Nanomedicine (London, England)最新文献

An uphill path to commercialization of silver nanoparticle antimicrobials: from bench to market. 银纳米颗粒抗菌剂商业化的艰难之路：从实验到市场。

Nanomedicine (London, England) Pub Date : 2025-06-19 DOI: 10.1080/17435889.2025.2518914

Sanil Nadar, Anan Safwat, Nan Qin, Daniel M Czyż

引用次数: 0

Cancer therapy with engineered nanozymes: from molecular design to tumour-responsive catalysis. 用工程纳米酶治疗癌症：从分子设计到肿瘤反应性催化。

Nanomedicine (London, England) Pub Date : 2025-06-18 DOI: 10.1080/17435889.2025.2520736

Austine Ofondu Chinomso Iroegbu, Moipone Linda Teffo, Emmanuel Rotimi Sadiku

{"title":"Cancer therapy with engineered nanozymes: from molecular design to tumour-responsive catalysis.","authors":"Austine Ofondu Chinomso Iroegbu, Moipone Linda Teffo, Emmanuel Rotimi Sadiku","doi":"10.1080/17435889.2025.2520736","DOIUrl":"10.1080/17435889.2025.2520736","url":null,"abstract":"Nanozymes, engineered nanomaterials that mimic natural enzyme activity, have emerged as powerful tools in precision cancer therapy due to their ability to generate reactive oxygen species (ROS), modulate the tumor microenvironment (TME), and facilitate cascade catalytic reactions. This review presents a comprehensive evaluation of recent innovations in nanozyme structural engineering aimed at improving catalytic performance, substrate specificity, and biocompatibility. Key design strategies, including dimensional tailoring, valence state tuning, and surface functionalisation, are discussed in the context of tumor-targeted therapies. Special focus is given to multifunctional and stimuli-responsive nanozymes that adapt to TME conditions or external triggers like light and pH. Despite significant progress, barriers such as biosafety, delivery efficiency, and lack of standardized catalytic performance metrics remain. This review critically addresses these challenges and highlights state-of-the-art nanozyme platforms, such as single-atom catalysts and cascade systems, which are leading the field toward clinical translation. Finally, it proposes strategic directions to bridge current knowledge gaps and advance nanozymes from bench to bedside, positioning them as next-generation catalytic platforms for personalized oncology.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144328013","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Applications of virus-like particles in the prevention of protozoan parasite infection. 病毒样颗粒在预防原生动物寄生虫感染中的应用。

Nanomedicine (London, England) Pub Date : 2025-06-18 DOI: 10.1080/17435889.2025.2518915

Ki Back Chu, Fu-Shi Quan

{"title":"Applications of virus-like particles in the prevention of protozoan parasite infection.","authors":"Ki Back Chu, Fu-Shi Quan","doi":"10.1080/17435889.2025.2518915","DOIUrl":"https://doi.org/10.1080/17435889.2025.2518915","url":null,"abstract":"Vaccination is widely regarded as the most effective control measure for disease prevention, as demonstrated by its success against numerous infectious diseases. However, the development of vaccines to prevent parasitic diseases in humans remains a significant challenge. Despite decades of effort, malaria continues to remain as the leading cause of death among parasitic diseases in tropical regions, while chronic infections caused by Leishmania spp. Toxoplasma gondii, and Trypanosoma spp. persist in causing severe morbidity and economic loss. As climate change increasingly facilitates the spread of arthropod vectors that transmit these diseases into temperate regions, the need for effective vaccines against parasitic infections has never been greater. Virus-like particle (VLP) vaccines targeting infections caused by the protozoan parasites T. gondii, Plasmodium spp. and Leishmania spp. have the potential to make a significant contribution to public health. In this review, we summarize recent advances in VLP-based vaccines targeting these globally important protozoan parasites and discuss key challenges impeding their development.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-06-18","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144318893","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Rewiring cell identity in vivo: the emerging role of extracellular vesicles. 体内细胞身份重组：细胞外囊泡的新作用。

