 1.2 nm particle size, 81 ± 2.4% encapsulation efficiency, increased cellular bioavailability and selective apoptosis of senescent chondrocytes compared with free Quercetin. Q-NP treatment also induced oxidative stress and reduced the expressions of senescence markers, including TRB3, p16, p62 and p21 suggesting their ability to eliminate senescent cells. Last, Q-NP arrested the cell cycle in the sub-G0 phase, potentially creating a beneficial environment for tissue repair.Conclusion: Q-NP propose a promising delivery system for treating OA by eliminating senescent chondrocytes through apoptosis. Furthermore, their enhanced cellular bioavailability and capacity to modify cell cycle and senescent pathways warrant further investigations.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Amitriptyline nanoparticle repositioning prolongs the anti-allodynic effect of enhanced microglia targeting. 阿米替林纳米粒子重新定位可延长增强小胶质细胞靶向的抗心律失常作用。

Nanomedicine (London, England) Pub Date : 2024-09-04 DOI: 10.1080/17435889.2024.2390349

Song I Kim, Jiah Yang, Juhee Shin, Nara Shin, Hyo Jung Shin, Jiyong Lee, Chan Noh, Dong Woon Kim, Sun Yeul Lee

{"title":"Amitriptyline nanoparticle repositioning prolongs the anti-allodynic effect of enhanced microglia targeting.","authors":"Song I Kim, Jiah Yang, Juhee Shin, Nara Shin, Hyo Jung Shin, Jiyong Lee, Chan Noh, Dong Woon Kim, Sun Yeul Lee","doi":"10.1080/17435889.2024.2390349","DOIUrl":"https://doi.org/10.1080/17435889.2024.2390349","url":null,"abstract":"Aim: Amitriptyline (AMI) has been used to treat neuropathic pain. However, the clinical outcomes remain unsatisfactory, presumably due to a limited understanding of the underlying molecular mechanisms. Here, we investigated a drug repositioning strategy using a low-dose of AMI encapsulated in poly (D, L lactic-co-glycolic acid) (PLGA) nanoparticles (AMI NPs) for neuropathic pain, since PLGA nanoparticles are known to enhance delivery to microglia.Methods: We evaluated the anti-allodynic effects of AMI and AMI NPs on neuropathic pain by assessing behaviors and inflammatory responses in a rat model of spinal nerve ligation (SNL). While the anti-allodynic effect of AMI (30 μg) drug injection on SNL-induced neuropathic pain persisted for 12 h, AMI NPs significantly alleviated mechanical allodynia for 3 days.Results: Histological and cytokine analyses showed AMI NPs facilitated the reduction of microglial activation and pro-inflammatory mediators in the spinal dorsal horn. This study suggests that AMI NPs can provide a sustained anti-allodynic effect by enhancing the targeting of microglia and regulating the release of pro-inflammatory cytokines from activated microglia.Conclusion: Our findings suggest that the use of microglial-targeted NPs continuously releasing AMI (2 μg) as a drug repositioning strategy offers long-term anti-allodynic effects.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127492","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Membrane-camouflaged biomimetic nanoplatform with arsenic complex for synergistic reinforcement of liver cancer therapy. 含砷复合物的膜掩蔽生物仿生纳米平台，用于协同强化肝癌治疗。

Nanomedicine (London, England) Pub Date : 2024-09-04 DOI: 10.1080/17435889.2024.2393076

