Nanomedicine (London, England)最新文献

Diethyldithiocarbamate-Cu₄O₃ nanocomplex induced mitochondrial and telomerase dysfunction in non-small cell lung cancer. 二乙基二硫代氨基甲酸盐- cu4o3纳米复合物诱导非小细胞肺癌线粒体和端粒酶功能障碍。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI: 10.1080/17435889.2025.2502321

Marwa M Abu-Serie, María A Blasco

{"title":"Diethyldithiocarbamate-Cu4O3 nanocomplex induced mitochondrial and telomerase dysfunction in non-small cell lung cancer.","authors":"Marwa M Abu-Serie, María A Blasco","doi":"10.1080/17435889.2025.2502321","DOIUrl":"10.1080/17435889.2025.2502321","url":null,"abstract":"Background: Targeting cancer stem cells (CSCs)-mediated aggressive features of non-small cell lung cancer (NSCLC) is a promising anticancer approach. This can be accomplished via suppressing critical mediators, such as functional mitochondria, aldehyde dehydrogenase (ALDH)1A, and telomere protectors (telomerase reverse transcriptase (TERT) and telomere repeat binding factor (TRF)1).Materials & methods: Copper nanocomplexes (diethyldithiocarbamate (DE)-Cu4O3 nanoparticles (NPs) and DE-Cu NPs) were prepared using the simplest green chemistry method and assessed for inducing mitochondrial dysfunction-dependent non-apoptotic pathway (cuproptosis) and repressing CSC markers.Results: DE-Cu4O3 NPs had higher growth inhibition for NSCLC (A549, H520, and H1299) spheroids than DE-Cu NPs. DE-Cu4O3 NPs had higher uptake rate and prooxidant effect resulting in lower mitochondrial membrane potential and mitochondrial DNA copy number, as well as stronger inhibition of telomerase and ALDH1A than DE-Cu NPs. This caused dramatic redox imbalance and lowering AKT pathway (activator of telomere stabilizers and stemness)-mediated repression of TERT and TRF1 protein levels as well as phosphorylated NF-κB subunit (p65) led to collapsing telomeres, as evidenced by downregulating TERT regulators and confocal microscopy. In animal study, this active nanocomplex revealed powerful and selective therapeutic tumor-targeting effects, with no evidence of toxicity to healthy tissues.Conclusion: DE-Cu4O3 nanocomplex is deemed as promising nanomedicine for NSCLC.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1267-1280"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges. 用于癌症治疗的核酸纳米生物系统：新兴趋势和挑战的概述。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2501919

Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito

{"title":"Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges.","authors":"Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito","doi":"10.1080/17435889.2025.2501919","DOIUrl":"10.1080/17435889.2025.2501919","url":null,"abstract":"Different cancers remain major global health challenges due to their diverse biological behaviors and significant treatment hurdles. The aging of populations and lifestyle factors increase cancer occurrence and place increasing pressure on healthcare systems. Despite continuous advancements, many cancers remain fatal due to late-stage diagnosis, tumor heterogeneity, and drug resistance, thus necessitating urgent development of innovative treatment solutions. Therapeutic nucleic acids, a new class of biological drugs, offer a promising approach to overcoming these challenges. The recent Nucleic Acids and Nanobiosystems in Cancer Theranostics (NANCT) conference brought together internationally recognized experts from 15 countries to discuss cutting-edge research, spanning from oncolytic viruses to anticancer RNA nanoparticles and other emerging nanotechnologies. This review captures key insights and developments, emphasizing the need for interdisciplinary translation of scientific advancements into clinical practice and shaping the future of personalized cancer treatments for improved therapeutic outcomes.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1281-1298"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiotechnologies for stroke treatment. 纳米生物技术用于中风治疗。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2501514

Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

引用次数: 0

Designing nanoparticles to minimize unintended inflammatory responses: a step toward safer and more effective precision nanomedicine. 设计纳米粒子以减少意外的炎症反应：迈向更安全、更有效的精密纳米医学的一步。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-03-11 DOI: 10.1080/17435889.2025.2476377

Feng Yuan, Zhong-Da Li, Qi Li, Yanqiao Zeng, Guofang Zhang, Yang Li

引用次数: 0

Drug-loaded nanoparticles induce immunogenic cell death and efficiently target cells from glioblastoma patients. 载药纳米颗粒诱导免疫原性细胞死亡并有效靶向胶质母细胞瘤患者的细胞。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2497747

