{"title":"How can nanotechnology be leveraged to produce multifunctional contrast agents to improve imaging and diagnostics?","authors":"Junxi Yi, Yun-Sheng Chen","doi":"10.1080/17435889.2025.2501515","DOIUrl":"10.1080/17435889.2025.2501515","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1991-1994"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330235/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144032125","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Jingmei Zhou, Min Lin, Yan Mo, Ruiyue Dang, Jin Zhou, Chengmin Li, Xin Deng, Alaa Aldeen Alsaeedi, Yingqi Zhao, Juan Huang, Lijuan Ma, Xueping Feng, Yong Liu, Yunyun Wang
{"title":"Formation and evaluation of docetaxel and triptolide polymer micelles for anti-cancer activity.","authors":"Jingmei Zhou, Min Lin, Yan Mo, Ruiyue Dang, Jin Zhou, Chengmin Li, Xin Deng, Alaa Aldeen Alsaeedi, Yingqi Zhao, Juan Huang, Lijuan Ma, Xueping Feng, Yong Liu, Yunyun Wang","doi":"10.1080/17435889.2025.2535281","DOIUrl":"10.1080/17435889.2025.2535281","url":null,"abstract":"<p><strong>Aim: </strong>To develop docetaxel (DTX) and triptolide (TPL) polymer micelles (DTX/TPL-PMs) with synergistic anti-cancer effect and to evaluate their anti-cancer activity.</p><p><strong>Methods: </strong>DTX/TPL-PMs were prepared by thin-film hydration. The drug loading (DL%), encapsulation efficiency (EE%), and cumulative release rate (CR%) were determined using HPLC. The anti-cancer activity was assessed using CCK-8, inverted microscopy, and laser scanning confocal microscope (LSCM).</p><p><strong>Results: </strong>DTX/TPL-PMs exhibited the average particle size of 178.58 ± 1.66 nm with a polydispersity index (PDI) of 0.102 ± 0.018 and a zeta potential of 1.19 ± 0.12 mV. These micelles showed a high EE% (89.43%) and a DL% (5.21%). In vitro release studies of DTX/TPL-PMs revealed that the loaded drug exhibited a slow-release phase in physiological fluids and a rapid-release phase under acidic conditions. Compared with the free DTX/TPL drugs, DTX/TPL-PMs were more readily taken up by cancer cells. The cytotoxicity of DTX/TPL-PMs was significantly higher than that of the free drugs, which showed stronger growth inhibitory effects and higher apoptosis rates in cancer cells.</p><p><strong>Conclusion: </strong>The research results demonstrate that DTX/TPL-PMs enhance the therapeutic efficacy against malignancies, while reducing adverse effects. It holds potential as an effective nanotherapeutic for combination chemotherapy and represents a promising clinical strategy.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1999-2011"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330271/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144746361","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Nabil K Alruwaili, Waleed H Almalki, Salem Salman Almujri, Abdulrahman Alhamyani, Abdulaziz Alzahrani, Alhussain Aodah, Majed Alrobaian, Tanuja Singh, Md Abul Barkat, Abdulkareem Ali Alanezi, Anjali Singh, Esraa M Haji, Mahfoozur Rahman
{"title":"Phospholipid-based nanolipid carriers for dual kinase inhibitors in triple-negative breast cancer.","authors":"Nabil K Alruwaili, Waleed H Almalki, Salem Salman Almujri, Abdulrahman Alhamyani, Abdulaziz Alzahrani, Alhussain Aodah, Majed Alrobaian, Tanuja Singh, Md Abul Barkat, Abdulkareem Ali Alanezi, Anjali Singh, Esraa M Haji, Mahfoozur Rahman","doi":"10.1080/17435889.2025.2533106","DOIUrl":"10.1080/17435889.2025.2533106","url":null,"abstract":"<p><strong>Aim: </strong>Current research is focused on developing phospholipid-based nanolipidic carrier (NLC) to deliver lapatinib (LNB) and imatinib (INB) to MDA-MB-231 breast cancer cells and an in vivo mammary tumor model.</p><p><strong>Materials and methods: </strong>Breast cancer (BC) was induced in female rats via the chemical carcinogen 7, 12-dimethylbenz(a)anthracene (DMBA). The dual drug-loaded phospholipid-based NLC were made via a hot microemulsion process. The developed NLC were also characterized, and tested in vitro, in vivo, and in a preclinical setting in a DMBA-induced rat model.</p><p><strong>Results: </strong>The dual drug-loaded phospholipid NLC exhibited favorable nanometric size (279.7 nm, PDI 0.323), high entrapment efficiency (94.21%), and robust loading capacity (13.11%). It achieved biphasic drug release (52.67% at 4 h; 92.12% cumulative), potent cytotoxicity with maximal IC₅₀ reduction at 48 h, and maintained stability under accelerated conditions. In vivo, it significantly reduced tumor burden, normalized hematological and biochemical markers, and demonstrated therapeutic efficacy in DMBA-induced breast cancer, highlighting its translational potential.</p><p><strong>Conclusions: </strong>The dual drug-loaded NLC not only achieved high entrapment efficiency but also enhanced cytotoxicity against MDA-MB-231 cells and significantly reduced tumor progression. The developed lipid-based nanocarrier system demonstrates strong potential as a targeted platform for the co-delivery of kinase inhibitors, addressing the therapeutic limitations associated with monotherapy and conventional drug formulations.