Nanomedicine (London, England)最新文献_第2页

Recent advances in nano-molybdenum oxide for photothermal cancer therapy.

Nanomedicine (London, England) Pub Date : 2025-03-10 DOI: 10.1080/17435889.2025.2476386

Shihai Chen, Ping Zhang, Hongmei Bai, Wenhui Yi

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The emerging role of graphene in spinal cord regeneration.

Nanomedicine (London, England) Pub Date : 2025-03-07 DOI: 10.1080/17435889.2025.2475732

Paula A A P Marques

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Application of pre-amplification-based CRISPR-Cas nanostructured biosensors for bacterial detection.

Nanomedicine (London, England) Pub Date : 2025-03-07 DOI: 10.1080/17435889.2025.2476384

Hehua Zhang, Li Xie, Hongmin Gao, Hongzhi Pan

{"title":"Application of pre-amplification-based CRISPR-Cas nanostructured biosensors for bacterial detection.","authors":"Hehua Zhang, Li Xie, Hongmin Gao, Hongzhi Pan","doi":"10.1080/17435889.2025.2476384","DOIUrl":"10.1080/17435889.2025.2476384","url":null,"abstract":"Bacterial infections are one of the primary triggers of global disease outbreaks. Traditional detection methods, such as bacterial culture and PCR, while reliable, are limited by their time-consuming procedures and operational complexity. In recent years, the CRISPR-Cas system has demonstrated significant potential in gene editing and diagnostics due to its high specificity and precision, offering innovative solutions for bacterial detection. By integrating pre-amplification techniques, the CRISPR-Cas system has substantially enhanced detection sensitivity, particularly excelling in detecting low-concentration target bacteria. This review summarizes the principles and application examples of CRISPR-Cas-based fluorescence, electrochemical, lateral flow, and colorimetric nanostructured biosensors developed over the past three years, categorizing them according to their recognition methods (e.g. bacterial genomes, aptamers, antibodies). It systematically explores the broad application prospects of these sensors in medical diagnostics, environmental monitoring, and food safety assessment. Additionally, this review discusses future research directions and potential development prospects, providing new insights and technical support for the rapid diagnosis and treatment of bacterial infections.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-13"},"PeriodicalIF":0.0,"publicationDate":"2025-03-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and application of antimicrobial nanomaterials in the treatment of periodontitis.

Nanomedicine (London, England) Pub Date : 2025-03-05 DOI: 10.1080/17435889.2025.2469492

Chunlin Wang, Yujun Yang, Ning Wang, Aohan Luan, Huilin Wang, Chen Hu

{"title":"Design and application of antimicrobial nanomaterials in the treatment of periodontitis.","authors":"Chunlin Wang, Yujun Yang, Ning Wang, Aohan Luan, Huilin Wang, Chen Hu","doi":"10.1080/17435889.2025.2469492","DOIUrl":"https://doi.org/10.1080/17435889.2025.2469492","url":null,"abstract":"Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to the destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy to scaling and root planning in periodontitis is a promising strategy. However, this administration method's effectiveness is constrained by the complexity of the periodontal environment. Nanomaterials have demonstrated significant potential in the antibacterial treatment of periodontitis, attributed to their controllable size, shape, and surface charge, high design flexibility, high reactivity, and high specific surface area. In this review, we summarize the complex periodontal microenvironment and the difficulties of local drug delivery in periodontitis, explicitly reviewing the application and design strategies of nanomaterials with unique properties in the distinct microenvironment of periodontitis. Furthermore, the review discusses the limitations of current research, proposes feasible solutions, and explores prospects for using nanomaterials in this context.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-03-05","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Correction.

Nanomedicine (London, England) Pub Date : 2025-03-05 DOI: 10.1080/17435889.2025.2475623

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A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy. 分别装载药物和氯素 e6 的纳米给药系统，实现光动力-化疗联合疗法。

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-04 DOI: 10.1080/17435889.2025.2460960

Guohao Yin, Hongli Zhao, Minbo Lan

{"title":"A nano drug delivery system loading drugs and chlorin e6 separately to achieve photodynamic-chemo combination therapy.","authors":"Guohao Yin, Hongli Zhao, Minbo Lan","doi":"10.1080/17435889.2025.2460960","DOIUrl":"10.1080/17435889.2025.2460960","url":null,"abstract":"Aim: To develop a new drug delivery system (DDS) that can load chemotherapy agents and photosensitizer chlorin e6 (Ce6) onto the pores and surfaces of mesoporous silica nanoparticle (MSN) separately.Methods: Doxorubicin (DOX) was loaded into the pores of MSNs. Then, polyethyleneimine (PEI) was used to coat the surface of MSN to protect DOX, and then manganese dioxide (MnO2) nanoparticles were loaded through adding potassium permanganate (KMnO4) to bind with Ce6. Finally, polydopamine (PDA) was coated and coupled with hyaluronic acid (HA).Results: The synthesized versatile nanoparticle was pH-sensitive and exhibited positive photodynamic therapy (PDT) performance. Besides, it could be observed that the nanoparticles were efficiently taken up by tumor cells through confocal laser scanning microscopy (CLSM) and flow cytometry. Additionally, in vitro experiments suggested that the nanoparticles had pleasing toxicity to various tumor cells and equally positive therapeutic effect when curcumin replaced DOX.Conclusion: Our work suggests that the nanoparticles designed by our strategy have satisfactory combination therapy performance and can enable more chemotherapy drugs to be used in photodynamic-chemo combination therapy.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"559-570"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881829/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143191494","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Formation and evaluation of doxorubicin and cromoglycate metal-organic framework for anti-cancer activity.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1080/17435889.2025.2459059

