Nanomedicine (London, England)最新文献

Nanomaterials for bacterial enrichment and detection in healthcare.

Nanomedicine (London, England) Pub Date : 2025-04-09 DOI: 10.1080/17435889.2025.2488724

Marwa Elhariry, Alina Oknianska, Jorge Garcia-Lara, Robert Shorten, Boris Oberheitmann, Tapas Sen

{"title":"Nanomaterials for bacterial enrichment and detection in healthcare.","authors":"Marwa Elhariry, Alina Oknianska, Jorge Garcia-Lara, Robert Shorten, Boris Oberheitmann, Tapas Sen","doi":"10.1080/17435889.2025.2488724","DOIUrl":"https://doi.org/10.1080/17435889.2025.2488724","url":null,"abstract":"Bacterial infections in the blood (sepsis) have been recognized as a leading cause of mortality in the clinical field due to limitations in the detection of bacteria at low concentration and their resistance to antibiotics by excessive misuse. Some of the common symptoms are fever, chills, rapid heartbeat, difficulty breathing, confusion, and changes in mental status with occasionally pale, clammy, and mottled skin. Early diagnosis and identification are the keys to a successful treatment for sepsis patients. Researchers have developed nanoparticles to enrich bacterial populations followed by detection and applied them to conventional methods such as phenotypic and molecular diagnostics to enhance different detectors' responses toward pathogens. This short review systematically overviews steps that are followed in clinical labs for bacterial detection, identification, and their drawbacks. In this context, we discuss the role that nanoparticles can play in overcoming the limits of traditional microbiology methods in terms of turnaround times (TATs) and accuracy. We believe that this short review will provide up-to-date information about the applications of nanoparticles in the enrichment, separation, and identification of bacterial infection in the clinical field and, therefore, a way of rapid treatment.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-16"},"PeriodicalIF":0.0,"publicationDate":"2025-04-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143812963","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Designing nanoparticle-based bioaffinity assays for the detection of extracellular vesicles.

Nanomedicine (London, England) Pub Date : 2025-04-09 DOI: 10.1080/17435889.2025.2488726

Md Khirul Islam, Imran Mahmud, Janne Leivo

引用次数: 0

Synergistic RNA particles for spontaneous and specific cancer targeting but low toxicity due to motility and deformation.

Nanomedicine (London, England) Pub Date : 2025-04-08 DOI: 10.1080/17435889.2025.2488727

Daniel W Binzel, Peixuan Guo

引用次数: 0

Recent strategies for enhanced delivery of mRNA to the lungs.

Nanomedicine (London, England) Pub Date : 2025-04-07 DOI: 10.1080/17435889.2025.2485669

Brittany J Heiser, Arian Veyssi, Debadyuti Ghosh

{"title":"Recent strategies for enhanced delivery of mRNA to the lungs.","authors":"Brittany J Heiser, Arian Veyssi, Debadyuti Ghosh","doi":"10.1080/17435889.2025.2485669","DOIUrl":"https://doi.org/10.1080/17435889.2025.2485669","url":null,"abstract":"mRNA-based therapies have emerged as a transformative tool in modern medicine, gaining significant attention following their successful use in COVID-19 vaccines. Delivery to the lungs offers several compelling advantages for mRNA delivery. The lungs are one of the most vascularized organs in the body, which provides an extensive surface area that can facilitate efficient drug transport. Local delivery to the lungs bypasses gastrointestinal degradation, potentially enhancing therapeutic efficacy. In addition, the extensive capillary network of the lungs provides an ideal target for systemic delivery. However, developing effective mRNA therapies for the lungs presents significant challenges. The complex anatomy of the lungs and the body's immune response to foreign particles create barriers to delivery. This review discusses key approaches for overcoming these challenges and improving mRNA delivery to the lungs. It examines both local and systemic delivery strategies aimed at improving lung delivery while mitigating off-target effects. Although substantial progress has been made in lung-targeted mRNA therapies, challenges remain in optimizing cellular uptake and achieving therapeutic efficacy within pulmonary tissues. The continued refinement of delivery strategies that enhance lung-specific targeting while minimizing degradation is critical for the clinical success of mRNA-based pulmonary therapies.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-27"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797356","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer.

Nanomedicine (London, England) Pub Date : 2025-04-07 DOI: 10.1080/17435889.2025.2489918

Kapil Dangi, Vijay Kumar, Disha Mittal, Pooja Yadav, Mansi Malik, Anita Kamra Verma

{"title":"Nanotherapeutics induced redox resetting of oxidative and nitrosative stress: targeting glutathione-depletion in cancer.","authors":"Kapil Dangi, Vijay Kumar, Disha Mittal, Pooja Yadav, Mansi Malik, Anita Kamra Verma","doi":"10.1080/17435889.2025.2489918","DOIUrl":"https://doi.org/10.1080/17435889.2025.2489918","url":null,"abstract":"Cancer cells display a distinctive defense mechanism against any exogenous moieties that renders all treatments inefficient. Glutathione, a thiol tripeptide plays a paradoxical role in cancer as intracellular glutathione (GSH) are voracious scavengers of free radicals produced by chemotherapy, generation of reactive oxygen species (ROS) and reactive nitrogen species (RNS). Cancer cells show Warburg effect, wherein the intracellular GSH levels are exceptionally enhanced to overcome the oxidative stress created by ROS/RNS production or by the other free radicals generated as side products of intracellular redox reactions. Therefore, redox resetting is essential to maintain the redox homeostasis for cell survival and their proliferation and trigger escalation of GSH levels. Nanotherapeutics have facilitated the targeted delivery of GSH-depleting agents in combination with radiotherapy, chemotherapy, and novel therapeutic interventions including chemodynamic therapy (CDT), photodynamic therapy (PDT), ferroptosis induction, sonodynamic therapy (SDT), and immunotherapy are being explored. This review aims to compile the strategic role of GSH in cancer cells, the importance of nanotherapeutics for GSH depletion in cancer to target numerous forms of programmed cell death (PCD), including apoptosis, ferroptosis, necroptosis, and autophagy.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-11"},"PeriodicalIF":0.0,"publicationDate":"2025-04-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143797344","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancing tendon healing through nanoparticle-based drug delivery systems. 通过纳米颗粒给药系统促进肌腱愈合。

