Nanomedicine (London, England)最新文献_第9页

Ultrasmall solid lipid nanoparticles as a potential innovative delivery system for a drug combination against glioma. 超小固体脂质纳米颗粒作为一种潜在的创新给药系统，用于联合治疗胶质瘤。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-11-29 DOI: 10.1080/17435889.2024.2434452

Luigi Battaglia, Chiara Dianzani, Elisabetta Muntoni, Elisabetta Marini, Annalisa Bozza, Valentina Bordano, Chiara Ferraris, Sara Garelli, Maria Carmen Valsania, Enzo Terreno, Martina Capozza, Diana Costanzo, Maria Teresa Capucchio, Talal Hassan, Stefania Pizzimenti, Elisa Pettineo, Maria Di Muro, Franco Scorziello

{"title":"Ultrasmall solid lipid nanoparticles as a potential innovative delivery system for a drug combination against glioma.","authors":"Luigi Battaglia, Chiara Dianzani, Elisabetta Muntoni, Elisabetta Marini, Annalisa Bozza, Valentina Bordano, Chiara Ferraris, Sara Garelli, Maria Carmen Valsania, Enzo Terreno, Martina Capozza, Diana Costanzo, Maria Teresa Capucchio, Talal Hassan, Stefania Pizzimenti, Elisa Pettineo, Maria Di Muro, Franco Scorziello","doi":"10.1080/17435889.2024.2434452","DOIUrl":"10.1080/17435889.2024.2434452","url":null,"abstract":"Introduction: High grade gliomas are characterized by a very poor prognosis due to fatal relapses after surgery. Current chemotherapy is only a palliative care, while potential drug candidates are limited by poor overcoming of the blood-brain barrier.Aims: A suitable chemotherapeutic approach should be engineered to overcome both the altered blood-brain barrier in the glioma site, as well as the intact one in the brain adjacent to tumor zone, and to target the multiple factors influencing glioma proliferation, differentiation, migration, and angiogenesis.Materials & methods: In this experimental research, ultrasmall solid lipid nanoparticles were prepared owing to the temperature phase inversion technology and loaded with a specific drug combination made of paclitaxel, regorafenib, and nanoceria.Results: Such solid lipid nanoparticles demonstrated capability to inhibit glioma cell proliferation and migration, as well as angiogenesis in vitro. Moreover, relevant in vivo evidence assessed the accumulation of solid lipid nanoparticles in the glioma site of the F98/Fischer rat model, without causing any off-target toxicity.Conclusions: Thus, promising results for glioma treatment were obtained with a technology characterized by safety and economy, allowing the perspective of successful scalability.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"37-52"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142752598","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Overcoming challenges in the design of drug delivery systems targeting the central nervous system. 克服以中枢神经系统为目标的给药系统设计中的挑战。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-11-20 DOI: 10.1080/17435889.2024.2421157

Abdulmajeed G Almutary, Payal Chauhan, Lalji Baldaniya, Soumya V Menon, M Ravi Kumar, Bhumi Chaturvedi, Naveen Sharma, Ashish Singh Chauhan, Mosleh Mohammad Abomughaid, Dhivyadharshni M, Ana Cláudia Paiva-Santos, Sorabh Lakhanpal, Niraj Kumar Jha

引用次数: 0

Evaluation of curcumin nanoparticles of various sizes for targeting multidrug-resistant lung cancer cells via inhalation. 不同大小的姜黄素纳米颗粒经吸入靶向多药耐药肺癌细胞的评价。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1080/17435889.2024.2439241

Ching-Yee Loo, Daniela Traini, Paul M Young, Stewart Yeung, Chean Ring Leong, Wing-Hin Lee

{"title":"Evaluation of curcumin nanoparticles of various sizes for targeting multidrug-resistant lung cancer cells via inhalation.","authors":"Ching-Yee Loo, Daniela Traini, Paul M Young, Stewart Yeung, Chean Ring Leong, Wing-Hin Lee","doi":"10.1080/17435889.2024.2439241","DOIUrl":"10.1080/17435889.2024.2439241","url":null,"abstract":"Introduction: Inhalation drug delivery can deliver high doses of chemotherapeutic drugs to the lung tumor. This study evaluates the efficacy and the mechanistic pathways of nebulized Cur NPs at various sizes to treat multidrug resistant lung cancer.Methods and results: Cur-NPs (30 nm and 200 nm) were nebulized separately onto the multidrug-resistant lung cancer cells (H69AR). Smaller NPs induced significantly higher cell death owing to a higher rate of particle internalization via dynamin-dependent clathrin-mediated endocytosis. Owing to the higher lysosome trafficking of Cur-NP30 nm compared to Cur-NP200 nm, oxidation of lysosome was higher (0.47 ± 0.08 vs 0.38 ± 0.08), contributing to significantly higher mitochondrial membrane potential loss (1.57 ± 0.17 vs 1.30 ± 0.11). MRP1 level in H69AR cells was reduced from 352 ± 12.3 ng/µg of protein (untreated cells) to 287 ± 12 ng/µg of protein (Cur-NP30 nm) and 303 ± 13.4 ng/µg of protein (Cur-NP200 nm). NF-κB, and various cytokine expressions were reduced after treatment with nebulized Cur-NPs.Conclusions: Nebulized Cur-NPs formulations could be internalized into the H69AR cells. The Cur-NPs toxicity toward the H69AR was size and time-dependent. Cur-NP30 nm was more effective than Cur-NP200 nm to retain within the cells to exert higher oxidative stresss-induced cell death.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"141-153"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731332/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808871","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Synthesis and characterization of poly (β-amino ester) polyplex nanocarrier with high encapsulation and uptake efficiency: impact of extracellular conditions. 高包封和吸收效率的聚（β-氨基酯）复合纳米载体的合成与表征：胞外条件的影响。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-16 DOI: 10.1080/17435889.2024.2440307

