Nanomedicine (London, England)最新文献_第3页

From conventional therapy to novel nano-based approaches. A focus on prostate cancer. 从传统疗法到新型纳米疗法。对前列腺癌的关注。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-07 DOI: 10.1080/17435889.2025.2501513

Lorenzo Chiaverini, Giarita Ferraro, Riccardo Di Leo, Elisabetta Barresi, Diego La Mendola, Francesco Bartoli, Luca Famlonga, Cristina Satriano, Pinuccia Faviana, Alessandro Zucchi, Matteo Pacini, Jürgen Gailer, Chiara Giacomelli, Tiziano Marzo

引用次数: 0

From innovation to application: safety concerns in nanomaterial implant coatings. 从创新到应用：纳米材料植入涂层的安全问题。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-03-19 DOI: 10.1080/17435889.2025.2480045

Eileen Tabrizi, Bingyun Li

引用次数: 0

Salvia miltiorrhiza-derived exosome-like nanoparticles improve diabetic cardiomyopathy by inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis via targeting the NEDD4/SGK1 axis. 丹参衍生的外泌体样纳米颗粒通过靶向NEDD4/SGK1轴抑制NLRP3炎症小体介导的巨噬细胞焦亡，改善糖尿病心肌病。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-20 DOI: 10.1080/17435889.2025.2506351

Zhijian Peng, Zefeng Gong, Zhiyong Wang, Bin Deng, Xiaoduo Zhang, Jiexing Lin

{"title":"Salvia miltiorrhiza-derived exosome-like nanoparticles improve diabetic cardiomyopathy by inhibiting NLRP3 inflammasome-mediated macrophage pyroptosis via targeting the NEDD4/SGK1 axis.","authors":"Zhijian Peng, Zefeng Gong, Zhiyong Wang, Bin Deng, Xiaoduo Zhang, Jiexing Lin","doi":"10.1080/17435889.2025.2506351","DOIUrl":"10.1080/17435889.2025.2506351","url":null,"abstract":"Aim: Exosome-like nanoparticles mediate intercellular communication and regulate gene expression. In this study, we isolated and purified exosome-like nanoparticles from Salvia miltiorrhiza (SM-ELNs), a traditional Chinese medicinal herb, and investigated their therapeutic effects on diabetic cardiomyopathy (DCM).Materials & methods: To investigate the effect of SM-ELNs on DCM, we established a mouse model via HFD/STZ treatment. Cardiac function was assessed by echocardiography. Cardiac hypertrophy was assessed by measuring the heart weight/body weight ratio and HE staining, while myocardial fibrosis was evaluated using Masson's trichrome staining. The role of SM-ELNs on NLRP3 inflammasome inhibition and macrophage pyroptosis were evaluated both in vivo and in vitro. The interaction between NEDD4 and SGK1 was analyzed by Co-IP and ubiquitination assays.Results: SM-ELNs treatment alleviated cardiac function and histopathological changes in DCM mice. Moreover, SM-ELNs suppressed NLRP3 inflammasome activation and subsequent macrophage pyroptosis in both in vivo and in vitro models. Mechanistically, NEDD4 facilitated the ubiquitination and degradation of SGK1 in macrophages. Both NEDD4 depletion and SGK1 addition could counteract the SM-ELNs-induced suppression of NLRP3 inflammasome-triggered macrophage pyroptosis in LPS/ATP-treated RAW264.7 cells.Conclusion: Our study provides the first evidence that SM-ELNs inhibit NLRP3 inflammasome-mediated macrophage pyroptosis in DCM by modulating the NEDD4/SGK1 axis.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1417-1428"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144112612","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in nanomaterial-based brain-targeted delivery systems for glioblastoma therapy. 基于纳米材料的脑靶向递送系统治疗胶质母细胞瘤的最新进展。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.1080/17435889.2025.2503694

Mingyue Qu, Quan Wang, Xinying Wang, Jie Tang, Xiyao Dong, Chaoyue Zhao, Qingxiang Guan