Nanomedicine (London, England) Pub Date : 2025-06-17 DOI: 10.1080/17435889.2025.2520151

Ana I Salazar Puerta, Daniel Gallego-Perez

引用次数: 0

Up to date production and utilization of plant and animal extracellular vesicles for therapeutic purposes. 动植物治疗用细胞外囊泡的生产和利用进展。

Nanomedicine (London, England) Pub Date : 2025-06-09 DOI: 10.1080/17435889.2025.2511467

Olga Janouskova, Michaela Kocholata

引用次数: 0

Can automated gold nanoparticle synthesis drive the next wave of biomedical innovation? 自动化的金纳米粒子合成能推动下一波生物医学创新吗？

Nanomedicine (London, England) Pub Date : 2025-06-05 DOI: 10.1080/17435889.2025.2514424

Masoud Negahdary, Ngoc Nhu Vu, Samuel Mabbott

引用次数: 0

Multifunctional nanozymes based on MoS₂ for synergistic catalytic activity and cancer photothermal therapy. 基于MoS 2的多功能纳米酶的协同催化活性和癌症光热治疗。

Nanomedicine (London, England) Pub Date : 2025-06-04 DOI: 10.1080/17435889.2025.2510891

Nishakavya Saravanan, Sakshi Bajhal, Johnson Thinakaran, Anandhakumar Sundaramurthy

{"title":"Multifunctional nanozymes based on MoS₂ for synergistic catalytic activity and cancer photothermal therapy.","authors":"Nishakavya Saravanan, Sakshi Bajhal, Johnson Thinakaran, Anandhakumar Sundaramurthy","doi":"10.1080/17435889.2025.2510891","DOIUrl":"https://doi.org/10.1080/17435889.2025.2510891","url":null,"abstract":"In recent years, molybdenum disulfide (MoS₂)-based nanozymes have demonstrated significant potential for enhancing the efficacy of photothermal therapy (PTT) in the treatment of cancer. The unique properties of two-dimensional MoS₂ such as high surface area, good biocompatibility, high photothermal conversion efficiency in the near-infrared region, catalytic activity and ability to modify their surfaces for targeted cancer therapy make them an ideal candidate for PTT-based combination therapies. MoS₂-based nanomaterials also function as nanozymes and exhibit peroxidase and Fenton-like catalytic activity within tumor cells while displaying superoxide dismutase-like activity in normal cells. Additionally, their intrinsic catalytic properties facilitate the generation of reactive oxygen species and enhance the anticancer efficacy. Hence, this review provides an in-depth examination of the structural properties, surface modifications, and atomic defects in MoS₂ nanozymes, highlighting strategies to optimize their photothermal efficiency and biocompatibility. We also explore the mechanisms of action, therapeutic outcomes, and the challenges associated with MoS₂-based nanozymes. The synergistic action of nanozymes supports their use in cancer PTT while preventing bacterial infections, highlighting the potential of MoS₂ as a multifunctional therapeutic agent. Finally, the review outlines future directions and the potential for integrating MoS₂ nanozymes into synergistic cancer treatments.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-15"},"PeriodicalIF":0.0,"publicationDate":"2025-06-04","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144217733","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Diethyldithiocarbamate-Cu₄O₃ nanocomplex induced mitochondrial and telomerase dysfunction in non-small cell lung cancer. 二乙基二硫代氨基甲酸盐- cu4o3纳米复合物诱导非小细胞肺癌线粒体和端粒酶功能障碍。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-16 DOI: 10.1080/17435889.2025.2502321

