Emerging anti-inflammatory nanosystems targeted to the brain.

IF 3.9
Nanomedicine (London, England) Pub Date : 2025-09-01 Epub Date: 2025-08-26 DOI:10.1080/17435889.2025.2552103
Arun Kumar Mahanta, Avinash Gothwal, Bivek Chaulagain, Chinenye Edith Muolokwu, Benjamin Tagoe, Babita Lamsal, Matheus Belin, Jagdish Singh
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Abstract

The neuroinflammation hypothesis suggests that neuroinflammation plays an important role in the progression of neurodegenerative diseases. Neuroinflammation is induced by several factors such as stimulatory signals derived from injured/dying cells, aggregated/modified proteins, and inflammatory mediators, including both proinflammatory and anti-inflammatory compounds produced by infiltrating immune cells such as microglia and astrocytes. Controlling the neuroinflammation in the brain might be a fruitful therapeutic strategy to manage the different kinds of neurodegenerative disorders. The delivery of anti-inflammatory agents to the brain is one of the challenging tasks in managing neuroinflammation due to the presence of the blood-brain barrier (BBB), which restricts the entry of the anti-inflammatory agent to the brain. With the advancement of nanoscience and nanotechnology, nanoparticle-based therapeutics are drawing great attention over conventional therapies, including high biocompatibility, more precise targeting, and the ability to cross the BBB. This review summarizes the recent progress in nanotechnology to deliver anti-inflammatory agents to the brain for the management of neurodegenerative disorders associated with neuroinflammation.

针对大脑的新兴抗炎纳米系统。
神经炎症假说提示神经炎症在神经退行性疾病的进展中起重要作用。神经炎症是由多种因素引起的,如来自损伤/死亡细胞的刺激信号、聚集/修饰的蛋白质和炎症介质,包括浸润免疫细胞(如小胶质细胞和星形胶质细胞)产生的促炎和抗炎化合物。控制大脑中的神经炎症可能是治疗各种神经退行性疾病的有效治疗策略。由于血脑屏障(BBB)的存在限制了抗炎药进入大脑,抗炎药的输送到大脑是治疗神经炎症的一项具有挑战性的任务。随着纳米科学和纳米技术的进步,基于纳米粒子的治疗方法比传统治疗方法更受关注,因为它具有高生物相容性、更精确的靶向性和跨越血脑屏障的能力。本文综述了纳米技术在治疗与神经炎症相关的神经退行性疾病方面的最新进展。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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