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pH-Sensitive Nanoparticles of Epigallocatechin-3-Gallate in Enhanced Colorectal Cancer Therapy. 对 pH 值敏感的增强型表没食子儿茶素-3-棓酸盐纳米颗粒在结直肠癌治疗中的应用。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-15 DOI: 10.2217/nnm-2023-0342
Sankha Bhattacharya, Preeti Chidambar Sangave, Sateesh Belemkar, Md Meraj Anjum
{"title":"pH-Sensitive Nanoparticles of Epigallocatechin-3-Gallate in Enhanced Colorectal Cancer Therapy.","authors":"Sankha Bhattacharya, Preeti Chidambar Sangave, Sateesh Belemkar, Md Meraj Anjum","doi":"10.2217/nnm-2023-0342","DOIUrl":"10.2217/nnm-2023-0342","url":null,"abstract":"<p><strong>Aim: </strong>Encapsulating epigallocatechin-3-gallate (EGCG) in pH-sensitive polymeric nanoparticles for targeted delivery of drugs could revolutionize colorectal cancer treatment.</p><p><strong>Materials & methods: </strong>Nanoparticles were synthesized to release drugs at colon pH. Dynamic light scattering measured their average diameter and ζ-potential, while differential scanning calorimetry and x-ray diffraction assessed EGCG encapsulation.</p><p><strong>Results: </strong>The nanoparticles showed stability and bioavailability in the gastrointestinal tract, efficiently encapsulating and releasing over 93% of EGCG at pH 7.2. They enhanced cytotoxicity against HT-29 cells and demonstrated antibacterial properties, increasing apoptosis and cell cycle arrest.</p><p><strong>Conclusion: </strong>The study underscores the potential of nanoparticles in enhancing EGCG delivery for colorectal cancer therapy, aiming to minimize side effects and improve therapeutic outcomes.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139467381","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Fabrication, Characterization and Wound-Healing Properties of Core-Shell SF@chitosan/ZnO/Astragalus Arbusculinus Gum Nanofibers. 核壳 SF@ 壳聚糖/氧化锌/黄芪胶纳米纤维的制备、表征和伤口愈合性能。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-01-31 DOI: 10.2217/nnm-2023-0311
Zahra Amiri, Amir Mahdi Molavi, Amir Amani, Kurosh Hamzanlui Moqadam, Mehran Vatanchian, Seyyed Ahmad Hashemi, Fatemeh Oroojalian
{"title":"Fabrication, Characterization and Wound-Healing Properties of Core-Shell SF@chitosan/ZnO/<i>Astragalus Arbusculinus</i> Gum Nanofibers.","authors":"Zahra Amiri, Amir Mahdi Molavi, Amir Amani, Kurosh Hamzanlui Moqadam, Mehran Vatanchian, Seyyed Ahmad Hashemi, Fatemeh Oroojalian","doi":"10.2217/nnm-2023-0311","DOIUrl":"10.2217/nnm-2023-0311","url":null,"abstract":"<p><strong>Aim: </strong>Silk fibroin/chitosan/ZnO/<i>Astragalus arbusculinus</i> (Ast) gum fibrous scaffolds along with adipose-derived mesenchymal stem cells (ADSCs) were investigated for accelerating diabetic wound healing.</p><p><strong>Methods: </strong>Scaffolds with a core-shell structure and different compositions were synthesized using the electrospinning method. Biological <i>in vitro</i> investigations included antibacterial testing, cell viability analysis and cell attachment evaluation. <i>In vivo</i> experiments, including the chicken chorioallantoic membrane (CAM) test, were conducted to assess wound-healing efficacy and histopathological changes.</p><p><strong>Results: </strong>The incorporation of <i>Ast</i> to the silk fibroin@ chitosan/ZnO scaffold improved wound healing in diabetic mice. In addition, seeding of ADSCs on the scaffold accelerated wound healing.</p><p><strong>Conclusion: </strong>These findings suggest that the designed scaffold can be useful for skin regeneration applications.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643525","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Sex-specific considerations in nanomedicine: highlighting the impact of the menstrual cycle on drug development. 纳米医学中的性别特异性考虑因素：强调月经周期对药物开发的影响。
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2023-12-21 DOI: 10.2217/nnm-2023-0347
Maria Poley
