Nanomedicine (London, England)最新文献_第3页

Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis. 氧化镁纳米粒子的溶胶凝胶合成及其作为骨关节炎治疗剂的评估。

Nanomedicine (London, England) Pub Date : 2024-08-07 DOI: 10.1080/17435889.2024.2382421

Sen Mei, Fangchao Jiang, Na Liu, Zhizi Feng, Yu Zheng, Wei Yang, Weizhong Zhang, Yingna Cui, Weiming Wang, Jin Xie, Nan Zhang

{"title":"Sol-gel synthesis of magnesium oxide nanoparticles and their evaluation as a therapeutic agent for the treatment of osteoarthritis.","authors":"Sen Mei, Fangchao Jiang, Na Liu, Zhizi Feng, Yu Zheng, Wei Yang, Weizhong Zhang, Yingna Cui, Weiming Wang, Jin Xie, Nan Zhang","doi":"10.1080/17435889.2024.2382421","DOIUrl":"https://doi.org/10.1080/17435889.2024.2382421","url":null,"abstract":"Aim: We synthesized MgO NPs via sol-gel reaction and investigated them as carriers to deliver Mg2+ to the affected joint for osteoarthritis (OA). Materials & methods: The physicochemical properties of samples were characterized by transmission electron microscope (TEM), dynamic light scattering (DLS) and x-ray diffraction (XRD). The release of Mg2+ was monitored by ICP-MS. The potential cytotoxicity was evaluated using MTT assay. The efficacy and biosafety were evaluated in a rabbit OA model. Results: MgO NPs can prolong the Mg2+ release time from 0.5 h to 12 h. No significant cytotoxicity was observed when concentrations below 250 μg/ml. Intra-articular samples could effectively alleviate the degeneration and destruction of the cartilage. Conclusion: this study demonstrates the potential of MgO NPs as a safe and effective treatment of OA. Simultaneously, the size of the particles may play a significant role in influencing the therapeutic outcome.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899084","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Prevention of chemotherapy-related bone loss with doxorubicin-loaded solid lipid nanoparticles. 多柔比星固体脂质纳米颗粒可预防化疗相关骨质流失。

Nanomedicine (London, England) Pub Date : 2024-08-07 DOI: 10.1080/17435889.2024.2382083

Marina Arantes Radicchi, Gabriel Ribeiro Farias, Victor Carlos Mello da Silva, Victória Paz Machado, Danielle Galdino de Souza, João Paulo Figueiró Longo, Sônia Nair Báo

{"title":"Prevention of chemotherapy-related bone loss with doxorubicin-loaded solid lipid nanoparticles.","authors":"Marina Arantes Radicchi, Gabriel Ribeiro Farias, Victor Carlos Mello da Silva, Victória Paz Machado, Danielle Galdino de Souza, João Paulo Figueiró Longo, Sônia Nair Báo","doi":"10.1080/17435889.2024.2382083","DOIUrl":"https://doi.org/10.1080/17435889.2024.2382083","url":null,"abstract":"Aim: Breast cancer and its metastases involve high mortality even with advances in chemotherapy. Solid lipid nanoparticles provide a platform for drug delivery, reducing side effects and treatment-induced bone loss. A solid nanoparticle containing doxorubicin was evaluated for its ability to prevent bone loss in a pre-clinical breast cancer model. Methods: We investigated the effects of SLNDox in an aggressive metastatic stage IV breast cancer model, which has some important features that are interesting for bone loss investigation. This study evaluates bone loss prevention potential from solid lipid nanoparticles containing doxorubicin breast cancer treatment, an evaluation of the attenuation of morphological changes in bone tissue caused by the treatment and the disease and an assessment of bone loss imaging using computed tomography and electron microscopy. Results: Chemotherapy-induced bone loss was also observed in tumor-free animals; a solid lipid nanoparticle containing doxorubicin prevented damage to the growth plate and to compact and cancellous bones in the femur of tumor-bearing and healthy animals. Conclusion: The association of solid lipid nanoparticles with chemotherapeutic drugs with proven efficacy promotes the prevention of serious consequences of chemotherapy, reducing tumor progression, increasing quality of life and improving prognosis and survival.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-07","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141899083","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanoparticles crossing blood-brain barrier need specific design for normal, neurodegenerative or cancerous brain conditions. 穿越血脑屏障的纳米粒子需要针对正常、神经退行性或癌症脑部疾病进行特定设计。

Nanomedicine (London, England) Pub Date : 2024-08-07 DOI: 10.1080/17435889.2024.2380241

Julia Y Ljubimova, Eggehard Holler, Keith L Black, Alexander V Ljubimov

引用次数: 0

Advanced biopolymeric materials and nanosystems for RNA/DNA vaccines: a review. 用于 RNA/DNA 疫苗的先进生物聚合物材料和纳米系统：综述。

Nanomedicine (London, England) Pub Date : 2024-08-07 DOI: 10.1080/17435889.2024.2382077

Luis F T Pereira, João G R Tredus, Larissa O Corá, Luisa L Novacki, Gabriel E D Oliveira, Mariana Vodiani, Isabela P Dias, Rafael X V Filho, Guilherme F Picheth

引用次数: 0

Antitumoral melatonin-loaded nanostructured lipid carriers. 抗肿瘤褪黑激素纳米脂质载体。

Nanomedicine (London, England) Pub Date : 2024-08-02 DOI: 10.1080/17435889.2024.2379757

Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, Maria Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López

{"title":"Antitumoral melatonin-loaded nanostructured lipid carriers.","authors":"Lorena Bonilla-Vidal, Marta Świtalska, Marta Espina, Joanna Wietrzyk, Maria Luisa García, Eliana B Souto, Anna Gliszczyńska, Elena Sánchez-López","doi":"10.1080/17435889.2024.2379757","DOIUrl":"https://doi.org/10.1080/17435889.2024.2379757","url":null,"abstract":"Aim: Cancer constitutes the second leading cause of death worldwide, with conventional therapies limited by significant side effects. Melatonin (MEL), a natural compound with antitumoral properties, suffers from instability and low solubility. To overcome these issues, MEL was encapsulated into nanostructured lipid carriers (MEL-NLC) containing rosehip oil to enhance stability and boost its antitumoral activity. Methods: MEL-NLC were optimized by a design of experiments approach and characterized for their physicochemical properties. Stability and biopharmaceutical behavior were assessed, along with interaction studies and in vitro antitumoral efficacy against various cancer cell lines. Results: Optimized MEL-NLC exhibited desirable physicochemical characteristics, including small particle size and sustained MEL release, along with long-term stability. In vitro studies demonstrated that MEL-NLC selectively induced cytotoxicity in several cancer cell lines while sparing healthy cells. Conclusion: MEL-NLC represent a promising alternative for cancer, combining enhanced stability and targeted antitumoral activity, potentially overcoming the limitations of conventional treatments.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-08-02","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141876902","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Oral inhalation of dacomitinib nanocarriers as a therapeutic strategy for non-small cell lung cancer. 口服吸入达科米替尼纳米载体作为非小细胞肺癌的治疗策略。

Nanomedicine (London, England) Pub Date : 2024-07-29 DOI: 10.1080/17435889.2024.2370225

Druva Sarika Rongala, Suyash M Patil, Nitesh K Kunda

引用次数: 0

Development and evaluation of berberine-loaded bigel for the treatment of hyperpigmentation on B16F10 melanoma cell line. 开发和评估用于治疗 B16F10 黑色素瘤细胞系色素沉着的小檗碱负载 bigel。

Nanomedicine (London, England) Pub Date : 2024-07-26 DOI: 10.1080/17435889.2024.2370759

Bharti Mangla, Pankaj Kumar, Zuber Ahamad, Shamama Javed, Waquar Ahsan, Geeta Aggarwal

引用次数: 0

Autologous serum protein stabilized silver quantum clusters as host-specific antibacterial agents. 作为宿主特异性抗菌剂的自体血清蛋白稳定银量子簇。

Nanomedicine (London, England) Pub Date : 2024-07-26 DOI: 10.1080/17435889.2024.2374231

Kritika Sood, Asifkhan Shanavas

引用次数: 0

Transethosomal gel for enhancing transdermal delivery of natural therapeutics. 用于加强天然疗法透皮给药的 Transethosomal 凝胶。

Nanomedicine (London, England) Pub Date : 2024-07-26 DOI: 10.1080/17435889.2024.2375193

Soki Daeme Malang, Shambhavi, Alakh N Sahu

引用次数: 0

Decitabine enclosed biotin-zein conjugated nanoparticles: synthesis, characterization, in vitro and in vivo evaluation. 地西他滨封闭生物素-zein共轭纳米颗粒：合成、表征、体外和体内评价。

Nanomedicine (London, England) Pub Date : 2024-07-23 DOI: 10.1080/17435889.2024.2374700

Akshada Mhaske, Jasleen Kaur, Saba Naqvi, Rahul Shukla

{"title":"Decitabine enclosed biotin-zein conjugated nanoparticles: synthesis, characterization, in vitro and in vivo evaluation.","authors":"Akshada Mhaske, Jasleen Kaur, Saba Naqvi, Rahul Shukla","doi":"10.1080/17435889.2024.2374700","DOIUrl":"https://doi.org/10.1080/17435889.2024.2374700","url":null,"abstract":"Aim: This study focuses on biotinylated nanocarriers designed to encapsulate amphiphilic molecules with self-biodegradable properties for enhanced drug delivery. Methods: Biotin-zein conjugated nanoparticles were synthesized and tested in C6 cell lines to evaluate their viability and cellular uptake. Optimization was achieved using a a central composite design. The nanoparticles underwent thermogravimetric analysis, and their pharmacokinetics and biodistribution were also studied. Results: The optimized nanoparticles displayed 96.31% drug encapsulation efficiency, a particle size of 95.29 nm and a zeta potential of -17.7 mV. These nanoparticles showed increased cytotoxicity and improved cellular uptake compared with free drugs. Thermogravimetric analysis revealed that the drug-loaded nanocarriers provided better protection against drug degradation. Pharmacokinetic and biodistribution studies indicated that the formulation had an extended brain residence time, highlighting its effectiveness. Conclusion: The biotin-zein conjugated nanoparticles developed in this study offer a promising nano-vehicle for in vivo biodistribution and pharmacokinetic applications. Their high drug encapsulation efficiency, stability and extended brain residence time suggest they are effective for targeted drug delivery and therapeutic uses.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-07-23","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"141749874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0