Nanomedicine (London, England)最新文献_第8页

Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy.

Nanomedicine (London, England) Pub Date : 2025-02-01 Epub Date: 2025-01-23 DOI: 10.1080/17435889.2025.2452151

Yan Shan Loo, Nur Aininie Yusoh, Wai Feng Lim, Chen Seng Ng, N Idayu Zahid, Intan Diana Mat Azmi, Thiagarajan Madheswaran, Tze Yan Lee

{"title":"Phytochemical-based nanosystems: recent advances and emerging application in antiviral photodynamic therapy.","authors":"Yan Shan Loo, Nur Aininie Yusoh, Wai Feng Lim, Chen Seng Ng, N Idayu Zahid, Intan Diana Mat Azmi, Thiagarajan Madheswaran, Tze Yan Lee","doi":"10.1080/17435889.2025.2452151","DOIUrl":"10.1080/17435889.2025.2452151","url":null,"abstract":"Phytochemicals are typically natural bioactive compounds or metabolites produced by plants. Phytochemical-loaded nanocarrier systems, designed to overcome bioavailability limitations and enhance therapeutic effects, have garnered significant attention in recent years. The coronavirus disease 2019 (COVID-19) pandemic has intensified interest in the therapeutic application of phytochemicals to combat viral infections. This review explores nanoparticle-based treatment strategies incorporating phytochemicals for antiviral application, highlighting their demonstrated antiviral mechanisms. It specifically examines the antiviral activities of phytochemical-loaded nanosystems against (i) influenza virus (IAV), respiratory syncytial virus (RSV), and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2); (ii) mosquito-borne viruses [dengue (DENV), Zika (ZIKV), and Chikungunya (CHIKV)]; and (iii) sexually transmitted/blood borne viruses [e.g. herpes simplex virus (HSV), human papillomavirus (HPV), and human immunodeficiency virus (HIV)]. Furthermore, this review highlights the emerging role of these nanosystems in photodynamic therapy (PDT)-mediated attenuation of viral proliferation, and offers a perspective on the future directions of research in this promising area of multimodal therapeutic approach.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"401-416"},"PeriodicalIF":0.0,"publicationDate":"2025-02-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11812329/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"143030365","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Transforming stroke treatment through nanotherapies.

Nanomedicine (London, England) Pub Date : 2025-01-28 DOI: 10.1080/17435889.2025.2459583

Huiying Ouyang, Yuying Mu, Xing Zhou, Jianxiang Zhang

引用次数: 0

The anti-glypican 1 AT101 antibody as targeting agent to effectively deliver chitosan nanobubbles to glioblastoma cells. 以抗glypican 1 AT101抗体为靶向剂，将壳聚糖纳米泡有效递送至胶质母细胞瘤细胞。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1080/17435889.2024.2434451

Federica Di Cintio, Monica Argenziano, Anna Scomparin, Sara Capolla, Davide Busato, Aharon Steffè, Alessandro Mangogna, Daniele Sblattero, Roberta Cavalli, Paolo Macor, Michele Dal Bo, Giuseppe Toffoli