{"title":"Sex-specific considerations in nanomedicine: highlighting the impact of the menstrual cycle on drug development.","authors":"Maria Poley","doi":"10.2217/nnm-2023-0347","DOIUrl":"10.2217/nnm-2023-0347","url":null,"abstract":"<p><p>Tweetable abstract The female menstrual cycle is one of the most overlooked sex-specific factors in drug distribution and response. Unlocking the potential of nanomedicine demands a fundamental understanding of the impact biological sex has on drug distribution, efficacy and adverse effects.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"138833319","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Copper oxide nanoparticles suppress retinal angiogenesis via inducing endothelial cell cuproptosis. 纳米氧化铜颗粒通过诱导内皮细胞杯突变抑制视网膜血管生成
Nanomedicine (London, England) Pub Date : 2024-03-01 Epub Date: 2024-02-01 DOI: 10.2217/nnm-2023-0301
Haorui Zhang, Chang Cai, Qing Li, Zheng Nie, Mengzhu Wang, Yongxuan Liu, Wei Shen, Hongyuan Song
{"title":"Copper oxide nanoparticles suppress retinal angiogenesis via inducing endothelial cell cuproptosis.","authors":"Haorui Zhang, Chang Cai, Qing Li, Zheng Nie, Mengzhu Wang, Yongxuan Liu, Wei Shen, Hongyuan Song","doi":"10.2217/nnm-2023-0301","DOIUrl":"10.2217/nnm-2023-0301","url":null,"abstract":"<p><p><b>Background:</b> Copper oxide nanoparticles (CuO NPs) exhibit antitumor activity; however, their potential as an antiangiogenesis agent is unknown. <b>Materials & methods:</b> The antiangiogenesis properties of CuO NPs were evaluated <i>in vitro</i> and <i>in vivo</i> and the underlying mechanism was examined using RNA sequencing and metabolomic analyses. <b>Results:</b> CuO NPs inhibited endothelial cell function <i>in vitro</i>. They also mitigated retinal vasculature development and alleviated pathological retinal angiogenesis <i>in vivo</i>. RNA sequencing and metabolomic analyses revealed that CuO NPs disrupt the tricarboxylic acid cycle and induce cuproptosis, which was further supported by evaluating cuproptosis-related metabolites and proteins. <b>Conclusion:</b> CuO NPs may be an effective antiangiogenic agent for the treatment of retinal angiogenesis.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-03-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139652320","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Enhancing antimicrobial activity and reducing cytotoxicity of silver nanoparticles through gelatin nanoparticles. 通过明胶纳米颗粒增强银纳米颗粒的抗菌活性并降低其细胞毒性。
Nanomedicine (London, England) Pub Date : 2024-02-01 Epub Date: 2024-01-25 DOI: 10.2217/nnm-2023-0246
Derya Ozhava, Petras Winkler, Yong Mao
{"title":"Enhancing antimicrobial activity and reducing cytotoxicity of silver nanoparticles through gelatin nanoparticles.","authors":"Derya Ozhava, Petras Winkler, Yong Mao","doi":"10.2217/nnm-2023-0246","DOIUrl":"10.2217/nnm-2023-0246","url":null,"abstract":"<p><p><b>Aim:</b> To develop a novel stabilizing agent for silver nanoparticles (AgNPs) with the aim of enhancing its antibacterial efficacy against wound associated pathogens while mitigating their cytotoxic effect on human cells. <b>Materials & methods:</b> In this study, monodispersed gelatin nanoparticles were synthesized to stabilize AgNPs. The stability, antibacterial activity and biocompatibility of the gelatin-stabilized AgNPs (Gel-AgNPs) were compared with citrate-stabilized AgNPs (citrate-AgNPs) or silver ions. <b>Results & conclusion:</b> Gelatin-stabilized AgNPs showed significantly better antibacterial activities compared with citrate-stabilized AgNPs against both Gram-positive and Gram-negative bacteria. These Gel-AgNPs showed significantly lower cytotoxicity to human dermal fibroblasts compared with Ag<sup>+</sup>. These findings provided the first evidence substantiating a novel functionality of gelatin nanoparticles in both stabilizing and enhancing the activity of AgNPs.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139563877","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Advanced nanomedicine approach of JAK inhibitors: supporting treatment of rheumatoid arthritis. JAK 抑制剂的先进纳米医学方法：支持类风湿性关节炎的治疗。