Alireza Gharatape, Hamid Sadeghi-Abandansari, Hossein Ghanbari, Mohsen Basiri, Reza Faridi-Majidi

{"title":"Synthesis and characterization of poly (β-amino ester) polyplex nanocarrier with high encapsulation and uptake efficiency: impact of extracellular conditions.","authors":"Alireza Gharatape, Hamid Sadeghi-Abandansari, Hossein Ghanbari, Mohsen Basiri, Reza Faridi-Majidi","doi":"10.1080/17435889.2024.2440307","DOIUrl":"10.1080/17435889.2024.2440307","url":null,"abstract":"Background: Poly (β-amino Ester) nanocarriers show promise for gene therapy, but their effectiveness can be limited by the environment within the body. This study aims to understand how common cell culture media components affect optimized PBAE nanocarrier performance in gene delivery.Methods: Optimized PBAE was synthesized based on Michael addition reaction and characterized by different assays, this study employed techniques like DLS and TEM to characterize PBAE nanocarriers, followed by cellular uptake analysis (flow cytometry and confocal imaging) and evaluation of gene expression under different polymer/DNA ratio ratios and media conditions.Results: The nanocarriers exhibited size under 200 nm and surface positive charge, with high encapsulation efficiency (up to 95%). Cellular uptake, transfection efficiency, and cytotoxicity were evaluated. Flow cytometry analysis revealed high cellular uptake (over 77% at 1 hour and up to 95% after 3 hours) and good viability. Transfection efficiency reached up to 80% with 2 μg DNA, particularly at weight ratios of 60 and 90.Conclusion: The study also identified factors affecting transfection efficiency, including serum concentration and antibiotics in the culture medium, highlighting the importance of optimizing these conditions for future applications.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"125-139"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11730802/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142830994","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Advances in Alzheimer's disease control approaches via carbon nanotubes. 通过碳纳米管控制阿尔茨海默氏症的研究进展。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-11-28 DOI: 10.1080/17435889.2024.2432855

Jinxia Cai, Bowen Li, Jie Zhang, Guoqing Feng, Yanqing Liu, Haojun Fan, Bin Zheng

{"title":"Advances in Alzheimer's disease control approaches via carbon nanotubes.","authors":"Jinxia Cai, Bowen Li, Jie Zhang, Guoqing Feng, Yanqing Liu, Haojun Fan, Bin Zheng","doi":"10.1080/17435889.2024.2432855","DOIUrl":"10.1080/17435889.2024.2432855","url":null,"abstract":"Global concern about Alzheimer's disease (AD) is justified by its increasingly younger onset and significant economic burden. AD leads to neurodegeneration and cognitive decline, ultimately resulting in loss of autonomy. Against this background, the field of biomedical research has seen a surge of interest in the potential of carbon-based nanomaterials, mainly due to their ease of degradation and high biocompatibility. Carbon nanotubes (CNTs) have been extensively studied in AD, including developing biosensors, drug delivery systems, and molecular imaging. Here, we introduced the biosafety and biodegradability of CNTs, with a particular focus on their uptake and degradation in brain tissue. The utilization of CNT in the context of AD therapy can facilitate the advancement of control approaches regimens and ensure the clinical safety of patients. This is achieved through the employment of these nanotubes as carriers for the delivery of drugs to the central nervous system (CNS), the detection of neurotransmitters such as acetylcholine (Ach) and monoamines, the development of biosensors and molecular imaging materials, the inhibition of Aβ formation and the detection of phosphorylated tau proteins, the promotion of CNS regeneration, and the modulation of ion-associated AD.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"63-77"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142741710","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Lipid-based nanosystems: a pivotal solution in drug delivery. 脂基纳米系统：药物输送的关键解决方案。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-11-14 DOI: 10.1080/17435889.2024.2426969

Marie Gabriele Santiago, Letícia Rocha de Moura, Yamara Viana Sousa, Caroline Dohanik da Silva, Gisele Assis Castro Goulart

