Nanomedicine (London, England)最新文献_第3页

Design and application of ferritin-based nanomedicine for targeted cancer therapy.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-03 DOI: 10.1080/17435889.2025.2459056

Baoli Zhang, Kelong Fan

{"title":"Design and application of ferritin-based nanomedicine for targeted cancer therapy.","authors":"Baoli Zhang, Kelong Fan","doi":"10.1080/17435889.2025.2459056","DOIUrl":"10.1080/17435889.2025.2459056","url":null,"abstract":"Owing to its unique structure and favorable biocompatibility, ferritin has been widely studied as a promising drug carrier over the past two decades. Since the identification of its inherent tumor-targeting property due to unique recognition ablity of the transferrin receptor 1 (TfR1), ferritin-based nanomedicine has attracted widespread attention and triggered a research surge in the field of targeted cancer therapy. Along with progress in structure studies and modification technology, diverse strategies have been carried out to equip ferritin with on-demand functions, further improving the antitumor efficacy and in vivo safety of ferritin-based cancer therapy. In this review, we highlight the structure-based rational design of ferritin and summarize the design strategies in detail from two main perspectives: multifunctional modification and drug loading. In particular, the critical issues that need attention in the design are discussed in depth. Furthermore, we provide an overview of the latest advances in the application of ferritin-based nanomedicines in chemotherapy, phototherapy and immunotherapy, with particular emphasis on emerging therapeutic approaches among these therapies.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"481-500"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875477/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143082484","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Versatile nanomaterials used in combatting biofilm infections.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1080/17435889.2025.2459049

Chenlong Wang, S M Shatil Shahriar, Yajuan Su, Jingwei Xie

{"title":"Versatile nanomaterials used in combatting biofilm infections.","authors":"Chenlong Wang, S M Shatil Shahriar, Yajuan Su, Jingwei Xie","doi":"10.1080/17435889.2025.2459049","DOIUrl":"10.1080/17435889.2025.2459049","url":null,"abstract":"Microbial infections are a pressing global health issue, exacerbated by the rise of antibiotic-resistant bacteria due to widespread antibiotic overuse. This resistance diminishes the effectiveness of current treatments, intensifying the need for new antimicrobial agents and innovative drug delivery strategies. Nanotechnology presents promising solutions, leveraging the unique properties of nanomaterials such as tunable optical and electronic characteristics, nanoscale size, and high surface-to-volume ratios. These features enhance their effectiveness as innovative antimicrobial agents and versatile drug delivery systems. This minireview classifies antimicrobial nanomaterials into four categories based on their mechanisms of action: thermal generation, reactive oxygen species generation, gas generation, and nanocarrier systems such as liposomes, polymersomes, and metal-organic frameworks. Uniquely, this review integrates a comparative analysis of these mechanisms, highlighting their relative advantages, limitations, and applications across diverse microbial targets. Additionally, it identifies emerging trends in the field, providing a forward-looking perspective on how recent advancements in nanotechnology can be leveraged to address unmet clinical needs. Finally, this article discusses future directions and emerging opportunities in antimicrobial nanotechnology.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"501-518"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875486/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143069498","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The therapeutic potential of nanoencapsulated anti-inflammatory drugs delivered to the gut.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-05 DOI: 10.1080/17435889.2025.2457321

Wenhao Li, Lili Qiu, Xiaoyu Wang

引用次数: 0

Exploiting differences in personal nanoparticle corona profiles for cancer diagnostics. 利用个人纳米粒子电晕谱的差异进行癌症诊断。

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2024-12-09 DOI: 10.1080/17435889.2024.2439238

Daniela Pozzi, Giulio Caracciolo

引用次数: 0

The therapeutic potential of immunomodulatory nucleic acid nanoparticles in the treatment of CNS infections. 免疫调节核酸纳米颗粒在治疗中枢神经系统感染中的治疗潜力。

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2024-12-04 DOI: 10.1080/17435889.2024.2435242

M Brittany Johnson

引用次数: 0

Dopamine stabilized in ultra-nanoreservoirs for controlled delivery in parkinson's disease.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-02-12 DOI: 10.1080/17435889.2025.2460228

Francisco J Padilla-Godínez, Tessy López-Goerne, Evelyn Y Calvillo-Muñoz, Mayra Angélica Álvarez-Lemus, Juan Navarrete-Bolaños, Omar Collazo-Navarrete, Obed R Lora-Marín, María-Del-Carmen Cárdenas-Aguayo, Myrian Velasco, Magdalena Guerra-Crespo