Nanomedicine (London, England) Pub Date : 2024-02-01 Epub Date: 2024-01-12 DOI: 10.2217/nnm-2023-0287
Radha Rani, Neha Raina, Akhilesh Kumar, Piyush K Gupta, Madhu Gupta
{"title":"Advanced nanomedicine approach of JAK inhibitors: supporting treatment of rheumatoid arthritis.","authors":"Radha Rani, Neha Raina, Akhilesh Kumar, Piyush K Gupta, Madhu Gupta","doi":"10.2217/nnm-2023-0287","DOIUrl":"10.2217/nnm-2023-0287","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139426206","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats. 纳米结构脂质载体在大鼠口服羟甲基硝基呋喃酮后的淋巴吸收。
Nanomedicine (London, England) Pub Date : 2024-02-01 Epub Date: 2024-01-25 DOI: 10.2217/nnm-2023-0263
Aline de Souza, Cauê Benito Scarim, Paulo Cesar Cotrim, Fernando Barbosa Junior, Bruno Alves Rocha, Leandro Augusto Calixto, Cristiano Jesus Correia, Gabriel Lima de Barros Araújo, Raimar Löbenberg, Nádia Araci Bou-Chacra, Ana Cristina Breithaupt-Faloppa
{"title":"Hydroxymethylnitrofurazone lymphatic uptake with nanostructured lipid carrier after oral administration in rats.","authors":"Aline de Souza, Cauê Benito Scarim, Paulo Cesar Cotrim, Fernando Barbosa Junior, Bruno Alves Rocha, Leandro Augusto Calixto, Cristiano Jesus Correia, Gabriel Lima de Barros Araújo, Raimar Löbenberg, Nádia Araci Bou-Chacra, Ana Cristina Breithaupt-Faloppa","doi":"10.2217/nnm-2023-0263","DOIUrl":"10.2217/nnm-2023-0263","url":null,"abstract":"<p><p><b>Background:</b> Leishmaniasis, caused by the protozoan <i>Leishmania</i> sp., infects phagocyte cells present in lymphatic organs. This study demonstrates the influence of nanostructured lipid carrier-loaded hydroxymethylnitrofurazone (NLC-NFOH) on lymphatic uptake using a chylomicron-blocking flow model in rats. <b>Method:</b> Lymphatic uptake of NFOH was assessed 1 h after oral administration of dimethyl sulfoxide with NFOH or NLC-NFOH with and without cycloheximide pretreatment. <b>Result:</b> Dimethyl sulfoxide with NFOH and NLC-NFOH showed NFOH serum concentrations of 0.0316 and 0.0291 μg/ml, respectively. After chylomicron blocking, NFOH was not detected. <b>Conclusion:</b> Despite log P below 5, NFOH was successfully taken up by the lymphatic system. Long-chain fatty acids and particle size might be main factors in these findings. NLC-NFOH is a promising and convenient platform for treating leishmaniasis via oral administration.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139547671","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Distearoyl phosphatidylglycerol and dioleoyl phosphatidylglycerol increase the retention and reduce the toxicity of amphotericin B-loaded in nanoemulsions. 二硬脂酰基磷脂酰甘油和二油酰基磷脂酰甘油可提高纳米乳剂中两性霉素 B 的保留率并降低其毒性。
Nanomedicine (London, England) Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.2217/nnm-2023-0256
Gabriel Silva Marques Borges, Thais Tunes Santos, Cristiane Monteiro Pinto, Frédéric Frézard, Verônica Freitas Blanco, Roberta Ondei, Stephen Rumbelow, Lucas Antônio Miranda Ferreira, Marta Marques Gontijo de Aguiar, Gisele Assis Castro Goulart
{"title":"Distearoyl phosphatidylglycerol and dioleoyl phosphatidylglycerol increase the retention and reduce the toxicity of amphotericin B-loaded in nanoemulsions.","authors":"Gabriel Silva Marques Borges, Thais Tunes Santos, Cristiane Monteiro Pinto, Frédéric Frézard, Verônica Freitas Blanco, Roberta Ondei, Stephen Rumbelow, Lucas Antônio Miranda Ferreira, Marta Marques Gontijo de Aguiar, Gisele Assis Castro Goulart","doi":"10.2217/nnm-2023-0256","DOIUrl":"10.2217/nnm-2023-0256","url":null,"abstract":"<p><p><b>Aim:</b> To develop nanoemulsions (NEs) loading amphotericin B (AmB) and to evaluate the influence of different excipients on the stability and the supramolecular organization, retention and toxicity of AmB. <b>Materials & methods:</b> The NEs were developed from different oils, surfactants, external media and anionic lipids (disteaoryl phosphatidylglycerol [DSPG] and dioleoyl phosphatidylglycerol [DOPG]). Their impact on the size, pH, zeta potential, AmB encapsulation efficiency, AmB retention and hemolytic potential of the NEs was evaluated. <b>Results & conclusion:</b> The use of soybean oil (lipid matrix), Span 80 (surfactant), phosphate buffer (external phase) and DSPG or DOPG (hydrophobic ion pair) provided better NE stability, higher AmB retention within the NEs and a safer formulation profile in hemolysis tests.