Nanomedicine (London, England)最新文献_第2页

How can surface-enhanced Raman spectroscopy improve diagnostics for bacterial infections?

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-02-17 DOI: 10.1080/17435889.2025.2466419

Jia-Wei Tang, Xin-Ru Wen, Yi-Wen Liao, Liang Wang

{"title":"How can surface-enhanced Raman spectroscopy improve diagnostics for bacterial infections?","authors":"Jia-Wei Tang, Xin-Ru Wen, Yi-Wen Liao, Liang Wang","doi":"10.1080/17435889.2025.2466419","DOIUrl":"10.1080/17435889.2025.2466419","url":null,"abstract":"Currently, bacterial infection is still a major global health issue. Although antibiotics have been widely used to control and treat bacterial infections, the overuse and misuse of antibiotics have led to widespread antimicrobial resistance among many bacterial pathogens. Therefore, reducing bacterial infections through rapid and accurate diagnostics is crucial for global public health. Traditional microbiological detection methods have limitations such as poor selectivity, high complexity, and excessive time consumption, highlighting the urgent need to develop efficient and sensitive bacterial diagnosis methods. Surface-enhanced Raman spectroscopy (SERS), as an emerging technique in clinical settings, holds a promising future for bacterial identification due to its rapid, nondestructive, and cost-effective nature. This invited special report discusses the application of SERS technology in bacterial diagnosis using pure culture, clinical samples, and single-cell Raman analysis. Current challenges and prospects of the technology are also addressed with in-depth discussion.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"701-706"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970747/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442807","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Terbinafine for prostate cancer: development of coated zein nanospheres for ameliorated pro-apoptosis in PC3 cells.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-04-02 DOI: 10.1080/17435889.2025.2481823

Majid M Al-Sawahli, Yasmin A El-Feky, Ahmed J Mohammed, Nada M Mohamed, Rania El-Telbany, Zaenah Zuhair Alamri, Sahar Jameel Melebary, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ayman M Noreddin, Ashraf B Abdel-Naim, Ebtesam M Alolayan, Dalia F El-Telbany

{"title":"Terbinafine for prostate cancer: development of coated zein nanospheres for ameliorated pro-apoptosis in PC3 cells.","authors":"Majid M Al-Sawahli, Yasmin A El-Feky, Ahmed J Mohammed, Nada M Mohamed, Rania El-Telbany, Zaenah Zuhair Alamri, Sahar Jameel Melebary, Mohammad Y Alfaifi, Serag Eldin I Elbehairi, Ayman M Noreddin, Ashraf B Abdel-Naim, Ebtesam M Alolayan, Dalia F El-Telbany","doi":"10.1080/17435889.2025.2481823","DOIUrl":"10.1080/17435889.2025.2481823","url":null,"abstract":"Aim: The purpose of this study was to investigate comparatively the anticancer potential of Terbinafine loaded Dextran Sulphate coated Zein nanospheres against human prostate cancer PC3 cells to enhance the repurposing profile of terbinafine utilizing optimized nano-sized delivery systems.Materials & methods: The formula was fabricated using the thin film hydration technique. Particle size analysis, drug diffusion, and encapsulation efficiency were considered when evaluating the fabricated formula, which were developed using a Box-Behnken statistical design.Results: Due to the formula optimization, the mean particle size was 273.2 ± 1.98 nm, the zeta potential was -38.4 ± 2.77 mV, and the amount released after 36 h was 97.4 ± 5.7%. The formula exhibited significantly reduced IC50 in PC3 cells by around 14-fold. A higher cellular uptake was observed. The cell cycle assay results obtained suppression of the proliferation, especially in the G0/G1 and S phases. This pro-apoptotic pattern of the optimized formula was confirmed by the increased mRNA expression of CASP3 and P53 and reduced expression of CDK1, CDK7, and CDK9. Furthermore, a higher production of reactive oxygen species was achieved.Conclusion: The optimized formula revealed enhanced pro-apoptosis in PC3 cells which support the repurposing profile of terbinafine toward prostate cancer.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"817-833"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143766168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-03-21 DOI: 10.1080/17435889.2025.2480046

Zheng Nie, Yongxuan Liu, Li Xu, Yang Wang, Mengzhu Wang, Wen Zhou, Huimin Zhu, Min Zhao, Shikun Wang, Hongjian Zhang, Meijing Geng, Mai Peng, Hao Zeng, Yuan Zhang, Pengxi Zhu, Wei Shen

