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Lipid polymer hybrid nanoparticles against lung cancer and their application as inhalable formulation. 抗肺癌的脂质聚合物混合纳米粒子及其作为吸入制剂的应用。
Nanomedicine (London, England) Pub Date : 2024-08-15 DOI: 10.1080/17435889.2024.2387530
Seyedeh Negin Kassaee, Derek Richard, Godwin A Ayoko, Nazrul Islam
{"title":"Lipid polymer hybrid nanoparticles against lung cancer and their application as inhalable formulation.","authors":"Seyedeh Negin Kassaee, Derek Richard, Godwin A Ayoko, Nazrul Islam","doi":"10.1080/17435889.2024.2387530","DOIUrl":"https://doi.org/10.1080/17435889.2024.2387530","url":null,"abstract":"<p><p>Lung cancer is a leading cause of global cancer mortality, often treated with chemotherapeutic agents. However, conventional approaches such as oral or intravenous administration of drugs yield low bioavailability and adverse effects. Nanotechnology has unlocked new gateways for delivering medicine to their target sites. Lipid-polymer hybrid nanoparticles (LPHNPs) are one of the nano-scaled delivery platforms that have been studied to exploit advantages of liposomes and polymers, enhancing stability, drug loading, biocompatibility and controlled release. Pulmonary administration of drug-loaded LPHNPs enables direct lung deposition, rapid onset of action and heightened efficacy at low doses of drugs. In this manuscript, we will review the potential of LPHNPs in management of lung cancer through pulmonary administration.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984128","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Gallic acid loaded self-nano emulsifying hydrogel-based drug delivery system against onychomycosis. 以没食子酸为载体的自纳米乳化水凝胶给药系统防治甲癣。
Nanomedicine (London, England) Pub Date : 2024-08-15 DOI: 10.1080/17435889.2024.2386923
Mohammad Sameer Khan, Mahak Fatima, Shadma Wahab, Mohammad Khalid, Prashant Kesharwani
{"title":"Gallic acid loaded self-nano emulsifying hydrogel-based drug delivery system against onychomycosis.","authors":"Mohammad Sameer Khan, Mahak Fatima, Shadma Wahab, Mohammad Khalid, Prashant Kesharwani","doi":"10.1080/17435889.2024.2386923","DOIUrl":"https://doi.org/10.1080/17435889.2024.2386923","url":null,"abstract":"<p><p><b>Aim:</b> To developed and investigate gallic acid (GA) loaded self-nanoemulsifying drug delivery systems (SNEDDS) for treating onychomycosis via transungual route. <b>Materials & methods:</b> The SNEDDS were prepared by direct dispersion technique and were evaluated for characteristics parameters using Fourier transform infrared, differential scanning calorimetry, confocal microscopy, transmission electron microscopy and zeta sizer. Furthermore, the safety of prepared formulation was evaluated via Hen's egg test-chorioallantoic membrane study and stability was confirmed using different parameters. Also, its effectiveness was evaluated against fungal strain <i>Trichophyton mentagrophytes</i>. <b>Results:</b> The SNEDDS displayed a particle size of 199.8 ± 4.21 nm and a zeta potential; of -22.75 ± 2.09 mV. Drug release study illustrated a sustained release pattern with a release of 70.34 ± 0.20% over a period of 24 h. The penetration across the nail plate was found to be 1.59 ± 0.002 µg/mg and 0.97 ± 0.001 µg/mg for GA loaded SNEDDS and GA solution respectively. An irritation score of 0.52 ± 0.005 and 3.84 ± 0.001 was reported for GA loaded SNEDDS hydrogel and GA solution, indicating a decrease in the drug's irritation potential from slightly irritating to non irritating due to its entrapment within the SNEDDS. <b>Conclusion:</b> GA loaded SNEDDS has potential to address limitations of conventional treatments, enhancing the drug's efficacy and reducing the likelihood of resistance in the treatment of Onychomycosis.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984127","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Recent advances in nanostructured delivery systems for vancomycin. 万古霉素纳米结构给药系统的最新进展。