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1865-1880"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320807/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144651419","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Advancements in hydrogel applications for osteoarthritis therapy.","authors":"Zhong-Xu Jing, Ying Lv, Yan-Hong Wang, Yu-Fei Feng","doi":"10.1080/17435889.2025.2535274","DOIUrl":"10.1080/17435889.2025.2535274","url":null,"abstract":"<p><p>Osteoarthritis (OA) is a prevalent degenerative joint disorder that significantly impacts patient quality of life. Conventional interventions, including pharmacological and surgical approaches, have demonstrated numerous limitations and are inadequate for cartilage regeneration. Recently, hydrogels, as biomaterials characterized by a distinctive three-dimensional network structure, superior biocompatibility, and adjustable mechanical properties, have shown promising potential in OA therapy. In January 2025, a literature review was performed on hydrogel research published between January 2020 and January 2025, utilizing PubMed and Web of Science databases. Due to the foundational and representative nature of the experimental methodologies, two seminal original research articles from 2017 and 2019 were explicitly cited. This article reviews the latest advancements in hydrogel-based OA treatments, focusing on innovative therapeutic strategies such as lubrication enhancement, anti-inflammatory effects, microenvironmental response activation, mesenchymal stem cells and their exosome derivatives, as well as piezoelectric smart hydrogels, with particular emphasis on their application in OA management. Finally, we summarize the clinical research and development of hydrogel products from 2015 to 2025. Despite challenges in OA treatment, such as precise drug delivery and mechanical durability, the potential of hydrogels in personalized medicine and improving therapeutic outcomes positions them as a pivotal direction for future OA therapies.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"2093-2116"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330244/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735912","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Research progress on mRNA drug delivery strategies in the nervous system.","authors":"Bo Yang, Anqi Liu, Xiaojing Li, Zhigang Miao","doi":"10.1080/17435889.2025.2530242","DOIUrl":"10.1080/17435889.2025.2530242","url":null,"abstract":"<p><p>There has been little progress in the treatment of central nervous system (CNS) disorders in recent decades. To date, new therapeutic agents such as small molecule drugs, cytokines, monoclonal antibodies and vaccines targeting specific antigens are still in the research and development stage and have not yet entered clinical use. With the discovery of gene-editing technology and the development of new therapeutic strategies, mRNA has been developed and used as a new type of drug, showing potential application value in the treatment of various neurological diseases. However, mRNA drugs face difficulties in being delivered to the CNS to exert therapeutic effects. We conducted a review by searching the PubMed database for relevant literature up to now, focusing on the research progress of mRNA drug delivery systems in the nervous system and their applications in neurological diseases, explore the challenges and prospects of mRNA drugs in neurological diseases, and provide reference for the development and implementation of mRNA drugs for neurological diseases.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1955-1970"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320854/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144577190","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"Bioengineered nanoparticles for targeted topical delivery in wound healing: advances and future outlook.","authors":"Ankita Sood, Vaidehi Patwardhan, Sudipta Nayak, Srinidhi Chintalapani, Sachin Mandal, Kulbhushan Tikoo","doi":"10.1080/17435889.2025.2535277","DOIUrl":"10.1080/17435889.2025.2535277","url":null,"abstract":"<p><p>The convergence of nanoscale engineering and biomimetics is revolutionizing wound care by enabling the development of bioengineered nanoparticles with exceptional therapeutic precision. This review synthesizes recent advances in nanoparticle-based interventions that mimic biological systems for targeted, controlled, and stage-specific wound healing. Innovations covered include receptor-specific ligand conjugation, bioactive scaffolds, nucleic acid-based systems, microenvironment-responsive nanomaterials, stimuli-activated metal nanoparticles, biosensing platforms, and exosome-mimicking systems. These approaches offer enhanced modulation of the wound microenvironment and promote tissue regeneration, addressing major drawbacks of conventional therapies. Therapeutic efficacy is critically evaluated using data from recent in vitro and in vivo studies. A structured literature search was conducted using PubMed, Scopus, Web of Science, and ScienceDirect, covering publications from January 2015 to June 2025. Relevant studies were selected based on their focus on nanoparticle-based wound-healing strategies, bioengineering innovations, and translational potential. The review also discusses challenges such as biocompatibility, biodistribution, manufacturing scalability, and regulatory hurdles that limit clinical adoption. Finally, this review explores the future paradigm of personalized nanotherapeutics, tailored to individual patient pathophysiology. By summarizing current developments and forecasting future directions, this review highlights the transformative role of bioengineered nanoparticles in next-generation wound healing and regenerative medicine.