Nanomedicine (London, England)最新文献_第7页

Tissue engineering with targeted delivery of nanotized S-nitrosyl mutant of NEMO ameliorates myocardial infarction. 组织工程靶向递送纳米s -亚硝基NEMO突变体可改善心肌梗死。

Nanomedicine (London, England) Pub Date : 2025-05-01 Epub Date: 2025-04-16 DOI: 10.1080/17435889.2025.2491989

Abhik Kar, Soumyadeep Gupta, Arkapravo Matilal, Sagartirtha Sarkar

{"title":"Tissue engineering with targeted delivery of nanotized S-nitrosyl mutant of NEMO ameliorates myocardial infarction.","authors":"Abhik Kar, Soumyadeep Gupta, Arkapravo Matilal, Sagartirtha Sarkar","doi":"10.1080/17435889.2025.2491989","DOIUrl":"https://doi.org/10.1080/17435889.2025.2491989","url":null,"abstract":"Background: Myocardial infarction (MI) is characterized by an elevated nitrosative and hypoxic microenvironment due to reduced coronary blood flow. NEMO (IKKγ) regulates the formation of the IKK holo-complex to activate NFκB-p65 signaling. This study reports successful restoration of MI through cardiomyocyte-targeted nanotized S-nitrosyl mutant of NEMO under elevated nitrosative stress.Methods: The MI model was generated in male Wistar rats. S-nitrosyl mutant of NEMO (R- NEMO) was selectively delivered to the cardiomyocytes via targeted chitosan nano-vehicle.Results: Nano-conjugated R- NEMO delivery to diseased cardiomyocytes resulted in downregulation of nitrosative stress and cellular apoptosis leading to regressed infarct area with improved cardiac pathophysiology. Mechanistically, NEMO-p300 binding in R- NEMO expressed cells destabilized p65-p300 complex leading to regressed nitrosative stress and cellular apoptosis. The NEMO mutant inhibits the PGC1α-p65 complex-mediated degradation of PGC1α, leading to upregulation of VEGF. A shift in the binding preference of p65 from PGC1α/p300 to HDAC1 results in the downregulation of the cell-cycle inhibitor and the induction of cell-cycle re-entry markers during MI.Conclusion: Tissue-targeted R- NEMO nanoconjugates show potential to ameliorate MI insult by downregulating apoptosis and promoting the proliferative prowess of the resident cardiomyocytes with potential revascularization at infarct sites; thus, repairing the damaged myocardium.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":"20 10","pages":"1085-1099"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068353/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144055073","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

MicroRNA-targeted nanoparticle delivery systems for cancer therapy: current status and future prospects. 用于癌症治疗的微rna靶向纳米颗粒递送系统：现状和未来展望。

Nanomedicine (London, England) Pub Date : 2025-05-01 Epub Date: 2025-04-15 DOI: 10.1080/17435889.2025.2492542

Yang Lou, Yutian Wang, Juan Lu, Xi Chen

{"title":"MicroRNA-targeted nanoparticle delivery systems for cancer therapy: current status and future prospects.","authors":"Yang Lou, Yutian Wang, Juan Lu, Xi Chen","doi":"10.1080/17435889.2025.2492542","DOIUrl":"https://doi.org/10.1080/17435889.2025.2492542","url":null,"abstract":"Recently, the regulatory effects of microRNAs (miRNAs) on gene expression have been exploited for applications in the diagnosis and treatment of cancer, neurological diseases, and cardiovascular diseases. However, the susceptibility of miRNAs to degradation during somatic circulation and the challenges associated with their delivery to target tissues and cells have limited the clinical application of miRNAs. For application in tumor therapy, it is essential for miRNAs to specifically target cancer cells. Therefore, various novel miRNA delivery systems that protect miRNA against the activity of serum nuclease and deliver miRNA to target cells have been developed and optimized. This review introduces the passive and active targeting strategies of nanoparticles, summarizes the recent progress of miRNA nanocarriers with tumor-targeting ability, and discusses various nanoparticle delivery systems and their antitumor applications. Additionally, this review focuses on the translational challenges and potential strategies for advancing miRNA-based therapies into the clinic.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":"20 10","pages":"1181-1194"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068351/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144025872","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exosome-based nanomedicines for digestive system tumors therapy. 基于外泌体的纳米药物用于消化系统肿瘤治疗。