Shu Wang, Yupei Su, Jiayang Li, Tianyi Wang, Hao Pan, Weisan Pan

{"title":"Membrane-camouflaged biomimetic nanoplatform with arsenic complex for synergistic reinforcement of liver cancer therapy.","authors":"Shu Wang, Yupei Su, Jiayang Li, Tianyi Wang, Hao Pan, Weisan Pan","doi":"10.1080/17435889.2024.2393076","DOIUrl":"https://doi.org/10.1080/17435889.2024.2393076","url":null,"abstract":"Aim: Arsenic has excellent anti-advanced liver cancer effects through a variety of pathways, but its severe systemic toxicity forces the need for a safe and effective delivery strategy.Methods: Based on the chelating metal ion properties of polydopamine (PDA), arsenic was immobilized on an organic carrier, and a M1-like macrophage cell membrane (MM)-camouflaged manganese-arsenic complex mesoporous polydopamine (MnAsOx@MP@M) nanoplatform was successfully constructed. MnAsOx@MP@M was evaluated at the cellular level for tumor inhibition and tumor localization, and in vivo for its anti-liver cancer effect in a Hepa1-6 tumor-bearing mouse model.Results: The nanoplatform targeted the tumor site through the natural homing property of MM, completely degraded and released drugs to kill tumor cells in an acidic environment, while playing an immunomodulatory role in promoting tumor-associated macrophages (TAMs) repolarization.Conclusion: MnAsOx@MP@M has synergistically enhanced the targeted therapeutics against liver cancer via nanotechnology and immunotherapy, and it is expected to become a safe and multifunctional treatment platform in clinical oncology.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142127493","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

LC-MS/MS method for simultaneous Doxorubicin and Baicalein estimation: formulation and pharmacokinetic applications. LC-MS/MS 法同时测定多柔比星和黄芩苷：制剂和药代动力学应用

Nanomedicine (London, England) Pub Date : 2024-09-03 DOI: 10.1080/17435889.2024.2390348

Pooja Yadav, Sanjay Singh, Divya Chauhan, Pavan Kumar Yadav, Amrendra Kumar Tiwari, Naresh Kothuri, Sonia Verma, Jvus Chakradhar, Mitali Sethi, Jiaur R Gayen, Manish Kumar Chourasia

引用次数: 0

Photothermal therapy co-localized with CD137 agonism improves survival in an SM1 melanoma model without hepatotoxicity. 光热疗法与CD137激动剂共定位可提高SM1黑色素瘤模型的存活率，且无肝毒性。

Nanomedicine (London, England) Pub Date : 2024-09-03 DOI: 10.1080/17435889.2024.2389770

Jacob A Medina, Debbie K Ledezma, Joshua Ghofrani, Jie Chen, Samantha J Chin, Preethi Bala Balakrishnan, Norman H Lee, Elizabeth E Sweeney, Rohan Fernandes

{"title":"Photothermal therapy co-localized with CD137 agonism improves survival in an SM1 melanoma model without hepatotoxicity.","authors":"Jacob A Medina, Debbie K Ledezma, Joshua Ghofrani, Jie Chen, Samantha J Chin, Preethi Bala Balakrishnan, Norman H Lee, Elizabeth E Sweeney, Rohan Fernandes","doi":"10.1080/17435889.2024.2389770","DOIUrl":"https://doi.org/10.1080/17435889.2024.2389770","url":null,"abstract":"Aim: We investigate combining Prussian Blue nanoparticles (PBNPs), as photothermal therapy (PTT) agents, with agonistic CD137 antibodies (αCD137) on a single nanoparticle platform to deliver non-toxic, anti-tumor efficacy in SM1 murine melanoma.Methods: We electrostatically coated PBNPs with αCD137 (αCD137-PBNPs) and quantified their physicochemical characteristics, photothermal and co-stimulatory capabilities. Next, we tested the efficacy and hepatotoxicity of PTT using αCD137-PBNPs (αCD137-PBNP-PTT) in SM1 tumor-bearing mice.Results: The αCD137-PBNPs retained both the photothermal and agonistic properties of the PBNPs and αCD137, respectively. In vivo, SM1 tumor-bearing mice treated with αCD137-PBNP-PTT exhibited a significantly higher survival rate (50%) without hepatotoxicity, compared with control treatments.Conclusion: These data suggest the potential utility of co-localizing PBNP-PTT with αCD137-based agonism as a novel combination nanomedicine.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121285","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Novel Tubeimoside I liposomal drug delivery system in combination with gemcitabine for the treatment of pancreatic cancer. 新型 Tubeimoside I 脂质体给药系统与吉西他滨联合治疗胰腺癌。

