Lorenzo Chiaverini, Giarita Ferraro, Riccardo Di Leo, Elisabetta Barresi, Diego La Mendola, Francesco Bartoli, Luca Famlonga, Cristina Satriano, Pinuccia Faviana, Alessandro Zucchi, Matteo Pacini, Jürgen Gailer, Chiara Giacomelli, Tiziano Marzo
{"title":"From conventional therapy to novel nano-based approaches. A focus on prostate cancer.","authors":"Lorenzo Chiaverini, Giarita Ferraro, Riccardo Di Leo, Elisabetta Barresi, Diego La Mendola, Francesco Bartoli, Luca Famlonga, Cristina Satriano, Pinuccia Faviana, Alessandro Zucchi, Matteo Pacini, Jürgen Gailer, Chiara Giacomelli, Tiziano Marzo","doi":"10.1080/17435889.2025.2501513","DOIUrl":null,"url":null,"abstract":"<p><p>The currently available clinical anticancer approaches pertaining to the treatment of prostate cancer are summarized here. After providing an overview of the main features of this highly impactful global disease, the currently available clinical treatments are briefly reviewed. Then, alternative and innovative nano-based therapeutic options that have been proposed or are currently being explored to significantly improve prostate cancer management (i.e. anti-prostate cancer polymeric nanoparticles loaded with drugs to promote their release and biological activity, including non-targeted and functionalized PLGA-PEG NPs and AuNPs), are introduced. Furthermore, the problem of gathering insights into the mechanistic aspects related to the fate of the nanoformulation in complex matrices, such as blood plasma, is addressed.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"1355-1372"},"PeriodicalIF":0.0000,"publicationDate":"2025-06-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine (London, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17435889.2025.2501513","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/5/7 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
The currently available clinical anticancer approaches pertaining to the treatment of prostate cancer are summarized here. After providing an overview of the main features of this highly impactful global disease, the currently available clinical treatments are briefly reviewed. Then, alternative and innovative nano-based therapeutic options that have been proposed or are currently being explored to significantly improve prostate cancer management (i.e. anti-prostate cancer polymeric nanoparticles loaded with drugs to promote their release and biological activity, including non-targeted and functionalized PLGA-PEG NPs and AuNPs), are introduced. Furthermore, the problem of gathering insights into the mechanistic aspects related to the fate of the nanoformulation in complex matrices, such as blood plasma, is addressed.
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