Nanomedicine (London, England) Pub Date : 2025-05-01 Epub Date: 2025-04-18 DOI: 10.1080/17435889.2025.2493037

Ge Song, Chenlu Zeng, Junru Li, Jiajia Liu, Juanxia Zhao, Bin Liu, Jialong Fan, Hailong Xie

{"title":"Exosome-based nanomedicines for digestive system tumors therapy.","authors":"Ge Song, Chenlu Zeng, Junru Li, Jiajia Liu, Juanxia Zhao, Bin Liu, Jialong Fan, Hailong Xie","doi":"10.1080/17435889.2025.2493037","DOIUrl":"https://doi.org/10.1080/17435889.2025.2493037","url":null,"abstract":"Digestive system tumors constitute a major subset of malignancies, consistently ranking among the leading causes of mortality globally. Despite limitations inherent in current therapeutic modalities, recent advancements in targeted therapy and drug delivery systems have led to significant improvements in the efficacy of pharmacotherapy for digestive system tumors. In this context, exosomes - naturally occurring nanoscale vesicles - have emerged as promising drug delivery candidates due to their intrinsic molecular transport capabilities, superior biocompatibility, and targeted recognition of tumor cells. The integration of exosomes into cancer therapeutics represents a novel and potentially transformative approach for treating digestive system tumors, which may drive further progress in this field. This review comprehensively examines the sources, loading mechanisms, and therapeutic efficacy of exosomes in the context of digestive system tumor treatment. Furthermore, it discusses the opportunities and challenges associated with exosomes, offering insights into their future role within the therapeutic armamentarium against digestive tumors.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":"20 10","pages":"1167-1180"},"PeriodicalIF":0.0,"publicationDate":"2025-05-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12068745/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144048224","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Toward a cure for type 1 diabetes: the innovative potential of Phosphatidylserine-rich liposomes. 迈向1型糖尿病的治疗：富含磷脂酰丝氨酸脂质体的创新潜力。

Nanomedicine (London, England) Pub Date : 2025-05-01 Epub Date: 2025-02-28 DOI: 10.1080/17435889.2025.2473872

Bruna Barneda-Zahonero, Lidia Almenara-Fuentes, David Perna-Barrull, Marta Vives-Pi

引用次数: 0

Self-assembling peptoid-based antimicrobial nanomaterials. 自组装肽基抗菌纳米材料。

Nanomedicine (London, England) Pub Date : 2025-05-01 Epub Date: 2025-02-23 DOI: 10.1080/17435889.2025.2469482

Håvard Jenssen

引用次数: 0

Precision oncology through SERS: emerging approaches for improved cancer diagnosis and prognosis. 通过SERS精确肿瘤学：改善癌症诊断和预后的新方法。

Nanomedicine (London, England) Pub Date : 2025-04-28 DOI: 10.1080/17435889.2025.2497745

Eduardo Garcia-Rico, Miguel A Correa-Duarte, Ramon A Alvarez-Puebla

引用次数: 0

Applying nanotechnology to glaucoma therapy: past, present, and future. 纳米技术在青光眼治疗中的应用：过去、现在和未来。

Nanomedicine (London, England) Pub Date : 2025-04-25 DOI: 10.1080/17435889.2025.2497748

Wenbing Jiang, Zeynep Ulker, Kai Xin Thong, Mengqi Qin, Cynthia Yu-Wai-Man

引用次数: 0

Defining the landscape of prenatal nanomedicine and a roadmap for future research. 确定产前纳米医学的前景和未来研究的路线图。

Nanomedicine (London, England) Pub Date : 2025-04-18 DOI: 10.1080/17435889.2025.2492540

Hagar I Labouta

引用次数: 0

Designing nanoparticle-based bioaffinity assays for the detection of extracellular vesicles. 设计基于纳米粒子的细胞外囊泡检测方法。

Nanomedicine (London, England) Pub Date : 2025-04-09 DOI: 10.1080/17435889.2025.2488726

Md Khirul Islam, Imran Mahmud, Janne Leivo

引用次数: 0

Synergistic RNA particles for spontaneous and specific cancer targeting but low toxicity due to motility and deformation. 协同RNA颗粒自发和特定的癌症靶向，但由于运动和变形的低毒性。

Nanomedicine (London, England) Pub Date : 2025-04-08 DOI: 10.1080/17435889.2025.2488727

Daniel W Binzel, Peixuan Guo

引用次数: 0