Considering the immunogenicity of PEG: strategies for overcoming issues with PEGylated nanomedicines.

IF 3.9
Nanomedicine (London, England) Pub Date : 2025-09-01 Epub Date: 2025-07-29 DOI:10.1080/17435889.2025.2538423
Kouichi Shiraishi
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Abstract

In the field of nanomedicine, there is considerable familiarity with both the various applications of poly(ethylene glycol) (PEG) and the related topic of anti-PEG antibodies (anti-PEG Abs). The worldwide spread of mRNA-LNP vaccines has focused much attention on the sometimes problematic relationship between immune responses and the various possible pharmacological uses of PEG. In this paper, which is a perspective review, I summarize the properties of PEG, the properties of anti-PEG Abs, and the various methods for evaluating the relationship between these two factors. I then offer suggestions for addressing the adverse effects that anti-PEG Abs have on the medicinal power of PEGylated nanomedicines. Ultimately, by exploring important developments in the above areas, this review offers an organized, synthesized presentation of information that should prove useful for the development of nanomedicines.

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考虑聚乙二醇的免疫原性:克服聚乙二醇化纳米药物问题的策略。
在纳米医学领域,人们对聚乙二醇(PEG)的各种应用以及抗PEG抗体(anti-PEG Abs)的相关主题都相当熟悉。mRNA-LNP疫苗在世界范围内的传播使人们更加关注免疫反应与PEG各种可能的药理用途之间有时存在问题的关系。本文对聚乙二醇的性质、抗聚乙二醇抗体的性质以及评价这两个因素之间关系的各种方法进行了综述。然后,我提出了解决抗peg抗体对聚乙二醇化纳米药物药效的不利影响的建议。最后,通过探索上述领域的重要发展,本综述提供了一个有组织的、综合的信息展示,这些信息将被证明对纳米药物的发展有用。
本文章由计算机程序翻译,如有差异,请以英文原文为准。
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