{"title":"The anti-glypican 1 AT101 antibody as targeting agent to effectively deliver chitosan nanobubbles to glioblastoma cells.","authors":"Federica Di Cintio, Monica Argenziano, Anna Scomparin, Sara Capolla, Davide Busato, Aharon Steffè, Alessandro Mangogna, Daniele Sblattero, Roberta Cavalli, Paolo Macor, Michele Dal Bo, Giuseppe Toffoli","doi":"10.1080/17435889.2024.2434451","DOIUrl":"10.1080/17435889.2024.2434451","url":null,"abstract":"Background: Recently, we developed AT101, an IgM-class mouse monoclonal antibody directed against glypican-1 (GPC1), a proteoglycan that can be considered as useful target for glioblastoma multiforme (GBM) treatment being specifically and highly expressed on GBM cell surface. Here, we proposed the use of AT101 as targeting agent in a drug delivery nanoplatfom to effectively deliver chitosan nanobubbles (NBs) for GBM treatment.Methods: Chitosan NBs were prepared and conjugated with AT101 or left unconjugated as control.Results: The ability of AT101 to bind the GPC1 protein was demonstrated by flow cytometry and immunofluorescence analysis in the \"GBM-like\" GPC1-expressing cell lines U-87 MG and T98G. AT101 was shown to bind GPC1-expressing GBM tumor samples by immunofluorescence. In-vivo experiments in the U-87 MG xenograft model showed that AT101 was able to bind GPC1 on cell surface and accumulate in U-87 MG tumor masses (p = 0.0002 respect to control). Moreover, in-vivo experiments showed that AT101 is able to target GPC1 when conjugated to chitosan NBs, thus increasing their specific deliver to GPC1-expressing cells of U-87 MG tumor, as compared to chitosan NBs not conjugated to AT101 (p = 0.02).Conclusions: AT101 is an useful targeting agent for the development of drug delivery nanoplatforms for GBM treatment.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"23-36"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775274","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Optimized strategies for precise messenger RNA delivery using site-specific lipid nanoparticle-based drug delivery systems. 使用基于位点特异性脂质纳米颗粒的药物输送系统精确输送信使 RNA 的优化策略。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-09-30 DOI: 10.1080/17435889.2024.2406218

Wei Cao, Tian Xia

引用次数: 0

Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy. 创新的纳米载体系统，用于增强癌症治疗中植物活性化合物的递送。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-20 DOI: 10.1080/17435889.2024.2440301

Khusbu Dwivedi, Ankit Sahoo, Waleed H Almalki, Salem Salman Almujri, Alhussain Aodah, Nabil K Alruwaili, Safia Obaidur Rab, Abdulkareem Ali Alanezi, Esraa M Haji, Md Abul Barkat, Tanuja Singh, Mahfoozur Rahman

{"title":"Innovative nanocarrier systems for enhanced delivery of phyto-active compounds in cancer therapy.","authors":"Khusbu Dwivedi, Ankit Sahoo, Waleed H Almalki, Salem Salman Almujri, Alhussain Aodah, Nabil K Alruwaili, Safia Obaidur Rab, Abdulkareem Ali Alanezi, Esraa M Haji, Md Abul Barkat, Tanuja Singh, Mahfoozur Rahman","doi":"10.1080/17435889.2024.2440301","DOIUrl":"10.1080/17435889.2024.2440301","url":null,"abstract":"Millions of people worldwide suffer from cancer, facing challenges such as treatments affecting healthy cells, suboptimal responses, adverse effects, recurrence risk, drug resistance, and nonspecific targeting. Chemoresistance leads to fatalities, but phytoactives show promise in cancer management despite limitations such as high metabolism, poor absorption, and high dosage requirements. Challenges in the large-scale isolation of phytoactive compounds, solubility, bioavailability, and targeting limit their development. Recent developments, including carbohydrate, lipid, and protein-based nanoparticles, have enhanced cancer treatment by improving the bioavailability and targeted delivery of phytoactives such as polyphenols, alkaloids, sulfur-containing compounds, flavonoids, and terpenes. Despite advancements, clinical application faces hurdles such as poor bioavailability and inconsistent immune responses. This article discusses the promise of phytoactive-loaded nanoformulations in cancer management, highlighting targeted drug delivery, unmet needs, and challenges. Further research is needed to overcome these challenges and fully understand the potential of phytoactives in cancer management.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"91-116"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142866547","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Nanotoxicology: developments and new insights. 纳米毒理学：发展和新见解。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-26 DOI: 10.1080/17435889.2024.2443385

Henry N Abonyi, Ikechukwu E Peter, Akachukwu M Onwuka, Paul A Achile, Chinonso B Obi, Maureen O Akunne, Paul M Ejikeme, Samson Amos, Theophine C Akunne, Anthony A Attama, Peter A Akah

