Localized treatment of glioblastoma: a review of clinical strategies and advances in drug delivery systems.

IF 3.9

Nanomedicine (London, England) Pub Date : 2025-10-01 Epub Date: 2025-08-28 DOI:10.1080/17435889.2025.2550239

Cristiano Pesce, Giulia Rodella, Agnese Fragassi, Mariangela Garofalo, Stefano Salmaso, Paolo Caliceti, Bernard Gallez, Alessio Malfanti

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Abstract

The prognosis for glioblastoma patients remains poor despite recent advances in neurosurgery, chemotherapy, and radiotherapy. One promising treatment strategy lies in the localized delivery of therapeutics through drug delivery systems designed to enhance existing clinical treatments by directly targeting the tumor site or surrounding area. This review explores the latest advancements in localized therapies for glioblastoma, highlighting recent preclinical and clinical studies and examining how we can integrate these approaches - including stereotactic techniques such as convection-enhanced delivery and therapies targeting the post-surgical resection cavity - with drug delivery systems. We describe the features that the drug delivery system should possess for the efficient transport of drugs for both inoperable and resectable glioblastoma local treatment. Finally, this review discusses future directions that may facilitate the clinical translation of localized treatment strategies for glioblastoma.

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胶质母细胞瘤的局部治疗：药物输送系统的临床策略和进展综述。

尽管最近神经外科、化疗和放疗取得了进展，但胶质母细胞瘤患者的预后仍然很差。一种有希望的治疗策略是通过药物递送系统局部递送治疗药物，通过直接靶向肿瘤部位或周围区域来增强现有的临床治疗。这篇综述探讨了胶质母细胞瘤局部治疗的最新进展，重点介绍了最近的临床前和临床研究，并研究了我们如何将这些方法-包括立体定向技术，如对流增强输送和靶向手术后切除腔的治疗-与药物输送系统相结合。我们描述的特点，药物输送系统应具备药物的有效运输，不可手术和可切除胶质母细胞瘤局部治疗。最后，本综述讨论了可能促进胶质母细胞瘤局部治疗策略临床转化的未来方向。

本文章由计算机程序翻译，如有差异，请以英文原文为准。

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Nanomedicine (London, England)

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