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643523","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Unlocking the power of sugar: carbohydrate ligands as key players in nanotherapeutic-assisted targeted cancer therapy. 释放糖的力量：碳水化合物配体是纳米疗法辅助癌症靶向治疗的关键角色。
Nanomedicine (London, England) Pub Date : 2024-02-01 Epub Date: 2024-01-30 DOI: 10.2217/nnm-2023-0276
Rajan Swami, Sahil Vij, Shubham Sharma
{"title":"Unlocking the power of sugar: carbohydrate ligands as key players in nanotherapeutic-assisted targeted cancer therapy.","authors":"Rajan Swami, Sahil Vij, Shubham Sharma","doi":"10.2217/nnm-2023-0276","DOIUrl":"10.2217/nnm-2023-0276","url":null,"abstract":"<p><p>Cancer cells need as much as 40-times more sugar than their normal cell counterparts. This sugar demand is attained by the excessive expression of inimitable transporters on the surface of cancer cells, driven by their voracious appetite for carbohydrates. Nanotechnological advances drive research utilizing ligand-directed therapeutics and diverse carbohydrate analogs. The precise delivery of these therapeutic cargos not only mitigates toxicity associated with chemotherapy but also reduces the grim toll of mortality and morbidity among patients. This in-depth review explores the potential of these ligands in advanced cancer treatment using nanoparticles. It offers a broader perspective beyond the usual ways we deliver drugs, potentially changing the way we fight cancer.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139577280","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
Nanocarrier-based localized and effective treatment of renal disorders: currently employed targeting strategies. 基于纳米载体的肾脏疾病局部有效治疗：目前采用的靶向策略。
Nanomedicine (London, England) Pub Date : 2024-02-01 Epub Date: 2024-01-31 DOI: 10.2217/nnm-2023-0251
Shafi Ullah, Samiullah Burki, Abu Bakar Munir, Ghulam Yousaf, Muhammad Shafique
{"title":"Nanocarrier-based localized and effective treatment of renal disorders: currently employed targeting strategies.","authors":"Shafi Ullah, Samiullah Burki, Abu Bakar Munir, Ghulam Yousaf, Muhammad Shafique","doi":"10.2217/nnm-2023-0251","DOIUrl":"10.2217/nnm-2023-0251","url":null,"abstract":"<p><p>Renal disorders pose a global health threat, with targeted drug-delivery systems emerging as a promising strategy to enhance therapy safety and efficacy. Recent efforts have harnessed targeted nanomaterials for kidney disease treatment. While some systems remain in the early stages, they show immense potential in delivering cargo to specific sites. Through animal model experimentations, it has been demonstrated to reduce systemic side effects and enhance treatment effectiveness. This review presents current strategies for kidney disorder treatment, emphasizing site-specific targeting critical to renal disease pathophysiology. Recent advancements in nano-drug delivery systems for kidney targeting are explored. Finally, toxicological aspects and prospects of the most promising kidney-targeting delivery systems are discussed in this review article.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":null,"pages":null},"PeriodicalIF":0.0,"publicationDate":"2024-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"139643526","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
引用次数: 0
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