Nanomedicine (London, England) Pub Date : 2025-04-06 DOI: 10.1080/17435889.2025.2488725

Emmanuela Adjei-Sowah, Sarea Y Recalde Phillips, Alayna E Loiselle, Danielle S W Benoit

引用次数: 0

Advances in cancer nanovaccines: a focus on colorectal cancer.

Nanomedicine (London, England) Pub Date : 2025-04-05 DOI: 10.1080/17435889.2025.2486930

Yalda Ghazizadeh, Hossein Salehi Shadkami, Fatemeh Madani, Sedigheh Niknam, Mahdi Adabi

引用次数: 0

PLGA nanoparticle-mediated anti-inflammatory gene delivery for the treatment of neuropathic pain.

Nanomedicine (London, England) Pub Date : 2025-04-05 DOI: 10.1080/17435889.2025.2487410

Boomin Choi, Subeen Lee, Seohyun Chung, Ellane Eda Barcelona, Jinpyo Hong, Sung Joong Lee

{"title":"PLGA nanoparticle-mediated anti-inflammatory gene delivery for the treatment of neuropathic pain.","authors":"Boomin Choi, Subeen Lee, Seohyun Chung, Ellane Eda Barcelona, Jinpyo Hong, Sung Joong Lee","doi":"10.1080/17435889.2025.2487410","DOIUrl":"https://doi.org/10.1080/17435889.2025.2487410","url":null,"abstract":"Aim: This study aimed to mitigate neuropathic pain behavior in a sciatic nerve transection (SNT)-induced mouse model by delivering anti-inflammatory cytokines - interleukin-4 (IL-4), interleukin-10 (IL-10), and transforming growth factor-beta 1 (TGF-β1) - via poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs).Materials & methods: Upon gene delivery of IL-4, IL-10, and TGF- β1, the anti-inflammatory effects and induction of microglia M2 polarization were evaluated. Plasmid (IL-4, IL-10, and TGF-β1)-encapsulated PLGA NPs (PLGA@IL-4, PLGA@IL-10, and PLGA@TGF-β1) were synthesized and characterized for size, zeta potential, cellular toxicity, and cellular uptake. The analgesic effect of anti-inflammatory gene delivery using PLGA NPs was then assessed in a mouse model of neuropathic pain.Results: Gene delivery of IL-4, IL-10, and TGF-β1 showed a significant anti-inflammatory effect in LPS-treated cells and IL-4 strongly promoted microglia M2 polarization in vitro. PLGA NPs successfully delivered the anti-inflammatory cytokine-coding genes into mouse spinal cord cells, specifically targeting microglia. PLGA@IL-4, PLGA@IL-10, and PLGA@TGF-β1 NPs produced analgesic effects in a SNT-induced mouse neuropathic pain model. Notably, PLGA@IL-4 demonstrated the most effective and remarkably long-lasting analgesic effect, strongly enhancing microglia M2 polarization in spinal cord microglia.Conclusion: Gene therapy using PLGA NPs for overexpression of anti-inflammatory cytokines could be a promising strategy for the treatment of neuropathic pain.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-12"},"PeriodicalIF":0.0,"publicationDate":"2025-04-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143789509","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Statement of Retraction: Tetraiodothyroacetic acid-conjugated PLGA nanoparticles: a nanomedicine approach to treat drug-resistant breast cancer.

Nanomedicine (London, England) Pub Date : 2025-04-03 DOI: 10.1080/17435889.2025.2488633

引用次数: 0

Nanomaterial-based approaches to neurotoxin neutralization in neurodegenerative diseases.

Nanomedicine (London, England) Pub Date : 2025-04-03 DOI: 10.1080/17435889.2025.2487409

Meng Cheng, Yan Dou

{"title":"Nanomaterial-based approaches to neurotoxin neutralization in neurodegenerative diseases.","authors":"Meng Cheng, Yan Dou","doi":"10.1080/17435889.2025.2487409","DOIUrl":"https://doi.org/10.1080/17435889.2025.2487409","url":null,"abstract":"Neurodegenerative diseases (NDs) are intricately linked to the accumulation of various neurotoxins, mainly including toxic proteins, inflammatory mediators, excess metal ions, and viral pathogens. Biological neutralization strategies that use agents to competitively bind harmful substances and thus inhibit their pathogenic activity hold promise for direct removal of neurotoxins but face many limitations and challenges in NDs. Nanomaterials provide a potential solution for neurotoxin neutralization in NDs due to their unique physicochemical and biological properties. This review summarizes recent advancements in nanomaterial-based approaches to neurotoxin neutralization in NDs, highlighting the diverse design principles and mechanisms of action. We also discuss the critical role of targeted delivery to optimize neutralization efficiency and the advantages of combining different neutralization mechanisms or introducing other therapeutic components to exert the synergistic effects. Furthermore, we reveal current limitations and future research directions aimed at paving the way for nanomedicine development based on neurotoxin neutralization for the treatment of NDs.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-04-03","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143782076","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0