Marwa M Abu-Serie, María A Blasco

{"title":"Diethyldithiocarbamate-Cu4O3 nanocomplex induced mitochondrial and telomerase dysfunction in non-small cell lung cancer.","authors":"Marwa M Abu-Serie, María A Blasco","doi":"10.1080/17435889.2025.2502321","DOIUrl":"10.1080/17435889.2025.2502321","url":null,"abstract":"Background: Targeting cancer stem cells (CSCs)-mediated aggressive features of non-small cell lung cancer (NSCLC) is a promising anticancer approach. This can be accomplished via suppressing critical mediators, such as functional mitochondria, aldehyde dehydrogenase (ALDH)1A, and telomere protectors (telomerase reverse transcriptase (TERT) and telomere repeat binding factor (TRF)1).Materials & methods: Copper nanocomplexes (diethyldithiocarbamate (DE)-Cu4O3 nanoparticles (NPs) and DE-Cu NPs) were prepared using the simplest green chemistry method and assessed for inducing mitochondrial dysfunction-dependent non-apoptotic pathway (cuproptosis) and repressing CSC markers.Results: DE-Cu4O3 NPs had higher growth inhibition for NSCLC (A549, H520, and H1299) spheroids than DE-Cu NPs. DE-Cu4O3 NPs had higher uptake rate and prooxidant effect resulting in lower mitochondrial membrane potential and mitochondrial DNA copy number, as well as stronger inhibition of telomerase and ALDH1A than DE-Cu NPs. This caused dramatic redox imbalance and lowering AKT pathway (activator of telomere stabilizers and stemness)-mediated repression of TERT and TRF1 protein levels as well as phosphorylated NF-κB subunit (p65) led to collapsing telomeres, as evidenced by downregulating TERT regulators and confocal microscopy. In animal study, this active nanocomplex revealed powerful and selective therapeutic tumor-targeting effects, with no evidence of toxicity to healthy tissues.Conclusion: DE-Cu4O3 nanocomplex is deemed as promising nanomedicine for NSCLC.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1267-1280"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140473/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144082604","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges. 用于癌症治疗的核酸纳米生物系统：新兴趋势和挑战的概述。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2501919

Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito

{"title":"Nucleic acid nanobiosystems for cancer theranostics: an overview of emerging trends and challenges.","authors":"Laura P Rebolledo, Luciana N S Andrade, Marcio C Bajgelman, Lawrence Banks, Xandra O Breakefield, Marina A Dobrovolskaia, Nikolay V Dokholyan, Edna T Kimura, Luisa Villa, Luiz F Zerbini, Valtencir Zucolotto, Kirill A Afonin, Bryan E Strauss, Roger Chammas, Renata de Freitas Saito","doi":"10.1080/17435889.2025.2501919","DOIUrl":"10.1080/17435889.2025.2501919","url":null,"abstract":"Different cancers remain major global health challenges due to their diverse biological behaviors and significant treatment hurdles. The aging of populations and lifestyle factors increase cancer occurrence and place increasing pressure on healthcare systems. Despite continuous advancements, many cancers remain fatal due to late-stage diagnosis, tumor heterogeneity, and drug resistance, thus necessitating urgent development of innovative treatment solutions. Therapeutic nucleic acids, a new class of biological drugs, offer a promising approach to overcoming these challenges. The recent Nucleic Acids and Nanobiosystems in Cancer Theranostics (NANCT) conference brought together internationally recognized experts from 15 countries to discuss cutting-edge research, spanning from oncolytic viruses to anticancer RNA nanoparticles and other emerging nanotechnologies. This review captures key insights and developments, emphasizing the need for interdisciplinary translation of scientific advancements into clinical practice and shaping the future of personalized cancer treatments for improved therapeutic outcomes.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1281-1298"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12140469/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143999865","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanobiotechnologies for stroke treatment. 纳米生物技术用于中风治疗。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-06 DOI: 10.1080/17435889.2025.2501514

Gui Wan, Lingui Gu, Yangyang Chen, Yiqing Wang, Ye Sun, Zhenwei Li, Wenbin Ma, Xinjie Bao, Renzhi Wang

引用次数: 0