Ada Tushe, Elena Marinelli, Beatrice Musca, Annavera Ventura, Sara Zumerle, Olga Slukinova, Giulia Zampardi, Francesco Volpin, Camilla Bonaudo, Alessandro Della Puppa, Mathieu Repellin, Giulia Guerriero, Giovanna Lollo, Susanna Mandruzzato

{"title":"Drug-loaded nanoparticles induce immunogenic cell death and efficiently target cells from glioblastoma patients.","authors":"Ada Tushe, Elena Marinelli, Beatrice Musca, Annavera Ventura, Sara Zumerle, Olga Slukinova, Giulia Zampardi, Francesco Volpin, Camilla Bonaudo, Alessandro Della Puppa, Mathieu Repellin, Giulia Guerriero, Giovanna Lollo, Susanna Mandruzzato","doi":"10.1080/17435889.2025.2497747","DOIUrl":"10.1080/17435889.2025.2497747","url":null,"abstract":"Aim: Glioblastoma multiforme (GBM) is characterized by a highly immunosuppressive tumor microenvironment (TME), posing significant challenges for efficient therapy's outcomes. Nanomedicine combined with immunotherapy holds the potential to modulate the TME and reactivate immune responses. This study proposes a polymeric nanosystem (NPs) encapsulating diaminocyclohexane-platinum II (DACHPt), an oxaliplatin derivative, to induce immunogenic cell death (ICD) in GBM cells.Materials & methods: An ionic-gelation technique was employed to generate polymeric nanoparticles (NPs) with an approximate size of 200 nm. NPs internalization was analyzed in GBM cell lines, in vitro-derived macrophages, and in leukocytes and tumor cells from GBM patient via flow cytometry and confocal imaging. ICD was assessed by measuring two of its main markers: adenosine triphosphate (ATP) and high-mobility group box 1 (HMGB1).Results: NPs were efficiently incorporated by myeloid and tumor cells, but not by lymphocytes. DACHPt-loaded NPs demonstrated enhanced cytotoxicity compared to free drug, with increased ATP and HMGB1 release from GBM cells, confirming ICD induction.Conclusions: Our findings suggest that DACHPt-loaded NPs represent a promising therapeutic strategy capable of targeting both tumor cells and tumor-promoting immune cells while inducing ICD.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1223-1234"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058141","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of single-walled carbon nanotube-based therapeutic platforms targeting astrocytes. 靶向星形胶质细胞的单壁碳纳米管治疗平台的潜力。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-03-10 DOI: 10.1080/17435889.2025.2476376

Kristina Pilipović, Vladimir Parpura

引用次数: 0

Recent advances in smart gold nanoparticles for photothermal therapy. 光热治疗用智能金纳米颗粒的研究进展。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2500912

André F Moreira, Hugo A L Filipe, Sónia P Miguel, Maximiano J Ribeiro, Paula Coutinho

{"title":"Recent advances in smart gold nanoparticles for photothermal therapy.","authors":"André F Moreira, Hugo A L Filipe, Sónia P Miguel, Maximiano J Ribeiro, Paula Coutinho","doi":"10.1080/17435889.2025.2500912","DOIUrl":"10.1080/17435889.2025.2500912","url":null,"abstract":"Gold nanoparticles (AuNPs) possess unique properties, including low toxicity and excellent optical characteristics, making them highly appealing for biomedical applications. The plasmonic photothermal effect of AuNPs has been explored to trigger localized hyperthermia. Four commonly explored gold nanoparticles (spheres, rods, stars, and cages) are produced and optimized to present the localized surface plasmon resonance effect in the near-infrared region, exploiting the increased penetration in the human body. Additionally, the production of hybrid AuNPs, combining them with other materials, such as silica, graphene, zinc oxide, polymers, and small molecules has been explored to amplify the photothermal effect (T ≥ 45ºC). This review provides an overview of AuNPs' application in photothermal therapy, describing the general synthesis processes and the main particle parameters that affect their application in photothermal therapy, including the hybrid nanomaterials. Associated with this rapid progress, surface functionalization can also improve colloidal stability, safety, and therapeutic outcomes. In this regard, we also highlight the emerging trend of applying cell-derived vesicles as biomimetic coatings, capable of evading immune recognition, increasing blood circulation, and targeting specific tissues. In addition, the challenges and future developments of AuNPs for accelerating the clinical translations are discussed in light of their therapeutic and theragnostic potential.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1339-1353"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999868","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could selection of biomolecular corona constituents through nanoparticle design produce more effective localized therapies? 通过纳米颗粒设计选择生物分子电晕成分能否产生更有效的局部治疗？