Nanomedicine (London, England) Pub Date : 2024-08-15 DOI: 10.1080/17435889.2024.2377063
Mohabbat Ansari, Mohsen Shahlaei, Simzar Hosseinzadeh, Sajad Moradi
{"title":"Recent advances in nanostructured delivery systems for vancomycin.","authors":"Mohabbat Ansari, Mohsen Shahlaei, Simzar Hosseinzadeh, Sajad Moradi","doi":"10.1080/17435889.2024.2377063","DOIUrl":"https://doi.org/10.1080/17435889.2024.2377063","url":null,"abstract":"<p><p>Despite the development of new generations of antibiotics, vancomycin remained as a high-efficacy antibiotic for treating the infections caused by MRSA. Researchers have explored various nanoformulations, aiming to enhance the therapeutic efficacy of vancomycin. Such novel formulations improve the effectiveness of drug cargoes in treating bacterial infections and minimizing the risk of adverse effects. The vast of researches have focuses on enhancing the permeation ability of vancomycin through different biological barriers especially those of gastrointestinal tract. Increasing the drug loading and tuning the drug release from nanocarrier are other important goal for many conducted studies. This study reviews the newest nano-based formulations for vancomycin as a key antibiotic in treating hospitalized bacterial infections.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984129","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The advancement of siRNA-based nanomedicine for tumor therapy. 基于 siRNA 的纳米药物在肿瘤治疗领域的发展。
Nanomedicine (London, England) Pub Date : 2024-08-15 DOI: 10.1080/17435889.2024.2377062
Muchuan Qiao, Chenlu Zeng, Changqing Liu, Ziwei Lei, Bin Liu, Hailong Xie
{"title":"The advancement of siRNA-based nanomedicine for tumor therapy.","authors":"Muchuan Qiao, Chenlu Zeng, Changqing Liu, Ziwei Lei, Bin Liu, Hailong Xie","doi":"10.1080/17435889.2024.2377062","DOIUrl":"https://doi.org/10.1080/17435889.2024.2377062","url":null,"abstract":"<p><p>Small interfering RNA (siRNA) has been proved to be able to effectively down-regulate gene expression through the RNAi mechanism. Thus, siRNA-based drugs have become one of the hottest research directions due to their high efficiency and specificity. However, challenges such as instability, off-target effects and immune activation hinder their clinical application. This review explores the mechanisms of siRNA and the challenges in siRNA-based tumor therapy. It highlights the use of various nanomaterials - including lipid nanoparticles, polymeric nanoparticles and inorganic nanoparticles - as carriers for siRNA delivery in different therapeutic modalities. The application strategies of siRNA-based nanomedicine in chemotherapy, phototherapy and immunotherapy are discussed in detail, along with recent clinical advancements. Aiming to provide insights for future research and therapeutic approaches.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141984130","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Immunogenicity of trivalent DNA vaccine candidate encapsulated in Chitosan-TPP nanoparticles against EV-A71 and CV-A16. 壳聚糖-TPP 纳米颗粒封装的三价 DNA 候选疫苗对 EV-A71 和 CV-A16 的免疫原性。
Nanomedicine (London, England) Pub Date : 2024-08-14 DOI: 10.1080/17435889.2024.2372243
Jia Sheng Yew, Seng-Kai Ong, Hui Xuan Lim, Soon Hao Tan, Kien Chai Ong, Kum Thong Wong, Chit Laa Poh