{"title":"Selenium nanoparticles attenuate retinal pathological angiogenesis by disrupting cell cycle distribution.","authors":"Zheng Nie, Yongxuan Liu, Li Xu, Yang Wang, Mengzhu Wang, Wen Zhou, Huimin Zhu, Min Zhao, Shikun Wang, Hongjian Zhang, Meijing Geng, Mai Peng, Hao Zeng, Yuan Zhang, Pengxi Zhu, Wei Shen","doi":"10.1080/17435889.2025.2480046","DOIUrl":"10.1080/17435889.2025.2480046","url":null,"abstract":"Aim: This study aims to explore the mechanism by which selenium nanoparticles (SeNPs) inhibit retinal neovascularization (RNV) and to identify a more effective treatment for pathological RNV.Materials & methods: The characterization and identification of the synthesized selenium nanoparticles (SeNPs) were conducted to investigate their effects on the function of human umbilical vein endothelial cells (HUVECs), retinal blood vessel development in mice, and the impact on oxygen-induced retinopathy. Tritium-labeled thymine was utilized to label newly synthesized DNA both in vivo and in vitro, allowing for the observation of SeNPs' effects on cell proliferation. Additionally, flow cytometry, immunofluorescence, and western blotting techniques were employed to elucidate the mechanisms by which SeNPs inhibit retinal neovascularization.Results: SeNPs can significantly inhibit the functions of vascular endothelial cells, particularly their proliferation, both in vivo and in vitro. The SeNPs achieve this by modulating the expression of cell cycle-related proteins through the regulation of the PI3K-AKT-p21 axis, which in turn inhibits the transition of the cell cycle from the G1 phase to the S phase.Conclusion: SeNPs may be a novel treatment for the interference of retinal neovascularization.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"803-816"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143672062","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Polyol-modified deformable liposomes fortified contact lenses for improved ocular permeability.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-02-18 DOI: 10.1080/17435889.2025.2463867

Jeel Dave, Harshilkumar Jani, Yashkumar Patel, Popat Mohite, Abhijeet Puri, Vijay R Chidrawar, Deepanjan Datta, Sony Priyanka Bandi, Ketan Ranch, Sudarshan Singh

{"title":"Polyol-modified deformable liposomes fortified contact lenses for improved ocular permeability.","authors":"Jeel Dave, Harshilkumar Jani, Yashkumar Patel, Popat Mohite, Abhijeet Puri, Vijay R Chidrawar, Deepanjan Datta, Sony Priyanka Bandi, Ketan Ranch, Sudarshan Singh","doi":"10.1080/17435889.2025.2463867","DOIUrl":"10.1080/17435889.2025.2463867","url":null,"abstract":"Aim: To develop a glycerol modified liposomes to effectively deliver active agents into posterior segment of the eye for the management of posterior uveitis.Materials and methods: The modified liposome enhanced with glycerol as an edge activator was fabricated using a 32 experimental design with independent variables being soya lecithin (mg) (X1) and glycerol (%) (X2) and vesicle size (nm) (Y1), deformability index (%) (Y2), and entrapment efficiency (%) (Y3) as dependent variable with improve permeability and entrapment efficacy. These modified liposomes were then integrated into pHEMA-based contact lenses via free radical polymerization using different monomer mixture, co-polymer, crosslinker, and photo-initiator to extend drug release.Results and conclusions: Nano-vesicles resulted in size and deformability index of 200.5 ± 15 nm and 11.58, respectively, with entrapment efficiency of 80.98% of the drug. Moreover, the optimized lenses demonstrated 71%) of swelling and transmittance of 87%). In addition, in vitro release of active component from the therapeutic contact lens demonstrated sustained drug release over 24 h. Whereas ex vivo studies displayed a 5-fold increase in drug permeation, compared to tested conventional eye drops. The results suggested that glycerosomes-loaded contact lens can be a promising alternative for regulated delivery of dexamethasone sodium phosphate in the management of posterior uveitis.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"649-662"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970793/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143442860","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advantages and challenges of polymer-lipid hybrid nanoparticles for the delivery of biotech drugs.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-01-24 DOI: 10.1080/17435889.2025.2457930

Ilaria Ottonelli, Cecilia Baraldi, Barbara Ruozi, Maria Angela Vandelli, Giovanni Tosi, Jason T Duskey

引用次数: 0

Transforming stroke treatment through nanotherapies.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-01-28 DOI: 10.1080/17435889.2025.2459583

Huiying Ouyang, Yuying Mu, Xing Zhou, Jianxiang Zhang

引用次数: 0

3D spheroid model reveals enhanced efficacy of mannose-decorated nanoparticles for TB treatment.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-03-18 DOI: 10.1080/17435889.2025.2478806

