Nanomedicine (London, England)最新文献_第2页

KRAS mutation-driven enhanced macropinocytosis: using albumin as a trojan horse for delivering nanomedicine. KRAS突变驱动的增强型巨噬细胞：利用白蛋白作为传递纳米药物的特洛伊木马。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-07-02 DOI: 10.1080/17435889.2025.2524312

Drishti Rathod, Mukti Vats, Poonam Gawali, Osaretin Otagho, Bhoomi Dholariya, Ketan Patel

引用次数: 0

Transcriptomics insight into occupational exposure to engineered nanoparticles. 转录组学洞察职业暴露于工程纳米颗粒。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-07-03 DOI: 10.1080/17435889.2025.2527020

Zuzana Simova, Michal Sima, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Jaroslav Schwarz, Ludmila Maskova, Jiri Klema, Stepanka Dvorackova, Pavel Rossner, Andrea Rossnerova

{"title":"Transcriptomics insight into occupational exposure to engineered nanoparticles.","authors":"Zuzana Simova, Michal Sima, Daniela Pelclova, Pavlina Klusackova, Vladimir Zdimal, Jaroslav Schwarz, Ludmila Maskova, Jiri Klema, Stepanka Dvorackova, Pavel Rossner, Andrea Rossnerova","doi":"10.1080/17435889.2025.2527020","DOIUrl":"10.1080/17435889.2025.2527020","url":null,"abstract":"Aim: To investigate the effect of acute (daily) inhalation of nanoparticles (NPs) on the transcriptomic profile of male nanocomposite research workers with a history of long-term exposure (years).Materials & methods: Whole genome mRNA and miRNA expression changes were analyzed from blood samples collected before and after machining or welding. Exposure in the work environment was assessed using stationary and personal monitoring.Results: Following PM0.1 exposure, a significant decrease in the expression of DDIT4 and FKBP5, genes involved in the stress response, was detected in exposed workers. In the Machining group, the DDIT4 expression correlated with the exposure dose. Increased levels of miR30-d-5p and miR-3613-5p (both involved in carcinogenesis) in welders were associated with the NP exposure dose, highlighting their potential suitability as inhalation exposure markers.Conclusion: The results from this pilot transcriptomic analysis (mRNA and miRNA) indicate that exposure to NPs contributes to immune system deregulation and alters the pathways related to cancer. Therefore, the use of protective equipment, as well as obtaining more data by additional research, is highly recommended.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1713-1727"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239771/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556050","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Thermo-responsive nano-hydrogel-based delivery of Saikosaponin a to enhance anti-PD-1 therapy in osteosarcoma. 基于热响应纳米水凝胶的柴草皂苷a递送增强骨肉瘤抗pd -1治疗。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-06-29 DOI: 10.1080/17435889.2025.2526322

Yan-Qiang Chen, Dan Yang, Kang Li, Jing-Sheng Liu, Hai-Jun Feng, Jian-Wei Zhou

{"title":"Thermo-responsive nano-hydrogel-based delivery of Saikosaponin a to enhance anti-PD-1 therapy in osteosarcoma.","authors":"Yan-Qiang Chen, Dan Yang, Kang Li, Jing-Sheng Liu, Hai-Jun Feng, Jian-Wei Zhou","doi":"10.1080/17435889.2025.2526322","DOIUrl":"10.1080/17435889.2025.2526322","url":null,"abstract":"Objective: This study aimed to identify key targets of Saikosaponin A (SSA) in treating osteosarcoma (OS) using network pharmacology and transcriptomics, and to develop a temperature-sensitive hydrogel nanocomplex delivering SSA in combination with the PD-1 inhibitor pembrolizumab to enhance anti-tumor effects.Methods: Through network pharmacology and transcriptomic analysis, 23 co-regulated genes were identified, leading to the construction of a prognostic risk model containing four core genes. Molecular dynamics simulations were employed to explore the binding interaction between SSA and the key target FASN. The Gel@PLGA@SSA@FA was synthesized and characterized. Its cytotoxicity and therapeutic effects were evaluated in OS cell lines, both alone and in combination with pembrolizumab.Results: FASN was validated as a poor prognostic marker in OS, and molecular simulations confirmed that SSA can effectively bind to FASN. Gel@PLGA@SSA@FA significantly downregulated FASN and CD279 mRNA expression, especially when combined with pembrolizumab. In vitro release studies demonstrated sustained drug release under tumor-mimicking conditions. Functional assays revealed that the combination treatment markedly suppressed OS cell proliferation and migration, induced apoptosis, and exhibited low toxicity toward normal cells.Conclusion: The combination of Gel@PLGA@SSA@FA with pembrolizumab shows strong synergistic anti-tumor effects, offering a promising and biocompatible strategy for enhanced OS therapy.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1677-1691"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239799/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144531463","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Near-infrared II nanomaterials for hypoxic TME diagnosis and therapy. 近红外ⅱ纳米材料在缺氧TME诊断和治疗中的应用。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-07-03 DOI: 10.1080/17435889.2025.2525057