{"title":"Nanotoxicology: developments and new insights.","authors":"Henry N Abonyi, Ikechukwu E Peter, Akachukwu M Onwuka, Paul A Achile, Chinonso B Obi, Maureen O Akunne, Paul M Ejikeme, Samson Amos, Theophine C Akunne, Anthony A Attama, Peter A Akah","doi":"10.1080/17435889.2024.2443385","DOIUrl":"10.1080/17435889.2024.2443385","url":null,"abstract":"The use of nanoparticles (NPs) in treatment of diseases have increased exponentially recently, giving rise to the science of nanomedicine. The safety of these NPs in humans has also led to the science of nanotoxicology. Due to a dearth of both readily available models and precise bio-dispersion characterization techniques, nanotoxicological research has obviously been constrained. However, the ensuing years were notable for the emergence of improved synthesis methods and characterization tools. Major advances have been made in linking certain physical variables, paralleling improvements in characterization size, shape, or coating factors to the resulting physiological reactions. Although significant progress has been a contribution to the development of nanotoxicology, however, it faces numerous difficulties and technical constraints distinct from those of conventional toxicological assessment as it attempts to improve the therapeutic effects of medicines. Determining thorough characterization standards, standardizing dosimetry, assessing the kinetics of ions dissolving and enhancing the accuracy of in vitro-in vivo correlation efficiency, also defining restrictions on exposure protection are some of the most important and pressing concerns. This article will explore the past advancement and potential prospects of nanotoxicology, standard models, emphasizing significant findings from earlier studies and examining current challenges, giving insight on the way forward.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"225-241"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731054/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142900777","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Application of nanoultrasonography in early diagnosis of coronary heart disease. 纳米超声在冠心病早期诊断中的应用。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-05 DOI: 10.1080/17435889.2024.2435255

Weiping Wan, Jianmin Zhou, Xiaoming Ha, Chao Han

引用次数: 0

A two-step hydrothermal method for micro/nanotextured titanium implants and their integration outcomes in goat mandible. 两步水热法制备微纳米钛植入物及其在山羊下颌骨的整合效果。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-02 DOI: 10.1080/17435889.2024.2435246

Surajit Mistry, Debarati Bhowmick, Moumita Nayek, Indrasri Das, Shuvojit Mistry, Nilendu Jyoti Maitra, Argha Rudra

{"title":"A two-step hydrothermal method for micro/nanotextured titanium implants and their integration outcomes in goat mandible.","authors":"Surajit Mistry, Debarati Bhowmick, Moumita Nayek, Indrasri Das, Shuvojit Mistry, Nilendu Jyoti Maitra, Argha Rudra","doi":"10.1080/17435889.2024.2435246","DOIUrl":"10.1080/17435889.2024.2435246","url":null,"abstract":"Background: A crucial aspect of contemporary dental implant research is modifying implant microdesign to achieve early and robust osseointegration. This study describes a new facile subtraction approach for microdesign modification of titanium implants using akali-hydrothermal followed by ion-exchange reaction (AHIE) in a salt solution, and compares osseointegration performance to machined titanium alloy (negative control) implants.Methods: The morphology, wettability, and roughness of the implant surfaces were evaluated. Twenty-four cylinders (two types/side) were inserted into the right and left mandibles of six Bengal goats in opposite order. The implant-bone interface was examined at 8 and 16 weeks following implantation using radiography, micro-computed tomography, histology, and scanning electron microscopy.Results: After AHIE treatment, average surface roughness increased marginally (p > 0.05) due to predominantly micron-scale with random nano-scale alterations, whereas wettability improved substantially (p < 0.05). In addition to micro/nano-scale defects, the AHIE treatment produced few honeycomb-like surface patterns. The AHIE implants demonstrated early and direct bone to implant body contact, and achieved stronger bone fixation in vivo than machined implants.Conclusions: Based on laboratory and in vivo data, we conclude that AHIE processing of titanium implants may be a promising technique for improving surface quality while assuring secure and effective osseointegration for dental implant.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"53-62"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142775271","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Enhanced safety and efficacy profile of CD40 antibody upon encapsulation in pHe-triggered membrane-adhesive nanoliposomes. 在ph触发的膜粘附纳米脂质体中包封CD40抗体增强了安全性和有效性。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-29 DOI: 10.1080/17435889.2024.2446008