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"2061-2092"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330261/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144755294","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"The synergistic potential of ultrasound and nanomaterials for enhanced diagnosis and therapy of head and neck cancers.","authors":"Hua Wang, Yuankun Gao, Dawei Wang, Yulei Wan","doi":"10.1080/17435889.2025.2528593","DOIUrl":"10.1080/17435889.2025.2528593","url":null,"abstract":"<p><p>Ultrasound and nanomaterials are becoming flexible and revolutionary approaches to diagnosing cancer, especially head and neck cancers. This review explores the synergistic combination of nanomaterials that improve diagnostic accuracy with ultrasonography. Despite the head and neck's complex anatomy, functionalized nanoparticles as contrast agents improve ultrasound resolution and tissue differentiation. Multifunctional nanomaterials go beyond imaging to give targeted drug administration, treatment monitoring, and real-time tumor visualization. They can additionally serve both diagnostic and therapeutic functions. Due to its versatility, the ultrasound-nanomaterial platform is particularly attractive for comprehensive cancer management. Future research must focus on optimizing the design of nanoparticles by enhancing their surface modification for improved biocompatibility and controlled drug-loading capacity, which are crucial for effective targeted delivery in oncology. The development of biodegradable nanoparticles with optimized pharmacokinetics will play a pivotal role in reducing systemic toxicity. This review systematically examines the integration of nanomaterials with ultrasound imaging techniques, particularly ultrasound-guided theranostics, which have the potential to enable real-time monitoring of tumor response to therapy. These advancements in nanoparticle design and ultrasound-based diagnostics can significantly improve the accuracy of early detection, precise drug delivery, and the customization of treatment strategies for head and neck cancers, ultimately enhancing patient outcomes.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1971-1986"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320887/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144676786","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Selene Tassoni, Paolo Bergese, Annalisa Radeghieri
{"title":"The extracellular vesicle biomolecular corona: current insights and diagnostic potential.","authors":"Selene Tassoni, Paolo Bergese, Annalisa Radeghieri","doi":"10.1080/17435889.2025.2538426","DOIUrl":"10.1080/17435889.2025.2538426","url":null,"abstract":"<p><p>Extracellular vesicles (or EVs) are biogenic nanoparticles released by all cell types, playing a central role in intercellular communication by transporting proteins, nucleic acids, and metabolites. Over the past 5 years, it has become evident that, similarly to synthetic nanoparticles, EVs acquire a dynamic layer of biomolecules from the surrounding biological fluids. These spatially correlated and time-resolved interactions between EVs and the other molecular and nanoscale components of the biological environment are named biomolecular corona, and concur in shaping the biological identity, function, and fate of EVs. In this review, we first outline the physicochemical interactions that drive biomolecular corona formation on EVs and its principal biomolecular components. We then compare <i>ex situ</i> and <i>in situ</i> characterization techniques currently employed to study the EVs and EV corona complexes, highlighting their respective advantages and limitations. Finally, we discuss how advancing our understanding of the EV corona could significantly improve the robustness of EV-based biomarkers and enhance the specificity of liquid biopsy strategies, ultimately contributing to the development of next-generation precision medicine and personalized diagnostics.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"2013-2021"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12330241/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144735914","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
Songpu Xie, Nazma F Ilahibaks, Zhiyong Lei, Joost P G Sluijter
{"title":"Harnessing extracellular vesicles to deliver genetic medicine for cardiac repair.","authors":"Songpu Xie, Nazma F Ilahibaks, Zhiyong Lei, Joost P G Sluijter","doi":"10.1080/17435889.2025.2500913","DOIUrl":"10.1080/17435889.2025.2500913","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1825-1827"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320855/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144036788","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}
{"title":"How could the affordable, reliable and continuous production of lipid nanoparticles revolutionize healthcare?","authors":"Luke Burroughs, Diane J Burgess","doi":"10.1080/17435889.2025.2500911","DOIUrl":"10.1080/17435889.2025.2500911","url":null,"abstract":"","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1829-1833"},"PeriodicalIF":3.9,"publicationDate":"2025-08-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12320805/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"144042201","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}