{"title":"Immunogenicity of trivalent DNA vaccine candidate encapsulated in Chitosan-TPP nanoparticles against EV-A71 and CV-A16.","authors":"Jia Sheng Yew, Seng-Kai Ong, Hui Xuan Lim, Soon Hao Tan, Kien Chai Ong, Kum Thong Wong, Chit Laa Poh","doi":"10.1080/17435889.2024.2372243","DOIUrl":"https://doi.org/10.1080/17435889.2024.2372243","url":null,"abstract":"<p><p><b>Aim:</b> To develop a trivalent DNA vaccine candidate encapsulated in Chitosan-TPP nanoparticles against hand foot and mouth disease (HFMD) and assess its immunogenicity in mice. <b>Materials & methods:</b> Trivalent plasmid carrying the VP1 and VP2 genes of EV-A71, VP1 gene of CV-A16 was encapsulated in Chitosan-TPP nanoparticles through ionic gelation. <i>In vitro</i> characterization and <i>in vivo</i> immunization studies of the CS-TPP-NPs (pIRES-VP121) were performed. <b>Results:</b> Mice administered with CS-TPP NPs (pIRES-VP121) intramuscularly were observed to have the highest IFN-γ response. Sera from mice immunized with the naked pDNA and CS-TPP-NPs (pIRES-VP121) demonstrated good viral clearance against wild-type EV-A71 and CV-A16 in RD cells. <b>Conclusion:</b> CS-TPP-NPs (pIRES-VP121) could serve as a prototype for future development of multivalent HFMD DNA vaccine candidates.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-14","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141977374","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The effects of conjugating anti-MUC1 aptamers on gold nanobipyramids and nanostars for photothermal cancer ablation. 在金纳米双锥体和纳米星上共轭抗 MUC1 合道体用于光热消融癌症的效果。
Nanomedicine (London, England) Pub Date : 2024-08-13 DOI: 10.1080/17435889.2024.2384351
Bankuru Navyatha, Seema Nara
{"title":"The effects of conjugating anti-MUC1 aptamers on gold nanobipyramids and nanostars for photothermal cancer ablation.","authors":"Bankuru Navyatha, Seema Nara","doi":"10.1080/17435889.2024.2384351","DOIUrl":"https://doi.org/10.1080/17435889.2024.2384351","url":null,"abstract":"<p><p><b>Aim:</b> To ascertain the impact of shape and surface modification of anisotropic nanoparticles on the toxicity and photothermal efficiency toward cancerous cell lines. <b>Methods:</b> Gold nanobipyramids and nanostars surface modified with MUC1 aptamer were used in the current study to explore the toxicity and photothermal efficiency on MCF7 breast cancer cell lines via MTT assay. <b>Results:</b> Surface functionalization with MUC1 aptamer showed significant reduction in % cytotoxicity and increase in % specific internalization of nanostructures into MCF7 cell lines. Further, the photothermal studies accomplished at IC<sub>50</sub> concentration for 6 h of treatment and laser exposure for 15 min reported that aptamer-conjugated nanobipyramids were more effective and specific toward MCF7 cell lines than aptamer-conjugated nanostars. <b>Conclusion:</b> This work establishes a platform for the development of tailored photoablation based gold nanostructures for <i>in vivo</i> studies.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-13","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141972420","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
To heat or not to heat: the impact of temperature on the aggregation state of amphotericin B in drug delivery systems. 加热还是不加热：温度对给药系统中两性霉素 B 聚合状态的影响。
Nanomedicine (London, England) Pub Date : 2024-08-09 DOI: 10.1080/17435889.2024.2382669
Valéria Moreira da Costa, Thais Tunes Santos, Natalha Vicentina Pinto, Guilherme Carneiro, Frédéric Frézard, Gabriel Silva Marques Borges
{"title":"To heat or not to heat: the impact of temperature on the aggregation state of amphotericin B in drug delivery systems.","authors":"Valéria Moreira da Costa, Thais Tunes Santos, Natalha Vicentina Pinto, Guilherme Carneiro, Frédéric Frézard, Gabriel Silva Marques Borges","doi":"10.1080/17435889.2024.2382669","DOIUrl":"https://doi.org/10.1080/17435889.2024.2382669","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-09","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141908855","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications. 通过 LC-MS/MS 同时估算紫杉醇和硼替佐米：制药和药代动力学应用。
Nanomedicine (London, England) Pub Date : 2024-08-08 DOI: 10.1080/17435889.2024.2382668
Pavan K Yadav, Saurabh Verma, Divya Chauhan, Pooja Yadav, Amrendra K Tiwari, Ravi Saklani, Deepak Gupta, Rafquat Rana, Aarti Abhishek Shah, Sonia Verma, Kothuri Naresh, Jiaur R Gayen, Manish K Chourasia