Qianqian Cai, Haoyu Zhang, Zhaohang Huang, Qiwei Tian

{"title":"Near-infrared II nanomaterials for hypoxic TME diagnosis and therapy.","authors":"Qianqian Cai, Haoyu Zhang, Zhaohang Huang, Qiwei Tian","doi":"10.1080/17435889.2025.2525057","DOIUrl":"10.1080/17435889.2025.2525057","url":null,"abstract":"Hypoxic tumor microenvironments (TME) drive cancer aggression and therapy resistance, necessitating precise diagnostic and therapeutic strategies. Near-Infrared II (NIR-II) nanomaterials have emerged as transformative tools for addressing hypoxic TME challenges, leveraging deeper tissue penetration, minimal scattering, and reduced autofluorescence. This review systematically summarizes the recent advancements in NIR-II nanomaterials, focusing on their applications in imaging and therapy for hypoxic tumors. NIR-II-based imaging techniques, including fluorescence, photoacoustic, and multimodal imaging, provide high sensitivity and resolution for detecting hypoxic regions, aiding in early diagnosis and personalized treatment planning. In therapeutic applications, NIR-II materials enhance the efficacy of photothermal therapy, photodynamic therapy, and photo-Fenton therapy, all of which overcome the limitations of traditional therapies in hypoxic areas. The combination of NIR-II materials with other treatment modalities holds promise for more effective cancer treatments. This review also discusses the challenges in the current research landscape, including the preparation, scalability, and clinical translation of NIR-II materials. It highlights the need for continued innovation to optimize these materials for broader clinical applications. Overall, NIR-II nanomaterials represent a significant step forward in addressing the challenges posed by hypoxic tumors, with the potential to revolutionize cancer diagnosis and therapy.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1745-1758"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239784/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144556049","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Harnessing multifunctional HBc virus-like particles for safe and effective delivery of melittin in cancer therapy. 利用多功能HBc病毒样颗粒在癌症治疗中安全有效地递送蜂毒素。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-07-05 DOI: 10.1080/17435889.2025.2528591

Chufan Wang, Fengrui Zhang, Haobo Tang, Zhengchan Su, Yufei Duan, Wei Feng, Xiaoning Lin, E Chen, Xiumin Wang, Lei Ren