Ebaa Abu Saleem, Zainab Lafi, Naeem Shalan, Walhan Alshaer, Imad Hamadneh

{"title":"Formation and evaluation of doxorubicin and cromoglycate metal-organic framework for anti-cancer activity.","authors":"Ebaa Abu Saleem, Zainab Lafi, Naeem Shalan, Walhan Alshaer, Imad Hamadneh","doi":"10.1080/17435889.2025.2459059","DOIUrl":"10.1080/17435889.2025.2459059","url":null,"abstract":"Aims: We develop and evaluate copper-based metal-organic frameworks (Cu-MOFs) incorporating cromolyn as a linker to enhance structural stability, drug delivery efficiency, and therapeutic potential, particularly for breast cancer treatment.Materials & methods: Two Cu-MOF formulations were synthesized: Cu-MOFs-BDC-DOX (using terephthalic acid) and Cu-MOFs-CROMO-DOX (using cromolyn as a linker). Characterization was performed using SEM/TEM for morphology, and FTIR, XRD, and TGA to confirm structural integrity. Drug encapsulation efficiency and release profiles were assessed, followed by in vitro cytotoxicity, cell migration, and colony formation assays using MDA-MB-231 breast cancer cells.Results: Both formulations demonstrated a high encapsulation efficiency (83-91%) and sustained drug release over 48 h at pH 7.4. Cu-MOFs-CROMO-DOX exhibited superior cytotoxicity with an IC50 of 0.88 ± 0.07 µM compared to 7.1 ± 0.11 µM for Cu-MOFs-BDC-DOX. Both formulations inhibit cancer cell migration and colony formation in a dose-dependent manner.Conclusions: The Cu-MOFs-CROMO-DOX formulation demonstrated enhanced therapeutic potential, outperforming its counterpart in targeting breast cancer cells. This study highlights the promise of MOF-based nanocarriers in overcoming the limitations of conventional chemotherapy, offering a pathway to more effective and targeted cancer treatments with reduced side effects.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"467-479"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875491/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070102","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

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Current views and trends of nanomaterials as vectors for gene delivery since the 21st century: a bibliometric analysis.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-29 DOI: 10.1080/17435889.2025.2457781

Xiao Xiao, Sheng Yang, Ge Jiang, Shisheng He

{"title":"Current views and trends of nanomaterials as vectors for gene delivery since the 21st century: a bibliometric analysis.","authors":"Xiao Xiao, Sheng Yang, Ge Jiang, Shisheng He","doi":"10.1080/17435889.2025.2457781","DOIUrl":"10.1080/17435889.2025.2457781","url":null,"abstract":"Background: Gene therapy is garnering increasing support due to its potential for a \"once-delivered, lifelong benefit.\" The limitations of traditional gene delivery methods have spurred the advancement of bionanomaterials. Despite this progress, a thorough analysis of the evolution, current state, key contributors, focal studies, and future directions of nanomaterials in gene delivery remains absent.Methods: This study scrutinizes articles from the Web of Science, spanning 1 January 2 000, to 31 December 2023, employing various online tools for analysis and visualization.Results: The 21st century has witnessed consistent growth in scholarly work in this domain globally, with notable contributions from China and the US. At the same time, the Chinese Academy of Sciences (CAS), Harvard University, and Massachusetts Institute of Technology (MIT) have emerged as the most productive institutions, with CAS's academician Weihong Tan becoming the field's leading author. While drug delivery and nanoparticles (NPs) have been central themes for two decades, the research focus has shifted from modifying NPs and ultrafine particles to exploring polymer-hybrid NPs, mRNA vaccines, immune responses, green synthesis, and CRISPR/Cas tools.Conclusions: This shift marks the transition from nanomaterials to bionanomaterials. The insights provided by this research offer a comprehensive overview of the field and valuable guidance for future investigations.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"439-454"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875476/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143061681","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Could encapsulation of natural compounds in BBB-permeable nanocarriers produce effective Alzheimer's disease treatments? 在血脑屏障可渗透的纳米载体中包封天然化合物是否能有效治疗阿尔茨海默病？

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2024-12-27 DOI: 10.1080/17435889.2024.2444859

Maria João Ramalho, Stéphanie Andrade, Joana Angélica Loureiro, Maria Carmo Pereira

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Design and application of ferritin-based nanomedicine for targeted cancer therapy.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1080/17435889.2025.2459056

Baoli Zhang, Kelong Fan

{"title":"Design and application of ferritin-based nanomedicine for targeted cancer therapy.","authors":"Baoli Zhang, Kelong Fan","doi":"10.1080/17435889.2025.2459056","DOIUrl":"10.1080/17435889.2025.2459056","url":null,"abstract":"Owing to its unique structure and favorable biocompatibility, ferritin has been widely studied as a promising drug carrier over the past two decades. Since the identification of its inherent tumor-targeting property due to unique recognition ablity of the transferrin receptor 1 (TfR1), ferritin-based nanomedicine has attracted widespread attention and triggered a research surge in the field of targeted cancer therapy. Along with progress in structure studies and modification technology, diverse strategies have been carried out to equip ferritin with on-demand functions, further improving the antitumor efficacy and in vivo safety of ferritin-based cancer therapy. In this review, we highlight the structure-based rational design of ferritin and summarize the design strategies in detail from two main perspectives: multifunctional modification and drug loading. In particular, the critical issues that need attention in the design are discussed in depth. Furthermore, we provide an overview of the latest advances in the application of ferritin-based nanomedicines in chemotherapy, phototherapy and immunotherapy, with particular emphasis on emerging therapeutic approaches among these therapies.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"481-500"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0