{"title":"Emerging self-assembled peptide hydrogels for enhanced wound healing.","authors":"Zixin Yang, Yinglu Wang, Hu Zhu","doi":"10.1080/17435889.2025.2544535","DOIUrl":null,"url":null,"abstract":"<p><p>Wound healing, particularly in chronic conditions such as diabetic ulcers, burns, and pressure injuries, represents a highly intricate and clinically challenging process. These wounds frequently exhibit persistent pathological inflammation, disrupting conventional healing trajectories and significantly compromising patient well-being. Consequently, the development of innovative therapeutic interventions is urgently needed. Self-assembling peptide-based hydrogels have emerged as novel biomaterials, demonstrating exceptional promise in wound management. This article reviews recent advancements in the design and application of self-assembling peptide-based hydrogels, with a focused analysis of their roles in antibacterial activity, hemostasis, and enhancing tissue regeneration. Engineered to exhibit injectability, controlled drug release, spatiotemporal targeting, stimuli-responsive behavior, and biocompatibility, these hydrogels enable precise, dynamic, and patient-tailored therapeutic strategies. By integrating peptide self-assembly with biomedical insights, this article highlights how peptide-based hydrogels address critical limitations in conventional wound care, offering scalable solutions to improve healing outcomes.</p>","PeriodicalId":74240,"journal":{"name":"Nanomedicine (London, England)","volume":" ","pages":"2217-2236"},"PeriodicalIF":3.9000,"publicationDate":"2025-09-01","publicationTypes":"Journal Article","fieldsOfStudy":null,"isOpenAccess":false,"openAccessPdf":"https://www.ncbi.nlm.nih.gov/pmc/articles/PMC12407649/pdf/","citationCount":"0","resultStr":null,"platform":"Semanticscholar","paperid":null,"PeriodicalName":"Nanomedicine (London, England)","FirstCategoryId":"1085","ListUrlMain":"https://doi.org/10.1080/17435889.2025.2544535","RegionNum":0,"RegionCategory":null,"ArticlePicture":[],"TitleCN":null,"AbstractTextCN":null,"PMCID":null,"EPubDate":"2025/8/13 0:00:00","PubModel":"Epub","JCR":"","JCRName":"","Score":null,"Total":0}
引用次数: 0
Abstract
Wound healing, particularly in chronic conditions such as diabetic ulcers, burns, and pressure injuries, represents a highly intricate and clinically challenging process. These wounds frequently exhibit persistent pathological inflammation, disrupting conventional healing trajectories and significantly compromising patient well-being. Consequently, the development of innovative therapeutic interventions is urgently needed. Self-assembling peptide-based hydrogels have emerged as novel biomaterials, demonstrating exceptional promise in wound management. This article reviews recent advancements in the design and application of self-assembling peptide-based hydrogels, with a focused analysis of their roles in antibacterial activity, hemostasis, and enhancing tissue regeneration. Engineered to exhibit injectability, controlled drug release, spatiotemporal targeting, stimuli-responsive behavior, and biocompatibility, these hydrogels enable precise, dynamic, and patient-tailored therapeutic strategies. By integrating peptide self-assembly with biomedical insights, this article highlights how peptide-based hydrogels address critical limitations in conventional wound care, offering scalable solutions to improve healing outcomes.