{"title":"Harnessing multifunctional HBc virus-like particles for safe and effective delivery of melittin in cancer therapy.","authors":"Chufan Wang, Fengrui Zhang, Haobo Tang, Zhengchan Su, Yufei Duan, Wei Feng, Xiaoning Lin, E Chen, Xiumin Wang, Lei Ren","doi":"10.1080/17435889.2025.2528591","DOIUrl":"10.1080/17435889.2025.2528591","url":null,"abstract":"Aim: To overcome the clinical limitations of melittin, a potent anticancer host defense peptide, by developing a multifunctional, virus-like particle (VLP)-based delivery system that enhances tumor targeting, immune activation, and therapeutic safety.Methods: A nanoplatform based on hepatitis B core virus-like particles (HBc VLPs) was engineered to encapsulate melittin. The design incorporated RGD peptides for improved tumor specificity, Tuftsin to promote phagocytosis, and M2pep to selectively target immunosuppressive M2 macrophages. An MMP-2-cleavable linker enabled tumor-specific activation, allowing controlled release of RGD-melittin and immune-stimulating peptides. Antitumor efficacy was evaluated in subcutaneous melanoma and lung metastasis mouse models.Results: The multifunctional HBc VLP platform effectively protected melittin from enzymatic degradation, reduced off-target cytotoxicity, and improved tumor selectivity. It demonstrated significant tumor suppression and immune modulation in both melanoma and lung metastasis models, outperforming free melittin treatment.Conclusion: This study presents a versatile, multifunctional VLP-based nanoplatform for the safe and effective delivery of melittin, offering enhanced tumor targeting and immune activation. The findings support its potential for clinical translation as a novel cancer immunotherapy strategy.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1661-1675"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12239800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144568189","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Current treatments and the future of nanomedicine in hepatitis C. 纳米药物治疗丙型肝炎的现状和未来。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-06-26 DOI: 10.1080/17435889.2025.2518912

Drue Julien, Horacio Bach

引用次数: 0

Luminescent protein-gold compounds for nanomedicine. 纳米医学用发光蛋白金化合物。

Nanomedicine (London, England) Pub Date : 2025-07-01 DOI: 10.1080/17435889.2025.2525748

Shunji Egusa

引用次数: 0

Defining the landscape of prenatal nanomedicine and a roadmap for future research. 确定产前纳米医学的前景和未来研究的路线图。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-04-18 DOI: 10.1080/17435889.2025.2492540

Hagar I Labouta

引用次数: 0

Synergistic RNA particles for spontaneous and specific cancer targeting but low toxicity due to motility and deformation. 协同RNA颗粒自发和特定的癌症靶向，但由于运动和变形的低毒性。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-04-08 DOI: 10.1080/17435889.2025.2488727

Daniel W Binzel, Peixuan Guo

引用次数: 0

Emerging nanomaterials capable of effectively facilitating osteoblast maturation. 能够有效促进成骨细胞成熟的新兴纳米材料。

Nanomedicine (London, England) Pub Date : 2025-07-01 Epub Date: 2025-05-27 DOI: 10.1080/17435889.2025.2511465

Hoda Elkhenany

{"title":"Emerging nanomaterials capable of effectively facilitating osteoblast maturation.","authors":"Hoda Elkhenany","doi":"10.1080/17435889.2025.2511465","DOIUrl":"10.1080/17435889.2025.2511465","url":null,"abstract":"Efficient osteoblast maturation is essential for successful bone regeneration, yet achieving this goal remains challenging. This review explores the emerging role of nanomaterials in promoting osteoblast differentiation and bone formation. A literature search was conducted in the Web of Science Core Collection in February 2025, covering publications from 2014 to 2024 and limited to articles and proceedings. Keywords included \"nanoparticles\" and \"osteoblast.\" Among the most extensively studied nanomaterials were hydroxyapatite, carbon-based, and bioactive glass nanoparticles (NPs). These materials influence osteoblast function through intracellular mechanisms, including enhanced mitochondrial activity, autophagy, and osteoinductive gene expression. Additionally, they modulate the extracellular microenvironment by mimicking the native bone matrix, releasing bioactive ions, and reducing inflammation and oxidative stress. Notably, several NP-based systems have reached clinical application, including Signafuse (a bioactive calcium phosphate composite), nanoLOCK (a nanostructured titanium spinal implant), and Vitoss (a synthetic bone graft of nanocrystalline calcium phosphate). More recently, multimodal NPs that integrate different NP types and combine surface roughness, ion release, and chemical cues offer synergistic effects. These materials provide a dual-function approach, targeting both intracellular processes and the bone microenvironment. Their ability to modulate inflammation, oxidative stress, and cellular signaling underscores their translational potential in regenerative medicine and bone tissue engineering.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1603-1619"},"PeriodicalIF":0.0,"publicationDate":"2025-07-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12233895/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0