Emerging self-assembled peptide hydrogels for enhanced wound healing.

IF 3.9
Nanomedicine (London, England) Pub Date : 2025-09-01 Epub Date: 2025-08-13 DOI:10.1080/17435889.2025.2544535
Zixin Yang, Yinglu Wang, Hu Zhu
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引用次数: 0

Abstract

Wound healing, particularly in chronic conditions such as diabetic ulcers, burns, and pressure injuries, represents a highly intricate and clinically challenging process. These wounds frequently exhibit persistent pathological inflammation, disrupting conventional healing trajectories and significantly compromising patient well-being. Consequently, the development of innovative therapeutic interventions is urgently needed. Self-assembling peptide-based hydrogels have emerged as novel biomaterials, demonstrating exceptional promise in wound management. This article reviews recent advancements in the design and application of self-assembling peptide-based hydrogels, with a focused analysis of their roles in antibacterial activity, hemostasis, and enhancing tissue regeneration. Engineered to exhibit injectability, controlled drug release, spatiotemporal targeting, stimuli-responsive behavior, and biocompatibility, these hydrogels enable precise, dynamic, and patient-tailored therapeutic strategies. By integrating peptide self-assembly with biomedical insights, this article highlights how peptide-based hydrogels address critical limitations in conventional wound care, offering scalable solutions to improve healing outcomes.

新兴的自组装肽水凝胶促进伤口愈合。
伤口愈合,特别是慢性疾病,如糖尿病溃疡、烧伤和压伤,是一个非常复杂和具有临床挑战性的过程。这些伤口经常表现出持续的病理性炎症,破坏传统的愈合轨迹,并显著损害患者的健康。因此,迫切需要开发创新的治疗干预措施。自组装肽基水凝胶已成为一种新型生物材料,在伤口管理方面表现出非凡的前景。本文综述了自组装肽基水凝胶的设计和应用的最新进展,重点分析了它们在抗菌活性、止血和促进组织再生方面的作用。这些水凝胶具有注射性、药物释放控制、时空靶向性、刺激反应行为和生物相容性,能够实现精确、动态和针对患者的治疗策略。通过将多肽自组装与生物医学见解相结合,本文重点介绍了基于多肽的水凝胶如何解决传统伤口护理中的关键限制,提供可扩展的解决方案以改善愈合结果。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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