Salma Althobaiti, Prahlad Parajuli, Duy Luong, Samaresh Sau, Lisa A Polin, Seongho Kim, Yubin Ge, Arun K Iyer, Navnath S Gavande

{"title":"Enhanced safety and efficacy profile of CD40 antibody upon encapsulation in pHe-triggered membrane-adhesive nanoliposomes.","authors":"Salma Althobaiti, Prahlad Parajuli, Duy Luong, Samaresh Sau, Lisa A Polin, Seongho Kim, Yubin Ge, Arun K Iyer, Navnath S Gavande","doi":"10.1080/17435889.2024.2446008","DOIUrl":"10.1080/17435889.2024.2446008","url":null,"abstract":"Aim: To develop pH (pHe)-triggered membrane adhesive nanoliposome (pHTANL) of CD40a to enhance anti-tumor activity in pancreatic cancer while reducing systemic toxicity.Materials and methods: A small library of nanoliposomes (NL) with various lipid compositions were synthesized to prepare pH (pHe)-triggered membrane adhesive nanoliposome (pHTANL). Physical and functional characterization of pHTANL-CD40a was performed via dynamic light scattering (DLS), Transmission Electron Microscopy (TEM), confocal microscopy, and flow cytometry. In vivo studies were performed using PDAC (Panc02) transplanted mice. Tumor tissue was analyzed by flow cytometry, and plasma cytokines and liver enzymes were analyzed by ELISA.Results: pHTANL-CD40a reduced tumor growth, enhanced tumor immune infiltration/activation, and enhanced survival compared to vehicle and free-CD40a. Importantly, pHTANL-CD40a treatment resulted in significantly lower systemic toxicity as indicated by unchanged body weight, minimal organ deformity, and reduced serum levels of liver enzyme alanine transaminase (ALT) and inflammatory cytokine IL-6.Conclusion: pHTANL-CD40a is more effective than free CD40a in anti-tumor activity, especially in altering the TME immune landscape for a potential therapeutic benefit in combination with immunotherapy.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":"20 2","pages":"155-166"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731328/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142985651","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advancements in nanotechnology for diagnostics: a literature review, part II: advanced techniques in nuclear and optical imaging. 纳米技术用于诊断的进展：文献综述，第二部分：核和光学成像的先进技术。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-13 DOI: 10.1080/17435889.2024.2439778

Ahmad Butt, Horacio Bach

{"title":"Advancements in nanotechnology for diagnostics: a literature review, part II: advanced techniques in nuclear and optical imaging.","authors":"Ahmad Butt, Horacio Bach","doi":"10.1080/17435889.2024.2439778","DOIUrl":"10.1080/17435889.2024.2439778","url":null,"abstract":"Modern molecular imaging routes, such as nuclear imaging and optical imaging, derive significant advantages from nanoparticles, where multimodality use and multipurpose are key benefits. Nanoparticles also showcase benefits over traditional imaging agents in nuclear and optical imaging, including improved resolution, penetration, and specificity. The goal of this literature review was to explore recent advancements in nanomaterials within these molecular imaging techniques to expand on the current state of nanomedicine in these modalities. This review derives findings from relevant reviews, original research papers, in-human clinical trials, and patents in the literature. Au- and Fe oxide-based nanosystems are just as ubiquitous within more modern modalities due to their multimodal diagnostic and therapeutic potential. It is also repeatedly highlighted in the literature, patents, and clinical trials that the use of nanoparticles, specifically in multimodal imaging techniques and theranostics, present innovative methods in recent years, enabling researchers and clinicians to overcome the limitations of unimodal imaging modalities and further advancing accuracy in the diagnosis and treatment of important pathologies, particularly cancer. Overall, nanoparticle-based imaging represents a transformative approach in advanced imaging modalities, offering new approaches to limitations of conventional agents currently being applied in clinical settings.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"183-206"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730800/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142820318","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0