引用次数: 0

Nanomedicine and clinical diagnostics part I: applications in conventional imaging (MRI, X-ray/CT, and ultrasound). 纳米医学和临床诊断第1部分：在常规成像（MRI， x射线/CT和超声）中的应用。

Nanomedicine (London, England) Pub Date : 2025-01-01 Epub Date: 2024-12-11 DOI: 10.1080/17435889.2024.2439776

Ahmad Butt, Horacio Bach

{"title":"Nanomedicine and clinical diagnostics part I: applications in conventional imaging (MRI, X-ray/CT, and ultrasound).","authors":"Ahmad Butt, Horacio Bach","doi":"10.1080/17435889.2024.2439776","DOIUrl":"10.1080/17435889.2024.2439776","url":null,"abstract":"Integrating nanotechnologies in diagnostic imaging presents a promising step forward compared to traditional methods, which carry certain limitations. Conventional imaging routes, such as X-ray/computed tomography and magnetic resonance imaging, derive significant advantages from nanoparticles (NPs), which allow researchers and clinicians to overcome some of the limitations of traditional imaging agents. In this literature review, we explore recent advancements in nanomaterials being applied in conventional diagnostic imaging techniques by exploring relevant reviews and original research papers (e.g. experimental models and theoretical model studies) in the literature. Collectively, there are numerous nanomaterials currently being examined for use in conventional imaging modalities, and each imaging technique has unique NPs with properties that can be manipulated to answer an array of clinical questions specific to that imaging modality. There are still challenges to consider, including getting regulatory approval for clinical research and routine use about long-term biocompatibility, which collectively emphasize the need for continued research to facilitate the integration of nanotechnology into routine clinical practice. Most importantly, there is a continued need for strong, collaborative efforts between researchers, biomedical engineers, clinicians, and industry stakeholders, which are necessary to bridge the persistent gap between translational ideas and implementation in clinical settings.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"167-182"},"PeriodicalIF":0.0,"publicationDate":"2025-01-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC11731363/pdf/","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142808874","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"OA","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0

Exploring the role of hydrogel scaffolds in cardiac regeneration: emphasis on natural extracellular matrix components. 探索水凝胶支架在心脏再生中的作用：强调天然细胞外基质成分。

Nanomedicine (London, England) Pub Date : 2024-12-17 DOI: 10.1080/17435889.2024.2443384

Elsa N Garza-Treviño, Michelle G Santoyo-Suarez, Jose F Islas

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Correction. 更正。

Nanomedicine (London, England) Pub Date : 2024-11-24 DOI: 10.1080/17435889.2024.2433864

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Harnessing the power of targeted metal nanocarriers mediated photodynamic and photothermal therapy. 利用靶向金属纳米载体介导的光动力和光热疗法。

Nanomedicine (London, England) Pub Date : 2024-11-15 DOI: 10.1080/17435889.2024.2419820

Jyoti Chandra, Nazim Nasir, Shadma Wahab, Amirhossein Sahebkar, Prashant Kesharwani

{"title":"Harnessing the power of targeted metal nanocarriers mediated photodynamic and photothermal therapy.","authors":"Jyoti Chandra, Nazim Nasir, Shadma Wahab, Amirhossein Sahebkar, Prashant Kesharwani","doi":"10.1080/17435889.2024.2419820","DOIUrl":"https://doi.org/10.1080/17435889.2024.2419820","url":null,"abstract":"The treatment of cancer has become a profoundly intricate procedure. Traditional treatment methods, including chemotherapy, surgery and radiotherapy, have been utilized, while notable progress has been achieved in recent years. Among targeted therapies for cancer, folic acid (FA) conjugated metal-based nanoparticles (NP) have emerged as an innovative strategy, namely for photodynamic therapy (PDT) and photothermal therapy (PTT). These NP exploit the strong attraction between FA and folate receptors, which are excessively produced in several cancer cells, in order to enable precise administration and improved effectiveness of treatment. During PDT, metal-based NP functionalized with FA are used as photosensitizers which are activated by light, and produce reactive oxygen species that cause cancer cells to undergo apoptosis. Within the framework of PTT, these NP effectively transform light energy into concentrated heat, specifically targeting and destroying tumor cells. This review examines the fundamental mechanisms by which these NP improve the effectiveness of PDT and PTT while simultaneously presenting important findings that demonstrate the effectiveness of FA-functionalized MNP in laboratory and animal models. In addition, the paper also discusses the problems and potential directions for their clinical translation.","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1-19"},"PeriodicalIF":0.0,"publicationDate":"2024-11-15","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":null,"resultStr":null,"platform":"Semanticscholar","paperid":"142640185","PeriodicalName":null,"FirstCategoryId":null,"ListUrlMain":null,"RegionNum":0,"RegionCategory":"","ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":"","EPubDate":null,"PubModel":null,"JCR":null,"JCRName":null,"Score":null,"Total":0}

引用次数: 0