Nanomedicine (London, England) Pub Date : 2024-09-03 DOI: 10.1080/17435889.2024.2382076

Shuhui Li, Yuansheng Liu, Xiaojun Sui, Yuzhen Zhuo, He Siqi, Zhang Sijia, Zhang Hui, Li Dihua, Zhang Dapeng, Yang Lei

引用次数: 0

A drug delivery system of HIF-1α siRNA nanoparticles loaded by mesenchymal stem cells on choroidal neovascularization. 间充质干细胞负载的 HIF-1α siRNA 纳米颗粒给药系统对脉络膜新生血管的影响。

Nanomedicine (London, England) Pub Date : 2024-09-03 DOI: 10.1080/17435889.2024.2393075

Lei Zhang, Qiang Wei, Li Mu-Qiong, Wang Si-Jia, Jia Wei, Wang Ru, Bai Shu-Wei, Wang Qian-Feng, Wang Hai-Yan

引用次数: 0

Mapping global research landscape and trend of nano-drug delivery system for urological cancers: a bibliometric analysis. 绘制泌尿系统癌症纳米给药系统的全球研究格局和趋势图：文献计量分析。

Nanomedicine (London, England) Pub Date : 2024-09-03 DOI: 10.1080/17435889.2024.2391267

Yibo Shi, Zean Fu, Xinyi Yu, Yuanfeng Zhang, Guangrui Fan, Zhiping Wang

{"title":"Mapping global research landscape and trend of nano-drug delivery system for urological cancers: a bibliometric analysis.","authors":"Yibo Shi, Zean Fu, Xinyi Yu, Yuanfeng Zhang, Guangrui Fan, Zhiping Wang","doi":"10.1080/17435889.2024.2391267","DOIUrl":"https://doi.org/10.1080/17435889.2024.2391267","url":null,"abstract":"Aim: We conducted a bibliometric analysis to quantitatively study the development pathway, research hotspots and evolutionary trends of nano-drug delivery systems (NDDS) in treating urological tumors.Materials & methods: We used the Web of Science Core Collection to retrieve the literature related to NDDS in the urological tumors up to November 1, 2023. Bibliometric analysis and visualization were conducted using CiteSpace, VOSviewer and R-Bibliometrix. The major aspects of analysis included contributions from different countries/regions, authors' contributions, keywords identification, citation frequencies and overall research trends.Results: We included 3,220 articles. The analysis of annual publication trends revealed significant growth in this field since 2010, which has continued to the present day. The United States and China have far exceeded other countries/regions in the publication volume of papers in this field. The progression of the shell structure of NDDS in the urinary system has gradually transitioned from non-biological materials to biocompatible materials and ultimately to completely biocompatible materials. Mucoadhesive NDDS for intravesical drug delivery is a hotspot and a potential research material for bladder cancer.Conclusion: The field of NDDS in urological tumors has emerged as a research hotspot. Future research should focus on synergistic effects of NDDS with other treatment modalities.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-09-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142121283","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipopolysaccharide targeting-peptide-capped chitosan gold nanoparticles for laser-induced antibacterial activity. 用于激光诱导抗菌活性的脂多糖靶向肽帽壳聚糖金纳米粒子。

Nanomedicine (London, England) Pub Date : 2024-09-03 DOI: 10.1080/17435889.2024.2382073

Samraggi Choudhury, Aakrati Mehra, Swapnil Srivastava, Manju Sharma, Manish Singh, Jiban Jyoti Panda

引用次数: 0

Collagen-hydroxyapatite based scaffolds for bone trauma and regeneration: recent trends and future perspectives. 用于骨创伤和骨再生的胶原羟磷灰石基支架：最新趋势和未来展望。

Nanomedicine (London, England) Pub Date : 2024-08-20 DOI: 10.1080/17435889.2024.2375958

Dong Han, Weijiao Wang, Jinpeng Gong, Yupeng Ma, Yu Li

引用次数: 0