{"title":"Recent advances in nanomaterial-based brain-targeted delivery systems for glioblastoma therapy.","authors":"Mingyue Qu, Quan Wang, Xinying Wang, Jie Tang, Xiyao Dong, Chaoyue Zhao, Qingxiang Guan","doi":"10.1080/17435889.2025.2503694","DOIUrl":"10.1080/17435889.2025.2503694","url":null,"abstract":"Glioblastoma (GBM) poses a formidable challenge because of its high morbidity and mortality. The therapeutic efficacy of GBM is significantly hampered by the intricate blood-brain barrier (BBB) and blood-brain tumor barrier (BBTB). Nanomaterial-based brain-targeted delivery systems have shown great potential for effectively delivering therapeutic agents for GBM treatment by overcoming the limitations of conventional drugs, such as poor BBB penetration, a short half-life, and low bioavailability. This review focuses on an in-depth analysis of the interplay between the BBB/BBTB and drug transport kinetics while analyzing innovative nanoparticle-mediated strategies for enhanced GBM treatment. Moreover, the delivery strategies of nanoparticle-based brain-targeted systems are emphasized, with particular attention given to biomimetic nanoparticles (BMNPs), whose unique advantages. The current challenges, translational potential, and future research directions in this rapidly evolving field are comprehensively discussed, highlighting advances in nanomaterial applications. This review aims to stimulate further research into GBM delivery systems, offering promising avenues for maximizing the therapeutic effects of gene drugs or chemotherapeutic agents in practical applications.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1495-1511"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055032","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Preparation and evaluation of oral enteric sustained-release liquid formulations of aspirin. 阿司匹林口服肠溶缓释液体制剂的制备与评价。

Nanomedicine (London, England) Pub Date : 2025-06-01 Epub Date: 2025-05-12 DOI: 10.1080/17435889.2025.2503699

Xiaolin Zeng, Baoyan Chen, Peng Qian, Dongjun Jiang, Xianwei Wu, Shiqi Wei, Yangchen Xing, Yuxin Chen, Qianyu Zhang, Huali Chen

{"title":"Preparation and evaluation of oral enteric sustained-release liquid formulations of aspirin.","authors":"Xiaolin Zeng, Baoyan Chen, Peng Qian, Dongjun Jiang, Xianwei Wu, Shiqi Wei, Yangchen Xing, Yuxin Chen, Qianyu Zhang, Huali Chen","doi":"10.1080/17435889.2025.2503699","DOIUrl":"10.1080/17435889.2025.2503699","url":null,"abstract":"Aim: To develop an enteric sustained-release nanoparticle formulations of aspirin for applicability to a broader population.Methods: Aspirin-loaded nanoparticles were prepared using poly(lactic-co-glycolic acid) (PLGA) and the enteric polymer Eudragit L100-55 through an optimized oil-in-water emulsification solvent evaporation method. The nanoparticles were subjected to comprehensive physicochemical characterization, including particle size, zeta potential, and morphological analysis. Additionally, their stability, in vitro drug release profile, cytotoxicity, intestinal absorption, and in vivo pharmacokinetics were systematically evaluated.Results: The nanoparticles exhibited well-defined spherical morphology, uniform particle size, and favorable surface charge, demonstrating excellent biocompatibility. In the in vitro drug release study, AS-PLGA@NPs exhibited pronounced enterolysis effect. The morphology of the nanoparticles was confirmed by scanning electron microscopy (SEM) at different release stages. In vivo intestinal absorption and pharmacokinetic studies in rats demonstrated that AS-PLGA-EL@NPs enhanced drug absorption, prolonged drug release, and showed higher bioavailability compared to conventional enteric-coated tablets.Conclusion: The development and preparation of an oral enteric sustained-release nanoparticle delivery system for aspirin has the potential to serve a broader population, with promising applications in various therapeutic contexts.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1391-1402"},"PeriodicalIF":0.0,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144052751","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in the application of polymeric nanoparticles to the pulmonary delivery of mRNA. 聚合纳米颗粒在mRNA肺传递中的应用进展。

Nanomedicine (London, England) Pub Date : 2025-05-30 DOI: 10.1080/17435889.2025.2509477