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-03-15 DOI: 10.1080/17435889.2025.2480048

Antonietta Greco, Claudia Corbo

引用次数: 0

Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method. 用乳液溶剂扩散法制备、表征和对接负载速尿纳米海绵的研究。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1080/17435889.2025.2501518

Rabia Liaqat, Fatima Rasool, Sobia Noreen, Nadia Rai, Ayesha Naseem, Muhammad Hamza Shoaib, Hassan Mahmood, Muhammad Azeem Ashraf

{"title":"Fabrication, characterization, and docking studies of furosemide-loaded nanosponges using the emulsion solvent diffusion method.","authors":"Rabia Liaqat, Fatima Rasool, Sobia Noreen, Nadia Rai, Ayesha Naseem, Muhammad Hamza Shoaib, Hassan Mahmood, Muhammad Azeem Ashraf","doi":"10.1080/17435889.2025.2501518","DOIUrl":"10.1080/17435889.2025.2501518","url":null,"abstract":"Aims: This study aimed to fabricate, characterize, and perform molecular docking of furosemide-loaded nanosponges (NSs) using the emulsion solvent diffusion method.Material and methods: Sustained-release NS formulations of furosemide were developed using ethylcellulose, polyvinyl alcohol (PVA), and dichloromethane (DCM) via the emulsion solvent diffusion technique. The formulations were evaluated for production yield, actual drug content, entrapment efficiency, drug-polymer compatibility, surface morphology, docking study, and in vitro drug release.Results: SEM images displayed the nanosized, spherical, porous, and spongy texture of furosemide NS. Fourier-transform infrared spectroscopy (FTIR) spectra showed no drug-polymer incompatibility. Powder X-ray diffraction (PXRD) analysis indicated an amorphous state of furosemide, while differential scanning calorimetry (DSC) suggested drug-polymer complexation. In vitro studies demonstrated sustained drug release for up to 10 h. Molecular docking supported stable interactions between furosemide and polymers. Molecular dynamics (MD) simulations further revealed adequate hydrogen bonding and diffusion behavior, confirming polymer composition-dependent release and structural stability.Conclusion: These findings indicate that furosemide-loaded NSs are a promising sustained-release delivery system capable of reducing dosing frequency and enhancing patient compliance.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1235-1247"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144058353","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Immunomodulatory nanoplatforms with multiple mechanisms of action in cancer treatment. 在癌症治疗中具有多种作用机制的免疫调节纳米平台。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1080/17435889.2025.2500906

Rodolfo Villa, Ya-Ping Shiau, Sohaib Mahri, Kelsey Jane Racacho, Menghuan Tang, Qiufang Zong, Donovan Ruiz, Judy Kim, Yuanpei Li

{"title":"Immunomodulatory nanoplatforms with multiple mechanisms of action in cancer treatment.","authors":"Rodolfo Villa, Ya-Ping Shiau, Sohaib Mahri, Kelsey Jane Racacho, Menghuan Tang, Qiufang Zong, Donovan Ruiz, Judy Kim, Yuanpei Li","doi":"10.1080/17435889.2025.2500906","DOIUrl":"10.1080/17435889.2025.2500906","url":null,"abstract":"Cancer immunotherapies have transformed oncology by utilizing the immune system to target malignancies; however, limitations in efficacy and potential side effects remain significant challenges. Nanoparticles have shown promise in enhancing drug delivery and improving immune activation, with the potential for numerous modifications to tailor them for specific environments or targets. Integrating nanoplatforms offers a promising avenue to overcome these hurdles, enhancing treatment outcomes and reducing adverse effects. By improving drug delivery, targeting, and immune modulation, nanoplatforms can unlock the full potential of cancer immunotherapy. This review explores the role of nanoplatforms in addressing these limitations and enhancing cancer immunotherapy outcomes, examining various types of nanoplatforms. Understanding the mechanisms of immunomodulation through nanoplatform deliveries is crucial. We discuss how these nanoplatforms interact with the tumor microenvironment, modulate tumor-associated macrophages and regulatory T cells, activate immune cells directly, enhance antigen presentation, and promote immunological memory. Further benefits include combination approaches integrating nanoplatforms with chemotherapy, radiotherapy, and phototherapy. Immunotherapy is a relatively new approach, but numerous clinical studies already utilize nanoplatform-based immunotherapies with promising results. This review aims to provide insights into the potential of nanoplatforms to enhance cancer immunotherapy and pave the way for more effective and personalized treatment strategies.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1321-1338"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144063429","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0