{"title":"Dopamine stabilized in ultra-nanoreservoirs for controlled delivery in parkinson's disease.","authors":"Francisco J Padilla-Godínez, Tessy López-Goerne, Evelyn Y Calvillo-Muñoz, Mayra Angélica Álvarez-Lemus, Juan Navarrete-Bolaños, Omar Collazo-Navarrete, Obed R Lora-Marín, María-Del-Carmen Cárdenas-Aguayo, Myrian Velasco, Magdalena Guerra-Crespo","doi":"10.1080/17435889.2025.2460228","DOIUrl":"10.1080/17435889.2025.2460228","url":null,"abstract":"Aims: Parkinson's disease (PD) is a neurodegenerative disorder caused by the progressive degeneration of dopaminergic neurons in the substantia nigra pars compacta, leading to impaired dopamine (DA) signaling and motor control. Intermittent dosing of current DA precursors results in side effects, prompting research into controlled drug release mechanisms for sustained and targeted delivery of DA.Materials & methods: In this work, we stabilized DA within a nanostructured silicate matrix (nanoreservoir) using the sol-gel method. We examined the physicochemical properties, kinetics of drug release, and biocompatibility in dopaminergic neurons and fibroblasts.Results: The optimized synthesis method allowed for the stabilization of DA by preventing its oxidation. The physicochemical and controlled release analysis showed a direct relationship between the mesoporous structure, interaction of the DA with the matrix, and the release kinetics followed, proving the possibility to modify the rate of release by adjusting the synthesis parameters. Furthermore, the nanoreservoirs were biocompatible with dopaminergic neurons and fibroblasts in vitro.Conclusions: The research sets the stage for potential in vivo evaluations and new strategies for managing PD, offering hope for improved treatments based on DA and not derivatives.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"543-557"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11881884/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143400953","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

The potential of nanoparticle-based siRNA delivery in breast cancer treatment. 基于纳米颗粒的siRNA递送在乳腺癌治疗中的潜力。

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2024-12-10 DOI: 10.1080/17435889.2024.2440302

Athirah Bakhtiar, Xi-Yuen Kuan, Ezharul Hoque Chowdhury

引用次数: 0

Synergistic anti-cancer effects of piezoelectric hexagonal boron nitride nanocarriers for controlled doxorubicin release.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-31 DOI: 10.1080/17435889.2025.2459055

Nilay Cicek, Zehra Cobandede, Sevin Adiguzel, Hulya Yilmaz, Mustafa Culha

{"title":"Synergistic anti-cancer effects of piezoelectric hexagonal boron nitride nanocarriers for controlled doxorubicin release.","authors":"Nilay Cicek, Zehra Cobandede, Sevin Adiguzel, Hulya Yilmaz, Mustafa Culha","doi":"10.1080/17435889.2025.2459055","DOIUrl":"10.1080/17435889.2025.2459055","url":null,"abstract":"Aims: This study aims to develop a piezoelectric drug delivery system based on hexagonal boron nitride nanosheets (hBNs).Materials and methods: hBNs were synthesized using the chemical vapor deposition (CVD) method and characterized through imaging and spectroscopic techniques. Their piezoelectric properties were evaluated to confirm their functionality. Subsequently, the potential of hBNs as nanocarriers was assessed through in vitro experiments with doxorubicin (Dox) as a model drug.Results: The piezoelectric hBNs were successfully synthesized and exhibited efficient loading and controlled release of Dox. In vitro experiments conducted on PC3 (human prostate cancer) and PNT1A (normal adult prostate epithelial) cell lines demonstrated that ultrasound (US)-induced Dox-loaded hBNs (hBN-Dox) significantly inhibited the proliferation of prostate cancer cells, achieving efficacy at a much lower Dox concentration compared to conventional methods. The system enhanced reactive oxygen species (ROS) generation, impaired cancer cell colony formation, and induced both early and late apoptosis.Conclusions: These findings highlight the potential of piezoelectric hBNs as nanocarriers for efficient drug delivery, leveraging the synergistic effect of piezoelectricity-induced drug release and the degradation products of hBNs in biological media. Their ability to enhance drug efficacy while reducing the required dose holds promise for advanced cancer therapies.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"455-466"},"PeriodicalIF":0.0,"publicationDate":"2025-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11875468/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143070103","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Recent advances in nanoultrasonography for the diagnosis and treatment of gastrointestinal diseases.

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-23 DOI: 10.1080/17435889.2025.2457319

Weiping Wan, Haina Tao, Zhixiao Chen, Fangming Guo, Yun Tian

引用次数: 0

The potential of nanofibrous matrices in muscular regeneration. 纳米纤维基质在肌肉再生中的潜力。

Nanomedicine (London, England) Pub Date : 2025-03-01 Epub Date: 2025-01-17 DOI: 10.1080/17435889.2025.2454893

Moon Sung Kang, Dong-Wook Han

引用次数: 0