Peyton M Panovich, Aditi Ganesan, Amogh R Angadi, Alexandra S Piotrowski-Daspit

{"title":"Recent advances in the application of polymeric nanoparticles to the pulmonary delivery of mRNA.","authors":"Peyton M Panovich, Aditi Ganesan, Amogh R Angadi, Alexandra S Piotrowski-Daspit","doi":"10.1080/17435889.2025.2509477","DOIUrl":"https://doi.org/10.1080/17435889.2025.2509477","url":null,"abstract":"Messenger RNA (mRNA)-based therapeutics offer the potential to treat a variety of pulmonary disorders that arise due to genetics, infectious diseases, and chronic respiratory conditions. However, various physiological barriers in the lungs, such as mucociliary clearance, macrophage phagocytosis, and lung surfactant interference, present challenges for efficient mRNA delivery. Polymeric nanoparticles (NPs) have emerged as a therapeutic platform for delivering mRNA therapeutics due to their stability, tunability, and controlled release properties, making them suitable and potentially ideal for encapsulating and protecting mRNA molecules for delivery in vivo. Continued advances in polymer and NP design have improved mucus penetration and cellular uptake upon lung delivery; further, administration via local and systemic routes enable modulation of NP biodistribution. These advancements benefit the potential treatment of a range of pulmonary diseases, including viral infections, cystic fibrosis (CF), asthma, and lung cancer, by facilitating immune modulation and genetic therapy delivery. In this review, we explore how polymeric NPs address disease-specific requirements and physiological challenges to expand the potential for therapeutic mRNAs in the lung.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-05-30","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144188647","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Correction. 修正。

Nanomedicine (London, England) Pub Date : 2025-05-30 DOI: 10.1080/17435889.2025.2514293

引用次数: 0

Emerging nanomaterials capable of effectively facilitating osteoblast maturation. 能够有效促进成骨细胞成熟的新兴纳米材料。

Nanomedicine (London, England) Pub Date : 2025-05-27 DOI: 10.1080/17435889.2025.2511465

Hoda Elkhenany

{"title":"Emerging nanomaterials capable of effectively facilitating osteoblast maturation.","authors":"Hoda Elkhenany","doi":"10.1080/17435889.2025.2511465","DOIUrl":"https://doi.org/10.1080/17435889.2025.2511465","url":null,"abstract":"Efficient osteoblast maturation is essential for successful bone regeneration, yet achieving this goal remains challenging. This review explores the emerging role of nanomaterials in promoting osteoblast differentiation and bone formation. A literature search was conducted in the Web of Science Core Collection in February 2025, covering publications from 2014 to 2024 and limited to articles and proceedings. Keywords included \"nanoparticles\" and \"osteoblast.\" Among the most extensively studied nanomaterials were hydroxyapatite, carbon-based, and bioactive glass nanoparticles (NPs). These materials influence osteoblast function through intracellular mechanisms, including enhanced mitochondrial activity, autophagy, and osteoinductive gene expression. Additionally, they modulate the extracellular microenvironment by mimicking the native bone matrix, releasing bioactive ions, and reducing inflammation and oxidative stress. Notably, several NP-based systems have reached clinical application, including Signafuse (a bioactive calcium phosphate composite), nanoLOCK (a nanostructured titanium spinal implant), and Vitoss (a synthetic bone graft of nanocrystalline calcium phosphate). More recently, multimodal NPs that integrate different NP types and combine surface roughness, ion release, and chemical cues offer synergistic effects. These materials provide a dual-function approach, targeting both intracellular processes and the bone microenvironment. Their ability to modulate inflammation, oxidative stress, and cellular signaling underscores their translational potential in regenerative medicine and bone tissue engineering.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-17"},"PeriodicalIF":0.0,"publicationDate":"2025-05-27","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144152867","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Repairing and preserving the cellular powerplant with nanotechnology. 用纳米技术修复和保存细胞动力装置。

Nanomedicine (London, England) Pub Date : 2025-05-26 DOI: 10.1080/17435889.2025.2510188

John Soukar, Kanwar Abhay Singh, Akhilesh K Gaharwar

引用次数: 0

Nanovesicular ultra-deformable transferosomes and transgelosomes for ocular drug delivery. 用于眼部药物传递的纳米泡状超变形转移体和转胶体。

Nanomedicine (London, England) Pub Date : 2025-05-26 DOI: 10.1080/17435889.2025.2510197

Debadatta Mohapatra, Timothy W Corson

引用次数: 0