Suyash M Patil, Apoorva Daram, Nitesh K Kunda

{"title":"3D spheroid model reveals enhanced efficacy of mannose-decorated nanoparticles for TB treatment.","authors":"Suyash M Patil, Apoorva Daram, Nitesh K Kunda","doi":"10.1080/17435889.2025.2478806","DOIUrl":"10.1080/17435889.2025.2478806","url":null,"abstract":"Aims: Tuberculosis (TB), caused by Mycobacterium tuberculosis remains a significant global health challenge aggravated by drug-resistant strains and prolonged treatment regimens. Innovative strategies to enhance treatment efficacy, improve patient adherence, and reduce adverse effects are urgently required.Methods: We explored a combination therapy using bedaquiline and pretomanid encapsulated in polymeric nanoparticles (pNPs). Further, active targeting was achieved through mannose-decorated nanoparticles (Man-pNPs) for macrophage-specific delivery. The drug-loaded pNPs and Man-pNPs were spray-dried into dry powder particles to improve drug solubility and enable local lung delivery via inhalation. Man-pNPs were prepared to target macrophages, wherein TB bacteria reside.Results: Formulations exhibited high drug loading and excellent aerosolization performance (MMAD 1-5 µm, FPF > 75%) for pNPs and Man-pNPs. Man-pNPs formulation enhanced macrophage targeting via receptor-mediated endocytosis and phagocytosis, improving bacterial inhibition. Man-pNPs demonstrated similar MIC in vitro and enhanced intracellular M.tb inhibition compared to free drug combination and pNPs. In addition, a TB spheroid model was developed for formulation screening, mimicking granulomas' physiological conditions. Man-pNPs formulation showed superior intracellular bacterial inhibition in TB spheroid model compared to free drug combination and pNPs.Conclusion: This research underscores the potential of combination therapy, particulate-based inhaled drug delivery, and active targeting to advance efficient and patient-friendly TB treatments.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"777-789"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143660012","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of erythrocyte-mimic nanoparticles in the treatment of cardiovascular diseases.

Nanomedicine (London, England) Pub Date : 2025-04-01 DOI: 10.1080/17435889.2025.2485674

Ni Zhu, Jing Yang

引用次数: 0

Application of pre-amplification-based CRISPR-Cas nanostructured biosensors for bacterial detection.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-03-07 DOI: 10.1080/17435889.2025.2476384

Hehua Zhang, Li Xie, Hongmin Gao, Hongzhi Pan

{"title":"Application of pre-amplification-based CRISPR-Cas nanostructured biosensors for bacterial detection.","authors":"Hehua Zhang, Li Xie, Hongmin Gao, Hongzhi Pan","doi":"10.1080/17435889.2025.2476384","DOIUrl":"10.1080/17435889.2025.2476384","url":null,"abstract":"Bacterial infections are one of the primary triggers of global disease outbreaks. Traditional detection methods, such as bacterial culture and PCR, while reliable, are limited by their time-consuming procedures and operational complexity. In recent years, the CRISPR-Cas system has demonstrated significant potential in gene editing and diagnostics due to its high specificity and precision, offering innovative solutions for bacterial detection. By integrating pre-amplification techniques, the CRISPR-Cas system has substantially enhanced detection sensitivity, particularly excelling in detecting low-concentration target bacteria. This review summarizes the principles and application examples of CRISPR-Cas-based fluorescence, electrochemical, lateral flow, and colorimetric nanostructured biosensors developed over the past three years, categorizing them according to their recognition methods (e.g. bacterial genomes, aptamers, antibodies). It systematically explores the broad application prospects of these sensors in medical diagnostics, environmental monitoring, and food safety assessment. Additionally, this review discusses future research directions and potential development prospects, providing new insights and technical support for the rapid diagnosis and treatment of bacterial infections.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"903-915"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143574983","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Design and application of antimicrobial nanomaterials in the treatment of periodontitis.

Nanomedicine (London, England) Pub Date : 2025-04-01 Epub Date: 2025-03-05 DOI: 10.1080/17435889.2025.2469492

Chunlin Wang, Yujun Yang, Ning Wang, Aohan Luan, Huilin Wang, Chen Hu

{"title":"Design and application of antimicrobial nanomaterials in the treatment of periodontitis.","authors":"Chunlin Wang, Yujun Yang, Ning Wang, Aohan Luan, Huilin Wang, Chen Hu","doi":"10.1080/17435889.2025.2469492","DOIUrl":"10.1080/17435889.2025.2469492","url":null,"abstract":"Periodontitis is a chronic inflammatory disease induced by the microbiome, leading to the destruction of periodontal structures and potentially resulting in tooth loss. Using local drug delivery systems as an adjunctive therapy to scaling and root planning in periodontitis is a promising strategy. However, this administration method's effectiveness is constrained by the complexity of the periodontal environment. Nanomaterials have demonstrated significant potential in the antibacterial treatment of periodontitis, attributed to their controllable size, shape, and surface charge, high design flexibility, high reactivity, and high specific surface area. In this review, we summarize the complex periodontal microenvironment and the difficulties of local drug delivery in periodontitis, explicitly reviewing the application and design strategies of nanomaterials with unique properties in the distinct microenvironment of periodontitis. Furthermore, the review discusses the limitations of current research, proposes feasible solutions, and explores prospects for using nanomaterials in this context.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"707-723"},"PeriodicalIF":0.0,"publicationDate":"2025-04-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11970792/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143560168","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0