{"title":"Simultaneous estimation of paclitaxel and bortezomib via LC-MS/MS: pharmaceutical and pharmacokinetic applications.","authors":"Pavan K Yadav, Saurabh Verma, Divya Chauhan, Pooja Yadav, Amrendra K Tiwari, Ravi Saklani, Deepak Gupta, Rafquat Rana, Aarti Abhishek Shah, Sonia Verma, Kothuri Naresh, Jiaur R Gayen, Manish K Chourasia","doi":"10.1080/17435889.2024.2382668","DOIUrl":"https://doi.org/10.1080/17435889.2024.2382668","url":null,"abstract":"<p><p><b>Aim & Objective:</b> This study evaluates the potential of combining paclitaxel (PTX) and bortezomib (BTZ) for breast cancer therapy. <b>Materials & Methods:</b> The nanoformulation was optimized via Box-Behnken Design (BBD), with method validation adhering to US-FDA guidelines. <b>Results:</b> Multiple reaction monitoring transitions for PTX, BTZ and internal standard were m/z 855.80→286.60, 366.80→226.00 and 179.80→110.00, respectively. Elution done on C18 Luna column with 0.1% FA in MeOH:10 mM ammonium acetate. The size of nanoformulation was 133.9 ± 1.97 nm, PDI 0.19 ± 0.01 and zeta potential -19.20 ± 1.36 mV. Pharmacokinetics showed higher C<sub>max</sub> for PTX-BTZ-NE (313.75 ± 10.71 ng/ml PTX, 11.92 ± 0.53 ng/ml BTZ) versus free PTX-BTZ (104 ± 13.06 ng/ml PTX, 1.9 ± 0.08 ng/ml BTZ). <b>Conclusion:</b> Future findings will contribute to the treatment of breast cancer using PTX and BTZ.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903883","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
The potential of nanomedicines for delivery of gaseous signaling molecules. 纳米药物传递气体信号分子的潜力。
Nanomedicine (London, England) Pub Date : 2024-08-08 DOI: 10.1080/17435889.2024.2386930
Urara Hasegawa
{"title":"The potential of nanomedicines for delivery of gaseous signaling molecules.","authors":"Urara Hasegawa","doi":"10.1080/17435889.2024.2386930","DOIUrl":"10.1080/17435889.2024.2386930","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903884","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia-reperfusion injury. 用于减轻肾缺血再灌注损伤的介孔锌多酚纳米酶
Nanomedicine (London, England) Pub Date : 2024-08-08 DOI: 10.1080/17435889.2024.2382667
Zepeng Li, Jingyue Qin, Youyou Feng, Chenguang Ding, Yingcong Guo, Zhenting Zhao, Shirui Sun, Jin Zheng, Mingzhen Zhang, Jing Zhang, Yilei Zhang, Jing Wei, Wujun Xue
{"title":"Mesoporous zinc-polyphenol nanozyme for attenuating renal ischemia-reperfusion injury.","authors":"Zepeng Li, Jingyue Qin, Youyou Feng, Chenguang Ding, Yingcong Guo, Zhenting Zhao, Shirui Sun, Jin Zheng, Mingzhen Zhang, Jing Zhang, Yilei Zhang, Jing Wei, Wujun Xue","doi":"10.1080/17435889.2024.2382667","DOIUrl":"https://doi.org/10.1080/17435889.2024.2382667","url":null,"abstract":"<p><p><b>Aim:</b> To target the reactive oxygen species (ROS) accumulation and renal tubular epithelial cell (rTEC) death in renal ischemia-reperfusion injury (IRI), we constructed a nanoparticle that offers ROS scavenging and rTEC-death inhibition: mesoporous zinc-tannic acid nanozyme (ZnTA). <b>Materials & methods:</b> After successfully constructing ZnTA, we proceeded to examine its effect on ROS accumulation, cellular ferroptosis and apoptosis, as well as injury severity. <b>Results:</b> Malondialdehyde, Fe<sup>2+</sup> amounts and 4-HNE staining demonstrated that ZnTA effectively attenuated rTEC ferroptosis. TUNEL staining confirmed that Zn<sup>2+</sup> carried by ZnTA could effectively inhibit caspase 3 and caspase 9, mitigating apoptosis. Finally, it reduced renal IRI through the synergistic effect of ROS scavenging and cell-death inhibition. <b>Conclusion:</b> This study is expected to provide a paradigm for a combined therapeutic strategy for renal IRI.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-08","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141903882","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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